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    • 5. 发明申请
    • SWITCHING FLUORESCENT NANOPARTICLE PROBE AND FLUORESCENT PARTICLE IMAGING METHOD USING SAME
    • 切换荧光纳米粒子探针和使用其的荧光颗粒成像方法
    • US20130149252A1
    • 2013-06-13
    • US13818392
    • 2011-08-08
    • Isao HaraEiichi OzekiHideo SajiShunsaku KimuraMasahiro OnoTakashi Temma
    • Isao HaraEiichi OzekiHideo SajiShunsaku KimuraMasahiro OnoTakashi Temma
    • A61K49/00
    • A61K49/0089A61K49/0032A61K49/0093Y10S977/773Y10S977/927
    • The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
    • 本发明提供了具有开关功能(在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能)的新型荧光纳米颗粒成像探针。 一种开关荧光纳米颗粒探针,包括:由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料,其中(a)所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元,(b)所述疏水性嵌段链包含: 必需的疏水结构单元,选自氨基酸单元和羟基酸单元的单元,和(c)荧光染料是由式(I)表示的花青化合物:和 荧光染料被封装在单分子组装中。
    • 8. 发明授权
    • Connector with a flexible printed circuit board
    • 带柔性印刷电路板的连接器
    • US07833041B2
    • 2010-11-16
    • US12421450
    • 2009-04-09
    • Masahiro OnoMasayuki Okamoto
    • Masahiro OnoMasayuki Okamoto
    • H01R13/62
    • H01R12/88H01R12/774
    • A connector has a base having an opening to be inserted with a tip portion of a flexible printed circuit board at a front surface, and having a plurality of insertion holes passing from the front surface to a rear surface juxtaposed at a predetermined pitch, a connection terminal arranged in a projecting manner with a substantially T-shaped operating piece having at one end a movable contacting point that comes into pressure contact with joints juxtaposed at the tip portion of the flexible printed circuit board, the connection terminal having one end that becomes a fixed contacting point inserted to the insertion hole from the rear surface side, and an operating lever in which a cam portion is fitted into a turning recessed portion arranged at an upper side of the connection terminal to act as a turning supporting point, the cam portion driving an operation receiving portion positioned at the other end of the operating piece. A position regulation contacting portion arranged at a lower surface of the operating lever locks to a slip-out preventing projection arranged in a projecting manner at an upper side of the connection terminal to prevent slip-out when the operating lever is turned and a locking operation is completed.
    • 连接器具有基部,其具有在前表面插入柔性印刷电路板的前端部的开口,并且具有从前表面延伸到以预定间距并置的后表面的多个插入孔,连接 端子布置成具有基本上T形的操作件的基本上T形的操作件,其一端具有与在柔性印刷电路板的顶端部分并列的接头进行压力接触的可动接触点,连接端子的一端变为 固定接触点从后表面侧插入插入孔;以及操作杆,其中凸轮部分装配到布置在连接端子的上侧的转向凹部中,以用作转动支撑点,凸轮部分 驱动位于操作件的另一端的操作接收部。 布置在操作杆的下表面处的位置调节接触部分锁定到突出地布置在连接端子的上侧的防滑突起,以防止当操作杆转动时滑脱,并且锁定操作 完成了。