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1. 发明申请

US20050239829A1 Novel piperidine compound 失效
标题翻译：新型哌啶化合物
公开(公告)号：US20050239829A1
公开(公告)日：2005-10-27
申请号：US10515845
申请日：2003-05-29
申请人： Masami Takahashi , Tsutomu Miyake , Yasunori Moritani , Hidetoshi Asai , Taketoshi Ishii , Rikako Kono
发明人： Masami Takahashi , Tsutomu Miyake , Yasunori Moritani , Hidetoshi Asai , Taketoshi Ishii , Rikako Kono
IPC分类号： A61K31/445 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/513 , A61K38/00 , C07D211/46 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D473/34 , C07K5/02 , C07K5/06 , C07K5/083 , C07K5/087 , C07K5/097 , C07K5/103 , C07D43/02
CPC分类号： C07D211/46 , A61K38/00 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D473/34 , C07K5/0202 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/1008
摘要： The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R11 and R12 are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R2 represents hydrogen atom, etc., Z represents oxygen atom or a group represented by —N(R3)—, R3 represents hydrogen atom or an alkyl group, etc., R4 represents hydrogen atom or an alkyl group, etc., or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式[I]的新的哌啶化合物：其中环A表示任选取代的苯环，环B表示任选取代的苯环，R 1表示任选取代的烷基，任选取代的羟基等，或下式的基团：（a）其中R 11和R 12相同或不同，并且各自表示氢原子取代的羰基，取代的磺酰基，任意取代的烷基等，R 2表示氢原子等，Z表示氧原子或-N（R' R 3表示氢原子或烷基等，R 4表示氢原子或烷基等，或其药学上可接受的盐。

2. 发明授权

US07619092B2 Piperidine compounds 失效
标题翻译：哌啶化合物
公开(公告)号：US07619092B2
公开(公告)日：2009-11-17
申请号：US10515845
申请日：2003-05-29
申请人： Masami Takahashi , Tsutomu Miyake , Yasunori Moritani , Hidetoshi Asai , Taketoshi Ishii , Rikako Kono
发明人： Masami Takahashi , Tsutomu Miyake , Yasunori Moritani , Hidetoshi Asai , Taketoshi Ishii , Rikako Kono
IPC分类号： C07D211/30 , A61K31/445
CPC分类号： C07D211/46 , A61K38/00 , C07D211/54 , C07D211/58 , C07D211/62 , C07D211/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D473/34 , C07K5/0202 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/1008
摘要： The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R11 and R12 are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R2 represents hydrogen atom, etc., Z represents oxygen atom or a group represented by —N(R3)—, R3 represents hydrogen atom or an alkyl group, etc., R4 represents hydrogen atom or an alkyl group, etc., or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供式[I]的新型哌啶化合物：其中环A表示任选取代的苯环，环B表示任选取代的苯环，R 1表示任选取代的烷基，任选取代的羟基等或下式的基团：（a）其中R 11和R 12相同或不同，各自表示氢原子，取代的羰基，取代的磺酰基，任选取代的烷基等，R 2表示氢原子等等，Z表示氧原子或由-N（R3） - 表示的基团，R3表示氢原子或烷基等，R4表示氢原子或烷基等，或其药学上可接受的盐。

