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1. 发明授权

US08368013B2 Analyzer, ionization apparatus and analyzing method 有权
标题翻译：分析仪，电离装置及分析方法
公开(公告)号：US08368013B2
公开(公告)日：2013-02-05
申请号：US13084930
申请日：2011-04-12
申请人： Masako Ishimaru , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Masuyuki Sugiyama , Hidetoshi Morokuma
发明人： Masako Ishimaru , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Masuyuki Sugiyama , Hidetoshi Morokuma
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/145
摘要： An analyzer performs dielectric barrier discharge and ionization of a sample by a reaction between the sample and excited molecules or ions generated by the dielectric barrier discharge at a pressure lower than an atmospheric pressure.
摘要翻译：分析仪通过在低于大气压的压力下通过介电阻挡放电产生的样品和激发的分子或离子之间的反应来进行介电阻挡放电和样品的离子化。

2. 发明申请

US20080128615A1 Real time analyzer and method for analysis 审中-公开
标题翻译：实时分析仪和分析方法
公开(公告)号：US20080128615A1
公开(公告)日：2008-06-05
申请号：US11987085
申请日：2007-11-27
申请人： Masuyoshi Yamada , Masako Ishimaru
发明人： Masuyoshi Yamada , Masako Ishimaru
IPC分类号： H01J49/04
CPC分类号： H01J49/0422
摘要： An analyzer carrying out analysis with a high degree of qualitative accuracy by separating impurities which hinder the analysis while analyzing in real time. An introducing tube is branched with one branched tube directly leading to an ion source for real time analysis. The other branched tube leads to the ion source so as to introduce the sample gas into the ion source at a later time. When a result of the real time analysis shows that a spectrum pattern on a MS spectrum is changed and an increase in the concentration of an impurity is observed, the introducing path for the sample gas is changed so that the sample gas is introduced into the ion source after the impurity is separated at the separation part.
摘要翻译：分析仪通过分析实时分析分析杂质，以高度的定性精度进行分析。引入管被分支，一个分支管直接通向离子源进行实时分析。另一个分支管通向离子源，以便稍后将样品气体引入离子源。当实时分析的结果表明MS谱上的光谱图变化并且观察到杂质浓度增加时，改变样品气体的引入路径，使样品气体被引入离子杂质在分离部分分离出来。

3. 发明授权

US08253097B2 Mass spectrometer and method of mass spectrometry 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US08253097B2
公开(公告)日：2012-08-28
申请号：US12039762
申请日：2008-02-29
申请人： Masako Ishimaru , Masuyoshi Yamada
发明人： Masako Ishimaru , Masuyoshi Yamada
IPC分类号： H01J49/00
CPC分类号： H01J49/168 , G01N30/461 , G01N30/7213 , H01J49/147
摘要： In a mass spectrometer having ion sources capable of switching between atmospheric pressure chemical ionization and electron impact ionization, a first gas chromatography device capable of separating a sample to meet a condition suitable for atmospheric pressure chemical ionization measurement is connected to upstream of an atmospheric pressure chemical ionization ion source. Part of the sample separated by the first gas chromatography device is introduced to a second gas chromatography device by distributing a flow channel. In the second gas chromatography device, a target substance and background ingredients contained in the sample are further separated and are introduced to an electron impact ionization ion source. By separating the target substance from the background ingredients, an electron impact ionization spectrum of the target substance is obtained without an effect of the background ingredients.
摘要翻译：在具有能够在大气压化学电离和电子轰击电离之间切换的离子源的质谱仪中，能够分离样品以满足适于大气压化学电离测量的条件的第一气相色谱装置连接到大气压化学品电离离子源。通过分配流动通道将由第一气相色谱装置分离的样品的一部分引入第二气相色谱装置。在第二气相色谱装置中，将样品中所含的目标物质和背景成分进一步分离并引入电子轰击离子化离子源。通过将目标物质与背景成分分离，可以获得目标物质的电子轰击电离光谱，而不影响背景成分。

