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    • 1. 发明申请
    • Anthelmintic oral homogeneous veterinary pastes
    • 驱虫药口服同类兽药
    • US20050176657A1
    • 2005-08-11
    • US11107048
    • 2005-04-15
    • Keith FreehaufMaryam Moaddeb
    • Keith FreehaufMaryam Moaddeb
    • A61K9/06A61K9/00A61K31/498A61K31/7048A61K47/36A61K47/38A61K47/44A61K31/517
    • A61K31/498A61K9/0056A61K31/7048A61K2300/00
    • This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agents contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent. The inventive oral homogeneous pastes achieve a better bioavailability of the two active anthelmintic agents than when the two actives are in suspension and not dissolved
    • 本发明特别提供了用于治疗,控制和预防温血动物或鸟类如马和家庭宠物中的内寄生虫和外寄生虫感染的口腔同质兽药。 本发明进一步提供了制备这些兽用糊剂的方法和用于增加包含在温血动物或鸟类中的糊剂中的驱肠剂的生物利用度的方法。 本发明的口腔均匀驱肠药膏包括第一驱肠虫剂,例如赞夸酮和/或吡柔比星,以及至少一种扑灭姜黄素的驱肠虫化合物,溶解第一驱肠虫剂和第二大环内酯类驱虫剂化合物的溶剂,以及增稠剂 。 与两种活性物质悬浮并不溶解时相比,本发明的口服均质膏实现了两种活性驱肠虫剂的更好的生物利用度
    • 2. 发明授权
    • Anthelmintic oral homogeneous veterinary pastes
    • 驱虫药口服同类兽药
    • US07563773B2
    • 2009-07-21
    • US11107048
    • 2005-04-15
    • Keith FreehaufMaryam Moaddeb
    • Keith FreehaufMaryam Moaddeb
    • A01N43/04A61K31/70A61K31/495
    • A61K31/498A61K9/0056A61K31/7048A61K2300/00
    • This invention provides for, inter alia, oral homogeneous veterinary pastes for the treating, controlling and preventing of endo- and ectoparasite infections in warm-blooded animals or birds, such as horses and household pets. This invention further provides for a process of preparing these veterinary pastes and for a method for increasing the bioavailability of the anthelmintic agents contained in the paste in the warm-blooded animal or bird. The inventive oral homogeneous anthelmintic pastes comprise a first anthelmintic agent, for example, prazequantel and/or pyrantel, and at least one marcrolide anthelmintic compound, a solvent, which dissolves both the first anthelmintic agent and second the macrolide anthelmintic compound, and a thickening agent. The inventive oral homogeneous pastes achieve a better bioavailability of the two active anthelmintic agents than when the two actives are in suspension and not dissolved
    • 本发明特别提供了用于治疗,控制和预防温血动物或鸟类如马和家庭宠物中的内寄生虫和外寄生虫感染的口腔同质兽药。 本发明进一步提供了制备这些兽用糊剂的方法和用于增加包含在温血动物或鸟类中的糊剂中的驱肠剂的生物利用度的方法。 本发明的口腔均匀驱肠药膏包括第一驱肠虫剂,例如赞夸酮和/或吡柔比星,以及至少一种扑灭姜黄素的驱肠虫化合物,溶解第一驱肠虫剂和第二大环内酯类驱虫剂化合物的溶剂,以及增稠剂 。 与两种活性物质悬浮并不溶解时相比,本发明的口服均质膏实现了两种活性驱肠虫剂的更好的生物利用度