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1. 发明申请

US20100160634A1 CRYSTALLINE MICROPOWDER PARTICLES 有权
标题翻译：晶体微波颗粒
公开(公告)号：US20100160634A1
公开(公告)日：2010-06-24
申请号：US12601150
申请日：2008-05-20
申请人： Masahiro Akimoto , Toshikazu Komagata , Motohiro Shiraki , Akihiro Ando
发明人： Masahiro Akimoto , Toshikazu Komagata , Motohiro Shiraki , Akihiro Ando
IPC分类号： C07D489/08
CPC分类号： A61K9/1688 , A61K9/2018 , A61K31/485 , C07D489/08
摘要： Crystalline particles of N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-phthalimide or a pharmaceutically acceptable salt thereof are disclosed. The crystalline particles have a particle diameter distribution in which a particle diameter (D50) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 50% is within a range of 1 to 30 μm, and a particle diameter (D90) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 90% is not more than 90 μm, which crystalline particles have a degree of crystallinity of not less than 80%. By the crystalline particles, bioavailability of the active substance may be increased while ensuring storage stability of the compound.
摘要翻译：公开了N-（17-环丙基甲基-4,5α-环氧-3,14-二羟基 - 吗啡喃-6'-基） - 邻苯二甲酰亚胺或其药学上可接受的盐的结晶颗粒。结晶粒子具有粒径分布，其中由具有小直径的颗粒累积计算的体积分布的累积频率达到50％的点处的粒径（D50）在1至30μm的范围内，并且粒径（D90）在由具有较小直径的颗粒累积计算的体积分布的累积频率达到90％的点处不超过90μm，该结晶颗粒的结晶度不小于80％。通过结晶颗粒，可以提高活性物质的生物利用度，同时确保化合物的储存稳定性。

2. 发明授权

US08198446B2 Crystalline micropowder particles 有权
标题翻译：结晶微粉颗粒
公开(公告)号：US08198446B2
公开(公告)日：2012-06-12
申请号：US12601150
申请日：2008-05-20
申请人： Masahiro Akimoto , Toshikazu Komagata , Motohiro Shiraki , Akihiro Ando
发明人： Masahiro Akimoto , Toshikazu Komagata , Motohiro Shiraki , Akihiro Ando
IPC分类号： C07D489/08
CPC分类号： A61K9/1688 , A61K9/2018 , A61K31/485 , C07D489/08
摘要： Crystalline particles of N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-phthalimide or a pharmaceutically acceptable salt thereof are disclosed. The crystalline particles have a particle diameter distribution in which a particle diameter (D50) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 50% is within a range of 1 to 30 μm, and a particle diameter (D90) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 90% is not more than 90 μm, which crystalline particles have a degree of crystallinity of not less than 80%. By the crystalline particles, bioavailability of the active substance may be increased while ensuring storage stability of the compound.
摘要翻译：公开了N-（17-环丙基甲基-4,5α-环氧-3,14-二羟基 - 吗啡喃-6'-基） - 邻苯二甲酰亚胺或其药学上可接受的盐的结晶颗粒。结晶粒子具有粒径分布，其中由具有小直径的颗粒累积计算的体积分布的累积频率达到50％的点处的粒径（D50）在1至30μm的范围内，并且粒径（D90）在由具有较小直径的颗粒累积计算的体积分布的累积频率达到90％的点处不超过90μm，该结晶颗粒的结晶度不小于80％。通过结晶颗粒，可以提高活性物质的生物利用度，同时确保化合物的储存稳定性。

3. 发明授权

US6051322A Process for surface-treating body made of metal and composition of matter produced thereby 失效
标题翻译：由金属制成的表面处理体及其制成的物质组成的方法
公开(公告)号：US6051322A
公开(公告)日：2000-04-18
申请号：US18672
申请日：1998-02-04
申请人： Masahiko Kakizaki , Masahiro Akimoto
发明人： Masahiko Kakizaki , Masahiro Akimoto
IPC分类号： C23C22/00 , B05D7/14 , C09D5/08 , C23C22/57 , C23C22/68 , B32B9/00
CPC分类号： C09D5/086 , B05D7/14 , C23C22/68 , B05D2202/20 , C23C2222/20
摘要： A process for surface-treating a body made of metal is disclosed, which includes a step of immersing the body made of metal in an aqueous solution containing at least one organometallic compound and at least one film-forming assistant, thereby forming a transparent film on a surface of the body made of metal. Further, in accordance with the present invention, there is provided a composition of matter including a substrate made of magnesium or a magnesium alloy and a transparent film formed on the substrate, which can be prepared by the process.
摘要翻译：公开了一种用金属表面处理体的方法，其包括将金属制的体浸渍在含有至少一种有机金属化合物和至少一种成膜助剂的水溶液中的步骤，从而在身体由金属制成的表面。此外，根据本发明，提供了一种包括由镁或镁合金制成的衬底的物质组合物以及可以通过该方法制备的在衬底上形成的透明膜。

