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1. 发明授权

US07078400B2 20-HETE synthase inhibitor 失效
标题翻译： 20-HETE合酶抑制剂
公开(公告)号：US07078400B2
公开(公告)日：2006-07-18
申请号：US10609547
申请日：2003-07-01
申请人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Kobayashi , Hideaki Amada
发明人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Kobayashi , Hideaki Amada
IPC分类号： A61P7/02
CPC分类号： A61K31/155 , A61K31/166 , A61K31/18 , A61K31/245 , A61K31/275 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4453 , A61K31/45 , A61K31/472 , A61K31/502 , A61K31/505 , A61K31/522 , A61K31/5375 , C07C311/21 , C07C311/46 , C07C317/40 , C07C323/12 , C07C323/19 , C07C323/41 , C07C323/52 , C07C323/65 , C07C335/26 , C07C2601/08 , C07C2601/14
摘要： The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present invention are useful as therapeutic agents for kidney diseases, cerebrovascular diseases, or circulatory diseases.In addition, the present invention also provides novel hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof.
摘要翻译：本发明涉及一种用于制备20-羟基二十碳烯四烯酸的抑制剂，其包含作为有效成分的特定羟基甲脒衍生物或其药学上可接受的盐。根据本发明的抑制剂可用作肾脏疾病，脑血管疾病或循环系统疾病的治疗剂。此外，本发明还提供新的羟基甲脒衍生物或其药学上可接受的盐。

2. 发明授权

US06864254B1 Inhibitor for 20-hete-yielding enzyme 失效
标题翻译：抑制剂为20-hte生产酶
公开(公告)号：US06864254B1
公开(公告)日：2005-03-08
申请号：US09869103
申请日：2000-11-01
申请人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Kobayashi , Hideaki Amada
发明人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Kobayashi , Hideaki Amada
IPC分类号： A61K31/155 , A61K31/166 , A61K31/18 , A61K31/245 , A61K31/275 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4453 , A61K31/45 , A61K31/472 , A61K31/502 , A61K31/505 , A61K31/522 , A61K31/5375 , C07C311/21 , C07C311/46 , C07C317/40 , C07C323/12 , C07C323/19 , C07C323/41 , C07C323/52 , C07C323/65 , C07C335/26 , A81K31/155
CPC分类号： A61K31/155 , A61K31/166 , A61K31/18 , A61K31/245 , A61K31/275 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/445 , A61K31/4453 , A61K31/45 , A61K31/472 , A61K31/502 , A61K31/505 , A61K31/522 , A61K31/5375 , C07C311/21 , C07C311/46 , C07C317/40 , C07C323/12 , C07C323/19 , C07C323/41 , C07C323/52 , C07C323/65 , C07C335/26 , C07C2601/08 , C07C2601/14
摘要： An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular diseases, or circulatory diseases. The novel hydroxyformamidine derivative or pharmacologically acceptable salt thereof is also provided.
摘要翻译：一种20-羟基二十碳烯四烯酸生产抑制剂，其包含作为活性成分的特定羟基甲脒衍生物或其药理学上可接受的盐。特别是作为肾脏疾病，脑血管疾病或循环系统疾病的补救措施是有用的。还提供了新的羟基甲脒衍生物或其药理学上可接受的盐。

