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1. 发明授权

US5093342A Use of omeprazole as an antimicrobial agent 失效
标题翻译：使用奥美拉唑作为抗微生物剂
公开(公告)号：US5093342A
公开(公告)日：1992-03-03
申请号：US572951
申请日：1990-09-12
申请人： Masaaki Tomoi , Yoshifumi Ikeda , Yoshiko Yokota
发明人： Masaaki Tomoi , Yoshifumi Ikeda , Yoshiko Yokota
IPC分类号： A61K20060101 , A61K31/44 , A61K31/4427 , A61P31/04 , C07D401/12
CPC分类号： C07D401/12
摘要： Use of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-sulfinyl]-1H-benzimidazole or a pharmaceutically acceptable salt thereof in the treatment of infectious diseases, especially such caused by Campylobacter pylori.
摘要翻译： PCT No.PCT / SE90 / 00070 Sec。 371 1990年9月12日第 102（e）1990年9月12日PCT PCT 1990年2月2日提交PCT公布。出版物WO90 / 09175 日期为1990年8月23日。使用5-甲氧基-2 [[（4-甲氧基-3,5-二甲基-2-吡啶基）甲基] - 亚磺酰基] -1H-苯并咪唑或其药学上可接受的盐在传染病，特别是幽门螺杆菌引起的。

2. 发明申请

US20070235284A1 Conveyer apparatus 有权
标题翻译：输送机
公开(公告)号：US20070235284A1
公开(公告)日：2007-10-11
申请号：US11607119
申请日：2006-12-01
申请人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
发明人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
IPC分类号： B66B23/00
CPC分类号： B66B23/022 , B65G21/22
摘要： A footstep guide rail (3) (rail body 3a) is arranged so that a level H of a horizontal surface is set at the position obtained by adding a designated offset 6 to a tangential line L of a drive sprocket (9) and the footstep guide rail (3) is provided, at its one end on an introductory side of the drive sprocket (9), with a curved part (13). At a reference position closest to the drive sprocket (9), the horizontal surface of the footstep guide rail (3) is changed to the curved part (13). Consequently, it is possible to absorb velocity unevenness of one footstep roller approaching the drive sprocket (9).
摘要翻译：脚踏导轨（3）（导轨体3a）被布置成使得水平表面的水平H被设置在通过将指定的偏移量6附加到驱动链轮（9）的切线L和脚踏导轨（3）的一端设置在驱动链轮（9）的入口侧，具有弯曲部（13）。在最靠近驱动链轮（9）的基准位置处，脚踏导轨（3）的水平面变成弯曲部（13）。因此，可以吸收接近驱动链轮（9）的一个脚踏辊的速度不均匀性。

3. 发明授权

US4889857A Quinolonecarboxylic acid compounds and pharmaceutical use thereof 失效
标题翻译：喹诺酮羧酸化合物及其药物用途
公开(公告)号：US4889857A
公开(公告)日：1989-12-26
申请号：US250634
申请日：1988-09-29
申请人： Kazuhiko Araki , Tsuyoshi Kuroda , Satoru Uemori , Akihiko Moriguchi , Yoshifumi Ikeda
发明人： Kazuhiko Araki , Tsuyoshi Kuroda , Satoru Uemori , Akihiko Moriguchi , Yoshifumi Ikeda
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： A quinolonecarboxylic acid compound of the formula: ##STR1## wherein R.sup.1 is an alkyl group, a cycloalkyl group, a haloalkyl group, an alkenyl group, mono- or di-alkylamino groups, a phenyl group or a phenyl group substituted by one to three substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxy group, a hydroxy group, a nitro group or an amino group, R.sup.2 is a hydrogen atom, an alkyl group, a cycloalkyl group, an acyl group or an alkoxycarbonyl group, R.sup.3 is a hydrogen atom, an alkyl group or an aralkyl group, or R.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a heterocyclic ring, R.sup.4 is a hydrogen atom or an alkyl group, R.sup.5 is a hydrogen atom, an alkyl group, an aralkyl group or an ester residue which is readily hydrolyzable in vivo, X is a hydrogen atom, a halogen atom or an alkyl group, n is interger of 1 to 3, and a salt thereof, and pharmaceutical use thereof.The compounds exhibit antibacterial activites and are useful for the treatment of various infectious diseases.

