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1. 外观设计

USD351913S Disposable electrochemical measurement cartridge for a portable medical analyzer 失效
公开(公告)号：USD351913S
公开(公告)日：1994-10-25
申请号：US5164
申请日：1993-02-25
申请人： Martin G. Hieb , Barbara E. Roth , Russell L. Morris , David W. Deetz
设计人： Martin G. Hieb , Barbara E. Roth , Russell L. Morris , David W. Deetz

2. 发明授权

US6060319A Temperature stabilized fluid reference system 失效
标题翻译：温度稳定的流体参考系统
公开(公告)号：US6060319A
公开(公告)日：2000-05-09
申请号：US083680
申请日：1993-06-25
申请人： David W. Deetz , Russell L. Morris
发明人： David W. Deetz , Russell L. Morris
IPC分类号： A61B5/145 , A01N1/00 , A61B5/00 , A61B5/1495 , G01N27/26 , G01N27/30 , G01N31/00 , G01N33/00 , G01N33/96 , G01N37/00 , G05D21/00
CPC分类号： G01N33/0006 , A61B5/1495 , G01N33/96 , G01N2496/70 , Y10T436/10 , Y10T436/102499 , Y10T436/106664
摘要： A method and system for controlling the concentration of one or more gaseous species of interest in a fluid reference medium throughout a range of temperatures in which a temperature related, dominant independent source of the gaseous species of interest is used to control the partial pressure of one or more gaseous species of interest contained in the reference medium in a manner such that the concentration of the gaseous species of interest in the reference medium is controlled as a predetermined, normally generally linear, function of temperature, f(T), over the temperature range. The source of the one or more gaseous species of interest is a separate reservoir containing an amount of a formulated temperature sensitive source of the one or more gaseous species of interest. The reference medium and the reservoir are contained in separate liquid-tight, gas-permeable enclosures contained in a common substantially gas-tight enclosure.
摘要翻译：一种用于在整个温度范围内控制流体参考介质中一种或多种感兴趣的气体物质的浓度的方法和系统，其中使用感兴趣的气体物种的温度相关的主要独立来源来控制一个或更多的气体物质包含在参考介质中，使得参考介质中感兴趣的气体物质的浓度被控制为温度f（T）超过温度的预定的，通常是线性的函数范围。一种或多种感兴趣的气体物质的来源是含有一定量的一种或多种感兴趣的气体物质的配制的温度敏感源的单独储存器。参考介质和储存器包含在包含在通用的基本上不透气的外壳中的分开的不透液体的透气外壳中。

3. 发明授权

US5325853A Calibration medium containment system 失效
标题翻译：校准介质遏制系统
公开(公告)号：US5325853A
公开(公告)日：1994-07-05
申请号：US940271
申请日：1992-09-02
申请人： Russell L. Morris , David W. Deetz
发明人： Russell L. Morris , David W. Deetz
IPC分类号： G01N33/483 , A61B5/145 , A61B5/1473 , A61B5/1495 , G01N1/00 , G01N27/26 , G01N27/416 , G01N33/49 , G01N33/84 , A61B5/05
CPC分类号： G01N27/4165
摘要： A method and apparatus which contemplates coverage control, and collateral containment of calibration media with respect to diverse electrodes in a flow-through calibration and measurement cell during storage and sensor calibration and in which the calibration media are displaced by the entry of a subsequent sample to be tested. The system is associated with a disposable cartridge insertable into a portable instrument that contains all of the electronics and other end support equipment associated with automated calibration and sample measurement.
摘要翻译：一种考虑覆盖控制的方法和装置，以及在存储和传感器校准期间相对于流通校准和测量单元中的不同电极的校准介质的旁路容纳，并且其中校准介质通过随后的样品进入而被移位被测试。该系统与可插入便携式仪器的一次性盒相关联，其包含与自动校准和样品测量相关联的所有电子设备和其他终端支持设备。