4. 发明授权

US07803942B2 Crystals of morphinan derivative and process for producing the same 有权
标题翻译：吗啡喃衍生物的晶体及其生产方法
公开(公告)号：US07803942B2
公开(公告)日：2010-09-28
申请号：US11887842
申请日：2006-04-06
申请人： Hisanori Wakita , Masahiro Akimoto , Takahiro Takeda
发明人： Hisanori Wakita , Masahiro Akimoto , Takahiro Takeda
IPC分类号： C07D489/08 , C07D489/00
CPC分类号： C07D489/08
摘要： The present invention is directed to provide 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride consistent in quality after production and having high purity. A crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride including a A-form, B-form or C-form crystal thereof, and a process for producing the same are provided.
摘要翻译：本发明涉及提供生产中质量一致的17-环丙基甲基-3,14-二羟基-4,5α-环氧-6α-[N-甲基 - 反-3-（3-呋喃基）丙烯酰氨基]吗啡喃盐酸盐并具有高纯度。包含A型，B型的17-环丙基甲基-3,14＆bgr-二羟基-4,5α-环氧-6α-[N-甲基 - 反-3-（3-呋喃基）丙烯酰氨基]吗啡喃的晶体或其C-型结晶，及其制造方法。

5. 发明申请

US20090062544A1 Crystals of Morphinan Derivative and Process for Producing the Same 有权
标题翻译：吗啡衍生物的晶体及其生产方法
公开(公告)号：US20090062544A1
公开(公告)日：2009-03-05
申请号：US11887842
申请日：2006-04-06
申请人： Hisanori Wakita , Masahiro Akimoto , Takahiro Takeda
发明人： Hisanori Wakita , Masahiro Akimoto , Takahiro Takeda
IPC分类号： C07D489/00
CPC分类号： C07D489/08
摘要： The present invention is directed to provide 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride consistent in quality after production and having high purity. A crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride including a A-form, B-form or C-form crystal thereof, and a process for producing the same are provided.
摘要翻译：本发明旨在提供在生产后质量保持一致的17-环丙基甲基-3,14β-二羟基-4,5α-环氧-6β-[N-甲基 - 反-3-（3-呋喃基）丙烯酰氨基]吗啡喃盐酸盐，并具有高纯度包含A型，B型或C型的17-环丙基甲基-3,14β-二羟基-4αα-环氧-Sbeta- [N-甲基 - 反式-3-（3-呋喃基）丙烯酰氨基]吗啡喃的晶体的结晶，及其制造方法。

6. 发明授权

US6136381A Process for surface-treating body made of metal and composition of matter produced thereby 失效
公开(公告)号：US6136381A
公开(公告)日：2000-10-24
申请号：US376252
申请日：1999-08-18
申请人： Masahiko Kakizaki , Masahiro Akimoto
发明人： Masahiko Kakizaki , Masahiro Akimoto
IPC分类号： C23C22/00 , B05D7/14 , C09D5/08 , C23C22/57 , C23C22/68 , B05D1/18 , B32B9/00
CPC分类号： C09D5/086 , B05D7/14 , C23C22/68 , B05D2202/20 , C23C2222/20
摘要： A process for surface-treating a body made of metal is disclosed, which includes a step of immersing the body made of metal in an aqueous solution containing at least one organometallic compound and at least one film-forming assistant, thereby forming a transparent film on a surface of the body made of metal. Further, in accordance with the present invention, there is provided a composition of matter including a substrate made of magnesium or a magnesium alloy and a transparent film formed on the substrate, which can be prepared by the process.

7. 发明申请

US20100032379A1 METHOD FOR TREATMENT OF SLUDGE OR WASTEWATER 审中-公开
标题翻译：用于处理污泥或废水的方法
公开(公告)号：US20100032379A1
公开(公告)日：2010-02-11
申请号：US12296578
申请日：2007-04-10
申请人： Toshiaki Komido , Masahiro Akimoto
发明人： Toshiaki Komido , Masahiro Akimoto
IPC分类号： C02F1/52
CPC分类号： C02F1/56 , C02F1/001 , C02F11/14 , C02F2209/44
摘要： A method of treating sludge or wastewater involving the following steps: a swelling step which prepares a swelling liquid by adding a powdery polymer flocculant to water; a dissolution step which obtains an aqueous flocculant solution by supplying the swelling liquid to a filtration component and passing a filtering area of the filtration component; a flocculation treatment step which adds the aqueous flocculant solution to sludge or wastewater, wherein the total processing time from the time point where the powdery polymer flocculant was added to water until just before adding to sludge or wastewater to the aqueous flocculant solution is less than 3 hours.
摘要翻译：一种处理污泥或废水的方法，包括以下步骤：通过向水中加入粉末状聚合物絮凝剂来制备溶胀液体的溶胀步骤; 溶出步骤，通过将溶胀液体供应到过滤组分并使过滤组分的过滤区域通过来获得水性絮凝剂溶液; 絮凝处理步骤，其将水性絮凝剂溶液添加到污泥或废水中，其中从添加到粉末状聚合物絮凝剂到水的时间点到在添加到絮凝剂水溶液的污泥或废水之前的总处理时间小于3 小时。

