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1. 发明授权

US5753707A Amide derivatives and their use in cosmetic composition 失效
标题翻译：酰胺衍生物及其在化妆品组合物中的用途
公开(公告)号：US5753707A
公开(公告)日：1998-05-19
申请号：US708974
申请日：1996-09-06
申请人： Masahide Hoshino , Hiroshi Kusuoku , Tadashi Hase , Atsuko Otsuka , Ichiro Tokimitsu , Akira Yamamuro , Yoshiya Sugai , Koji Yoshino , Youichi Arai , Shinichi Meguro
发明人： Masahide Hoshino , Hiroshi Kusuoku , Tadashi Hase , Atsuko Otsuka , Ichiro Tokimitsu , Akira Yamamuro , Yoshiya Sugai , Koji Yoshino , Youichi Arai , Shinichi Meguro
IPC分类号： A61K8/68 , A61K31/16 , A61K31/335 , A61Q17/00 , A61Q19/00 , C07C233/18 , C07C235/08 , C07C237/14 , C07C237/22 , C07D317/30 , A61K6/00 , C07C233/00
CPC分类号： A61Q17/00 , A61K8/68 , A61Q19/00 , C07C237/22 , C07D317/30 , Y10S514/847
摘要： An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.
摘要翻译：由下式（1）表示的酰胺衍生物：其中R1表示C1-40烃; R2代表C1-6亚烷基; R3表示H，OH或烷氧基; R4代表C1-39烃; R5表示，条件是当R 5表示R 3不表示OH时; 以及用于局部施用于人皮肤的酰胺衍生物的组合物。该组合物改善角质层的屏障功能，提供改善和预防皮炎，皮肤粗糙度或类似疾病。

2. 发明授权

US07056949B2 Oil/fat composition 有权
标题翻译：油/油组成
公开(公告)号：US07056949B2
公开(公告)日：2006-06-06
申请号：US10343742
申请日：2001-08-07
申请人： Shin Koike , Takeshi Yasumasu , Tadashi Hase , Takatoshi Murase
发明人： Shin Koike , Takeshi Yasumasu , Tadashi Hase , Takatoshi Murase
IPC分类号： A61K31/22 , A61K31/20 , C11B5/00 , A23D7/00 , A23D9/013
CPC分类号： A23G1/36 , A21D2/16 , A21D2/165 , A23D9/00 , A23D9/013 , A23G3/40 , A23G9/327 , A23K20/158 , A23L7/111 , A23L13/428 , A23L13/43 , A23L13/60 , A23L33/11 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K45/06 , C11C3/02 , C11C3/06 , A23V2250/1882 , A23V2250/2136 , A23V2250/6422 , A23V2250/642 , A23V2250/032 , A23V2250/182 , A23V2250/192 , A23V2250/194 , A23V2250/5108 , A23V2250/1874 , A23V2250/156 , A23V2250/70 , A23V2250/5118 , A23V2250/54246 , A23V2250/628
摘要： An oil/fat composition comprising 5 to 99.9 wt. % of a monoglyccride having, as fatty acid constituents thereof, 15 to 90 wt % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt. % of an ω 9-unsaturated fatty acid and 2 to 50 wt. % of an ω 9-unsaturated fatty acid; and 0.1 to 49.9 wt. % of a diglyceride, wherein a weight ratio of the diglyceride to the monoglyceride is less than 1 and the content of a polyunsaturated fatty acid having at least 4 carbon-to-carbon double bonds is 20% or less in all the fatty acid constituents. The oil/fat composition according to the present invention has excellent processing properties, good taste and excellent lowering action against glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in blood. It is useful not only for pharmaceuticals but also for preventive or remedial foods of feeds effective for hepatic function disturbances or obesity.
摘要翻译：一种油/脂肪组合物，其包含5至99.9wt。作为其脂肪酸组分，具有少于20个碳原子的ω-3-不饱和脂肪酸为15〜90重量％，1〜80重量％％的不饱和脂肪酸和2〜50重量％％的不饱和脂肪酸的％; 和0.1〜49.9wt。甘油二酯的百分比，其中甘油二酯与单酸甘油酯的重量比小于1，并且在所有脂肪酸组分中具有至少4个碳 - 碳双键的多不饱和脂肪酸的含量为20％以下。根据本发明的油/脂肪组合物具有优异的加工性能，良好的味道和对谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）水平的降低作用。它不仅用于药物，而且对于有用于肝功能障碍或肥胖的饲料的预防或补救食物是有用的。

