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1. 发明授权

US06372431B1 Mammalian toxicological response markers 失效
标题翻译：哺乳动物毒理学反应标志物
公开(公告)号：US06372431B1
公开(公告)日：2002-04-16
申请号：US09443184
申请日：1999-11-19
申请人： Mary Jane Cunningham , Gary B. Zweiger , Matthew R. Kaser , Scott R. Panzer , Jeffrey J. Seilhamer , Henry Yue , Mariah R. Baughn , Yalda Azimzai , Preeti Lal
发明人： Mary Jane Cunningham , Gary B. Zweiger , Matthew R. Kaser , Scott R. Panzer , Jeffrey J. Seilhamer , Henry Yue , Mariah R. Baughn , Yalda Azimzai , Preeti Lal
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/158
摘要： The present invention relates to mammalian nucleic acid and protein molecules comprising a plurality of nucleic acid and protein molecules. The mammalian nucleic acid molecules can be used as hybridizable array elements in a microarray in diagnostic and therapeutic applications including detecting metabolic and toxicological responses, and in monitoring drug mechanism of action. The protein molecules can be used in a pharmaceutical composition. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound or molecule.
摘要翻译：本发明涉及包含多个核酸和蛋白质分子的哺乳动物核酸和蛋白质分子。哺乳动物核酸分子可以在诊断和治疗应用中用作微阵列中的可杂交阵列元件，包括检测代谢和毒理反应，以及监测药物作用机制。蛋白质分子可以用于药物组合物中。本发明还涉及用于筛选指示有毒化合物或分子的代谢反应的化合物和治疗剂的方法。

2. 发明授权

US06222027B1 Molecules expressed in hippocampus 失效
标题翻译：分子在海马中表达
公开(公告)号：US06222027B1
公开(公告)日：2001-04-24
申请号：US09313300
申请日：1999-05-17
申请人： Matthew R. Kaser , Preeti Lal , Henry Yue , Y. Tom Tang , Mariah R. Baughn , Yalda Azimzai
发明人： Matthew R. Kaser , Preeti Lal , Henry Yue , Y. Tom Tang , Mariah R. Baughn , Yalda Azimzai
IPC分类号： C07H2102
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , Y10S435/803 , Y10S436/808 , Y10S436/811 , Y10T436/143333
摘要： The invention provides novel developmentally-regulated hippocampal genes and polypeptides encoded by those genes. The invention also provides expression vectors, host cells, and antibodies. The invention also provides methods for diagnosing, treating or preventing diseases associated with hippocampus.
摘要翻译：本发明提供了由这些基因编码的新型发育调节的海马基因和多肽。本发明还提供表达载体，宿主细胞和抗体。本发明还提供了用于诊断，治疗或预防与海马相关的疾病的方法。

3. 发明授权

US06558935B1 Human transferase proteins 失效
标题翻译：人转移蛋白
公开(公告)号：US06558935B1
公开(公告)日：2003-05-06
申请号：US09786240
申请日：2002-03-12
申请人： Y. Tom Tang , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Preeti Lal , Henry Yue , Jennifer L. Hillman , Yalda Azimzai
发明人： Y. Tom Tang , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Preeti Lal , Henry Yue , Jennifer L. Hillman , Yalda Azimzai
IPC分类号： C12N910
CPC分类号： C12N9/10
摘要： The invention provides human transferase proteins (TRNSFS) and polynucleotides which identify and encode TRNSFS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provide methods for diagnosing, treating, or preventing disorders, associated with expression of TRNSFS.
摘要翻译：本发明提供鉴定和编码TRNSFS的人转移酶蛋白（TRNSFS）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供诊断，治疗或预防与TRNSFS表达相关的病症的方法。

