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1. 发明申请

US20090131502A1 Biologically active compounds 审中-公开
标题翻译：生物活性化合物
公开(公告)号：US20090131502A1
公开(公告)日：2009-05-21
申请号：US12072414
申请日：2008-02-25
申请人： Martin Quibell , John Paul Watts , Yikang Wang , Lee Patient , Jonathan R. Heal
发明人： Martin Quibell , John Paul Watts , Yikang Wang , Lee Patient , Jonathan R. Heal
IPC分类号： A61K31/407 , A61P19/00 , A61P33/06 , A61P35/00 , G01N33/53 , C07D487/04 , C07D491/04
CPC分类号： C07D491/048 , C07D487/04 , C07D498/04
摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease and diseases involving matrix or cartilate degradation.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐。本发明还涉及包含式（I）化合物的药物组合物，以及这些化合物在治疗选自骨质疏松症，佩吉特氏病，恰加斯病，疟疾，牙龈疾病，高钙血症，代谢性骨病和涉及基质或软骨退化。

2. 发明授权

US06721663B1 Method for manipulating protein or DNA sequence data in order to generate complementary peptide ligands 失效
标题翻译：用于操纵蛋白质或DNA序列数据以产生互补肽配体的方法
公开(公告)号：US06721663B1
公开(公告)日：2004-04-13
申请号：US09571854
申请日：2000-05-16
申请人： Gareth W. Roberts , Jonathan R. Heal
发明人： Gareth W. Roberts , Jonathan R. Heal
IPC分类号： C12Q168
CPC分类号： G06F19/22 , G06F19/16
摘要： This method enables computational analysis and manipulation of DNA and protein sequence data such as is found in large public databases. The method allows systematic searches of such data to identify portions of sequences which code for key intermolecular surfaces or regions of specific protein targets. In a first example, two amino acid sequences are input (steps 1, 2) to an iterative procedure (steps 4-6). A frame size is selected in terms of a number of sequence elements. The procedure then compares pairs of frames, one from each sequence, to identify intramolecular and intermolecular regions on the basis of relationships between amino acids according to a predetermined coding scheme. The probability of existence of each region within the coding scheme is then evaluated and those regions for which the probability is greater than a predetermined threshold are discarded. The procedure outputs the remaining regions. In a second example, protein structure data is input to an iterative procedure which evaluates for each frame in the protein structure a complementary relationship score between the amino acids in the frame and each amino acid within a predetermined distance from the frame. The procedure outputs each frame for which the score equals or exceeds a predetermined threshold score.
摘要翻译：该方法能够对大量公共数据库中的DNA和蛋白质序列数据进行计算分析和操作。该方法允许系统地搜索这些数据来识别编码关键分子间表面或特定蛋白质靶标区域的序列部分。在第一个实例中，输入两个氨基酸序列（步骤1,2）至迭代过程（步骤4-6）。根据序列元素的数量来选择帧大小。该方法然后根据预定的编码方案，根据氨基酸之间的关系，比较来自每个序列的一对帧，以鉴定分子内和分子间区域。然后评估编码方案内的每个区域的存在概率，并且丢弃概率大于预定阈值的那些区域。该过程输出剩余的区域。在第二个例子中，将蛋白质结构数据输入到迭代过程中，其对蛋白质结构中的每个帧评估帧中的氨基酸与距帧的预定距离内的每个氨基酸之间的互补关系得分。该过程输出得分等于或超过预定阈值分数的每个帧。

3. 发明申请

US20140018540A1 CASEIN KINASE 1DELTA (CK 1DELTA) INHIBITORS 审中-公开
标题翻译： CASEIN KINASE 1DELTA（CK 1DELTA）抑制剂
公开(公告)号：US20140018540A1
公开(公告)日：2014-01-16
申请号：US13993303
申请日：2011-12-14
申请人： Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton , Ian Pike
发明人： Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton , Ian Pike
IPC分类号： C07D471/04 , C07D209/42
CPC分类号： A61K31/517 , A61K31/397 , A61K31/4045 , A61K31/4192 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/55 , C07D209/42 , C07D277/68 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/12 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D495/14
摘要： The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
摘要翻译：本发明涉及包含酪蛋白激酶1δ（CK1delta）的药物组合物以及所述抑制剂在治疗神经变性疾病如阿尔茨海默氏病中的用途。

4. 发明授权

US10208293B2 Compositions and methods for the biosynthesis of vanillan or vanillin beta-D-glucoside 有权
公开(公告)号：US10208293B2
公开(公告)日：2019-02-19
申请号：US14236991
申请日：2012-08-07
申请人： Joergen Hansen , Esben Halkjaer Hansen , Honey Polur , Joseph M. Sheridan , Jonathan R. Heal , William D. O. Hamilton
发明人： Joergen Hansen , Esben Halkjaer Hansen , Honey Polur , Joseph M. Sheridan , Jonathan R. Heal , William D. O. Hamilton
IPC分类号： C07K14/395 , C12N15/52 , C12N15/82 , C12N9/04 , C12N9/10 , C12N9/88 , C12P7/24 , C12P19/46 , A23L33/105
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.

5. 发明申请

US20140245496A1 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF VANILLAN OR VANILLIN BETA-D-GLUCOSIDE 审中-公开
标题翻译： VANILLAN或VANILLIN BET-D-GLUCOSIDE的生物合成的组合物和方法
公开(公告)号：US20140245496A1
公开(公告)日：2014-08-28
申请号：US14236991
申请日：2012-08-07
申请人： Joergen Hansen , Esben Halkjaer Hansen , Honey Polur , Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton
发明人： Joergen Hansen , Esben Halkjaer Hansen , Honey Polur , Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton
IPC分类号： C12P7/24 , C12N9/88 , A23L1/30 , C12P19/46
CPC分类号： C12P7/24 , A23L33/105 , C07K14/395 , C12N9/0006 , C12N9/1011 , C12N9/88 , C12N15/8221 , C12P19/46 , C12Y101/01025 , C12Y201/01006 , C12Y402/01118
摘要： Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
摘要翻译：已经公开了重组微生物，植物和植物细胞，其被单独或与一种或多种香草醛生物合成酶或UDP-糖基转移酶（UGT）组合表达突变型AROM多肽和/或突变型儿茶酚-O-甲基转移酶多肽。这样的微生物，植物或植物细胞可以产生香草醛或香草醛β-D-葡萄糖苷。

6. 发明申请

US20140031547A1 CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES 审中-公开
标题翻译： CASEIN KINASE 1Delta（CK 1delta）抑制剂及其在治疗神经源性疾病如TAUOPATHIES中的应用
公开(公告)号：US20140031547A1
公开(公告)日：2014-01-30
申请号：US13993288
申请日：2011-12-14
申请人： Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton , Ian Pike
发明人： Joseph M. Sheridan , Jonathan R. Heal , William D.O. Hamilton , Ian Pike
IPC分类号： C07D401/12
CPC分类号： A61K31/517 , A61K31/397 , A61K31/4045 , A61K31/4192 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/55 , C07D209/42 , C07D277/68 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/12 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04 , C07D487/14 , C07D495/14
摘要： The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
摘要翻译：本发明涉及包含酪蛋白激酶1δ（CK1delta）的药物组合物以及所述抑制剂在治疗神经变性疾病如阿尔茨海默病中的用途。

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