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1. 发明授权

US5541182A Benzodiazepine aryl urea derivatives 失效
标题翻译：苯并二氮杂芳基脲衍生物
公开(公告)号：US5541182A
公开(公告)日：1996-07-30
申请号：US391835
申请日：1995-02-16
申请人： Masato Satoh , Yutaka Kondoh , Yoshinori Okamoto , Akito Nishida , Kazuo Honda , Masayuki Saito
发明人： Masato Satoh , Yutaka Kondoh , Yoshinori Okamoto , Akito Nishida , Kazuo Honda , Masayuki Saito
IPC分类号： A61K31/55 , B65D25/52 , B65D83/08 , B65H35/10 , C07D243/24 , C07D243/26 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/06
CPC分类号： C07D401/06 , B65D83/0847 , B65H35/10 , C07D243/24 , C07D403/04 , C07D409/06 , B65H2701/11231
摘要： This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, ##STR1## (wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-membered monocyclic or 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted), to medicinal compositions comprising the same, and to a process for producing the same. The compounds of formula (I) shown above exhibit antagonism for the CCK-B receptor and the action of depressing the gastric acid secretion caused by the stimulus of pentagastrin, and are therefore useful as a drug for the relief of diseases related to the CCK-B receptor and the gastrin receptor.
摘要翻译：本发明涉及由以下通式（I）表示的新型苯并二氮杂衍生物或其药学上可接受的盐，其中R 1为芳基或5元单环，6元环的芳族杂环基单环或5-和6-元双环结构，其可任选被取代;和R 2是可任选被取代的芳基），包含它们的药用组合物及其制备方法。上述式（I）的化合物对CCK-B受体表现出拮抗作用，并且抑制由五肽胃泌素刺激引起的胃酸分泌的作用，因此可用作缓解与CCK- B受体和胃泌素受体。

2. 发明授权

US5688943A Benzodiazepine derivatives useful as CCK-receptor antagonists 失效
标题翻译：苯并二氮杂衍生物可用作CCK受体拮抗剂
公开(公告)号：US5688943A
公开(公告)日：1997-11-18
申请号：US284462
申请日：1994-09-14
申请人： Hamish Ryder , Graeme Semple , David Alan Kendrick , Michael Szelke , Masato Satoh , Mitsuaki Ohta , Keiji Miyata , Akito Nishida
发明人： Hamish Ryder , Graeme Semple , David Alan Kendrick , Michael Szelke , Masato Satoh , Mitsuaki Ohta , Keiji Miyata , Akito Nishida
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P1/04 , A61P25/00 , A61P43/00 , C07D243/24 , C07D243/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06
CPC分类号： C07D401/04 , C07D243/24 , C07D403/06
摘要： This invention relates to benzodiazepine derivatives which are useful as drugs exhibiting antagonism at the gastrin and/or CCK-B receptor, and to their production.
摘要翻译： PCT No.PCT / GB93 / 00404 Sec。 371日期：1994年9月14日 102（e）1994年9月14日PCT PCT 1993年2月26日PCT公布。公开号WO93 / 16999 日期1993年9月2日本发明涉及苯并二氮杂衍生物，其可用作在胃泌素和/或CCK-B受体上表现出拮抗作用的药物及其制备。

3. 发明授权

US5728829A Process of preparing benzodiazepine compounds useful as antagonists of CCK or of gastrine 失效
标题翻译：制备可用作CCK或胃激素拮抗剂的苯并二氮杂类化合物的方法
公开(公告)号：US5728829A
公开(公告)日：1998-03-17
申请号：US591567
申请日：1996-05-02
申请人： Graeme Semple , Hamish Ryder , Michael Szelke , Masato Satoh , Mitsuaki Ohta , Keiji Miyata , Akito Nishida , Masato Ishii
发明人： Graeme Semple , Hamish Ryder , Michael Szelke , Masato Satoh , Mitsuaki Ohta , Keiji Miyata , Akito Nishida , Masato Ishii
IPC分类号： A61K31/55 , A61P1/00 , A61P1/04 , A61P1/14 , A61P3/04 , A61P25/20 , A61P35/00 , C07D401/04 , C07D403/04 , C07D417/04 , C07D243/24 , A61K31/33 , C07D403/02
CPC分类号： C07D401/04 , C07D403/04 , C07D417/04
摘要： A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: ##STR1## wherein: (a) R.sup.4 is an alkyl, cycloalkyl or aryl group. (b) R.sup.10 is chosen from halo, OH, CH.sub.3, OCH.sub.3, NR.sup.11 R.sup.12, NO.sub.2, NHCHO, CO.sub.2 H and CN, and R.sup.11 and R.sup.12 are independently selected from H and alkyl (C.sub.1 -C.sub.5) or together NR.sup.11 R.sup.12 form a cyclic structure II, ##STR2## wherein a is 1-6; and (c) R.sup.2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists.
摘要翻译： PCT No.PCT / GB94 / 01859 Sec。 371日期：1996年5月2日 102（e）日期1996年5月2日PCT 1994年8月25日PCT公布。出版物WO95 / 06040 日期：1995年3月2日式I的苯并二氮杂衍生物或其药学上可接受的盐：其中：（a）R 4是烷基，环烷基或芳基。（b）R 10选自卤素，OH，CH 3，OCH 3，NR 11 R 12，NO 2，NHCHO，CO 2 H和CN，R 11和R 12独立地选自H和烷基（C 1 -C 5）或NR 11 R 12一起形成环状结构II，其中a为1-6; 和（c）R 2是含有至少两个其中至少一个是氮的杂原子的芳族5-或6-元，取代或未取代的杂环。这些化合物是胃泌素和/或CCK-B受体拮抗剂。