3. 发明授权

US06670382B2 Hydroxyformamidine derivatives and medicines containing the same 失效
标题翻译：羟基甲脒衍生物和含有其的药物
公开(公告)号：US06670382B2
公开(公告)日：2003-12-30
申请号：US10311003
申请日：2002-12-12
申请人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Kobayashi , Hideaki Amada
发明人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Kobayashi , Hideaki Amada
IPC分类号： C07D21353
CPC分类号： C07D213/74
摘要： Pharmaceutical agents for inhibiting the production of 20-HETE which participates in constriction or dilation of microvessels in major organs such as the kidneys and the cerebral blood vessels, or participates in causing cell proliferation are provided. The present invention relates to hydroxyamidine compounds represented by the formula: wherein R1 represents a group represented by the formula: R2—(CH2)m— (wherein R2 represents a C3-8 cycloalkyl group, a C2-6 alkoxycarbonyl group, a C2-10 alkenyl group, a C2-6 alkynyl group, a substituted or non-substituted aryl group, or the like, and m is an integer of 1 to 8), a group represented by the formula: R3—A— (wherein R3 represents a hydrogen atom, a C1-6 alkoxy group, a C3-8 cycloalkoxy group, or the like, and A represents a straight-chain C2-10 alkylene group which may be substituted with a C1-6 alkyl group or a trifluoromethyl group), or a C3-8 cycloalkyl group, and X represents an oxygen atom or a sulfur atom, or pharmaceutically acceptable salts thereof, and relates to medicines including the same as active ingredients.
摘要翻译：提供了用于抑制参与诸如肾脏和脑血管等主要器官的微血管收缩或扩张的20-HETE的生产的药剂，或参与引起细胞增殖。本发明涉及由下式表示的羟基脒化合物：其中R 1表示由下式表示的基团：R 2 - （CH 2）m - （其中R 2表示C 3-8环烷基， C 2-6烷氧基羰基，C 2-10烯基，C 2-6炔基，取代或未取代的芳基等，m为1〜8的整数），式 R 3 -A-（其中R 3表示氢原子，C 1-6烷氧基，C 3-8环烷氧基等，A表示直链C 2-10亚烷基，可以被C 1-6烷基或三氟甲基取代）或C 3-8环烷基，X表示氧原子或硫原子，或其药学上可接受的盐，并且涉及含有活性的药物配料。

4. 发明授权

US07214714B2 20-hydroxyeicosatetraenoic acid production inhibitors 有权
标题翻译： 20-羟基二十碳四烯酸生产抑制剂
公开(公告)号：US07214714B2
公开(公告)日：2007-05-08
申请号：US10475869
申请日：2002-04-26
申请人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Matsunaga , Hideaki Amada
发明人： Masakazu Sato , Noriyuki Miyata , Takaaki Ishii , Yuko Matsunaga , Hideaki Amada
IPC分类号： A61K31/136 , A61K31/402 , C07C259/14 , C07D207/20 , C07D211/00 , C07D213/00 , C07D215/00 , C07D241/00 , C07D295/00 , C07D491/00
CPC分类号： C07D213/75 , A61K31/136 , A61K31/402 , A61K31/4418 , A61K31/451 , A61K31/4525 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/54 , A61K31/55 , C07C259/14 , C07D207/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/70 , C07D213/74 , C07D217/04 , C07D295/13 , C07D295/135 , C07D295/15 , C07D401/04 , C07D491/10
摘要： A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazepin-1-yl group, a perhydroazocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrrolin-1-yl group, etc.; X represents a nitrogen atom or a group represented by CR5; and R2 to R5 are the same or different and each represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a trifluoromethyl group or a halogen atom.] There is provided a drug which inhibits an enzyme producing 20-HETE participating in a contracting or dilating action for microvessels and an inducing action for cell proliferation in main organs such as kidney and cerebrovascular vessels.
摘要翻译：由下式表示的羟基脒化合物或其药学上可接受的盐[其中R 1表示取代的吗啉代基，取代的哌啶子基，哌嗪-1-基，取代的哌嗪-1-基，吡咯啉-1-基，四氢吡啶-1-基，吡咯啉-1-基，四氢吡啶-1-基，四氢吡啶-1-基，四氢吡啶-1-基，吡咯啉-1-基等。 X表示氮原子或由CR 5表示的基团; R 5和R 5相同或不同，各自表示氢原子，C 1-4烷基，C 1-4烷基， SUB 1-4个烷氧基，三氟甲基或卤素原子。]提供了抑制参与微血管的收缩或扩张作用的20-HETE的酶和细胞增殖诱导作用的药物在主要器官如肾脏和脑血管血管。