3. 发明授权

US07390905B2 Piperidine compound and process for preparing the same 失效
标题翻译：哌啶化合物及其制备方法
公开(公告)号：US07390905B2
公开(公告)日：2008-06-24
申请号：US10581045
申请日：2004-11-26
申请人： Masami Takahashi , Tsutomu Miyake , Takeshi Yamanaka , Hidetoshi Asai , Rikako Kono
发明人： Masami Takahashi , Tsutomu Miyake , Takeshi Yamanaka , Hidetoshi Asai , Rikako Kono
IPC分类号： C07D211/30 , C07D211/32
CPC分类号： C07D211/38 , C07D211/46 , C07D211/54 , C07D211/58
摘要： The present invention relates to a piperidine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted hydoxyl group, a substituted thiol group, a substituted sulfonyl group, etc., or a group represented by the formula: R11 represents a substituted carbonyl group or a substituted sulfonyl group, R12 represents hydrogen atom or an optionally substituted alkyl group, R2 represents hydrogen atom, etc., Z represent oxygen atom or a group represented by —N(R3)—, R3 represents an optionally substituted alkyl group, etc., R4a represents an optionally substituted alkyl group, R4b represents an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, having an excellent tachykinin receptor antagonistic action.
摘要翻译：本发明涉及由式[I]表示的哌啶化合物：其中环A表示任选取代的苯环，环B表示任选取代的苯环，R 1表示任选取代的羟基取代的硫醇基，取代的磺酰基等，或由下式表示的基团：R 11表示取代的羰基或取代的磺酰基，R 12 >表示氢原子或任选取代的烷基，R 2表示氢原子等，Z表示氧原子或由-N（R 3 O 3） - 表示的基团， R 3表示任选取代的烷基等，R 4a表示任选取代的烷基，R 4b表示任选取代的烷基基团或其药学上可接受的盐，具有优异的速激肽受体拮抗作用。

4. 发明申请

US20070112029A1 Piperidine compound and process for preparing the same 失效
标题翻译：哌啶化合物及其制备方法
公开(公告)号：US20070112029A1
公开(公告)日：2007-05-17
申请号：US10581045
申请日：2004-11-26
申请人： Masami Takahashi , Tsutomu Miyake , Takeshi Yamanaka , Hidetoshi Asai , Rikako Kono
发明人： Masami Takahashi , Tsutomu Miyake , Takeshi Yamanaka , Hidetoshi Asai , Rikako Kono
IPC分类号： A61K31/445 , C07D211/56
CPC分类号： C07D211/38 , C07D211/46 , C07D211/54 , C07D211/58
摘要： Disclosed are a novel piperidine compound represented by the general formula [I] below which has an excellent tachykinin receptor antagonizing activity and pharmacologically acceptable salts thereof. [I] In the formula, ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted benzene ring; R1 represents an optionally substituted hydroxyl group, a thiol group having a substituent, a sulfonyl group having a substituent, or a group represented by the following formula [II]: wherein R11 represents a carbonyl group having a substituent or a sulfonyl group having a substituent and R12 represents a hydrogen atom or an optionally substituted alkyl group; R2 represents a hydrogen atom or the like; Z represents an oxygen atom or a group represented by —N(R3)— wherein R3 represents an optionally substituted alkyl group or the like; R4a represents an optionally substituted alkyl group; and R4b represents an optionally substituted alkyl group.
摘要翻译：公开了由下述通式[I]表示的新型哌啶化合物，其具有优异的速激肽受体拮抗活性及其药理学上可接受的盐。式中，环A表示任选取代的苯环; 环B表示任选取代的苯环; R 1表示任选取代的羟基，具有取代基的硫醇基，具有取代基的磺酰基或由下式[II]表示的基团：其中R 11， SUP>表示具有取代基的羰基或具有取代基的磺酰基，R 12表示氢原子或任选取代的烷基; R 2表示氢原子等; Z表示氧原子或由-N（R 3 O 3）表示的基团，其中R 3表示任选取代的烷基等; R 4a表示任选取代的烷基; R 4b表示任选取代的烷基。