4. 发明授权

US5223433A Temperature stabilized fluid calibration system 失效
标题翻译：温度稳定液体校准系统
公开(公告)号：US5223433A
公开(公告)日：1993-06-29
申请号：US806495
申请日：1991-12-13
申请人： David W. Deetz , Russell L. Morris
发明人： David W. Deetz , Russell L. Morris
IPC分类号： A61B5/145 , A01N1/00 , A61B5/00 , A61B5/1495 , G01N27/26 , G01N27/30 , G01N31/00 , G01N33/00 , G01N33/96 , G01N37/00 , G05D21/00
CPC分类号： G01N33/0006 , A61B5/1495 , G01N33/96 , G01N2496/70 , Y10T436/10 , Y10T436/102499 , Y10T436/106664
摘要： A method and system for controlling the concentration of one or more gaseous species of interest in a sample medium throughout a range of temperatures in which a temperature related, time variable dominant independent source of the gaseous species of interest is used to control the partial pressure of one or more gaseous species of interest contained in the sample medium in a manner such that the concentration of the gaseous species of interest in the sample medium remains essentially the same over the temperature range. The source of the gaseous species of interest comprises a reservoir containing an amount of a temperature sensitive source of the gaseous species of interest. The sample and the reservoir are contained in separate fluid-tight, gas-permeable enclosures further confined by a common substantially gas-tight enclosure.
摘要翻译：一种用于在整个温度范围内控制样品介质中一种或多种感兴趣的气体物质的浓度的方法和系统，其中使用感兴趣的气体物质的温度相关的，时间可变的显性独立来源来控制样品介质中包含的一种或多种感兴趣的气体物质，使得样品介质中感兴趣的气态物质的浓度在温度范围内基本保持不变。感兴趣的气态物质的来源包括含有一定量的感兴趣的气态物质的温度敏感源的储存器。样品和储存器容纳在另一个不透气的气体可渗透的外壳中，进一步被普通的基本上不透气的外壳限制。

5. 发明授权

US5231030A Temperature insensitive calibration system 失效
标题翻译：温度不敏感校准系统
公开(公告)号：US5231030A
公开(公告)日：1993-07-27
申请号：US837205
申请日：1992-02-18
申请人： David W. Deetz , Russell L. Morris
发明人： David W. Deetz , Russell L. Morris
IPC分类号： G01N33/00
CPC分类号： G01N33/0006 , Y10T436/10 , Y10T436/100833 , Y10T436/102499 , Y10T436/106664 , Y10T436/107497
摘要： A multi-phase control and/or calibration system consists of a liquid phase containing an amount of dissolved oxygen (O.sub.2) in which the O.sub.2 partial pressure is made relatively temperature insensitive over an ambient temperature range of interest, and an amount of dissolved carbon dioxide (CO.sub.2) and one or more solute species that provide temperature stability with respect to the partial pressure of CO.sub.2 over the ambient temperature range of interest. The liquid phase is in equilibrium with a vapor phase and the system sealed with a storage atmosphere.
摘要翻译：多相控制和/或校准系统由含有一定量的溶解氧（O 2）的液相组成，其中O 2分压在感兴趣的环境温度范围内相对温度不敏感，并且溶解的二氧化碳的量（CO 2）和一种或多种在所关注的环境温度范围内相对于CO 2分压提供温度稳定性的溶质物质。液相与气相平衡，系统用储存气氛密封。

6. 发明授权

US07856263B2 Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis 有权
标题翻译：用于使用离子电渗法递送治疗剂（包括格拉司琼）的透皮系统
公开(公告)号：US07856263B2
公开(公告)日：2010-12-21
申请号：US11112196
申请日：2005-04-22
申请人： Carter R. Anderson , Walter L. Sembrowich , Russell L. Morris , Robert Cohen
发明人： Carter R. Anderson , Walter L. Sembrowich , Russell L. Morris , Robert Cohen
IPC分类号： A61N1/30 , A61M31/00 , A61F13/00 , A61K9/70
CPC分类号： A61N1/30 , A61M2037/0007 , A61N1/0428 , A61N1/044
摘要： A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.
摘要翻译：一种一次性皮肤佩戴的装置，用于透皮输送至少一个剂量的带电治疗物质，包括格拉司琼，通过离子电渗疗法，该装置包括供体储存器，该供体储存器含有通过离子电渗法透皮递送的治疗物质的量，供电源连接在供体储存器和反向储存器之间的电路中，以及控制系统，用于控制电路中的电流流动，以使得至少一个剂量的治疗物质能够通过离子电渗疗法经皮递送，并且其中控制系统包括从由外部信号激活的传感器和开关组成的组中选择的控制元件。

