专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07022732B2 Propanolamine derivative having 1, 4-benzodioxane ring 失效
标题翻译：具有1,4-苯并二恶烷环的丙醇胺衍生物
公开(公告)号：US07022732B2
公开(公告)日：2006-04-04
申请号：US10489332
申请日：2001-09-13
申请人： Masahiro Ueno , Koji Kawamura , Makoto Yanai , Toshihiro Takahashi , Nobuhiro Kinoshita , Koichi Katsuyama , Satoko Fuchizawa , Shigeru Hiramoto
发明人： Masahiro Ueno , Koji Kawamura , Makoto Yanai , Toshihiro Takahashi , Nobuhiro Kinoshita , Koichi Katsuyama , Satoko Fuchizawa , Shigeru Hiramoto
IPC分类号： A61K31/36 , C07D319/20
CPC分类号： C07D405/12 , A61K31/357 , A61K31/404 , A61K31/4433 , A61K31/506 , C07D319/20
摘要： This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein R1-3 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C1–C6)alkyl group, a (C1–C6)alkoxy group, a (C1–C6)alkylsulfonamido group, or a phenyl group; R4-5 each represents a hydrogen atom or a (C1–C6)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring.This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.
摘要翻译：本发明涉及含有作为活性成分的具有1,4-苯并二恶烷环的新型丙醇胺或其药学上可接受的盐的药物：本发明化合物由上式表示，其中R 1〜3 3 可以相同或不同，各自表示氢原子，卤素原子，羟基，（C 1 -C 6）烷基，（C 1 -C 6 -C 6）烷基，（C 1 -C 6 -C 6烷基磺酰氨基）或苯基（C 1 -C 6）组; R 4-5各自表示氢原子或（C 1 -C 6 -C 6）烷基; A表示苯环，吡啶环和嘧啶环中的任一个。该化合物可用作糖尿病，肥胖症，高脂血症，抑郁症，呼吸系统疾病或胃肠道疾病的预防或治疗剂。

2. 发明授权

US5621010A Urea derivatives and their use as ACAT inhibitors 失效
标题翻译：尿素衍生物及其作为ACAT抑制剂的用途
公开(公告)号：US5621010A
公开(公告)日：1997-04-15
申请号：US245013
申请日：1994-05-18
申请人： Noriyoshi Sueda , Kazuhiko Yamada , Makoto Yanai , Katsutoshi Miura , Masato Horigome , Norio Oshida , Shigeru Hiramoto , Koichi Katsuyama , Fumihisa Nakata , Nobuhiro Kinoshita , Yoko Tsukada
发明人： Noriyoshi Sueda , Kazuhiko Yamada , Makoto Yanai , Katsutoshi Miura , Masato Horigome , Norio Oshida , Shigeru Hiramoto , Koichi Katsuyama , Fumihisa Nakata , Nobuhiro Kinoshita , Yoko Tsukada
IPC分类号： C07C275/32 , C07C275/34 , C07C323/44 , C07D207/14 , C07D209/08 , C07D209/16 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/48 , C07D211/56 , C07D211/58 , C07D211/60 , C07D213/40 , C07D213/75 , C07D213/82 , C07D215/08 , C07D217/06 , C07D249/08 , C07D265/30 , C07D295/13 , C07D295/135 , C07D295/215 , C07D295/26 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/06 , C07D401/12 , C07D451/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D491/10 , C07D498/08 , C07D521/00 , A61K31/17 , C07C273/00 , C07D217/12
CPC分类号： C07D213/40 , A61K9/1623 , A61K9/2018 , A61K9/4866 , C07C275/32 , C07C275/34 , C07C323/44 , C07D207/14 , C07D209/08 , C07D209/16 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/48 , C07D211/56 , C07D211/58 , C07D211/60 , C07D213/75 , C07D213/82 , C07D215/08 , C07D217/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/30 , C07D295/13 , C07D295/135 , C07D295/215 , C07D295/26 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/06 , C07D401/12 , C07D451/04 , C07D453/02 , C07D471/04 , C07D471/08 , C07D491/10 , C07C2101/08 , C07C2101/14 , C07C2101/18 , C07C2101/20 , C07C2102/10 , C07C2102/22 , C07C2103/74 , Y10S514/824
摘要： Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.
摘要翻译：式（I）的脲衍生物其中有价值基团如说明书中所定义，其具有ACAT抑制活性和抗氧化活性。这些衍生物可用于预防和治疗高胆固醇血症和动脉粥样硬化。

