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1. 发明授权

US09459175B2 Method and device for inspecting flexible container 有权
标题翻译：检查柔性容器的方法和装置
公开(公告)号：US09459175B2
公开(公告)日：2016-10-04
申请号：US14129665
申请日：2012-05-15
申请人： Martin Dahlberg , Lars Boettcher , Thomas Regen , Stefan Obermann , Marc Hogreve
发明人： Martin Dahlberg , Lars Boettcher , Thomas Regen , Stefan Obermann , Marc Hogreve
IPC分类号： G01M3/32
CPC分类号： G01M3/3218
摘要： A method for testing a flexible container includes arranging the flexible container on a winding core that can be rotated about a winding axis W and forms an internal support. The method continues by winding the flexible container around the winding axis W arranging an external support around the wound container and connecting at least one container opening of the container to a fluid source. The method proceeds by filling the container with a fluid from the fluid source to generate a predetermined positive pressure P1 in the flexible container at a first time T1 and determining whether the container is sufficiently leaktight.
摘要翻译：用于测试柔性容器的方法包括将柔性容器布置在卷绕芯上，绕组芯可围绕卷绕轴W旋转并形成内部支撑。该方法继续通过将柔性容器缠绕在卷绕轴线W上，将卷绕的容器周围布置外部支撑件并将容器的至少一个容器开口连接到流体源。该方法通过用来自流体源的流体填充容器来进行，以在第一时间T1在柔性容器中产生预定的正压力P1，并确定容器是否充分泄漏。

2. 发明申请

US20140193897A1 BIOREACTOR CONTAINER AND INTEGRITY CHECK METHOD FOR BIOREACTOR CONTAINERS 有权
标题翻译：生物反应器容器和生物反应器容器的完整性检查方法
公开(公告)号：US20140193897A1
公开(公告)日：2014-07-10
申请号：US14130061
申请日：2012-06-15
申请人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
发明人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
IPC分类号： C12M1/00 , G01M3/04
CPC分类号： C12M23/14 , A61J1/10 , A61J1/16 , B32B1/02 , B32B3/30 , B32B5/022 , B32B5/024 , B32B5/18 , B32B2307/726 , B32B2307/7265 , C12M23/02 , C12M23/26 , F04C2270/0421 , G01M3/04 , G01M3/22 , G01M3/3218 , G01M3/3272
摘要： A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided.
摘要翻译：生物反应器容器包括至少局部柔性壁和至少一个容器开口。生物反应器容器的壁具有流体密封的内部片材和至少局部流体可渗透或结构化的外部片材。还提供了用于测试生物反应器容器的完整性的方法。

3. 发明申请

US20140165707A1 TEST METHOD AND APPARATUS FOR BIOREACTOR CONTAINERS AND USE 有权
标题翻译：用于生物反应器容器的测试方法和设备和使用
公开(公告)号：US20140165707A1
公开(公告)日：2014-06-19
申请号：US14130035
申请日：2012-06-26
申请人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
发明人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
IPC分类号： G01M3/32
CPC分类号： G01M3/32 , C12M41/00 , G01M3/329
摘要： A method for testing the integrity of a bioreactor container includes providing a bioreactor container having a fluid-tight, at least locally flexible wall and having at least one container opening and providing a test apparatus having a bioreactor container compartment and a fluid-permeable and/or structured reception sheet arranged replaceably on the bioreactor container compartment. The method continues by arranging the bioreactor container in the bioreactor container compartment so that the bioreactor container wall contacts the reception sheet in the bioreactor container compartment, connecting the container opening of the bioreactor container to a fluid source filling the bioreactor container with a fluid from the fluid source to generate a predetermined positive pressure Pi in the bioreactor container at a first time Ti and determining whether the bioreactor container is sufficiently leaktight.
摘要翻译：用于测试生物反应器容器的完整性的方法包括提供具有流体密封的至少局部柔性壁的生物反应器容器，并且具有至少一个容器开口并提供具有生物反应器容器隔室和流体可渗透和/ 或结构化接收片可更换地布置在生物反应器容器隔室上。该方法继续通过将生物反应器容器布置在生物反应器容器隔室中，使得生物反应器容器壁与生物反应器容器隔室中的接收片接触，将生物反应器容器的容器开口连接到填充生物反应器容器的流体源，流体源，以在第一时间Ti在生物反应器容器中产生预定的正压力Pi，并确定生物反应器容器是否充分泄漏。

4. 发明授权

US10240117B2 Bioreactor container and integrity check method for bioreactor containers 有权
公开(公告)号：US10240117B2
公开(公告)日：2019-03-26
申请号：US14886617
申请日：2015-10-19
申请人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
发明人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
IPC分类号： C12M1/34 , C12M1/00 , A61J1/10 , B32B1/02 , B32B3/30 , B32B5/02 , B32B5/18 , G01M3/22 , G01M3/32 , G01M3/04 , A61J1/16
摘要： A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided.