7. 发明授权

US07844327B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US07844327B2
公开(公告)日：2010-11-30
申请号：US10545761
申请日：2003-10-02
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.
摘要翻译：用于经皮给药活性治疗物种的离子电渗装置的电极组件具有包括优先吸收（氧化或还原）于水的连接导电基材的基层，涂覆在第一上层的牺牲材料基底层的第一部分，其中牺牲材料优先地消耗到基底层的连接导电基底材料。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，第二上层由保留在其间的基层材料的窄暴露的连接区连接。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层将被完全消耗，之后是基底层的暴露的连接区域的连接导电基底材料，其切断基底层，从而破坏器件中的电路连续性失效活动。可以提供视觉指示器，允许佩戴者监视连接区域的反应状态。

8. 发明授权

US07031769B2 Dosage control electrode for iontophoresis device 有权
标题翻译：离子电渗装置用量控制电极
公开(公告)号：US07031769B2
公开(公告)日：2006-04-18
申请号：US10371532
申请日：2003-02-21
申请人： Carter R. Anderson , Russell L. Morris
发明人： Carter R. Anderson , Russell L. Morris
IPC分类号： A61N1/30 , A61N1/00 , A61N1/04 , A61N1/05 , A61M31/00
CPC分类号： A61N1/0436 , A61N1/044
摘要： An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species includes a base layer of conductive material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the conductive material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, a narrow exposed linking area of the base layer material remaining therebetween. The exposed linking area of the base layer extends across the base layer. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be followed by the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity in the device.
摘要翻译：用于经皮给药活性治疗物种的离子电渗疗法装置的电极组件包括优先被消耗（氧化或减少）水的导电材料的基底层，涂覆在第一部分上的第一牺牲材料上层其中牺牲材料优先地消耗到基层的导电材料的基层。第二上层非导电材料被涂覆在基层的第二部分上，第二上层与第一上层隔开，基层材料残留在其间的窄暴露的连接区域。基底层的暴露的连接区域延伸穿过基底层。在相关联的离子电渗装置的操作期间，牺牲材料将被顺序消耗; 第一上层之后将是基底层的暴露的连接区域，从而破坏器件的电路连续性。

9. 发明授权

US07016723B2 Rate adjustable drug delivery system 有权
公开(公告)号：US07016723B2
公开(公告)日：2006-03-21
申请号：US10162473
申请日：2002-06-03
申请人： Russell L. Morris , Carter R. Anderson
发明人： Russell L. Morris , Carter R. Anderson
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： A transdermal iontophoretic therapeutic agent delivery system which is provided with a plurality of self-contained serially connected galvanic sources.

10. 发明授权

US06653014B2 Power sources for iontophoretic drug delivery systems 有权
公开(公告)号：US06653014B2
公开(公告)日：2003-11-25
申请号：US09867949
申请日：2001-05-30
申请人： Carter R. Anderson , Clayton J. Anderson , Lori A. Grace , Russell L. Morris
发明人： Carter R. Anderson , Clayton J. Anderson , Lori A. Grace , Russell L. Morris
IPC分类号： H01M228
CPC分类号： A61N1/30 , H01M6/12 , H01M6/26 , H01M6/30 , H01M6/40 , H01M6/50 , H01M6/5016 , H01M16/00
摘要： The capacity of an electro-chemical power source having an initial amount of an oxidizable material and an initial amount of a reducible material, is adjusted to a target capacity by altering the initial amount of one or both of the oxidizable material and the reducible material available to participate in the source by a technique selected from the group consisting of adding, removing and isolating a known fraction of the initial amount from the power source.

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