3. 发明授权

US06255286B1 Depsipeptides and drugs containing the same as the active ingredient 有权
标题翻译：含有与活性成分相同的多肽和药物
公开(公告)号：US06255286B1
公开(公告)日：2001-07-03
申请号：US09214002
申请日：1998-12-24
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K3800
CPC分类号： C07K5/1021 , A61K38/00 , C07K5/06043 , C07K5/06052 , C07K5/06104 , C07K5/101 , C07K7/06 , C07K11/00
摘要： Depsipeptides represented by the formula (1): (wherein: R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is —A—B, —A—B—W, —A—B—W—D or —A—B—W—D—E, R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, —Z, —Z—G or —Z—G—J, the above A, B, D, E, G and J independently each other are a residue of an amino acid selected from alanine, valine, leucine, isoleucine, serine, threonine, lysine, hydroxylysine, arginine, cysteine, methionine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamic acid, glutamine and the like or an N—(C1-C4) alkyl derivative of these amino acid residues; the above W and Z independently each other are a residue of an amino acid selected from aspartic acid, asparagine, glutamic acid, glutamine, alanine, serine or lysine) or pharmacologically acceptable salts thereof. The depsipeptides have an activity of promoting the production of apolipoprotein E and are useful as a therapeutic agent for neurologic damages, especially for dementia, and further as a therapeutic agent for hyperlipemia.
摘要翻译：由式（1）表示的缩肽：其中：R1是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; R2是-AB，-ABW，-ABWD 或-ABWDE，R3是羟基，低级烷氧基，苄氧基，-Z，-ZG或-ZGJ，上述A，B，D，E，G和J彼此独立地是氨基的残基选自丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，赖氨酸，羟赖氨酸，精氨酸，半胱氨酸，甲硫氨酸，苯丙氨酸，酪氨酸，天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺等的N-酸或N-（C1-C4）这些氨基酸残基的烷基衍生物;上述W和Z彼此独立地是选自天冬氨酸，天冬酰胺，谷氨酸，谷氨酰胺，丙氨酸，丝氨酸或赖氨酸的氨基酸的残基）或其药理学上可接受的盐。脱脂肽具有促进载脂蛋白E的产生的活性并且可用作治疗用于神经损伤的特异剂，特别是对于痴呆，并且作为高脂血症的治疗剂。

4. 发明授权

US06288038B1 Depsipeptide derivatives bearing piperazinone rings 失效
标题翻译：含有哌嗪酮环的多肽衍生物
公开(公告)号：US06288038B1
公开(公告)日：2001-09-11
申请号：US09509132
申请日：2000-04-03
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K3150
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0207
摘要： The present invention provides a new depsipeptide derivative having a piperazinone ring within the molecule which is represented by formula (1) wherein X1 represents N(R4)—CO, N(R5)—CH2, CH2—CO, CH2—CH2, CH═CH, CH2—CH(OH) or CH(OH)—CH(OH), R1 represents a C5-C20 alkyl group or a C5-C15 alkoxy C1-C4 alkyl group, R2-R5 represent a hydrogen atom or a C1-C6 alkyl group, and A represents a group of formula (2), (3) or (4) The depsipeptide derivative has a function of accelerating the production of apolipoprotein E and is useful as an agent for the treatment of neurologic injury, an agent for the treatment of dementia and an antihyperlipidemic agent.
摘要翻译：本发明提供了在分子内具有哌嗪酮环的新的脱脂肽衍生物，其由式（1）表示，其中X 1表示N（R 4）-CO，N（R 5）-CH 2，CH 2 -CO，CH 2 -CH 2，CH = CH ，CH 2 -CH（OH）或CH（OH）-CH（OH），R 1表示C 5 -C 20烷基或C 5 -C 15烷氧基C 1 -C 4烷基，R 2 -R 5表示氢原子或C 1 -C 6 烷基，A表示式（2），（3）或（4）的基团。三肽衍生物具有加速载脂蛋白E的产生的功能，可用作治疗神经损伤的药剂，治疗痴呆症和抗高血脂药物。

5. 发明授权

US06252041B1 Depsipeptides containing non-natural amino acids 失效
标题翻译：含有非天然氨基酸的脱脂肽
公开(公告)号：US06252041B1
公开(公告)日：2001-06-26
申请号：US09235479
申请日：1999-01-22
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： C07K508
CPC分类号： C07K5/06043 , A61K38/00 , C07C237/10 , C07K5/06052 , C07K5/101 , Y02P20/55
摘要： A depsipeptide containing a non-natural amino acid(s) having the formula (1) wherein R1 represents a C5-C20 alkyl group and others; R2 represents —O—CO—CH(R5)—X—CH(R6)—NH— (wherein X represents N(R7)—CO, CH2—CO, CH2—CH2 and others, R5, R6, and R7 represent a hydrogen atom or a C1-C6 alkyl group); R3 represents and wherein the remaining substituent variables are as defined herein. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.
摘要翻译：含有具有式（1）的非天然氨基酸的前肽，其中R1表示C5-C20烷基等; R2表示-O-CO-CH（R5）-X-CH（R6）-NH-（其中X表示N（R7）-CO，CH2-CO，CH2-CH2等，R5，R6和R7表示氢原子或C1-C6烷基）; R3代表并且其中剩余的取代基变量如本文所定义。上述脱肽对载脂蛋白E的产生具有促进活性，并且可用作神经损伤，特别是痴呆和高脂血症的治疗剂。

