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1. 发明申请

US20170360850A1 PROBIOTIC ORGANISMS FOR DIAGNOSIS, MONITORING, AND TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
公开(公告)号：US20170360850A1
公开(公告)日：2017-12-21
申请号：US15535831
申请日：2015-12-22
申请人： Massachusetts Institute of Technology , Synlogic, Inc.
发明人： Timothy Kuan-Ta Lu , Jacob Rosenblum Rubens , Isaak Elis Mueller , Gianluca Selvaggio , Paul Miller , Dean Falb , Vincent Isabella , Jonathan Kotula
IPC分类号： A61K35/741 , C07K16/24 , C07K14/54 , A61K39/395 , A61K38/20 , A61K36/064 , A61K31/122 , C12N15/70 , A61K9/00
CPC分类号： A61K35/741 , A61K9/0053 , A61K31/122 , A61K35/74 , A61K36/064 , A61K38/19 , A61K38/204 , A61K38/2066 , A61K39/3955 , C07K14/5428 , C07K16/241 , C12N15/63 , C12N15/70 , G01N33/573 , G01N33/6863
摘要： Aspects of the present disclosure relate to genetically engineered organisms useful for the diagnosis and treatment of inflammatory bowel disease.

2. 发明申请

US20170362599A1 FRONT-END ANALOG SIGNAL PROCESSING FOR CELLULAR COMPUTATION 审中-公开
公开(公告)号：US20170362599A1
公开(公告)日：2017-12-21
申请号：US15535804
申请日：2015-12-22
申请人： Massachusetts Institute of Technology
发明人： Ramez Daniel , Timothy Kuan-Ta Lu , Jacob Rosenblum Rubens
IPC分类号： C12N15/63 , C12Q1/68 , C12N15/70
CPC分类号： C12N15/635 , C12N15/63 , C12N15/70 , C12Q1/6897
摘要： Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.

3. 发明申请

US20170335411A1 CORRECTING CROSSTALK IN BIOLOGICAL SYSTEMS 审中-公开
公开(公告)号：US20170335411A1
公开(公告)日：2017-11-23
申请号：US15521917
申请日：2015-10-27
申请人： Massachusetts Institute of Technology
发明人： Timothy Kuan-Ta Lu , Isaak Elis Mueller , Jacob Rosenblum Rubens
IPC分类号： C12Q1/68 , C12N15/70 , C12N9/50 , G06N3/00 , C07K14/245
CPC分类号： C12Q1/6897 , C07K14/245 , C07K2319/50 , C12N9/506 , C12N15/70 , C12Y304/22044 , G06N3/002 , G16B50/00
摘要： Aspects of the present disclosure are directed to biosensing circuits that correct crosstalk.

4. 发明申请

US20150087055A1 ANALOG AND MIXED-SIGNAL COMPUTATION AND CIRCUITS IN LIVING CELLS 审中-公开
标题翻译：模拟和混合信号计算和电路在生活细胞
公开(公告)号：US20150087055A1
公开(公告)日：2015-03-26
申请号：US14391817
申请日：2013-04-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Rahul Sarpeshkar , Timothy Kuan-Ta Lu , Ramez Danial , Jacob Rosenblum Rubens
IPC分类号： G06N3/00
CPC分类号： G06N3/002 , B82Y10/00
摘要： Provided herein are molecular analog gene circuits that exploit positive and negative feedback to implement logarithmically linear sensing, addition, subtraction, and scaling thus enabling multiplicative, ratiometric, and power-law computations. The circuits exhibit Weber's Law behavior as in natural biological systems, operate over a wide dynamic range of up to four orders of magnitude, and can be architected to have tunable transfer functions. The molecular circuits described herein can be composed together to implement higher-order functions that are well-described by both intricate biochemical models and by simple mathematical functions. The molecular circuits described herein enable logarithmically linear analog computation within in-vitro and in-vivo systems with a broad class of molecules, all of which obey the Boltzmann exponential equations of thermodynamics that govern molecular association, attenuation, transformation, and degradation.
摘要翻译：本文提供了分子模拟基因电路，其利用正反馈来实现对数线性感测，加法，减法和缩放，从而实现乘法，比例和幂律计算。电路表现出韦伯定律的行为，如在自然生物系统中，在多达四个数量级的宽动态范围内运行，并且可以被设计为具有可调谐的传递函数。本文描述的分子电路可以组合在一起以实现由复杂的生物化学模型和简单的数学函数所描述的高阶函数。本文描述的分子电路能够在具有广泛分子类型的体外和体内系统中进行对数线性模拟计算，所有这些分子都遵守支配分子缔合，衰减，转化和降解的热力学的Boltzmann指数方程。

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