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1. 发明授权

US5974165A Automated method and system for the alignment and correlation of images from two different modalities 失效
标题翻译：用于两种不同模式的图像对准和相关的自动方法和系统
公开(公告)号：US5974165A
公开(公告)日：1999-10-26
申请号：US523210
申请日：1995-09-05
申请人： Maryellen L. Giger , Chin-Tu Chen , Samuel Armato , Kunio Doi
发明人： Maryellen L. Giger , Chin-Tu Chen , Samuel Armato , Kunio Doi
IPC分类号： G01N23/04 , A61B6/00 , G06T1/00 , G06T3/00 , G06T5/00 , G06T7/60 , G06K9/36 , G06T5/40
CPC分类号： G06T7/0012 , G06T3/0075 , G06T7/0083 , G06T7/0091 , G06T7/606 , G06T2207/10116 , G06T2207/30061
摘要： A method and system for the computerized registration of radionuclide images with radiographic images, including generating image data from radiographic and radionuclide images of the thorax. Techniques include contouring the lung regions in each type of chest image, scaling and registration of the contours based on location of lung apices, and superimposition after appropriate shifting of the images. Specific applications are given for the automated registration of radionuclide lungs scans with chest radiographs. The method in the example given yields a system that spatially registers and correlates digitized chest radiographs with V/Q scans in order to correlate V/Q functional information with the greater structural detail of chest radiographs. Final output could be the computer-determined contours from each type of image superimposed on any of the original images, or superimposition of the radionuclide image data, which contains high activity, onto the radiographic chest image.
摘要翻译：一种用放射性图像计算机化注册放射线图像的方法和系统，包括从放射照相和胸部放射性核素图像生成图像数据。技术包括在每种类型的胸部图像中轮廓化肺部区域，基于肺顶点的位置缩放和对准轮廓，以及在适当移动图像之后叠加。给出了用于放射性核素肺扫描的胸部X光照片的自动登记的具体应用。在给出的示例中的方法产生一个系统，其将数字化胸部X光片与V / Q扫描空间寄存和相关联，以便将V / Q功能信息与胸部X光片的较大结构细节相关联。最终输出可以是来自叠加在任何原始图像上的每种类型的图像的计算机确定的轮廓，或者包含高活性的放射性核素图像数据叠加到放射照相胸部图像上。

2. 发明授权

US5638458A Automated method and system for the detection of gross abnormalities and asymmetries in chest images 失效
标题翻译：自动化方法和系统，用于检测胸部图像的总体异常和不对称性
公开(公告)号：US5638458A
公开(公告)日：1997-06-10
申请号：US159133
申请日：1993-11-30
申请人： Maryellen L. Giger , Samuel Armato , Heber MacMahon
发明人： Maryellen L. Giger , Samuel Armato , Heber MacMahon
IPC分类号： A61B6/00 , G06T1/00 , G06T7/00 , G06T7/60 , G06K9/00
CPC分类号： G06T7/608 , G06T7/0012 , G06T2207/10116 , G06T2207/30061
摘要： A method for the automated detection of gross abnormalities and asymmetries in chest images, including generating image data from radiographic images of the thorax. The image data are then analyzed in order to produce the boundaries of the aerated lung regions in the thorax. This analysis comprises location of the mediastinum and lung apices, iterative global thresholding with centroid testing of contours, local thresholding on regions along initial contours of the aerated lung, correction for regions near the costo- and cardiophrenic angles in the chest, analysis of the areas and density distribution within the aerated lung regions in the chest and determination of the likelihood of the presence of a gross abnormality or asymmetry. Final output could be the computer determined contours of the lungs or the likelihood for abnormality.
摘要翻译：一种用于自动检测胸部图像的总体异常和不对称的方法，包括从胸部的放射照相图像生成图像数据。然后分析图像数据以产生胸部中充气肺区域的边界。该分析包括纵隔和肺顶点的位置，具有轮廓重心测试的迭代全局阈值，沿着充气肺初始轮廓的区域的局部阈值，胸部附近和心脏心脏角度附近的区域的校正，区域分析以及胸部充气肺部区域内的密度分布，并确定存在严重异常或不对称的可能性。最终输出可能是计算机确定的肺部轮廓或异常的可能性。

3. 发明申请

US20050111718A1 Automated method and system for the evaluation of disease and registration accuracy in the subtraction of temporally sequential medical images 有权
标题翻译：自动化方法和系统，用于评估疾病和注册精度，减少时间顺序的医学图像
公开(公告)号：US20050111718A1
公开(公告)日：2005-05-26
申请号：US10721827
申请日：2003-11-26
申请人： Heber MacMahon , Samuel Armato
发明人： Heber MacMahon , Samuel Armato
IPC分类号： G06F20060101 , G06K9/00 , G06T5/50 , G06T7/00
CPC分类号： A61B6/482 , A61B6/463 , G06T5/50 , G06T7/0012 , G06T7/30 , G06T2207/30061
摘要： An apparatus, method and computer program product for performing computer aided diagnosis on temporal subtraction images of objects. A mode of a gray-level histogram is identified, and a gray-level threshold is established at a predefined fraction of this modal value. All pixels with gray levels below this threshold that lie within the lung regions of the temporal subtraction image remain “on,” while all other pixels are set to zero. Area and circularity requirements are imposed to eliminate false-positive regions. Areas of pathologic change identified in this manner may be presented as outlines in the subtraction image or as highlighted regions in the original radiographic image so that, in effect, temporal subtraction becomes a “background” process for computer-aided diagnosis. The present invention is also directed to method, apparatus, and computer program product for performing temporal subtraction on energy subtraction images, with or without subsequent computer aided diagnosis, of objects.
摘要翻译：一种用于对物体的时间减影图像执行计算机辅助诊断的装置，方法和计算机程序产品。识别灰度直方图的模式，并以该模态值的预定分数建立灰度级阈值。位于时间减影图像的肺区域内的灰度级低于该阈值的所有像素保持“开”，而所有其它像素被设置为零。区域和圆度要求是为了消除假阳性区域。以这种方式识别的病理变化区域可以作为减法图像中的轮廓或作为原始放射照相图像中的突出显示区域呈现，使得实际上，时间相减成为计算机辅助诊断的“背景”过程。本发明还涉及用于在有或无后续计算机辅助诊断的情况下对能量减影图像进行时间减法的方法，装置和计算机程序产品。

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