4. 发明授权

US5962451A Benzodiazepin derivatives useful as CCK-receptor antagonists 失效
标题翻译：苯并二氮杂衍生物可用作CCK受体拮抗剂
公开(公告)号：US5962451A
公开(公告)日：1999-10-05
申请号：US867422
申请日：1997-06-06
申请人： Hamish Ryder , Graeme Semple , David Alan Kendrick , Michael Szelke , Masato Satoh , Mitsuaki Ohta , Keiji Miyata , Akito Nishida
发明人： Hamish Ryder , Graeme Semple , David Alan Kendrick , Michael Szelke , Masato Satoh , Mitsuaki Ohta , Keiji Miyata , Akito Nishida
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P1/04 , A61P25/00 , A61P43/00 , C07D243/24 , C07D243/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D243/10
CPC分类号： C07D401/04 , C07D243/24 , C07D403/06
摘要： A benzodiazepine derivative of formula (I), or a pharmaceutically acceptable salt thereof, wherein (a) R.sup.1 is --CH.sub.2 CHOH(CH.sub.2).sub.a R.sup.4 or a ketone group --CH.sub.2 CO(CH.sub.2).sub.a R.sup.5 in which a is 0 or 1 and R.sup.4 and R.sup.5 are selected from alkyl and cycloalkyl groups and saturated heterocyclic groups optionally substituted at a hetero-atom; (b) R.sup.2 and R.sup.3 are independently selected from aromatic carbocyclic and heterocylic residues; and (c) W and X are selected independently from halogen and hydrogen atoms and alkyl and alkoxy groups. These compounds are gastrin and/or CCK-B receptor antagonists. ##STR1##
摘要翻译：式（I）的苯并二氮杂衍生物或其药学上可接受的盐，其中（a）R 1为-CH 2 CHOH（CH 2）aR 4或酮基-CH 2 CO（CH 2）a R 5，其中a为0或1，且R 4和R 5为选自烷基和环烷基和任选在杂原子处被取代的饱和杂环基; （b）R2和R3独立地选自芳族碳环和杂环残基; 和（c）W和X独立地选自卤素和氢原子以及烷基和烷氧基。这些化合物是胃泌素和/或CCK-B受体拮抗剂。

5. 发明授权

US4551769A Picture image processing magnetic disc controlling method and apparatus therefor 失效
标题翻译：图像处理磁盘控制方法及其装置
公开(公告)号：US4551769A
公开(公告)日：1985-11-05
申请号：US447363
申请日：1982-12-06
申请人： Masato Satoh
发明人： Masato Satoh
IPC分类号： G06F12/00 , G06Q10/10 , G06T11/60 , G11B5/02 , H04N1/21 , H04N1/387 , H04N5/91 , H04N1/00
CPC分类号： H04N1/3873 , H04N1/2104 , H04N5/91
摘要： A method and apparatus for controlling a plurality of magnetic discs for processing a composite picture image. The composite picture image is made up of a first picture image and a second picture image which is inserted into the first picture image. The first picture image is digitized and is stored in first predetermined positions on one track on one side or recording surface of a magnetic disc. The second picture image is digitized and stored in second predetermined positions between the first predetermined positions on the same track on another side or recording surface of the disc. Both sides or recording surfaces of the disc are read out, and a logic product is formed between the two stored signals therefrom. In another embodiment, the first picture image is OR'd processed with an image mask prior to combination with the second image signal. An apparatus to achieve the foregoing method includes a multiplexer code register for receiving an access code and controlling the actuation of the magnetic read-write heads accordingly.
摘要翻译：一种用于控制用于处理复合图像图像的多个磁盘的方法和装置。合成图像由插入第一图像的第一图像图像和第二图像图像构成。第一图像被数字化并存储在磁盘的一侧或记录表面上的一个轨道上的第一预定位置。第二图像数字化并存储在盘的另一侧或记录表面上的相同轨道上的第一预定位置之间的第二预定位置。读出光盘的两面或记录面，在两个存储的信号之间形成逻辑积。在另一个实施例中，在与第二图像信号组合之前，用图像掩模对第一图像进行OR'处理。实现上述方法的装置包括用于接收访问代码并且相应地控制磁读写头的致动的多路复用器代码寄存器。