5. 发明授权

US09534980B2 Test method and apparatus for bioreactor containers having reception sheet clamped between bioreactor container and bioreactor container compartment 有权
标题翻译：具有夹在生物反应器容器和生物反应器容器室之间的接收片的生物反应器容器的测试方法和装置
公开(公告)号：US09534980B2
公开(公告)日：2017-01-03
申请号：US14130035
申请日：2012-06-26
申请人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
发明人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
IPC分类号： G01M3/04 , G01M3/32 , C12M1/34
CPC分类号： G01M3/32 , C12M41/00 , G01M3/329
摘要： A method for testing the integrity of a bioreactor container includes providing a bioreactor container having a fluid-tight, at least locally flexible wall and having at least one container opening and providing a test apparatus having a bioreactor container compartment and a fluid-permeable and/or structured reception sheet arranged replaceably on the bioreactor container compartment. The method continues by arranging the bioreactor container in the bioreactor container compartment so that the bioreactor container wall contacts the reception sheet in the bioreactor container compartment, connecting the container opening of the bioreactor container to a fluid source filling the bioreactor container with a fluid from the fluid source to generate a predetermined positive pressure P1 in the bioreactor container at a first time T1 and determining whether the bioreactor container is sufficiently leaktight.
摘要翻译：用于测试生物反应器容器的完整性的方法包括提供具有流体密封的至少局部柔性壁的生物反应器容器，并且具有至少一个容器开口并提供具有生物反应器容器隔室和流体可渗透和/ 或结构化接收片可更换地布置在生物反应器容器隔室上。该方法继续通过将生物反应器容器布置在生物反应器容器隔室中，使得生物反应器容器壁与生物反应器容器隔室中的接收片接触，将生物反应器容器的容器开口连接到填充生物反应器容器的流体源，流体源，以在第一时间T1在生物反应器容器中产生预定的正压力P1，并确定生物反应器容器是否充分密封。

6. 发明申请

US20160040109A1 BIOREACTOR CONTAINER AND INTEGRITY CHECK METHOD FOR BIOREACTOR CONTAINERS 审中-公开
标题翻译：生物反应器容器和生物反应器容器的完整性检查方法
公开(公告)号：US20160040109A1
公开(公告)日：2016-02-11
申请号：US14886617
申请日：2015-10-19
申请人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
发明人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
IPC分类号： C12M1/00
CPC分类号： C12M23/14 , A61J1/10 , A61J1/16 , B32B1/02 , B32B3/30 , B32B5/022 , B32B5/024 , B32B5/18 , B32B2307/726 , B32B2307/7265 , C12M23/02 , C12M23/26 , F04C2270/0421 , G01M3/04 , G01M3/22 , G01M3/3218 , G01M3/3272
摘要： A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided.
摘要翻译：生物反应器容器包括至少局部柔性壁和至少一个容器开口。生物反应器容器的壁具有流体密封的内部片材和至少局部流体可渗透或结构化的外部片材。还提供了用于测试生物反应器容器的完整性的方法。

7. 发明授权

US09637716B2 Bioreactor container and integrity check method for bioreactor containers 有权
公开(公告)号：US09637716B2
公开(公告)日：2017-05-02
申请号：US14130061
申请日：2012-06-15
申请人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
发明人： Martin Dahlberg , Isabelle Gay , Lars Boettcher , Stefan Obermann , Rainer Sandrock
IPC分类号： C12M1/34 , C12M1/00 , A61J1/10 , B32B1/02 , B32B3/30 , B32B5/02 , B32B5/18 , G01M3/22 , G01M3/32 , G01M3/04 , A61J1/16
CPC分类号： C12M23/14 , A61J1/10 , A61J1/16 , B32B1/02 , B32B3/30 , B32B5/022 , B32B5/024 , B32B5/18 , B32B2307/726 , B32B2307/7265 , C12M23/02 , C12M23/26 , F04C2270/0421 , G01M3/04 , G01M3/22 , G01M3/3218 , G01M3/3272
摘要： A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided.