5. 发明授权

US07067535B2 5-Phenylbenzylamine compounds, process for their production and intermediates for their synthesis 失效
标题翻译： 5-苯基苄胺化合物，其制备方法及其合成中间体
公开(公告)号：US07067535B2
公开(公告)日：2006-06-27
申请号：US10380754
申请日：2001-09-26
申请人： Masami Takahashi , Tsutomu Miyake , Hirokazu Yamakita , Akira Saito , Hidetoshi Asai
发明人： Masami Takahashi , Tsutomu Miyake , Hirokazu Yamakita , Akira Saito , Hidetoshi Asai
IPC分类号： A61K31/445 , C07D211/26
CPC分类号： C07D211/56
摘要： The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: wherein Ring A represents a phenyl group having a substituent(s), Ra, Rb1 and Rb2 each represent hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group or a lower alkoxy group, Rc1 represents hydrogen atom, a lower alkyl group optionally substituted by a heterocyclic group, or an acyl group, Rc2 and Re each represent hydrogen atom or a lower alkyl group, Rd represents hydrogen atom, a lower alkyl group or an acyl group, and Rf represents a lower alkyl group or a cyclic lower alkyl group, or a pharmaceutically acceptable salt thereof, a process for preparing the same and synthetic intermediate thereof.
摘要翻译：本发明涉及由式[1]表示的5-苯基苄胺化合物：其中环A表示具有取代基的苯基，R a，O，R b1， >和R b2各自表示氢原子，卤素原子，低级烷基，卤代低级烷基或低级烷氧基，R C1表示氢原子，任选被杂环基取代的低级烷基或酰基，R b2和R e各自表示氢原子或低级烷基，R d 代表氢原子，低级烷基或酰基，R f表示低级烷基或环状低级烷基，或其药学上可接受的盐，其制备方法其相同和合成的中间体。

6. 发明申请

US20090005355A1 Piperidine Compound and Process for Preparing the Same 审中-公开
标题翻译：哌啶化合物及其制备方法
公开(公告)号：US20090005355A1
公开(公告)日：2009-01-01
申请号：US11631282
申请日：2005-07-01
申请人： Tsutomu Miyake , Takeshi Yamanaka , Hidetoshi Asai , Yoshihiro Terakawa
发明人： Tsutomu Miyake , Takeshi Yamanaka , Hidetoshi Asai , Yoshihiro Terakawa
IPC分类号： A61K31/445 , C07D211/40 , C07D401/04 , C07D401/14 , C07D417/06 , A61P13/00 , A61K31/397 , A61K31/4545 , A61K31/496 , A61K31/541
CPC分类号： C07D211/62 , C07D211/78 , C07D211/96 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/06
摘要： The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or —N(R3)—, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or may be bonded to each other at the both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.
摘要翻译：本发明提供由式[I]表示的哌啶化合物：其中环A是任选取代的苯环，环B是任选取代的苯环，R 1是氢原子或氨基的取代基，R 2是氢原子，任选取代的羟基，任选取代的氨基，任选取代的烷基，取代的羰基或卤素原子，Z是氧原子或-N（R 3） - ，R 3是氢原子或任选取代的烷基基团，R4a和R4b可以相同或不同，并且各自为氢原子或任选取代的烷基，或者可以在两端彼此键合形成亚烷基或其药学上可接受的盐，其具有优秀的速激肽受体拮抗作用。

7. 发明申请

US20070244158A1 Piperdine Compound and Process for Preparing the Same 审中-公开
标题翻译：哌啶化合物及其制备方法
公开(公告)号：US20070244158A1
公开(公告)日：2007-10-18
申请号：US11660046
申请日：2005-09-16
申请人： Tsutomu Miyake , Takeshi Yamanaka , Rie Kino , Hidetoshi Asai
发明人： Tsutomu Miyake , Takeshi Yamanaka , Rie Kino , Hidetoshi Asai
IPC分类号： A61K31/445 , A61K31/4545 , A61P43/00 , C07D211/40 , C07D401/04 , C07D401/06
CPC分类号： C07D211/58 , C07D211/62 , C07D211/78 , C07D211/96 , C07D257/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/06
摘要： The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or —N(R3)—, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or may be bonded to each other at the both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.
摘要翻译：本发明提供由式[I]表示的哌啶化合物：其中环A是任选取代的苯环，环B是任选取代的苯环，R 1是氢原子或氨基的取代基R 2是氢原子，任选取代的羟基，任选取代的氨基，任选取代的烷基，取代的羰基或卤素原子，Z是氧原子或 -N（R 3） - ，R 3是氢原子或任选取代的烷基，R 4a和R 4b， / SUP>可以相同或不同，并且各自为氢原子或任选取代的烷基，或者可以在两端彼此键合形成亚烷基或其药学上可接受的盐，其具有优异的速激肽受体拮抗作用。

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