5. 发明授权

US07307101B2 Use of 20-HETE synthesizing enzyme inhibitors as therapy for cerebral vascular disease 失效
标题翻译：使用20-HETE合成酶抑制剂作为脑血管病的治疗
公开(公告)号：US07307101B2
公开(公告)日：2007-12-11
申请号：US09937946
申请日：2001-09-06
申请人： Richard J. Roman , David R. Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
发明人： Richard J. Roman , David R. Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
IPC分类号： A01N37/34 , A61K37/275 , C12N9/10
CPC分类号： A61K31/15 , A61K31/20 , A61K31/4164 , A61K31/4192 , A61K48/00
摘要： A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.
摘要翻译：公开了一种用于治疗人或非人动物的脑血管疾病的方法。所述方法包括充分抑制20-HETE合成酶活性以增加或防止人或非人动物中脑血流量的降低。

6. 发明申请

US20050153871A1 Use of 20-hete synthesizing enzyme inhibitors as therapy for cerebral vascular disease 失效
标题翻译：使用20-mL合成酶抑制剂作为脑血管病的治疗
公开(公告)号：US20050153871A1
公开(公告)日：2005-07-14
申请号：US09937946
申请日：2001-09-06
申请人： Richard Roman , David Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
发明人： Richard Roman , David Harder , Noriyuki Miyata , Masakazu Sato , Kazuya Kameo , Shigeru Okuyama
IPC分类号： A61K45/00 , A61K31/15 , A61K31/155 , A61K31/18 , A61K31/20 , A61K31/4164 , A61K31/4174 , A61K31/4192 , A61K31/7105 , A61K31/711 , A61K38/54 , A61K39/395 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P31/00 , A61P31/04 , A61P43/00
CPC分类号： A61K31/15 , A61K31/20 , A61K31/4164 , A61K31/4192 , A61K48/00
摘要： A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent a decrease in cerebral blood flow in the human or non-human animal.
摘要翻译：公开了一种用于治疗人或非人动物的脑血管疾病的方法。所述方法包括充分抑制20-HETE合成酶活性以增加或防止人或非人动物中脑血流量的降低。

7. 发明授权

US07407224B2 Molding attaching structure, molding attaching clip, and molding 有权
标题翻译：成型安装结构，成型安装夹和成型
公开(公告)号：US07407224B2
公开(公告)日：2008-08-05
申请号：US10590051
申请日：2005-02-22
申请人： Kenji Okabe , Tsukasa Murase , Keiichi Fukushima , Masahiro Kuwabara , Noriyuki Miyata
发明人： Kenji Okabe , Tsukasa Murase , Keiichi Fukushima , Masahiro Kuwabara , Noriyuki Miyata
IPC分类号： B60J7/00 , B42F1/00
CPC分类号： B60R13/04 , F16B5/125 , F16B5/126 , F16B5/128 , Y10T24/304 , Y10T24/309 , Y10T24/44017 , Y10T24/45597
摘要： A molding attaching clip 30 includes a fixed portion 31 to be fixed in a groove 15 of a roof panel 10, a pair of elastically deformable wall portions 32 which are erected from the fixed portion 31, a pair of engaging portions 33 which are provided on the pair of wall portions 32, and an elastically deformable guide portion 36 which is projected from the fixed portion 31. A roof molding 20 includes a head portion 21 for covering the groove 15, and a projected portion 27 which is protruded from a back face of the head portion 21. The projected portion has a pair of locking portions 24 which are provided on both side faces thereof, and a receiving groove 26 which is formed in the projected portion 27. On occasion of engaging the roof molding 20 with the molding attaching clip 30, the roof molding 20 is positioned so that the pair of locking portions 24 can be engaged with the pair of engaging portions 33, by butting the receiving groove 26 against the guide portion 36.
摘要翻译：成型安装夹30包括固定在顶板10的槽15中的固定部分31，从固定部分31竖立的一对可弹性变形的壁部分32，一对接合部分33，一对壁部32以及从固定部31突出的可弹性变形的引导部36。屋顶模制件20包括用于覆盖槽15的头部21和从头部21的背面突出的突出部27。突出部分具有设置在其两个侧面上的一对锁定部分24和形成在突出部分27中的接收槽26。在将屋顶模制件20与模制安装夹30接合的情况下，屋顶模制件20被定位成使得一对锁定部分24能够与一对接合部分33接合，通过将接收槽26抵靠引导部分 36。

