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1. 发明申请

US20070224251A1 Hemostatic material 审中-公开
标题翻译：止血材料
公开(公告)号：US20070224251A1
公开(公告)日：2007-09-27
申请号：US11385750
申请日：2006-03-22
申请人： Masao Tanihara , Hisao Kinoshita , Takayuki Imamura , Chikateru Nozaki
发明人： Masao Tanihara , Hisao Kinoshita , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61K38/48 , A61L15/00
CPC分类号： A61K38/4833 , A61L15/225 , A61L15/32 , A61L24/043 , A61L24/10 , A61L2400/04
摘要： The present invention provides a hemostatic material which is excellent in hemostatic property, biodegradability and bioabsorbability, uniformity and stability of the quality, as well as reduces a risk of contamination with a pathogenic organism derived from an animal. The hemostatic material comprises a thrombin and a synthetic polypeptide capable of forming a triple helical structure. The polypeptide may show a peak of the molecular weight in the range from 5×104 to 100×104 in the molecular weight distribution. The polypeptide may contain at least a peptide unit represented by the formula: -Pro-X-Gly- (in the formula, X represents Pro or Hyp). The thrombin may be a recombinant. In the hemostatic material, the proportion of the thrombin may be about 0.1 to 500 units (U) relative to 1 mg of the polypeptide. The hemostatic material may further comprise a binder component having biodegradability and bioabsorbability. The hemostatic material may be formed on a substrate.
摘要翻译：本发明提供止血性，生物降解性和生物吸收性，质量的均匀性和稳定性优异的止血材料，并且降低了来自动物的病原体的污染的风险。止血材料包含能够形成三重螺旋结构的凝血酶和合成多肽。多肽可以在分子量分布中显示分子量在5×10 4至100×10 4范围内的峰。多肽可以至少含有由下式表示的肽单元：-Pro-X-Gly-（在该式中，X表示Pro或Hyp）。凝血酶可以是重组体。在止血材料中，相对于1mg多肽，凝血酶的比例可以为约0.1至500单位（U）。止血材料还可以包含具有生物降解性和生物吸收性的粘合剂组分。止血材料可以形成在基底上。

2. 发明申请

US20060127460A1 Trombin-carrying bioabsorbable synthetic nonwoven fabric 审中-公开
标题翻译：含凝血因子的生物可吸收合成无纺布
公开(公告)号：US20060127460A1
公开(公告)日：2006-06-15
申请号：US10534715
申请日：2003-11-12
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/00 , B32B27/04 , B32B27/12
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

3. 发明申请

US20050164365A1 Genetically modified ecarin and process for producing the same 审中-公开
标题翻译：转基因茄子及其生产方法
公开(公告)号：US20050164365A1
公开(公告)日：2005-07-28
申请号：US10482925
申请日：2002-07-04
申请人： Hiroshi Yonemura , Takayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
发明人： Hiroshi Yonemura , Takayuki Imamura , Hiroshi Nakatake , Kenji Soejima , Chikateru Nozaki
IPC分类号： C12N9/64 , C12N15/12 , C07H21/04 , C12N1/21 , C12N5/06 , C12N15/74
CPC分类号： C12N9/6418
摘要： A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.
摘要翻译：一种特异性激活凝血酶原的重组ecarin蛋白，所述蛋白通过遗传工程技术有效地制备，包括以下步骤：（1）培养用表达载体转化的转化体微生物或动物细胞，其中将编码ecarin的基因并入到促进剂，以在培养上清液或所述转化体内产生和积累ecarin并回收所产生的ecarin; 和（2）纯化含有回收的ecarin的溶液以获得纯化的ecarin。本发明允许以工业规模生产重组ecarin。

4. 发明授权

US08043629B2 Bioabsorbable synthetic nonwoven fabric holding thrombin 有权
标题翻译：生物可吸收的合成无纺布保持凝血酶
公开(公告)号：US08043629B2
公开(公告)日：2011-10-25
申请号：US11941779
申请日：2007-11-16
申请人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori Uchida , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/32 , A61K9/70 , A61K38/48 , C12N9/74
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