4. 发明授权

US06808895B1 DNA encoding oxidoreductase and polypeptide encoded thereby 失效
标题翻译：编码氧化还原酶的DNA和由此编码的多肽
公开(公告)号：US06808895B1
公开(公告)日：2004-10-26
申请号：US09806536
申请日：2001-03-28
申请人： Preeti Lal , Karl J. Guegler , Gina A. Gorgone , Neil C. Corley , Mariah R. Baughn , Y. Tom Tang , Jennifer L. Hillman , Olga Bandman , Yalda Azimzai , Janice Au-Young , Henry Yue , Dyung Aina M. Lu , Junming Yang
发明人： Preeti Lal , Karl J. Guegler , Gina A. Gorgone , Neil C. Corley , Mariah R. Baughn , Y. Tom Tang , Jennifer L. Hillman , Olga Bandman , Yalda Azimzai , Janice Au-Young , Henry Yue , Dyung Aina M. Lu , Junming Yang
IPC分类号： C12N510
CPC分类号： C12N9/0004 , A61K38/00
摘要： The invention provides human oxidoreductase molecules (OXRE) and polynucleotides which identify and encode OXRE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of OXRE.
摘要翻译：本发明提供人氧化还原酶分子（OXRE）和识别和编码OXRE的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与OXRE表达相关的障碍的方法。

5. 发明申请

US20120270809A1 HUMAN TRANSMEMBRANE PROTEINS 审中-公开
标题翻译：人类跨膜蛋白
公开(公告)号：US20120270809A1
公开(公告)日：2012-10-25
申请号：US13477843
申请日：2012-05-22
申请人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra Patterson , Gina A. Gorgone , Matthew R. Kaser , Mariah R. Baughn , Janice Au-Young
发明人： Y. Tom Tang , Preeti Lal , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra Patterson , Gina A. Gorgone , Matthew R. Kaser , Mariah R. Baughn , Janice Au-Young
IPC分类号： C07K14/435 , G01N33/566 , C07K17/00 , A61K38/17 , C07K16/18
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2317/622 , C07K2317/76 , G01N33/68
摘要： The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
摘要翻译：本发明提供了人跨膜蛋白（HTMPN）和识别和编码HTMPN的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与HTMPN表达相关的障碍的方法。

6. 发明授权

US06322977B1 Tapasin-like protein 失效
标题翻译：小蛋白样蛋白
公开(公告)号：US06322977B1
公开(公告)日：2001-11-27
申请号：US09292097
申请日：1999-04-14
申请人： Preeti Lal , Matthew R. Kaser , Mariah R. Baughn
发明人： Preeti Lal , Matthew R. Kaser , Mariah R. Baughn
IPC分类号： C12Q168
CPC分类号： C07K14/47
摘要： The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of the nucleic acid sequence for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with gene expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.
摘要翻译：本发明提供哺乳动物核酸序列及其片段。它还提供使用核酸序列来表征，诊断，评估，治疗或预防与基因表达相关的病症，疾病和病症以及模型系统的生产。本发明另外提供用于产生由哺乳动物核酸序列编码的蛋白质的表达载体和宿主细胞。

7. 发明授权

US06475752B1 Mammalian imidazoline receptor 失效
标题翻译：哺乳动物咪唑啉受体
公开(公告)号：US06475752B1
公开(公告)日：2002-11-05
申请号：US09364206
申请日：1999-07-30
申请人： Preeti Lal , Y. Tom Tang , Mariah R. Baughn , Matthew R. Kaser
发明人： Preeti Lal , Y. Tom Tang , Mariah R. Baughn , Matthew R. Kaser
IPC分类号： C12P2106
CPC分类号： C07K14/705
摘要： The invention provide a mammalian nucleic acid molecule and fragments thereof. It also provides for the use of the mammalian nucleic acid molecule for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with its expression and for the production of a model system. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid molecule. The invention further provides a mammalian protein or portions thereof. The invention still further provides for the use of the nucleic acid molecule and protein in assays to detect or purify ligands.
摘要翻译：本发明提供哺乳动物核酸分子及其片段。它还提供了哺乳动物核酸分子用于表征，诊断，评估，治疗或预防与其表达相关的病症和病症以及用于模型系统的生产的用途。本发明另外提供用于产生由哺乳动物核酸分子编码的蛋白质的表达载体和宿主细胞。本发明还提供哺乳动物蛋白质或其部分。本发明还进一步提供核酸分子和蛋白质在测定中用于检测或纯化配体的用途。