6. 发明授权

US06858585B1 Cyclic depsipeptides and drugs containing the same as the active ingredient 失效
标题翻译：循环利肽和含有与活性成分相同的药物
公开(公告)号：US06858585B1
公开(公告)日：2005-02-22
申请号：US09147434
申请日：1997-06-25
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K38/00 , C07K7/06 , A61K38/15 , C07K7/00
CPC分类号： C07K7/06 , A61K38/00
摘要： Cyclic depsipeptides represented by the formula wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15-carbon atoms; A, B, D, E and F independently each other are alanine, valine, leucine, isoleucine, phenylalanine, etc.; W and Z independently each other are aspartic acid, asparagine, glutamic acid or glutamine; and m and n independently each other is 0 or 1, or pharmacologically acceptable salts thereof. The present compounds are prepared according to a method conventionally used in peptide synthesis. The present compounds are useful as an agent for promoting the production of apolipoprotein E, a therapeutic agent for neurologic damages, a therapeutic agent for dementia, an agent for inhibiting the production of apolipoprotein B, an agent for promoting the production of apolipoprotein A1 or a therapeutic agent for hyperlipemia.
摘要翻译：以下式表示的环状缩酚酸酯：R为5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; A，B，D，E和F独立地为丙氨酸，缬氨酸，亮氨酸，异亮氨酸，苯丙氨酸等; W和Z独立地是天冬氨酸，天冬酰胺，谷氨酸或谷氨酰胺; m和n彼此独立地为0或1，或其药理学上可接受的盐。本发明化合物根据肽合成中常规使用的方法制备。本发明化合物可用作促进载脂蛋白E的产生，神经损伤治疗剂，痴呆治疗剂，抑制载脂蛋白B的制备的试剂，促进载脂蛋白A1的制造的试剂或高脂血症治疗剂。

7. 发明授权

US06211145B1 Bicyclic depsipeptides 失效
标题翻译：双环脱肽
公开(公告)号：US06211145B1
公开(公告)日：2001-04-03
申请号：US09212481
申请日：1998-12-16
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K3808
CPC分类号： C07K7/06 , A61K38/00 , C07K7/56 , C07K7/64
摘要： The present invention provides a bicyclic depsipeptide having the formula (1) wherein: R is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; A, D, E and J independently are a residue of an amino acid selected from the group of alanine, valine, leucine, etc.; B and F are the same or different and a residue of an amino acid selected from the group consisting of cysteine, aspartic acid, glutamic acid, lysine, hydroxylysine and serine; G is a disulfide bond, an amido bond or an ester bond; W is a residue of an amino acid selected from the group consisting of aspartic acid and glutamic acid; Z is a residue of an amino acid selected from the group consisting of aspartic acid, asparagine, glutamic acid and glutamine; l, m, n, p and q independently are 0 or 1; or a pharmacologically acceptable salt thereof.
摘要翻译：本发明提供具有式（1）的双环脱肽酶，其中：R是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; A，D，E和J独立地是选自丙氨酸，缬氨酸，亮氨酸等的氨基酸的残基; B和F相同或不同，并且选自半胱氨酸，天冬氨酸，谷氨酸，赖氨酸，羟赖氨酸和丝氨酸的氨基酸残基; G是二硫键，酰胺键或酯键; W是选自天冬氨酸和谷氨酸的氨基酸残基; Z是选自天冬氨酸，天冬酰胺，谷氨酸和谷氨酰胺的氨基酸的残基; l，m，n，p和q独立地为0或1; 或其药理学上可接受的盐。

8. 发明授权

US06316406B1 Depsipeptides containing N-substituted glycine residue 失效
标题翻译：含有N-取代的甘氨酸残基的三肽
公开(公告)号：US06316406B1
公开(公告)日：2001-11-13
申请号：US09379614
申请日：1999-08-24
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K3815
CPC分类号： C07K7/06 , A61K38/00
摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): (wherein R1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R2 is a group of the formula —A—B—W—(D)m—(E)n, —A—B—W—(D)m—(E)n—F or —A—B—W—(D)m—(E)n—F—Z; R3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula —Z, —Z—G or —Z—G—J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof. The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.
摘要翻译：含有具有式（1）或（2）的N-取代甘氨酸残基的缩酚酸肽:(其中R 1是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; R2 是式-ABW-（D）m-（E）n，-ABW-（D）m-（E）nF或-ABW-（D）m-（E）nFZ的基团; R3是羟基，低级烷氧基，苄氧基或式-Z，-ZG或-ZGJ的基团; A，B，D，E，F，G和J独立地为N-取代的甘氨酸残基或选自丙氨酸，缬氨酸，亮氨酸，丝氨酸等的氨基酸; W和Z独立地是选自天冬氨酸，谷氨酸等的氨基酸的残基;至少 A，B，D，E，F，G和J之一是N-取代的甘氨酸残基）或其药理学上可接受的盐。上述脱脂肽对载脂蛋白E的产生具有促进作用，可用作神经损伤的治疗剂，特别是痴呆和高脂血症。

