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1. 发明申请

US20060052380A1 Novel compounds 失效
标题翻译：新型化合物
公开(公告)号：US20060052380A1
公开(公告)日：2006-03-09
申请号：US10542194
申请日：2004-01-15
申请人： Martin Cooper , Simon Guile , Anthony Ingall , Rukhsana Rasul
发明人： Martin Cooper , Simon Guile , Anthony Ingall , Rukhsana Rasul
IPC分类号： A61K31/503 , C07D498/02
CPC分类号： C07D495/04
摘要： The invention relates to thienopyridazinones of formula (I): wherein: R1 is C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl which is optionally substituted by C1-6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R2 is C1-6 alkyl; R3 is a group CO-G or SO2-G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally substituted by up to 3 groups selected from hydroxyl and C1-4 alkyl; Q is CR5R6 where R5 and R6 are as defined in the specification; and R4 is a 5- to 10-membered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted as described in the specification, and pharmaceutically acceptable salts and solvates thereof. Processes for their preparation, pharmaceutical compositions containing them and their use in therapy, in particular in the modulation of autoimmune disease are also described.
摘要翻译：本发明涉及式（I）的噻吩并哒嗪酮：其中：R 1是C 1-6烷基，C 2-6链烯基或C 任选被C 1-6烷基取代的，任选被一个或多个卤素原子取代的C 3-6环烷基; R 2是C 1-6烷基; R 3是基团CO-G或SO 2 -G，其中G是含有氮原子的5-或6-元环，和选自氧和/ 硫邻近氮，并且任选地被多至3个选自羟基和C 1-4烷基的基团取代; Q是CR 5，其中R 5和R 6如说明书中所定义; 并且R 4是含有0至4个独立地选自氮，氧和硫的杂原子的5至10元单环或双环芳族环系统，所述环系统如上所述被任选地取代在本说明书及其药学上可接受的盐和溶剂化物中。还描述了其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是在调节自身免疫疾病中

2. 发明申请

US20060223809A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20060223809A1
公开(公告)日：2006-10-05
申请号：US11447343
申请日：2006-06-06
申请人： Martin Cooper , Simon Guile , Anthony Ingall , Rukhsana Rasul
发明人： Martin Cooper , Simon Guile , Anthony Ingall , Rukhsana Rasul
IPC分类号： A61K31/503 , C07D498/02
CPC分类号： C07D495/04
摘要： The invention relates to thienopyridazinones of formula (I): wherein: R1 is C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl which is optionally substituted by C1-6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R2 is C1-6 alkyl; R3 is a group CO-G or SO2-G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally substituted by up to 3 groups selected from hydroxyl and C1-4 alkyl; Q is CR5R6 where R5 and R6 are as defined in the specification; and R4 is a 5- to 10-membered mono- or bi-cyclic aromatic ring system, containing 0 to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted as described in the specification, and pharmaceutically acceptable salts and solvates thereof. Processes for their preparation, pharmaceutical compositions containing them and their use in therapy, in particular in the modulation of autoimmune disease are also described.
摘要翻译：本发明涉及式（I）的噻吩并哒嗪酮：其中：R 1是C 1-6烷基，C 2-6链烯基或C 任选被C 1-6烷基取代的，任选被一个或多个卤素原子取代的C 3-6环烷基; R 2是C 1-6烷基; R 3是基团CO-G或SO 2 -G，其中G是含有氮原子的5-或6-元环，和选自氧和/ 硫邻近氮，并且任选地被多至3个选自羟基和C 1-4烷基的基团取代; Q是CR 5，其中R 5和R 6如说明书中所定义; 并且R 4是含有0至4个独立地选自氮，氧和硫的杂原子的5至10元单环或双环芳族环系统，所述环系统如上所述被任选地取代在本说明书及其药学上可接受的盐和溶剂化物中。还描述了其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是在调节自身免疫疾病中。

3. 发明申请

US20060025590A1 Novel compounds 有权
公开(公告)号：US20060025590A1
公开(公告)日：2006-02-02
申请号：US11230493
申请日：2005-09-21
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.