5. 发明申请

US20080286347A1 BIOABSORBABLE SYNTHETIC NONWOVEN FABRIC HOLDING THROMBIN 有权
标题翻译：生物可溶性合成非织造织物保持薄膜
公开(公告)号：US20080286347A1
公开(公告)日：2008-11-20
申请号：US11941779
申请日：2007-11-16
申请人： Takanori UCHIDA , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
发明人： Takanori UCHIDA , Noriko Shinya , Hiroshi Kaetsu , Takayuki Imamura , Chikateru Nozaki
IPC分类号： A61L15/00 , A61K38/48 , A61P7/04 , B32B27/04
CPC分类号： A61L15/44 , A61K47/6953 , A61L15/26 , A61L15/32 , A61L15/64 , A61L33/0041 , A61L2300/418 , A61L2400/04 , Y10T442/2525 , Y10T442/2566 , C08L67/04
摘要： A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.
摘要翻译：提供安全有效的止血剂。本发明涉及一种保持凝血酶作为有效成分的生物可吸收合成无纺布和包含所述生物可吸收合成无纺织物的止血剂。根据本发明的保持凝血酶的生物吸收性合成无纺布可以通过包括以下步骤的方法制备，所述方法包括将生物可吸收的合成非织造织物浸入含有凝血酶的溶液中并将所得的无纺织物冻干。根据本发明的保持凝血酶的生物可吸收合成非织造织物可以更快更有效地止血。

6. 发明授权

US09114098B2 Method for using inactivated Japanese encephalitis virus particles as adjuvant 有权
标题翻译：使用灭活的日本脑炎病毒颗粒作为佐剂的方法
公开(公告)号：US09114098B2
公开(公告)日：2015-08-25
申请号：US12996236
申请日：2009-05-27
申请人： Makoto Moriyama , Kazuyoshi Kaminaka , Junichi Matsuda , Chikateru Nozaki
发明人： Makoto Moriyama , Kazuyoshi Kaminaka , Junichi Matsuda , Chikateru Nozaki
IPC分类号： C07K14/18 , A61K39/00
CPC分类号： A61K39/00 , A61K2039/5252 , A61K2039/55588 , Y02A50/388 , Y02A50/39 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.
摘要翻译：提供了使用灭活的日本脑炎病毒颗粒作为疫苗佐剂的方法。使用灭活的日本脑炎病毒（JEV）颗粒作为各种疫苗或混合疫苗的佐剂的方法，所述JEV颗粒通过将JEV Beijing-1菌株接种到Vero细胞获得，培养所述JEV感染的细胞以产生培养的细胞或培养上清液，从所述培养细胞或培养上清液中纯化JEV颗粒，并用福尔马林灭活所述JEV颗粒，制备包含使灭活的日本脑炎病毒的步骤的（混合）疫苗的方法，以及由所述方法。

7. 发明授权

US08106015B2 Method for enhancing immune response with peptide 有权
标题翻译：用肽增强免疫应答的方法
公开(公告)号：US08106015B2
公开(公告)日：2012-01-31
申请号：US12596741
申请日：2008-04-18
申请人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
发明人： Junichi Matsuda , Kazuyoshi Kaminaka , Chikateru Nozaki
IPC分类号： A61K38/17 , A61K39/00 , A61P25/00 , A61P37/04 , C07K14/435
CPC分类号： A61K39/0007 , A61K31/711 , C07K14/4711
摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.
摘要翻译：本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白诱导增强的免疫应答的肽。淀粉样蛋白肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白肽或其部分诱导增强的免疫应答。可能具有相同作用的DNA疫苗，其包含编码淀粉样蛋白的基因; 肽或其部分，其通过加入或插入半胱氨酸诱导增强的免疫应答。

