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1. 发明授权

US06630991B2 Thermal processing apparatus 失效
公开(公告)号：US06630991B2
公开(公告)日：2003-10-07
申请号：US09838566
申请日：2001-04-20
申请人： Masayuki Kitamura , Eisuke Morisaki , Yun Mo
发明人： Masayuki Kitamura , Eisuke Morisaki , Yun Mo
IPC分类号： G01J548
CPC分类号： H01L21/67248 , G01J5/0003
摘要： A method of detecting a temperature of an object in a multiple-reflection environment by a radiation pyrometer includes the steps of detecting a radiation strength emitted from a target region of an object, applying a correction to the radiation strength so as to correct the effect of multiple reflections of a radiation emitted from the object, applying a correction to the radiation strength so as to correct a reflection loss caused at an end surface of an optical medium interposed between the object and a sensing head of the pyrometer, applying a correction to the radiation strength with regard to an optical absorption loss caused in the optical medium, and applying a correction to the radiation strength with regard to a stray radiation coming in to the sensing head from a source other than the target region of the object.

2. 外观设计

USD580901S1 Handset 有权
公开(公告)号：USD580901S1
公开(公告)日：2008-11-18
申请号：US29282638
申请日：2007-07-25
申请人： Bin Su , Yun Mo , Zhiyan Yang
设计人： Bin Su , Yun Mo , Zhiyan Yang

3. 发明申请

US20110059903A1 Formulations Comprising Linaclotide 有权
标题翻译：含有利那洛肽的制剂
公开(公告)号：US20110059903A1
公开(公告)日：2011-03-10
申请号：US12851330
申请日：2010-08-05
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
IPC分类号： A61K38/12 , A61P1/00
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含利那洛肽的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

4. 外观设计

USD586772S1 Handset 有权
公开(公告)号：USD586772S1
公开(公告)日：2009-02-17
申请号：US29282636
申请日：2007-07-25
申请人： Bin Su , Yun Mo , Zhiyan Yang
设计人： Bin Su , Yun Mo , Zhiyan Yang

5. 发明授权

US08802628B2 Stable solid formulation of a GC-C receptor agonist polypeptide suitable for oral administration 有权
标题翻译：适用于口服给药的GC-C受体激动剂多肽的稳定的固体制剂
公开(公告)号：US08802628B2
公开(公告)日：2014-08-12
申请号：US12541410
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
IPC分类号： A61K38/10 , A61P1/00
CPC分类号： A61J3/00 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/167 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译：适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”; SEQ ID NO：1）或其药学上可接受的盐组成的多肽。本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

6. 发明申请

US20130012454A1 Orally Disintegrating Compositions of Linaclotide 审中-公开
标题翻译：立即排卵组合物
公开(公告)号：US20130012454A1
公开(公告)日：2013-01-10
申请号：US13389919
申请日：2010-08-11
申请人： Yun Mo , Mahendra Dedhiya , Anil Chhettry , Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
发明人： Yun Mo , Mahendra Dedhiya , Anil Chhettry , Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao
IPC分类号： A61K38/12 , A61P1/10 , A61P1/00
CPC分类号： A61K38/12 , A61K38/10
摘要： The present invention relates to orally disintegrating or dissolving pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及口服崩解或溶解包含利那洛肽或其药学上可接受的盐的药物组合物，以及用于制备和使用组合物的各种方法和方法。

7. 发明授权

US08748573B2 Formulations comprising linaclotide 有权
标题翻译：包含利那洛肽的制剂
公开(公告)号：US08748573B2
公开(公告)日：2014-06-10
申请号：US12851330
申请日：2010-08-05
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： A61K9/50 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： The present invention relates to stable compositions comprising linaclotide, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含利那洛肽的稳定组合物，以及用于制备和使用组合物的各种方法和方法。

