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1. 发明授权

US08263121B2 Solid pharmaceutical preparation 有权
标题翻译：固体药物制剂
公开(公告)号：US08263121B2
公开(公告)日：2012-09-11
申请号：US11578450
申请日：2005-04-13
申请人： Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
发明人： Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
IPC分类号： A61K31/4439 , A61K31/155 , A61K9/201
CPC分类号： A61K9/209 , A61K9/2027 , A61K9/2054 , A61K9/2853 , A61K9/2866 , A61K31/155 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The present invention provides a solid preparation containing an insulin sensitizer and an active ingredient (except insulin sensitizers), which shows in vivo dissolution behavior of an insulin sensitizer, which is similar to the dissolution behavior of an insulin sensitizer from “a solid preparation containing an insulin sensitizer alone as an active ingredient”.The present invention provides a solid preparation containing (1) a layer containing an insulin sensitizer, and (2) a layer containing (a) an active ingredient (except insulin sensitizers), (b) microcrystalline cellulose having a mean particle size of 5-25 μm, (c) microcrystalline cellulose having a mean particle size of 30-100 μm and (d) polyvinylpyrrolidone K-90.
摘要翻译：本发明提供了含有胰岛素敏化剂和活性成分（胰岛素敏化剂除外）的固体制剂，其显示胰岛素敏化剂的体内溶出行为，其类似于胰岛素敏化剂从“含有单独的胰岛素敏化剂作为活性成分“。本发明提供一种固体制剂，其含有（1）含有胰岛素敏化剂的层，和（2）含有（a）活性成分（胰岛素敏化剂除外）的层，（b）平均粒径为5〜 25μm，（c）平均粒径为30-100μm的微晶纤维素和（d）聚乙烯吡咯烷酮K-90。

2. 发明授权

US4191082A Key range dividing type electronic musical instrument 失效
标题翻译：键范围分类电子乐器
公开(公告)号：US4191082A
公开(公告)日：1980-03-04
申请号：US950328
申请日：1978-10-11
申请人： Masahiko Koike
发明人： Masahiko Koike
IPC分类号： G10H1/06 , G10H1/18 , G10H1/02
CPC分类号： G10H1/06 , G10H1/18 , Y10S84/09
摘要： An electronic musical instrument having the key range divided into upper and lower divisions, including a logical circuit converting the change-over position outputs of a key range dividing position selecting switch into gate control signals specifying corresponding key range dividing positions and a plurality of gates controlled by these gate control signals, thereby controlling the distributive mode of keyed tone signals to different tone color filters.
摘要翻译：一种电子乐器，具有分为上下分割的键范围，包括将键范围分割位置选择开关的转换位置输出转换为指定对应键范围分割位置的门控制信号和多个门控制的逻辑电路通过这些门控制信号，从而将键控音调信号的分配模式控制到不同的音调滤色器。

3. 发明授权

US07976853B2 Process for producing coated preparation 有权
标题翻译：生产涂层制剂的方法
公开(公告)号：US07976853B2
公开(公告)日：2011-07-12
申请号：US10542997
申请日：2004-01-28
申请人： Kazuhiro Ohkouchi , Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
发明人： Kazuhiro Ohkouchi , Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
IPC分类号： A61K9/20
CPC分类号： A61K31/155 , A61K9/2086 , A61K9/209 , A61K31/439 , A61K31/4439
摘要： The present invention provides a production method of a preparation coated with pioglitazone hydrochloride, which is useful as a therapeutic agent for diabetes and the like, and which is superior in the characteristics of the preparation such as dissolution property of pioglitazone hydrochloride.
摘要翻译：本发明提供一种包被盐酸吡格列酮的制剂的制备方法，其可用作糖尿病等的治疗剂，并且其制备特性如盐酸吡格列酮的溶解性优异。

4. 发明授权

US06306414B1 Aqueous suspension of agrochemical 失效
标题翻译：农药的水悬浮液
公开(公告)号：US06306414B1
公开(公告)日：2001-10-23
申请号：US09341813
申请日：1999-07-19
申请人： Masahiko Koike
发明人： Masahiko Koike
IPC分类号： A01N2502
CPC分类号： A01N51/00 , A01N25/04 , A01N25/10 , A01N25/30 , A01N2300/00
摘要： The present invention relates to an aqueous suspension comprising (i) a compound of the formula: or a salt thereof, (ii) a condensate of formaldehyde with an aromatic sulfonic acid or a salt thereof or a polyoxyalkylene allyl phenyl ether sulfate, and (iii) an absorptive water-soluble polymer. The aqueous suspension of the invention can be used with advantage as a stable aqueous suspension of low viscosity providing for excellent delivery from a container, with excellent dispersibility in diluent water and excellent long-term fluidity free from caking due to precipitation of the suspended particles.
摘要翻译：本发明涉及一种水性悬浮液，其包含（i）下式化合物或其盐，（ii）甲醛与芳族磺酸或其盐或聚氧化烯烯丙基苯基醚硫酸盐的缩合物，和（iii））吸收性水溶性聚合物。本发明的水性悬浮液可以有利地用作低粘度的稳定的水性悬浮液，其提供了从容器的良好输送，在稀释水中具有优异的分散性，并且由于悬浮颗粒的沉淀而具有优异的长期流动性。