8. 发明申请

US20120228673A1 FIELD-EFFECT TRANSISTOR, SEMICONDUCTOR WAFER, METHOD FOR PRODUCING FIELD-EFFECT TRANSISTOR AND METHOD FOR PRODUCING SEMICONDUCTOR WAFER 失效
标题翻译：场效应晶体管，半导体晶体管，生产场效应晶体管的方法和生产半导体晶体管的方法
公开(公告)号：US20120228673A1
公开(公告)日：2012-09-13
申请号：US13413216
申请日：2012-03-06
申请人： Masahiko HATA , Hisashi Yamada , Noboru Fukuhara , Shinichi Takagi , Mitsuru Takenaka , Masafumi Yokoyama , Tetsuji Yasuda , Yuji Urabe , Noriyuki Miyata , Taro Itatani , Hiroyuki Ishii
发明人： Masahiko HATA , Hisashi Yamada , Noboru Fukuhara , Shinichi Takagi , Mitsuru Takenaka , Masafumi Yokoyama , Tetsuji Yasuda , Yuji Urabe , Noriyuki Miyata , Taro Itatani , Hiroyuki Ishii
IPC分类号： H01L29/78 , H01L21/336 , H01L21/20
CPC分类号： H01L29/7786 , H01L21/26553 , H01L29/4966 , H01L29/517 , H01L29/66318 , H01L29/66522
摘要： Provided is a field-effect transistor including a gate insulating layer, a first semiconductor crystal layer in contact with the gate insulating layer, and a second semiconductor crystal layer lattice-matching or pseudo lattice-matching the first semiconductor crystal layer. Here, the gate insulating layer, the first semiconductor crystal layer, and the second semiconductor crystal layer are arranged in the order of the gate insulating layer, the first semiconductor crystal layer, and the second semiconductor crystal layer, the first semiconductor crystal layer is made of Inx1Ga1-x1Asy1P1-y1 (0
摘要翻译：提供了一种场效应晶体管，其包括栅极绝缘层，与栅极绝缘层接触的第一半导体晶体层和第二半导体晶体层与第一半导体晶体层的晶格匹配或伪晶格匹配。这里，栅绝缘层，第一半导体晶体层和第二半导体晶体层按栅极绝缘层，第一半导体晶体层和第二半导体晶体层的顺序排列，第一半导体晶体层被制成的In x Ga 1-x As y 1 P 1-y 1（0

9. 发明授权

US07183322B2 Remedy for hypertension 失效
标题翻译：补救高血压
公开(公告)号：US07183322B2
公开(公告)日：2007-02-27
申请号：US10504585
申请日：2003-02-17
申请人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi , Kenzo Takahashi
发明人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi , Kenzo Takahashi
IPC分类号： A61K31/135
CPC分类号： A61K31/136
摘要： A therapeutic agent for hypertension, which comprises as an active ingredient a compound capable of inhibiting Na+/Ca2+ exchanger 1.
摘要翻译：一种高血压治疗剂，其包含作为活性成分的能够抑制Na + + / Ca 2+交换体1的化合物。

10. 发明申请

US20050222268A1 Remedy for hypertension 失效
标题翻译：补救高血压
公开(公告)号：US20050222268A1
公开(公告)日：2005-10-06
申请号：US10504585
申请日：2003-02-17
申请人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi , Kenzo Takahashi
发明人： Noriyuki Miyata , Shigeru Okuyama , Teisuke Takahashi , Kenzo Takahashi
IPC分类号： A61K31/136 , A61P9/12 , A61P43/00 , A61K31/135
CPC分类号： A61K31/136
摘要： A therapeutic agent for hypertension, which comprises as an active ingredient a compound capable of inhibiting Na+/Ca2+ exchanger 1.
摘要翻译：一种高血压治疗剂，其包含作为活性成分的能够抑制Na + + / Ca 2+交换体1的化合物。

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