8. 发明申请

US20140005128A1 TREATMENTS OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：胃肠疾病的治疗
公开(公告)号：US20140005128A1
公开(公告)日：2014-01-02
申请号：US13816154
申请日：2011-08-11
申请人： Yun Mo , Angelika Fretzen , Brian Cali , Mahendra Dedhiya
发明人： Yun Mo , Angelika Fretzen , Brian Cali , Mahendra Dedhiya
IPC分类号： A61K38/10
CPC分类号： A61K38/12 , A61K9/1611 , A61K9/1641 , A61K9/1676 , A61K38/10 , A61K47/18
摘要： The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
摘要翻译：本发明涉及包含利那洛肽或其药学上可接受的盐的稳定的药物组合物，以及用于制备和使用组合物的各种方法和方法。

9. 发明申请

US20130062035A1 SUBSTRATE COOLING DEVICE, SUBSTRATE COOLING METHOD AND HEAT TREATMENT APPARATUS 审中-公开
标题翻译：基板冷却装置，基板冷却方法和热处理装置
公开(公告)号：US20130062035A1
公开(公告)日：2013-03-14
申请号：US13597513
申请日：2012-08-29
申请人： Masato Kawakami , Hiromi Nitadori , Yun Mo
发明人： Masato Kawakami , Hiromi Nitadori , Yun Mo
IPC分类号： F27D9/00 , F24F7/00
CPC分类号： H01L21/67757 , H01L21/67109
摘要： A substrate cooling device includes a cylindrical heat shielding member 30 configured to be movable between an insertion position where the heat shielding member 30 is inserted between the substrate holding member 15 in a processing vessel 11 and a heating member 12 and an unloading position where the heat shielding member 30 is unloaded from the insertion position, and configured to block radiant heat toward the substrates W after completing a heat treatment; and an air cooling port 21 provided at an outside of the processing vessel 11. The heat shielding member 30 includes two half-cylindrical members 31 that are assembled and separated at the unloading position, and is movable between the unloading position and the insertion position. An outer surface and an inner surface of the heat shielding member 30 are made of materials having a relatively low emissivity and a relatively high emissivity, respectively.
摘要翻译：基板冷却装置包括圆筒形的热屏蔽构件30，该圆筒形的热屏蔽构件30能够在热屏蔽构件30插入处理容器11中的基板保持构件15和加热构件12之间的插入位置与加热构件12的卸载位置之间移动遮蔽构件30从插入位置卸载，并且构造成在完成热处理之后阻挡朝向基板W的辐射热; 以及设置在处理容器11的外侧的空气冷却端口21.隔热构件30包括在卸载位置组装和分离的两个半圆柱形构件31，并且可在卸载位置和插入位置之间移动。隔热构件30的外表面和内表面分别由具有相对低的发射率和相对高的发射率的材料制成。

10. 发明申请

US20120213846A1 Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration 审中-公开
标题翻译：适用于口服给药的GC-C受体激动剂多肽的稳定制剂
公开(公告)号：US20120213846A1
公开(公告)日：2012-08-23
申请号：US13059154
申请日：2009-08-14
申请人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
发明人： Angelika Fretzen , Steven Witowski , Alfredo Grossi , Hong Zhao , Mahendra Dedhiya , Yun Mo
IPC分类号： A61K38/12 , A61K9/48 , A61P1/10 , A61P1/04 , A61P1/00 , B05D5/00 , A61K9/20
CPC分类号： A61K9/50 , A61J3/00 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/167 , A61K9/205 , A61K9/2054 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5078 , A61K38/10 , A61K38/12 , A61K47/02 , A61K47/183 , A61K47/36 , B65D81/26 , G01N30/02 , G01N2030/027
摘要： Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译：适用于口服给药的利那洛肽的固体稳定制剂在本文中描述为制备这些制剂的方法。本文描述的制剂含有由氨基酸序列Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr（“linaclotide”）或其药学上可接受的盐组成的多肽。本文所述的利那洛肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

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