5. 发明授权

US4233875A Electronic musical instrument with automatic trill performance function 失效
标题翻译：电子乐器具有自动颤振性能功能
公开(公告)号：US4233875A
公开(公告)日：1980-11-18
申请号：US939954
申请日：1978-09-06
申请人： Takeshi Adachi , Masahiko Koike , Toshiyuki Takahashi
发明人： Takeshi Adachi , Masahiko Koike , Toshiyuki Takahashi
IPC分类号： G10H1/043 , G10H1/30 , G10H5/00 , G10H1/02
CPC分类号： G10H5/002 , G10H1/043
摘要： An electronic musical instrument comprises a keyboard circuit providing a pitch determining voltage signal whose magnitude corresponds to the note of a key depressed, a rectangular wave generation circuit generating a rectangular wave voltage signal, and a voltage controlled oscillator connected to receive the pitch determining voltage signal and the rectangular wave voltage signal to produce alternately first and second tone signals for trill performance. The tone pitch of the first tone signal depends on the magnitude of pitch determining voltage signal and the tone pitch of the second tone signal depends on the magnitudes of pitch determining voltage signal and rectangular wave voltage signal. The musical intervals between tone pitches of the first and second tone signals depends on the magnitude of rectangular wave voltage signal.
摘要翻译：一种电子乐器包括提供音调确定电压信号的键盘电路，其幅度对应于按键的音符，产生矩形波电压信号的矩形波产生电路和连接以接收音调确定电压信号的压控振荡器和矩形波电压信号，以产生交替的第一和第二音调信号用于颤振性能。第一音调信号的音调音调取决于音高确定电压信号的大小，并且第二音调信号的音调音调取决于音调确定电压信号和矩形波电压信号的大小。第一和第二音调信号的音调间距之间的音程取决于矩形波电压信号的大小。

6. 发明申请

US20110189282A1 TABLET 有权
标题翻译：片剂
公开(公告)号：US20110189282A1
公开(公告)日：2011-08-04
申请号：US13082890
申请日：2011-04-08
申请人： Masahiko Koike , Hiroyoshi Koyama
发明人： Masahiko Koike , Hiroyoshi Koyama
IPC分类号： A61K9/28
CPC分类号： A61K9/2072
摘要： The present invention can retain the volume of a tablet large without increasing the thickness of the tablet or the like dimension and prevents a plurality of tablets from sticking to each other even if they are subjected to a film-coating or the like treatment, so as to improve the yield. The tablet is a tablet (1) longer in one direction when seen in plan. The tablet (1) has side edges (6) each of which extends in a longitudinal direction and is formed in the shape of a curve projecting outwardly in plan view. The curve has a radius of curvature (R1) set to at least 1.5 times a length (L) of the tablet. This makes a projected area of the tablet (1) in plan view at least 97% with respect to a projected area of a standard elliptical tablet having opposite end portions each of which is formed by a semi-circle having a diameter of a width (W) of the tablet.
摘要翻译：本发明可以在不增加片剂厚度等的情况下保持片剂的体积，并且即使进行薄膜包衣或类似的处理，也可以防止多个片剂彼此粘附，从而提高产量。平板电脑是平板电脑（1）在计划中看到的时间长一个方向。片剂（1）具有侧边缘（6），每个边缘沿纵向方向延伸并且形成为在平面图中向外突出的曲线形状。曲线的曲率半径（R1）设定为片剂长度（L）的至少1.5倍。这使得平面图（1）中的平板（1）的投影面积相对于具有相对端部的标准椭圆形片的投影面积至少为97％，每个端部均由直径为宽度的半圆形成 W）。

7. 发明申请

US20060286168A1 Process for producing coated preparation 审中-公开
标题翻译：生产涂层制剂的方法
公开(公告)号：US20060286168A1
公开(公告)日：2006-12-21
申请号：US10520747
申请日：2003-07-10
申请人： Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
发明人： Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
IPC分类号： A61K31/426 , A61K31/155 , A61K9/28 , A61K9/26
CPC分类号： A61K31/4439 , A61K9/209 , A61K31/155
摘要： The present invention provides a production method of a preparation coated with pioglitazone hydrochloride, which is useful as a therapeutic agent for diabetes and the like and superior in the characteristics of the preparation such as dissolution property of pioglitazone hydrochloride and the like.
摘要翻译：本发明提供一种包被盐酸吡格列酮的制剂的制备方法，其可用作糖尿病等的治疗剂，并且具有优异的盐酸吡格列酮的溶出性等制剂的特性。