3. 发明申请

US20080249171A1 METHOD FOR ACTIVATING THE LIPID CATABOLIC METABOLISM IN ENTERIC EPITHELIUM AND IMPROVING THE LIPID METABOLISM IN ENTERIC EPITHELIUM 审中-公开
标题翻译：用于激活肠上皮细胞中脂质代谢物的方法，并改善肠系膜上皮脂肪代谢
公开(公告)号：US20080249171A1
公开(公告)日：2008-10-09
申请号：US12125795
申请日：2008-05-22
申请人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
发明人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
IPC分类号： A61K31/225 , A61P3/00
CPC分类号： A61K31/231
摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.
摘要翻译：公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。二酰基甘油的摄入导致脂肪酸在小肠中的积累。如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

4. 发明授权

US07182971B2 Oil composition 有权
标题翻译：油组成
公开(公告)号：US07182971B2
公开(公告)日：2007-02-27
申请号：US10488251
申请日：2002-09-12
申请人： Hideto Takase , Shin Koike , Hideaki Sakai , Tsutomu Nishide , Tadashi Hase , Takatoshi Murase
发明人： Hideto Takase , Shin Koike , Hideaki Sakai , Tsutomu Nishide , Tadashi Hase , Takatoshi Murase
IPC分类号： A23D7/005
CPC分类号： A23K20/158 , A21D2/16 , A23D7/0053 , A23D7/0056 , A23D9/007 , A23L27/60 , A23L33/105 , A23L33/11 , A23L33/12
摘要： Disclosed herein is an oil composition comprising the following components (A) and (B):(A) 15 to 70% by weight of diglycerides in which less than 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids; and (B) 30 to 85% by weight of a triglyceride in which at least 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids. The oil composition is good in flavor, hard to be colored, excellent in hydrolytic stability and resistance to oxidation, good in emulsion stability and excellent in intake balance among fatty acids even under severe conditions that heating is performed at a high temperature for a long period of time, can be widely developed to medicinal preparations and foods and moreover exhibit an excellent inhibitory effect on accumulation of body fat by ingestion of a small amount of diglycerides.
摘要翻译：本文公开了一种油组合物，其包含以下组分（A）和（B）：（A））15至70重量％的甘油二酸酯，其中小于15重量％的组成型脂肪酸为（3型不饱和脂肪酸; 和（B）30-85重量％的甘油三酯，其中至少15重量％的组成型脂肪酸是（3型不饱和脂肪酸），油组合物的味道好，难以着色，水解性优异稳定性和耐氧化性，乳化稳定性好，即使在长时间在高温下进行加热的苛刻条件下，脂肪酸的摄取量平衡优异，可以广泛地发展成药用制剂和食品，通过摄取少量甘油二酯对身体脂肪的积累具有优异的抑制作用。

5. 发明授权

US07090886B2 Oil/fat composition 有权
标题翻译：油/油组成
公开(公告)号：US07090886B2
公开(公告)日：2006-08-15
申请号：US10343748
申请日：2001-08-07
申请人： Shin Koike , Takeshi Yasumasu , Tadashi Hase , Takatoshi Murase , Yoshihisa Katsuragi , Akira Takei
发明人： Shin Koike , Takeshi Yasumasu , Tadashi Hase , Takatoshi Murase , Yoshihisa Katsuragi , Akira Takei
IPC分类号： A23D9/007
CPC分类号： A23G3/40 , A21D2/16 , A23D7/011 , A23D7/013 , A23D7/015 , A23D9/013 , A23G3/346 , A23G2200/08 , A23K20/158 , A23L27/60 , A23L33/11 , A23L33/115 , A23L33/12 , A23L33/40 , A23V2002/00 , C11B5/0092 , C11C1/04 , C11C3/02 , C11C3/06 , A23V2250/182 , A23V2250/194 , A23V2250/1874 , A23V2250/188 , A23V2250/1882
摘要： Abstract Provided is an oil/fat composition comprising 60 to 100 wt. % of a diglyceride wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt. % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms and a cis ω 3-unsaturated fatty acid/(cis ω 6-unsaturated fatty acid+saturated fatty acid+trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.
摘要翻译：提供一种油/脂肪组合物，其包含60至100重量％甘油二酯的百分比，其中甘油二酯作为其脂肪酸组分具有15至90重量％％的少于20个碳原子的ω-3-不饱和脂肪酸和顺式ω3-不饱和脂肪酸/（顺式ω6-不饱和脂肪酸+饱和脂肪酸+反式不饱和脂肪酸）的重量比为1〜 6.内脏脂肪燃烧性能，身体脂肪燃烧性能和抗氧化稳定性优良。