8. 发明授权

US5851597A "Process for surface-treating body made of metal" 失效
标题翻译： “金属表面处理体系”
公开(公告)号：US5851597A
公开(公告)日：1998-12-22
申请号：US802532
申请日：1997-02-18
申请人： Masahiko Kakizaki , Masahiro Akimoto
发明人： Masahiko Kakizaki , Masahiro Akimoto
IPC分类号： C23C22/00 , B05D7/14 , C09D5/08 , C23C22/57 , C23C22/68 , B05D1/18
CPC分类号： C09D5/086 , B05D7/14 , C23C22/68 , B05D2202/20 , C23C2222/20 , Y10T428/31678
摘要： A process for surface-treating a body made of metal is disclosed, which includes a step of immersing the body made of metal in an aqueous solution containing at least one organometallic compound and at least one film-forming assistant, thereby forming a transparent film on a surface of the body made of metal. Further, in accordance with the present invention, there is provided a composition of matter including a substrate made of magnesium or a magnesium alloy and a transparent film formed on the substrate, which can be prepared by the process.
摘要翻译：公开了一种用金属表面处理体的方法，其包括将金属制的体浸渍在含有至少一种有机金属化合物和至少一种成膜助剂的水溶液中的步骤，从而在身体由金属制成的表面。此外，根据本发明，提供了一种包括由镁或镁合金制成的衬底的物质组合物以及可以通过该方法制备的在衬底上形成的透明膜。

9. 发明授权

US5800693A Method for surface-treating substrate and substrate surface-treated by the method 失效
标题翻译：通过该方法表面处理基材和表面处理的基材的方法
公开(公告)号：US5800693A
公开(公告)日：1998-09-01
申请号：US771154
申请日：1996-12-20
申请人： Masahiko Kakizaki , Masahiro Akimoto
发明人： Masahiko Kakizaki , Masahiro Akimoto
IPC分类号： C25D11/30
CPC分类号： C25D11/30
摘要： A method for surface-treating a substrate made of a magnesium-based metal material is disclosed, which includes immersing the substrate in an electrolyte composed of an aqueous solution containing at least one component selected from the group consisting of hydroxides, carbonates and bicarbonates of alkali metals or alkali earth metals, and a film-forming stabilizer, and conducting an electrolysis to form an anodic oxide film on a surface of the substrate. The film-forming stabilizer includes one component selected from salts of mineral acids, fluorides, silicates and silicofluorides and an additional component selected from ethylene glycol, trihydroxypropane, dihydroxyethyl ether and sodium hydroxybenzoate. Further, in accordance with the present invention, there is provided the substrate which is surface-treated by the method.
摘要翻译：公开了一种用于表面处理由镁基金属材料制成的衬底的方法，其包括将衬底浸入由含有至少一种选自氢氧化物，碳酸盐和碱金属碳酸盐的组分的水溶液组成的电解质中金属或碱土金属和成膜稳定剂，并且在基材的表面上进行电解以形成阳极氧化膜。成膜稳定剂包括选自无机酸，氟化物，硅酸盐和硅氟化物的盐的一种组分和选自乙二醇，三羟基丙烷，二羟乙基醚和羟基苯甲酸钠的另外的组分。此外，根据本发明，提供了通过该方法进行表面处理的基板。

10. 发明授权

US4437465A Medical treatment sewing machine 失效
标题翻译：医疗缝纫机
公开(公告)号：US4437465A
公开(公告)日：1984-03-20
申请号：US344774
申请日：1982-02-01
申请人： Reishi Nomoto , Masahiro Akimoto , Masayoshi Takahashi
发明人： Reishi Nomoto , Masahiro Akimoto , Masayoshi Takahashi
IPC分类号： A61B17/04 , D05B81/00 , A61B17/06
CPC分类号： D05B81/00 , A61B17/0491
摘要： A suturing instrument for a surgical operation includes a suturing portion having a base, a vertically reciprocating needle holder carrying a needle with an upper thread, a device for supplying a predetermined amount of the upper thread to the needle and a loop taker supported in the base for turnable movement relative thereto and operative for catching a thread loop formed on the needle. The device for supplying the upper thread, the loop taker and the needle holder are activated for sequential operation by a control portion of the instrument which includes a fluid drive device connected to the suturing portion and including a plurality of hydraulic cylinders. The control portion is activated by a manually operated switch which actuates an electric circuit and a switching device operating a plurality of the cylinders for sequentially imparting the reciprocating movements to the needle, the loop taker and the thread supplying device.
摘要翻译：用于外科手术的缝合器具包括具有基部的缝合部分，承载带有面线的针的垂直往复运动的针保持器，用于向针提供预定量的面线的装置以及支撑在基部中的环接受器用于相对于其可转动的运动，并且用于捕捉形成在针上的螺纹环。用于供应面线，回路接收器和针保持器的装置被启动以由仪器的控制部分顺序操作，该装置的控制部分包括连接到缝合部分并且包括多个液压缸的流体驱动装置。控制部分由手动操作的开关激活，该开关致动电路和操作多个气缸的开关装置，以顺序地向针，回路接收器和线供给装置施加往复运动。

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