8. 发明授权

US08206947B2 Human transmembrane proteins 有权
标题翻译：人跨膜蛋白
公开(公告)号：US08206947B2
公开(公告)日：2012-06-26
申请号：US11594148
申请日：2006-11-08
申请人： Y. Tom Tang , Preeti G. Lal , Jennifer L. Jackson , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra S. Arvizu , Gina A. Gorgone Simone , Matthew R. Kaser , Mariah R. Baughn , Janice K. Au-Young
发明人： Y. Tom Tang , Preeti G. Lal , Jennifer L. Jackson , Henry Yue , Karl J. Guegler , Neil C. Corley , Olga Bandman , Chandra S. Arvizu , Gina A. Gorgone Simone , Matthew R. Kaser , Mariah R. Baughn , Janice K. Au-Young
IPC分类号： C12P21/06 , C12P21/04 , C07H21/04
CPC分类号： C07K16/28 , A61K38/00 , C07K14/705 , C07K2317/24 , C07K2317/622 , C07K2317/76 , G01N33/68
摘要： The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
摘要翻译：本发明提供了人跨膜蛋白（HTMPN）和识别和编码HTMPN的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与HTMPN表达相关的障碍的方法。

9. 发明授权

US06245526B1 Lipid metabolism transcription factor 失效
标题翻译：脂质代谢转录因子
公开(公告)号：US06245526B1
公开(公告)日：2001-06-12
申请号：US09318978
申请日：1999-05-26
申请人： Henry Yue , Matthew R. Kaser , Mariah R. Baughn
发明人： Henry Yue , Matthew R. Kaser , Mariah R. Baughn
IPC分类号： C12P2106
CPC分类号： C07K14/4702
摘要： The invention provides a mammalian nucleic acid sequence and fragments thereof. It also provides for the use of these nucleic acid sequences in a model system for the characterization, diagnosis, evaluation, treatment, or prevention of conditions, diseases and disorders associated with expression of the mammalian nucleic acid sequence. The invention additionally provides expression vectors and host cells for the production of the protein encoded by the mammalian nucleic acid sequence.
摘要翻译：本发明提供哺乳动物核酸序列及其片段。它还提供在模型系统中使用这些核酸序列来表征，诊断，评估，治疗或预防与哺乳动物核酸序列表达相关的病症，疾病和病症。本发明另外提供用于产生由哺乳动物核酸序列编码的蛋白质的表达载体和宿主细胞。

10. 发明申请

US20110053217A1 Polynucleotides encoding signal peptide-containing molecules 有权
标题翻译：编码含有信号肽的分子的多核苷酸
公开(公告)号：US20110053217A1
公开(公告)日：2011-03-03
申请号：US12457389
申请日：2009-06-09
申请人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
发明人： Preeti Lal , Y. Tom Tang , Gina A. Gorgone , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn , Ingrid E. Akerblom , Janice Au-Young , Henry Yue , Chandra Patterson , Roopa Reddy , Jennifer L. Hillman , Olga Bandman
IPC分类号： C12P21/00 , C07H21/04 , C12N1/21 , C07H21/02 , C07K14/435
CPC分类号： G01N33/57419 , A61K38/00 , A61K38/1709 , A61K39/3955 , A61K45/06 , C07K14/47 , C07K16/18 , C07K16/40 , C07K2317/76 , G01N2333/916
摘要： The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.
摘要翻译：本发明提供了人信号肽肽蛋白（HSPP）和识别和编码HSPP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSPP表达相关的障碍的方法。

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