8. 发明申请

US20100113338A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL/CONJUNCTIVAL DISEASE 审中-公开
标题翻译：预防或治疗神经系统疾病
公开(公告)号：US20100113338A1
公开(公告)日：2010-05-06
申请号：US11993580
申请日：2006-06-21
申请人： Masanao Watanabe , Kazuo Tsubota , Masaki Hirashima , Chikateru Nozaki
发明人： Masanao Watanabe , Kazuo Tsubota , Masaki Hirashima , Chikateru Nozaki
IPC分类号： A61K38/16 , C07K14/00 , A61P27/02
CPC分类号： A61K38/1761 , A61K9/0048
摘要： Disclosed is a novel composition for the treatment of a corneal/conjunctival disease. A prophylactic or therapeutic agent for a corneal/conjunctival disease comprising selenoprotein P as an active ingredient, more specifically a prophylactic or therapeutic agent for a corneal/conjunctival disease such as dry eye, keratoconjunctivitis sicca, superficial punctate keratopathy, corneal erosion or corneal ulcer comprising selenoprotein P as an active ingredient, particularly a prophylactic or therapeutic agent for a corneal/conjuncrtival disease such as dry eye, keratoconjunctivitis sicca, superficial punctate keratopathy, corneal erosion or corneal ulcer accompanied by a corneal/conjunctival epithelial discorder.
摘要翻译：公开了用于治疗角膜/结膜疾病的新型组合物。一种用于角膜/结膜疾病的预防或治疗剂，其包含硒蛋白P作为活性成分，更具体地，涉及用于角膜/结膜疾病如干眼症，圆锥形结膜炎丝氨酸，浅表性点状角膜病，角膜侵蚀或角膜溃疡的预防或治疗剂，其包括硒蛋白P作为活性成分，特别是用于角膜/结膜性疾病例如干眼症，透角圆锥形结膜炎，浅表性点状角膜病变，伴随角膜/结膜上皮发生器的角膜侵蚀或角膜溃疡的预防或治疗剂。

9. 发明申请

US20060251655A1 Antibody against enzyme specifically cleaving von villebrand factor and assay system using the same 有权
标题翻译：针对酶的抗体特异性切割von villebrand因子和使用其的测定系统
公开(公告)号：US20060251655A1
公开(公告)日：2006-11-09
申请号：US10529009
申请日：2003-09-25
申请人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
发明人： Kenji Soejima , Noriko Mimura , Hiroaki Maeda , Chikateru Nozaki , Takayoshi Hamamoto , Tomohiro Nakagaki
IPC分类号： A61K39/395 , G01N33/53 , C07H21/04 , C07K16/40 , C12P21/06 , C12N5/06
CPC分类号： C12N9/6489 , C07K16/40
摘要： It is intended to provide an antibody showing immunoreactivity selectively to ADAMTS-13 and applications of this antibody in epitope analysis or diagnosis of an ADAMTS-13 autoantibody-positive patient. Alternatively, it is intended to provide a process for producing and use of a modified ADAMTS-13 molecule partially deleted aiming at the application in pharmaceutical products. An antibody specific for ADAMTS-13 which can be obtained from a warm-blooded animal immunized and sensitized with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; a process for producing an antibody comprising a step of immunizing and sensitizing a warm-blooded animal with a polypeptide containing a part or the whole of ADAMTS-13 amino acid sequence; use of the above-described antibody including a method of detecting and purifying ADAMTS-13; and a modified ADAMTS-13 molecule partially deleted are provided.
摘要翻译：旨在提供一种抗体，显示ADAMTS-13的免疫反应性和该抗体在ADAMTS-13自身抗体阳性患者的表位分析或诊断中的应用。或者，旨在提供一种制备和使用针对在药物产品中应用的部分缺失的修饰的ADAMTS-13分子的方法。对于ADAMTS-13特异的抗体，其可从用含有部分或全部ADAMTS-13氨基酸序列的多肽免疫并致敏的温血动物获得; 一种制备抗体的方法，其包括用含有部分或全部ADAMTS-13氨基酸序列的多肽对温血动物进行免疫和致敏的步骤; 使用上述抗体，包括检测和纯化ADAMTS-13的方法; 并提供部分缺失的修饰的ADAMTS-13分子。

10. 发明申请

US20050143310A1 Novel remedies for neurodegenerative disease 审中-公开
标题翻译：神经退行性疾病的新方法
公开(公告)号：US20050143310A1
公开(公告)日：2005-06-30
申请号：US10477216
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Hidenao Fukushima
IPC分类号： A61K38/17 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61K38/10
CPC分类号： A61K38/1709
摘要： A medicament for treating neurodegenerative diseases, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from the C-terminal of selenoprotein P. An excellent medicament for treating neurodegenerative diseases, especially suitable for treating neurodegenerative diseases with ataxia as a principal symptom is provided.
摘要翻译：一种用于治疗神经变性疾病的药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列衍生自硒蛋白P的C末端的肽片段。用于治疗神经变性疾病的优异药物，特别适用于治疗神经变性疾病提供共济失调作为主要症状。

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