4. 发明申请

US20100069408A1 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition 审中-公开
标题翻译：用于血小板聚集抑制的三取代三唑并嘧啶
公开(公告)号：US20100069408A1
公开(公告)日：2010-03-18
申请号：US12591395
申请日：2009-11-18
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K31/519 , C07D487/04 , A61P9/00 , A61P9/10
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
摘要翻译：本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。

5. 发明授权

US06251910B1 1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists 有权
标题翻译： 1,2,3-三唑并[4,5-d]嘧啶作为P2T受体拮抗剂
公开(公告)号：US06251910B1
公开(公告)日：2001-06-26
申请号：US09155023
申请日：1998-09-21
申请人： Simon Guile , Anthony Ingall , Brian Springthorpe , Paul Willis
发明人： Simon Guile , Anthony Ingall , Brian Springthorpe , Paul Willis
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： Compounds of formula having the following stereochemistry wherein R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful as P2T receptor antagonists.
摘要翻译：在R，R 1，R 2，R 3和R 4中具有以下立体化学的式的化合物如说明书中所定义。该化合物可用作P2T受体拮抗剂。

6. 发明申请

US20130072503A1 TRISUBSTITUTED TRIAZOLOPYRIMIDINES FOR USE IN PLATELET AGGREGATION INHIBITION 审中-公开
公开(公告)号：US20130072503A1
公开(公告)日：2013-03-21
申请号：US13423848
申请日：2012-03-19
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.

7. 发明申请

US20070265282A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20070265282A1
公开(公告)日：2007-11-15
申请号：US11711838
申请日：2007-02-28
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K31/519 , A61P9/10
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
摘要翻译：本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。

8. 发明授权

US07250419B2 Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition 有权
标题翻译：用于血小板聚集抑制的三取代三唑并嘧啶
公开(公告)号：US07250419B2
公开(公告)日：2007-07-31
申请号：US11230493
申请日：2005-09-21
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K31/519 , C07D487/04 , A61P7/02 , A61P9/10
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
摘要翻译：本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。

9. 发明申请

US20060135539A1 Thienopyridazinones and their use in modulation of autoimmune disease 失效
标题翻译：噻吩并哒嗪酮及其在调节自身免疫性疾病中的应用
公开(公告)号：US20060135539A1
公开(公告)日：2006-06-22
申请号：US10542457
申请日：2004-01-15
申请人： Simon Guile , Anthony Ingall
发明人： Simon Guile , Anthony Ingall
IPC分类号： A61K31/519 , C07D498/02
CPC分类号： C07D495/04
摘要： The invention relates to thienopyridazinones compound of formula (I) wherein: R1, R2 and Q are as defined in the specification, and Ar and Ar2 are selected from certain aromatic ring systems which may be optionally substituted, as defined in the specification. Processes for the preparation of compounds of formula (I), pharmaceutical compositions containing them and their use in therapy is also described and claimed.
摘要翻译：本发明涉及式（I）的噻吩并哒嗪酮化合物，其中：R 1，R 2和Q如说明书中所定义，Ar和Ar 2，选自某些芳族环系统，其可以任选地被取代，如说明书中所定义的。还描述和要求保护制备式（I）化合物的方法，含有它们的药物组合物及其在治疗中的用途。

10. 发明授权

US06974868B2 Compounds 有权
标题翻译：化合物
公开(公告)号：US06974868B2
公开(公告)日：2005-12-13
申请号：US10323655
申请日：2002-12-20
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K20060101 , A61K31/00 , A61K31/519 , A61P20060101 , A61P7/00 , A61P9/00 , A61P9/10 , C07C211/40 , C07D20060101 , C07D239/48 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
摘要翻译：本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。

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