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1. 发明授权

US5710142A Vitamin D analogues 失效
标题翻译：维生素D类似物
公开(公告)号：US5710142A
公开(公告)日：1998-01-20
申请号：US428187
申请日：1995-05-02
申请人： Martin John Calverley , Henrik Pedersen
发明人： Martin John Calverley , Henrik Pedersen
IPC分类号： A61K31/59 , A61K31/593 , A61P5/12 , A61P9/12 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/00 , A61P43/00 , C07C401/00
CPC分类号： C07C401/00
摘要： The invention relates to 20(S)-vitamin D compounds having the following formula ##STR1## where U and R' are as defined in the specification. The compounds have strong antiinflammatory and immunomodulating activity. There are also useful in the inhibition of proliferation of undesirable cells.
摘要翻译： PCT No.PCT / DK93 / 00351 Sec。 371日期：1995年5月2日 102（e）日期1995年5月2日PCT提交1993年11月1日PCT公布。公开号WO94 / 10139 日期：1994年5月11日本发明涉及具有下式（IMAGE）的20（S） - 维生素D化合物，其中U和R'如说明书中所定义。该化合物具有很强的抗炎和免疫调节活性。抑制不想要的细胞的增殖也是有用的。

2. 发明授权

US06310226B1 Vitamin D analogues 有权
标题翻译：维生素D类似物
公开(公告)号：US06310226B1
公开(公告)日：2001-10-30
申请号：US09297387
申请日：1999-04-30
申请人： Martin John Calverley , Henrik Pedersen
发明人： Martin John Calverley , Henrik Pedersen
IPC分类号： A61K31593
CPC分类号： C07C401/00
摘要： The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R1 and R2 which may be the same or different, stand for hydrogen or C1-C5 hydrocarbyl; or R1 and R2, taken together with the carbon atom bearing the group X, can form a C3C8 carbocyclic ring; Q is methylene, ethylene, tri- or tetra-methylene and may optionally be substituted with an oxy group, —OR3, in which R3 is hydrogen, methyl or ethyl; Y is either a single bond or C1-C2 hydrocarbylene; and one or more carbons with in R1, R2, and/or Y may optionally be substituted with one or more fluorine atoms, or with a hydroxyl group. The compounds show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
摘要翻译：本发明涉及式（I）化合物，其中式X为氢或羟基; R 1和R 2可以相同或不同，代表氢或C 1 -C 5烃基; 或者R 1和R 2与带有基团X的碳原子一起可以形成C 3 C 8碳环; Q是亚甲基，亚乙基，三 - 或四亚甲基并且可以任选地被氧基取代，-OR 3，其中R 3是氢，甲基或乙基; Y是单键或C1-C2亚烃基; 并且在R1，R2和/或Y中具有一个或多个碳可以任选地被一个或多个氟原子或羟基取代。这些化合物显示出抗炎和免疫调节作用，以及在诱导分化和抑制某些细胞的不期望的增殖方面具有很强的活性。

3. 发明申请

US20210230381A1 DESIGN OF COMPOSITE MATERIALS WITH DESIRED CHARACTERISTICS 有权
公开(公告)号：US20210230381A1
公开(公告)日：2021-07-29
申请号：US17158665
申请日：2021-01-26
申请人： Mikkel Dybro Lundorf , Henrik Pedersen , NANOCORE APS
发明人： Mikkel Dybro Lundorf , Henrik Pedersen , Tore Dehli
IPC分类号： C08J5/00 , B82Y30/00 , B82Y40/00 , C08K9/04 , C08K9/08 , C01B32/05 , C01B32/174 , C01B32/194 , C04B35/565 , C04B35/58 , C04B35/50 , C04B35/10 , C04B35/56 , C04B35/48 , C04B28/02 , C01B32/156 , C01B32/168 , C04B14/38 , C04B16/06 , C04B35/80 , C08F292/00 , C08J5/06 , C09D5/24 , C09D11/03 , C09D11/04 , C09D11/107 , C09D11/52 , C09D133/14
摘要： A type of composite material where the matrix material and additive are held together by covalently or non-covalently bound ligands is described. A particularly useful composite material covered by the present invention is a carbon nanotube-reinforced composite material where the matrix consists of a polymer, covalently attached to a linker, where said linker is non-covalently attached to the carbon nanotube.
Methods for the preparation of such composite materials are provided.

4. 发明授权

US10336808B2 MHC peptide complexes and uses thereof in infectious diseases 有权
公开(公告)号：US10336808B2
公开(公告)日：2019-07-02
申请号：US13482472
申请日：2012-05-29
申请人： Jøgen Schøller , Henrik Pedersen , Liselotte Brix
发明人： Jøgen Schøller , Henrik Pedersen , Liselotte Brix
IPC分类号： C07K14/74 , A61K47/64 , G01N33/569 , A61K49/18 , G01N33/574 , A61K47/61 , A61K38/00
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