4. 发明授权

US4440752A Antibiotics Y-16482 .alpha. and/or Y-16482 .beta., a process for production thereof, and a pharmaceutical composition containing either or both of them 失效
标题翻译：抗生素Y-16482α和/或Y-16482β，其制备方法和含有其中任一种或两者的药物组合物
公开(公告)号：US4440752A
公开(公告)日：1984-04-03
申请号：US355735
申请日：1982-02-19
申请人： Tomohiko Munakata , Katsuyoshi Isagai , Yoshifumi Ikeda , Junichi Sakai , Hideo Matsuki
发明人： Tomohiko Munakata , Katsuyoshi Isagai , Yoshifumi Ikeda , Junichi Sakai , Hideo Matsuki
IPC分类号： C07D471/18 , A61K35/74 , A61P31/04 , C07C11/00 , C07G11/00 , C12P1/04 , C12P1/06 , C12P17/18 , C12R1/465 , A61K35/00
CPC分类号： C12R1/38 , C12P1/04
摘要： Antibiotics Y-16482 .alpha. and/or Y-16482 .beta., obtained by cultivating a strain belonging to the genus Pseudomonas and capable of producing Y-16482, process of producing either or both of them, and a pharmaceutical composition containing these compounds. Antibiotics Y-16482 .alpha. and/or Y-16482 .beta. show an antibacterial activity to gram-positive and gram-negative bacteria and indicate an antitumor activity to experimental tumors.
摘要翻译： PCT No.PCT / JP81 / 00151 Sec。 371日期1982年2月19日 102（e）日期1982年2月19日PCT提交1981年7月1日PCT公布。出版物WO82 / 00146 1982年1月21日。抗生素Y-16482α和/或Y-16482β，通过培养属于假单胞菌属并能够生产Y-16482的菌株获得，其生产任一种或两者的方法和药物含有这些化合物的组合物。抗生素Y-16482α和/或Y-16482β对革兰氏阳性和革兰氏阴性细菌具有抗菌活性，并表明对实验性肿瘤的抗肿瘤活性。

5. 发明授权

US08083048B2 Conveyer apparatus 有权
标题翻译：输送机
公开(公告)号：US08083048B2
公开(公告)日：2011-12-27
申请号：US11607119
申请日：2006-12-01
申请人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
发明人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
IPC分类号： B66B21/00 , B66B21/02
CPC分类号： B66B23/022 , B65G21/22
摘要： A footstep guide rail (3) (rail body 3a) is arranged so that a level H of a horizontal surface is set at the position obtained by adding a designated offset δ to a tangential line L of a drive sprocket (9) and the footstep guide rail (3) is provided, at its one end on an introductory side of the drive sprocket (9), with a curved part (13). At a reference position closest to the drive sprocket (9), the horizontal surface of the footstep guide rail (3) is changed to the curved part (13). Consequently, it is possible to absorb velocity unevenness of one footstep roller approaching the drive sprocket (9).
摘要翻译：脚踏导轨（3）（导轨体3a）被布置成使得水平表面的水平H被设置在通过将指定的偏移δ加到驱动链轮（9）的切线L和脚步导轨（3）的一端设置在驱动链轮（9）的前导侧，具有弯曲部（13）。在最靠近驱动链轮（9）的基准位置处，脚踏导轨（3）的水平面变成弯曲部（13）。因此，可以吸收接近驱动链轮（9）的一个脚踏辊的速度不均匀性。