8. 发明申请

US20130040372A1 BIOREACTOR ARRANGEMENT, SHAKING DEVICE AND METHOD FOR IRRADIATING A MEDIUM IN A BIOREACTOR 审中-公开
标题翻译：生物反应器装置，SHAKING装置和用于在生物反应器中辐射介质的方法
公开(公告)号：US20130040372A1
公开(公告)日：2013-02-14
申请号：US13635769
申请日：2011-04-21
申请人： Marcel Roell , Lars Boettcher
发明人： Marcel Roell , Lars Boettcher
IPC分类号： C12M1/42 , C12N1/12 , B01L9/00
CPC分类号： C12M31/02 , C12M21/02 , C12M23/04 , C12M23/26 , C12M23/28 , C12M27/16
摘要： A bioreactor arrangement has a bioreactor and an illuminating body for illuminating a medium in a reactor interior. The illuminating body has at least one emission surface via which light, reflected by at least one end surface into the reactor interior, is emitted. The bioreactor is formed as a container having a transparent wall. The illuminating body is outside the reactor interior, next to at least one subregion of the transparent wall. The illuminating body forms a support surface for the bioreactor with its emission surface. A shaking device has a reactor holder that can be in oscillated, for a bioreactor with a transparent wall. The reactor holder has a two-dimensional illuminating body, the emission surface of which forms a support surface for the bioreactor, via which light can be reflected into the reactor interior of the bioreactor.
摘要翻译：生物反应器装置具有用于照射反应器内部的介质的生物反应器和照明体。照明体具有至少一个发射表面，通过该发射表面发射由至少一个端面反射到反应器内部的光。生物反应器形成为具有透明壁的容器。照明体在反应器内部的外部，靠近透明壁的至少一个分区。照明体形成具有其发射表面的生物反应器的支撑表面。摇动装置具有可以摆动的反应器支架，用于具有透明壁的生物反应器。反应器保持器具有二维照明体，其发射表面形成用于生物反应器的支撑表面，光可通过该支撑表面反射到生物反应器的反应器内部。

9. 发明申请

US20120097880A1 Diaphragm Valve 有权
标题翻译：隔膜阀
公开(公告)号：US20120097880A1
公开(公告)日：2012-04-26
申请号：US13062308
申请日：2009-09-02
申请人： Lars Boettcher , Jan Schaefer , Kai-Uwe Wolpert , Juergen Mayer
发明人： Lars Boettcher , Jan Schaefer , Kai-Uwe Wolpert , Juergen Mayer
IPC分类号： F16K7/12
CPC分类号： F16K7/126 , F16K31/06
摘要： Diaphragm valve having a valve body with an inlet and an outlet, a sealing membrane, and a connecting piece connecting the sealing membrane to a pressure piece of a drive. The valve body, the sealing membrane and the connecting piece are rigidly connected together to form an interchangeable, sealed valve body unit that can be connected to the drive. The connecting piece is molded on the sealing membrane, and the valve body and the sealing membrane are welded ultrasonically to one another.
摘要翻译：隔膜阀具有具有入口和出口的阀体，密封膜和将密封膜连接到驱动器的压力片的连接件。阀体，密封膜和连接件刚性地连接在一起，形成可以连接到驱动器的可互换的密封阀体单元。连接件在密封膜上成型，阀体和密封膜彼此超声波焊接。

10. 发明授权

US10766003B2 Presterilizable filtration system to be disposed of after a single use 有权
公开(公告)号：US10766003B2
公开(公告)日：2020-09-08
申请号：US12933433
申请日：2009-03-13
申请人： Lars Boettcher , Frank Guthof , Jan Schaefer , Isabelle Gay
发明人： Lars Boettcher , Frank Guthof , Jan Schaefer , Isabelle Gay
IPC分类号： B01D61/18 , A61M1/36
摘要： A presterilizable filtration system is provided and is to be disposed of after a single use. The system has a recirculation tank and a filtration module that are connected to each other in a circuit via a hose system that can be regulated by at least one valve. The valve has a disposable separate valve part that can be integrated in the hose system and a reusable actuator.

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