6. 发明申请

US20050148666A1 Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium 审中-公开
标题翻译：激活肠上皮中脂质分解代谢和改善肠上皮细胞脂质代谢的方法
公开(公告)号：US20050148666A1
公开(公告)日：2005-07-07
申请号：US11054557
申请日：2005-02-10
申请人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
发明人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
IPC分类号： A61K31/231 , A61K31/225
CPC分类号： A61K31/575 , A61K31/231
摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.
摘要翻译：公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。二酰基甘油的摄入导致脂肪酸在小肠中的积累。如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

7. 发明授权

US5126434A Monoclonal antibody specific for a human macrophage chemotactic factor 失效
标题翻译：人类抗肿瘤因子的单克隆抗体特异性
公开(公告)号：US5126434A
公开(公告)日：1992-06-30
申请号：US561762
申请日：1990-08-02
申请人： Toshiaki Osawa , Tadashi Hase , Naonobu Yoshizuka
发明人： Toshiaki Osawa , Tadashi Hase , Naonobu Yoshizuka
IPC分类号： G01N33/53 , A61K39/395 , C07K16/24 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/24
摘要： The present invention relates to a monoclonal antibody which specifically binds to a peptide having amino acid sequence (I) described below or having in part at least continuous 4 amino acid sequences of the amino acid sequence (I), and also to a process for producing a monoclonal antibody capable of specifically binding to the peptide represented by the following amino acid sequence:H-Y-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH (I)wherein X represents Glu or Gln and Y represents Trp or Arg.

8. 发明授权

US07008661B2 Oil/fat composition 有权
公开(公告)号：US07008661B2
公开(公告)日：2006-03-07
申请号：US10343831
申请日：2001-08-07
申请人： Shin Koike , Takeshi Yasumasu , Tadashi Hase , Takatoshi Murase , Yoshihisa Katsuragi , Akira Takei
发明人： Shin Koike , Takeshi Yasumasu , Tadashi Hase , Takatoshi Murase , Yoshihisa Katsuragi , Akira Takei
IPC分类号： A23D9/007
CPC分类号： A21D13/068 , A21D2/16 , A21D13/02 , A21D13/80 , A23D7/011 , A23D7/013 , A23D7/015 , A23D9/013 , A23K20/158 , A23L15/20 , A23L27/60 , A23L33/115 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K31/232 , A61K31/56 , A61K45/06 , A61K2300/00 , A23V2250/1882 , A23V2250/182 , A23V2250/192 , A23V2250/194 , A23V2250/5108 , A23V2250/1874 , A23V2250/156 , A23V2250/70 , A23V2250/5118 , A23V2250/54246
摘要： Provided is an oil/fat composition comprising 10.1 to 94.9 wt. % of a triglyceride, 0.1 to 30 wt. % of a monoglyceride and 5 to 59.9 wt. % of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt. % of an ω3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

9. 发明申请

US20050256190A1 Method for activating the lipid catabolic metabolism in enteric epithelium and improving the lipid metabolism in enteric epithelium 审中-公开
标题翻译：激活肠上皮中脂质分解代谢和改善肠上皮细胞脂质代谢的方法
公开(公告)号：US20050256190A1
公开(公告)日：2005-11-17
申请号：US11185813
申请日：2005-07-21
申请人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
发明人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
IPC分类号： A61K31/231 , A61K31/225
CPC分类号： A61K31/575 , A61K31/231
摘要： Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to α-cumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of β-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of β-oxidation and activating lipid catabolism.
摘要翻译：公开了一种在小肠上皮中激活脂质代谢的方法，还有一种促进脂肪酸向小肠上皮中积累的方法，其特征在于施用有效量的二酰基甘油。还公开了改善摄取二酰基甘油的糖尿病各种症状的方法。二酰基甘油的摄取导致小肠中脂肪酸的α-累积。如此积累的脂肪酸促进β-氧化的诱导，从而不仅激活脂质分解代谢，而且使得难以使脂质作为三酰基甘油积累。这一系列动作最终导致降低血液残留样脂蛋白水平的作用，降低血液瘦素水平的作用，从而改善脂质代谢。此外，通过促进β-氧化的诱导和激活脂质分解代谢来增加能量消耗。

10. 发明授权

US06956058B2 Method for improving insulin resistance 有权
标题翻译：改善胰岛素抵抗的方法
公开(公告)号：US06956058B2
公开(公告)日：2005-10-18
申请号：US10238720
申请日：2002-09-11
申请人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
发明人： Tadashi Hase , Takatoshi Murase , Hiroyuki Watanabe , Hidehiko Kondo
IPC分类号： A61K31/231 , A61K31/225
CPC分类号： A61K31/575 , A61K31/231
摘要： Methods are disclosed for improving insulin resistance in a diabetic comprising administering a diacylglycerol.
摘要翻译：公开了改善糖尿病患者胰岛素抵抗的方法，包括给予二酰基甘油。

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