5. 发明申请

US20180298154A1 DESIGN OF COMPOSITE MATERIALS WITH DESIRED CHARACTERISTICS 审中-公开
公开(公告)号：US20180298154A1
公开(公告)日：2018-10-18
申请号：US15525741
申请日：2015-11-11
申请人： Mikkel Dybro Lundorf , Henrik Pedersen , NANOCORE APS
发明人： Mikkel Dybro Lundorf , Henrik Pedersen , Tore Dehli
IPC分类号： C08J5/00 , C08F292/00 , C08J5/06 , C01B32/156 , C01B32/168 , C01B32/194 , C09D11/52 , C09D11/107 , C09D11/04 , C09D11/03 , C09D5/24 , C09D133/14 , C04B16/06 , C04B14/38 , C04B35/80
CPC分类号： C08J5/005 , B82Y30/00 , B82Y40/00 , C01B32/05 , C01B32/152 , C01B32/156 , C01B32/168 , C01B32/174 , C01B32/194 , C04B14/386 , C04B16/0675 , C04B35/80 , C04B2235/48 , C08F292/00 , C08F2810/20 , C08J5/06 , C08J2323/06 , C08J2363/00 , C08J2367/00 , C08J2369/00 , C08J2375/04 , C08J2377/06 , C08K3/041 , C08K3/042 , C08K9/04 , C08K9/08 , C08K2201/001 , C08K2201/011 , C09D5/24 , C09D11/03 , C09D11/04 , C09D11/107 , C09D11/52 , C09D133/14 , C22C26/00 , C22C2026/001 , H01B1/04 , C08L23/04
摘要： Composite material, where the matrix material and the additive are held together by covalently or non-covalently bound ligands. The linker unit between matrix and additive has the structure Ligand1-LinkerL-Ligand 2, wherein Ligand1 and Ligand2 are a bond or a chemical entity that is capable of binding covalently or non-covalently to a structural entity, such as a polymer matrix or the additive (ex. CNT, graphene, carbon nanofiber, etc), and LinkerL is a chemical bond or entity that links Ligand1 and Ligand2.

6. 发明授权

US08426183B2 Glucoamylase variants 失效
公开(公告)号：US08426183B2
公开(公告)日：2013-04-23
申请号：US13329550
申请日：2011-12-19
申请人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
IPC分类号： C12N9/34 , C12P19/20 , C07H21/04 , C07K1/00
CPC分类号： C12N9/2428 , C12P19/14 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.

7. 发明申请

US20120264161A1 MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES 审中-公开
标题翻译： MHC肽复合物及其在感染性疾病中的应用
公开(公告)号：US20120264161A1
公开(公告)日：2012-10-18
申请号：US13482472
申请日：2012-05-29
申请人： Jørgen Schøller , Henrik Pedersen , Liselotte Brix
发明人： Jørgen Schøller , Henrik Pedersen , Liselotte Brix
IPC分类号： C07K19/00 , C12N5/0783 , C12Q1/02
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K49/1896 , G01N33/56905 , G01N33/56911 , G01N33/56972 , G01N33/56977 , G01N33/574 , G01N2333/70539 , G01N2800/24 , Y02A50/401 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及治疗领域，包括治疗方法和治疗组合物。本发明还包括MHC复合物和MHC多聚体的样品安装用途。

8. 发明授权

US08012732B2 Fungal lypolytic and amylase enzyme composition and methods using the same 有权
标题翻译：真菌溶血酶和淀粉酶组成及使用方法
公开(公告)号：US08012732B2
公开(公告)日：2011-09-06
申请号：US12552572
申请日：2009-09-02
申请人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
发明人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
IPC分类号： C12P1/00 , C12N9/00 , C12N9/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A21D8/042 , A23C19/0328 , A23D7/02 , A23K20/189 , A23K50/75 , A23L7/107 , A23L7/109 , A23L7/111 , A23L27/60 , A23L29/06 , C11B3/003 , C12N9/18 , C12P7/62 , C12P19/44 , C12Y301/01
摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.
摘要翻译：与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂：甘油三酯水解活性比至少为1.5。在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列，与其具有至少90％的同一性。本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸第7号（b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

9. 发明申请

US20100248257A1 Compiled Methods for Analysing and Sorting Samples 审中-公开
标题翻译：分析和分类样品的编译方法
公开(公告)号：US20100248257A1
公开(公告)日：2010-09-30
申请号：US12647747
申请日：2009-12-28
申请人： Kivin Jacobsen , Henrik Pedersen , Liselotte Brix , Jesper Lohse , Jørgen Schøller , Tina Jakobsen
发明人： Kivin Jacobsen , Henrik Pedersen , Liselotte Brix , Jesper Lohse , Jørgen Schøller , Tina Jakobsen
IPC分类号： G01N33/53
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K47/665 , B82Y5/00
摘要： The present invention relates to the fields of analysis, diagnostics, prognostics, standardization, characterization and enumeration of entities such as biological cells, as well as therapeutical applications. Accordingly, the present invention in preferred aspects is directed to methods for the detection and/or analysis and/or isolation and optionally further manipulation of entities, such as cells, particles, and supra-molecular structures.
摘要翻译：本发明涉及诸如生物细胞的实体以及治疗应用的分析，诊断，预测，标准化，表征和计数的领域。因此，本发明在优选方面涉及用于检测和/或分析和/或分离和任选地进一步操纵诸如细胞，颗粒和超分子结构的实体的方法。

10. 发明授权

US07354753B2 Glucoamylase variants 失效
标题翻译：葡糖淀粉酶变体
公开(公告)号：US07354753B2
公开(公告)日：2008-04-08
申请号：US10421586
申请日：2003-04-23
申请人： Bjarne Ronfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Ronfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
IPC分类号： C12N9/34 , C07H21/04
CPC分类号： C12N9/2428 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
摘要翻译：本发明涉及亲本真菌葡糖淀粉酶的变体，其具有改变的性质，特别是改进的热稳定性和/或增加的比活性。

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