6. 发明授权

US06555162B1 Coating layer forming machine and method of forming it 有权
公开(公告)号：US06555162B1
公开(公告)日：2003-04-29
申请号：US09623483
申请日：2000-09-14
申请人： Kouichi Takimoto , Kiyoshi Yasuda , Masato Satoh
发明人： Kouichi Takimoto , Kiyoshi Yasuda , Masato Satoh
IPC分类号： B05D142
CPC分类号： B05C11/021 , B05C5/0208 , B05C11/04 , B05C11/041
摘要： A coating layer forming apparatus for minimizing the amount of the coating solution when forming a coating layer on a part and enhancing a dimensional precision of a formed surface of the coating layer. The coating layer forming apparatus has a rotation supporting device, a feeder (15), a layer former, and a coating removing device, maintains the inclined angle of a coating former for forming the coating layer at 30 to 70 degrees with respect to a tangential direction of rotation of a coating of a coating surface, and removes excess coating solution deposited on the coating former by a coating removing device.

7. 再颁专利

USRE40961E1 Coating layer forming machine and method of forming it 有权
标题翻译：涂层成型机及其成型方法
公开(公告)号：USRE40961E1
公开(公告)日：2009-11-10
申请号：US11117775
申请日：2000-01-12
申请人： Kouichi Takimoto , Kiyoshi Yasuda , Masato Satoh
发明人： Kouichi Takimoto , Kiyoshi Yasuda , Masato Satoh
IPC分类号： B05D1/42
CPC分类号： B05C11/021 , B05C5/0208 , B05C11/04 , B05C11/041
摘要： A coating layer forming apparatus for minimizing the amount of the coating solution when forming a coating layer on a part and enhancing a dimensional precision of a formed surface of the coating layer. The coating layer forming apparatus has a rotation supporting device, a feeder (15), a layer former, and a coating removing device, maintains the inclined angle of a coating former for forming the coating layer at 30 to 70 degrees with respect to a tangential direction of rotation of a coating of a coating surface, and removes excess coating solution deposited on the coating former by a coating removing device.
摘要翻译：一种涂层形成装置，用于在部件上形成涂层时使涂布液的量最小化并提高涂层的成形表面的尺寸精度。涂层形成装置具有旋转支撑装置，进料器（15），成层剂和涂层去除装置，用于将涂层形成剂的倾斜角相对于切线维持在30至70度涂覆表面的涂层的旋转方向，并且通过涂层去除装置去除沉积在涂层成形器上的多余涂层溶液。

8. 发明授权

US5081116A Cephalosporin derivatives 失效
公开(公告)号：US5081116A
公开(公告)日：1992-01-14
申请号：US504926
申请日：1990-04-05
申请人： Noriaki Nagano , Masato Satoh , Masauki Komiya , Toshio Okazaki , Tetsuya Maeda , Tadao Shibanuma
发明人： Noriaki Nagano , Masato Satoh , Masauki Komiya , Toshio Okazaki , Tetsuya Maeda , Tadao Shibanuma
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/24 , C07D501/36
CPC分类号： C07D501/24 , Y02P20/55
摘要： A 7-[2-(2-amino-4-thiazolyl)-2-(hydroxyimino)-acetamido]-3-(1,3-dithiolan-2-yl)-3-cephem-4-carboxylic acid derivative is provided which can be represented by the general formula: ##STR1## wherein A represents a hydrogen atom, a 1-acetoxyethyl group, a 1-cyclohexylacetoxyethyl group or a pivaloyloxy-methyl group.

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