4. 发明申请

US20050092917A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20050092917A1
公开(公告)日：2005-05-05
申请号：US10875635
申请日：2004-06-25
申请人： Atsumu Hirabayashi , Masako Ishimaru , Masahiro Yamaoka
发明人： Atsumu Hirabayashi , Masako Ishimaru , Masahiro Yamaoka
IPC分类号： G01N27/62 , H01J49/04
CPC分类号： H01J49/167 , G01N30/7266
摘要： The invention relates to an LC/MS interface provided with structure that the end of a spray capillary is rarely damaged and the object is to provide the LC/MS interface which a general user can easily operate, which inhibits the extension of a separation band and the deterioration of detection sensitivity and which enables high separation and sensitive analysis. A metallic member having a hole for connecting a separation column and a spray capillary and a resin member for fixing the upstream side of the short spray capillary are used. Further, to enhance operability, spray ionization using gas spraying is used.
摘要翻译：本发明涉及一种LC / MS接口，其具有喷雾毛细管的端部很少被损坏的结构，并且目的是提供一般用户可以容易地操作的LC / MS接口，这阻碍了分离带的扩展，检测灵敏度的恶化，能够进行高分离和敏感分析。使用具有用于连接分离柱和喷雾毛细管的孔的金属构件和用于固定短喷雾毛细管的上游侧的树脂构件。此外，为了提高可操作性，使用使用气体喷雾的喷雾电离。

5. 发明申请

US20110101215A1 QUANTITATIVE ANALYSIS METHOD USING MASS SPECTROMETER 审中-公开
标题翻译：使用质谱仪的量化分析方法
公开(公告)号：US20110101215A1
公开(公告)日：2011-05-05
申请号：US12921087
申请日：2009-03-27
申请人： Atsumu Hirabayashi , Masako Ishimaru , Kiyomi Yoshinari , Naomi Manri
发明人： Atsumu Hirabayashi , Masako Ishimaru , Kiyomi Yoshinari , Naomi Manri
IPC分类号： H01J49/00
CPC分类号： G01N30/8675 , G01N30/7233 , H01J49/0009
摘要： In quantitation without using the isotope labeling technique, there is no means to detect the presence/absence and the time region of the occurrence of quantitative analysis-inhibitory factors in data for the analysis, and the reliability of the data for the analysis cannot be evaluated. Also, the error of the data due to the occurrence of the quantitative analysis-inhibitory factors cannot be evaluated. In order to solve the problems, first, an internal standard to be detected simultaneously with a component for the analysis is mixed in a mobile phase or an eluate of a liquid chromatograph; under the condition where no quantitative analysis-inhibitory factors occur, a blank sample is analyzed to acquire a mass chromatogram of ions originated from the internal standard; and the result is stored in a data storage unit. Then, a sample for the analysis is mixed to acquire data for the analysis of the sample; and the intensity of ions originated from the internal standard is compared with that of the blank sample in the analysis real time in a data analysis unit. At this time, if an inconsistency exceeding a predetermined threshold is detected, the occurrence of the quantitative analysis-inhibitory factors can be detected. Further, based on the inconsistency, the error range of the data can be given to a data set and the like.
摘要翻译：在不使用同位素标记技术的定量中，无法检测分析数据中定量分析抑制因子的发生的存在/不存在和时间区域，并且不能评估用于分析的数据的可靠性。此外，由于定量分析抑制因子的发生导致的数据误差不能被评估。为了解决上述问题，首先，将与分析用成分同时检测的内标与液相色谱仪的流动相或洗脱液混合，在没有定量分析抑制因子发生的条件下，分析空白样品以获得源自内标的离子的质谱图; 结果存储在数据存储单元中。然后，将用于分析的样本混合以获取用于样品分析的数据; 在数据分析单元中实时分析从内部标准产生的离子强度与空白样本的强度进行比较。此时，如果检测到超过预定阈值的不一致，则可以检测定量分析抑制因子的发生。此外，基于不一致性，可以向数据集等提供数据的误差范围。