6. 发明申请

US20060108196A1 Conveyer apparatus 审中-公开
标题翻译：输送机
公开(公告)号：US20060108196A1
公开(公告)日：2006-05-25
申请号：US11223797
申请日：2005-09-12
申请人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Tomohiko Matsuura , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
发明人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Tomohiko Matsuura , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
IPC分类号： B66B21/00
CPC分类号： B66B23/022
摘要： A mountainous or valley-shaped curved part 13 is provided in a part of a footstep guide rail 3 for guiding a movement of footstep rollers 5 linked by a footstep chain 7, the part being positioned in the vicinity of a drive sprocket 9. Consequently, owing to meshing of the footstep rollers 5 with the drive sprocket 9, an unevenness in velocity of the footstep rollers 5 is absorbed by the curved part 13, so that a moving velocity of the footstep rollers 5 moving on the downstream of the curved part 13 is maintained constantly, suppressing vibrating of the footsteps 4.
摘要翻译：在脚踏导轨3的一部分设置有山形或谷状的弯曲部13，用于引导由脚步链7连接的脚踏辊5的移动，该脚部滚子5位于驱动链轮9的附近。因此，由于脚踏辊5与驱动链轮9的啮合，脚踏辊5的速度不均匀被弯曲部13吸收，使脚踏辊5的移动速度在弯曲部13的下游移动保持不间断，抑制脚步4的振动。

7. 发明授权

US07401691B2 Conveyer apparatus having footsteps 有权
标题翻译：具有脚步声的输送设备
公开(公告)号：US07401691B2
公开(公告)日：2008-07-22
申请号：US10504855
申请日：2003-02-28
申请人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Tomohiko Matsuura , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
发明人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Tomohiko Matsuura , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
IPC分类号： B66B21/04 , B66B21/12
CPC分类号： B66B23/022 , B66B23/147
摘要： A mountainous or valley-shaped curved part 13 is provided in a part of a footstep guide rail 3 for guiding a movement of footstep rollers 5 linked by a footstep chain 7, the part being positioned in the vicinity of a drive sprocket 9. Consequently, owing to meshing of the footstep rollers 5 with the drive sprocket 9, an unevenness in velocity of the footstep rollers 5 is absorbed by the curved part 13, so that a moving velocity of the footstep rollers 5 moving on the downstream of the curved part 13 is maintained constantly, suppressing vibrating of the footsteps 4.
摘要翻译：在脚踏导轨3的一部分设置有山形或谷状的弯曲部13，用于引导由脚步链7连接的脚踏辊5的运动，该部分位于驱动链轮9的附近。因此，由于脚踏辊5与驱动链轮9的啮合，脚踏辊5的速度不均匀被弯曲部13吸收，使脚踏辊5的移动速度在弯曲部部分13保持不间断，抑制脚步4的振动。

8. 发明申请

US20070235285A1 Conveyer apparatus 审中-公开
标题翻译：输送机
公开(公告)号：US20070235285A1
公开(公告)日：2007-10-11
申请号：US11402256
申请日：2006-04-12
申请人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
发明人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hitoshi Kawamoto , Kenichi Fujii , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
IPC分类号： B66B21/12
CPC分类号： B66B23/022 , B65G21/22
摘要： A footstep guide rail (3) (rail body 3a) is arranged so that a level H of a horizontal surface is set at the position obtained by adding a designated offset δ to a tangential line L of a drive sprocket (9) and the footstep guide rail (3) is provided, at its one end on an introductory side of the drive sprocket (9), with a curved part (13). At a reference position closest to the drive sprocket (9), the horizontal surface of the footstep guide rail (3) is changed to the curved part (13). Consequently, it is possible to absorb velocity unevenness of one footstep roller approaching the drive sprocket (9).
摘要翻译：脚踏导轨（3）（导轨体3a）被布置成使得水平表面的水平H被设置在通过将指定的偏移增量附加到驱动链轮（9）的切线L而获得的位置，并且脚踏导轨（3）的一端设置在驱动链轮（9）的入口侧，具有弯曲部（13）。在最靠近驱动链轮（9）的基准位置处，脚踏导轨（3）的水平面变成弯曲部（13）。因此，可以吸收接近驱动链轮（9）的一个脚踏辊的速度不均匀性。