8. 发明申请

US20060141128A1 Process for producing coated preparation 有权
标题翻译：生产涂层制剂的方法
公开(公告)号：US20060141128A1
公开(公告)日：2006-06-29
申请号：US10542997
申请日：2004-01-28
申请人： Kazuhiro Ohkouchi , Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
发明人： Kazuhiro Ohkouchi , Masahiko Koike , Hiroyoshi Koyama , Naoru Hamaguchi
IPC分类号： A61L33/00 , C07C277/00
CPC分类号： A61K31/155 , A61K9/2086 , A61K9/209 , A61K31/439 , A61K31/4439
摘要： The present invention provides a production method of a preparation coated with pioglitazone hydrochloride, which is useful as a therapeutic agent for diabetes and the like, and which is superior in the characteristics of the preparation such as dissolution property of pioglitazone hydrochloride.
摘要翻译：本发明提供一种包被盐酸吡格列酮的制剂的制备方法，其可用作糖尿病等的治疗剂，并且其制备特性如盐酸吡格列酮的溶解性优异。

9. 发明授权

US06306417B2 Wettable or water-soluble granular agrochemical composition 有权
标题翻译：可湿性或水溶性颗粒状农药组合物
公开(公告)号：US06306417B2
公开(公告)日：2001-10-23
申请号：US09341811
申请日：1999-07-19
申请人： Masahiko Koike
发明人： Masahiko Koike
IPC分类号： A01N2514
CPC分类号： A01N25/14 , A01N51/00 , A01N25/30 , A01N2300/00
摘要： The present invention provides a wettable or water-soluble granular agrochemical composition which comprises a guanidine derivative of the formula: wherein R1 represents a homocyclic or heterocyclic group which may optionally be substituted; n is 0 or 1; R2 represents hydrogen or a hydrocarbon group which may optionally be substituted; R3 represents a primary, secondary, or tertiary amino group; X represents an electron attractive group; or a salt thereof, an alkenylsulfonate and a carrier. The agrochemical composition has excellent disintegrability and dispersibility in water.
摘要翻译：本发明提供一种可湿性或水溶性的颗粒状农药组合物，其包含下式的胍衍生物：其中R 1表示可任选被取代的碳环或杂环基团; n为0或1; R 2表示氢或可任选被取代的烃基; R3表示伯，仲或叔氨基; X表示吸电子基团; 或其盐，链烯基磺酸盐和载体。该农药组合物在水中具有优异的崩解性和分散性。

10. 发明授权

US4947724A Electric music instrument with the capability of memorizing and producing different musical scales 失效
标题翻译：电音乐器具有记忆和制作不同音阶的能力
公开(公告)号：US4947724A
公开(公告)日：1990-08-14
申请号：US418907
申请日：1989-10-05
申请人： Katsuhiko Hirano , Masahiko Koike , Hiroyuki Toda
发明人： Katsuhiko Hirano , Masahiko Koike , Hiroyuki Toda
IPC分类号： G10H1/10 , G10H7/00
CPC分类号： G10H7/004 , G10H1/10 , G10H2210/331 , G10H2210/401 , G10H2210/481 , Y10S84/04
摘要： An electronic musical instrument with plural pitch data generating functions includes a keyboard, a plurality of tone generating units, a pitch designating unit, a plural pitch data generating unit, and a musical tone generating unit. The keyboard has a plurality of keys. The tone generating units generate at least two tone signals in response to operation of a key among the plural keys. The pitch designating unit designates a pitch of a musical tone to be produced. The plural pitch data generating unit generates at least two pitch data based on the pitch and in accordance with different scale characteristics. The musical tone generating unit generates at least two musical tone signals based on at least two pitch data respectively, so that at least two musical tone signals have the different scale characteristics.
摘要翻译：具有多个音调数据生成功能的电子乐器包括键盘，多个乐音发生单元，音调指定单元，多音高数据产生单元和乐音发生单元。键盘具有多个键。响应于多个键中的键的操作，乐音产生单元产生至少两个音调信号。音调指定单元指定要产生的乐音的音调。多音调数据生成单元根据音调并根据不同的比例特性生成至少两个音调数据。乐音产生单元分别基于至少两个音调数据产生至少两个音乐信号，使得至少两个乐音信号具有不同的音阶特征。

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