6. 发明授权

US06989531B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06989531B2
公开(公告)日：2006-01-24
申请号：US10875635
申请日：2004-06-25
申请人： Atsumu Hirabayashi , Masako Ishimaru , Masahiro Yamaoka
发明人： Atsumu Hirabayashi , Masako Ishimaru , Masahiro Yamaoka
IPC分类号： H01J49/10
CPC分类号： H01J49/167 , G01N30/7266
摘要： The invention relates to an LC/MS interface provided with structure that the end of a spray capillary is rarely damaged and the object is to provide the LC/MS interface which a general user can easily operate, which inhibits the extension of a separation band and the deterioration of detection sensitivity and which enables high separation and sensitive analysis. A metallic member having a hole for connecting a separation column and a spray capillary and a resin member for fixing the upstream side of the short spray capillary are used. Further, to enhance operability, spray ionization using gas spraying is used.
摘要翻译：本发明涉及一种LC / MS接口，其具有喷雾毛细管的端部很少被损坏的结构，并且目的是提供一般用户可以容易地操作的LC / MS接口，这阻碍了分离带的扩展，检测灵敏度的恶化，能够进行高分离和敏感分析。使用具有用于连接分离柱和喷雾毛细管的孔的金属构件和用于固定短喷雾毛细管的上游侧的树脂构件。此外，为了提高可操作性，使用使用气体喷雾的喷雾电离。

7. 发明授权

US07538321B2 Method of identifying substances using mass spectrometry 失效
标题翻译：使用质谱鉴定物质的方法
公开(公告)号：US07538321B2
公开(公告)日：2009-05-26
申请号：US11431482
申请日：2006-05-11
申请人： Masako Ishimaru , Atsumu Hirabayashi , Kinya Kobayashi , Kisaburo Deguchi
发明人： Masako Ishimaru , Atsumu Hirabayashi , Kinya Kobayashi , Kisaburo Deguchi
IPC分类号： H01J49/00 , H01J49/26 , H01J49/40
CPC分类号： G01N30/8675 , G01N30/7233 , G01N30/8679 , G01N2030/8813 , G06F19/703 , H01J49/00
摘要： An object of the present invention is to provide a mass spectrometry system capable of improving an efficiency of obtaining information on a structure of substances, shortening a time taken for a measurement and substance identification, and improving identification accuracy. The system comprises: a process of mass analyzing an ionized analyte; a first fragmentation process where a first ion is selected from the ions observed in a mass spectrometry to fragment it; a process of mass analyzing a plurality of the ions generated in the first fragmentation process; a process of determining fragment ion combination capable of reconstructing the first ion using a result of the mass spectrometry; a second fragmentation process where the fragment ions contained in the fragment ion combination are fragmented; and a process of mass analyzing the fragment ions generated in the second fragmentation.
摘要翻译：本发明的目的是提供一种能够提高获得关于物质结构的信息的效率，缩短测量所需时间和物质识别以及提高识别精度的质谱系统。该系统包括：大量分析电离分析物的过程; 第一碎片过程，其中第一离子选自在质谱中观察到的离子以将其分裂; 批量分析在第一分段处理中产生的多个离子的过程; 使用质谱的结果确定能够重建第一离子的碎片离子组合的方法; 碎片离子组合中包含的碎片离子碎裂的第二碎裂过程; 以及质量分析在第二次碎裂中产生的碎片离子的过程。

8. 发明申请

US20060255263A1 Method of identifying substances using mass spectrometry 失效
公开(公告)号：US20060255263A1
公开(公告)日：2006-11-16
申请号：US11431482
申请日：2006-05-11
申请人： Masako Ishimaru , Atsumu Hirabayashi , Kinya Kobayashi , Kisaburo Deguchi
发明人： Masako Ishimaru , Atsumu Hirabayashi , Kinya Kobayashi , Kisaburo Deguchi
IPC分类号： H01J49/00
CPC分类号： G01N30/8675 , G01N30/7233 , G01N30/8679 , G01N2030/8813 , G06F19/703 , H01J49/00
摘要： An object of the present invention is to provide a mass spectrometry system capable of improving an efficiency of obtaining information on a structure of substances, shortening a time taken for a measurement and substance identification, and improving identification accuracy. The system comprises: a process of mass analyzing an ionized analyte; a first fragmentation process where a first ion is selected from the ions observed in a mass spectrometry to fragment it; a process of mass analyzing a plurality of the ions generated in the first fragmentation process; a process of determining fragment ion combination capable of reconstructing the first ion using a result of the mass spectrometry; a second fragmentation process where the fragment ions contained in the fragment ion combination are fragmented; and a process of mass analyzing the fragment ions generated in the second fragmentation.

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