9. 发明申请

US20070007106A1 Conveyer apparatus 有权
标题翻译：输送机
公开(公告)号：US20070007106A1
公开(公告)日：2007-01-11
申请号：US10504855
申请日：2003-02-28
申请人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hiroshi Kawamoto , Kenichi Fujii , Tomohiko Matsuura , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
发明人： Yoshinobu Ishikawa , Tadashi Munakata , Yoshio Ogimura , Nobuhiko Teshima , Shigeo Nakagaki , Hiroshi Kawamoto , Kenichi Fujii , Tomohiko Matsuura , Yoshifumi Ikeda , Kazuhisa Hara , Takayuki Kikuchi
IPC分类号： B66B23/02
CPC分类号： B66B23/022 , B66B23/147
摘要： A mountainous or valley-shaped curved part 13 is provided in a part of a footstep guide rail 3 for guiding a movement of footstep rollers 5 linked by a footstep chain 7, the part being positioned in the vicinity of a drive sprocket 9. Consequently, owing to meshing of the footstep rollers 5 with the drive sprocket 9, an unevenness in velocity of the footstep rollers 5 is absorbed by the curved part 13, so that a moving velocity of the footstep rollers 5 moving on the downstream of the curved part 13 is maintained constantly, suppressing vibrating of the footsteps 4.
摘要翻译：在脚踏导轨3的一部分设置有山形或谷状的弯曲部13，用于引导由脚步链7连接的脚踏辊5的运动，该部分位于驱动链轮9的附近。因此，由于脚踏辊5与驱动链轮9的啮合，脚踏辊5的速度不均匀被弯曲部13吸收，使脚踏辊5的移动速度在弯曲部部分13保持不间断，抑制脚步4的振动。

10. 发明授权

US5929299A Helicobacter pylori-colonized mongolian gerbils, method for preparation thereof, and method for screening anti-Helicobacter pylori substance using them 失效
标题翻译：幽门螺杆菌定殖的蒙古沙鼠，其制备方法，幽门螺杆菌分离培养基及使用它们的抗幽门螺杆菌物质筛选方法
公开(公告)号：US5929299A
公开(公告)日：1999-07-27
申请号：US693100
申请日：1996-08-09
申请人： Yoshifumi Ikeda , Fumihiro Hirayama , Shiro Takagi
发明人： Yoshifumi Ikeda , Fumihiro Hirayama , Shiro Takagi
IPC分类号： A01K67/027 , A61K49/00 , C12Q1/04 , C12N5/00 , C12N1/00 , C12N15/00
CPC分类号： C12R1/01 , A01K67/027 , A61K49/0008 , C12Q1/04 , G01N2333/205
摘要： Helicobacter pylori-colonized Mongolian gerbils prepared by oral inoculation of a broth culture obtained from a liquid culture of Helicobacter pylori, to the Mongolian gerbils for intragastric colonization of Helicobacter pylori. These Mongolian gerbil models are useful for screening the therapeutic efficacies of drugs against Helicobacter pylori, as well as elucidation of pathology of Helicobacter pylori disease in humans. Moreover, the medium of the present invention for isolating Helicobacter pylori, which is supplemented with vancomycin, trimethoprim, amphotericin B, polymyxin B and 2,3,5-triphenyltetrazolium chloride, enables selective and efficient detection of Helicobacter pylori colonized in their Mongolian gerbils which have microorganisms living in stomach. A combined use of the above-mentioned Mongolian gerbil models and the medium for isolating Helicobacter pylori enables screening of an anti-Helicobacter pylori substance at an animal levels thereby enabling accurate prediction of clinical effects of the anti-Helicobacter pylori substance.
摘要翻译： PCT No.PCT / JP95 / 02531 Sec。 371日期：1996年8月9日 102（e）日期1996年8月9日PCT提交1995年12月8日PCT公布。第WO96 / 18291号公报日期1996年6月20日幽门螺杆菌定殖的蒙古沙鼠通过口服接种从幽门螺杆菌液体培养物获得的肉汤培养物制备成蒙古沙鼠用于幽门螺杆菌胃内定殖。这些蒙古沙鼠模型可用于筛选药物对幽门螺杆菌的治疗功效，以及阐明人幽门螺杆菌病的病理学。此外，本发明的用于分离补充有万古霉素，甲氧苄氨嘧啶，两性霉素B，多粘菌素B和2,3,5-三苯基四氮唑氯化物的幽门螺杆菌的培养基能够选择性和有效地检测在其蒙古沙鼠中定居的幽门螺杆菌，有微生物住在胃里。综合使用上述的蒙古沙鼠模型和用于分离幽门螺杆菌的培养基使得能够以动物水平筛选抗幽门螺杆菌物质，从而能够准确预测抗幽门螺杆菌物质的临床效果。

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