9. 发明授权

US6001815A Depsipeptides containing N-substituted glycine residue 失效
标题翻译：含有N-取代的甘氨酸残基的三肽
公开(公告)号：US6001815A
公开(公告)日：1999-12-14
申请号：US218125
申请日：1998-12-21
申请人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
发明人： Makoto Yanai , Masashi Suzuki , Norio Oshida , Koji Kawamura , Shigeru Hiramoto , Orie Yasuda , Nobuhiro Kinoshita , Akiko Shingai , Masako Takasu
IPC分类号： A61K38/00 , C07K7/06
CPC分类号： C07K7/06 , A61K38/00
摘要： A depsipeptide containing N-substituted glycine residue having the formula (1) or (2): ##STR1## (wherein R.sub.1 is a straight or branched alkyl group of 5-20 carbon atoms or a straight or branched alkoxymethyl group of 5-15 carbon atoms; R.sub.2 is a group of the formula --A--B--W--(D).sub.m --(E).sub.n, --A--B--W--(D).sub.m --(E).sub.n --F or --A--B--W--(D).sub.m --(E).sub.n --F--Z; R.sub.3 is a hydroxyl group, a lower alkoxy group, a benzyloxy group, or a group of the formula --Z, --Z--G or --Z--G--J; A, B, D, E, F, G and J independently are an N-substituted glycine residue or a residue of an amino acid selected from the group consisting of alanine, valine, leucine, serine, etc.; W and Z independently are a residue of an amino acid selected from the group consisting of an aspartic acid, a glutamic acid, etc.; at least one of A, B, D, E, F, G and J is an N-substituted glycine residue) or a pharmacologically acceptable salt thereof.The above depsipeptides have a promoting activity on the production of apolipoprotein E, and are useful as a therapeutic agent for neurologic damages, especially dementia, and hyperlipemia.
摘要翻译：含有具有式（1）或（2）的N-取代甘氨酸残基的depsipeptide：（其中R1是5-20个碳原子的直链或支链烷基或5-15个碳原子的直链或支链烷氧基甲基; R2 是式-ABW-（D）m-（E）n，-ABW-（D）m-（E）nF或-ABW-（D）m-（E）nFZ的基团; R3是羟基，低级烷氧基，苄氧基或式-Z，-ZG或-ZGJ的基团; A，B，D，E，F，G和J独立地为N-取代的甘氨酸残基或选自丙氨酸，缬氨酸，亮氨酸，丝氨酸等的氨基酸; W和Z独立地是选自天冬氨酸，谷氨酸等的氨基酸的残基;至少 A，B，D，E，F，G和J之一是N-取代的甘氨酸残基）或其药理学上可接受的盐。上述脱脂肽对载脂蛋白E的产生具有促进作用，可用作神经损伤的治疗剂，特别是痴呆和高脂血症。

10. 发明授权

US5576335A Urea derivatives and their use as ACAT inhibitors 失效
标题翻译：尿素衍生物及其作为ACAT抑制剂的用途
公开(公告)号：US5576335A
公开(公告)日：1996-11-19
申请号：US314814
申请日：1994-09-29
申请人： Noriyoshi Sueda , Kazuhiko Yamada , Makoto Yanai , Katsutoshi Miura , Masato Horigome , Norio Oshida , Shigeru Hiramoto , Koichi Katasuyama , Fumihisa Nakata , Nobuhiro Kinoshita , Yoko Tsukada
发明人： Noriyoshi Sueda , Kazuhiko Yamada , Makoto Yanai , Katsutoshi Miura , Masato Horigome , Norio Oshida , Shigeru Hiramoto , Koichi Katasuyama , Fumihisa Nakata , Nobuhiro Kinoshita , Yoko Tsukada
IPC分类号： C07C275/34 , C07C275/40 , C07C275/42 , C07D295/215 , C07D211/26 , A61K31/44 , A61K31/445 , C07D213/36
CPC分类号： C07D295/215 , C07C275/34 , C07C275/40 , C07C275/42 , C07C2101/08 , C07C2103/74
摘要： Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.
摘要翻译：式（1）的脲衍生物其中有价值基团如说明书中所定义，其具有ACAT抑制活性和抗氧化活性。这些衍生物可用于预防和治疗高胆固醇血症和动脉粥样硬化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式