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1. 发明授权

US06867851B2 Scanning of biological samples 有权
标题翻译：扫描生物样品
公开(公告)号：US06867851B2
公开(公告)日：2005-03-15
申请号：US10211113
申请日：2002-08-02
申请人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders , Scott A. Nelson , Kraig Anderson , Steven A. Lewis
发明人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders , Scott A. Nelson , Kraig Anderson , Steven A. Lewis
IPC分类号： C12N20060101 , G01N21/00 , G01N21/03 , G01N21/64 , G02B21/06 , G02B21/16
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2021/6484 , G02B21/06 , G02B21/16
摘要： An image detection apparatus comprises a light source and a holding apparatus adapted to hold a substrate on which a biological sample may be mounted. Light from the light source impinges on the biological sample and causes light that is representative of the sample to be emitted from the sample. A light detector is positioned in the path of the emitted light and is scanned across the emitted light. The emitted light may be focused on the light detector with an optical assembly. The emitted light may be generated by chromophores on probes in the biological sample.
摘要翻译：图像检测装置包括光源和适于保持其上可以安装生物样品的基底的保持装置。来自光源的光照射在生物样品上并导致代表样品的光从样品中发射出来。光检测器位于发射光的路径中，并在发射的光线上扫描。发射的光可以用光学组件聚焦在光检测器上。发射的光可以由生物样品中的探针上的发色团产生。

2. 发明授权

US07145645B2 Imaging of biological samples using electronic light detector 有权
公开(公告)号：US07145645B2
公开(公告)日：2006-12-05
申请号：US09852375
申请日：2001-05-10
申请人： Martin Blumenfeld , Mark A. Sanders , Joseph J. Talghader , Jesse R. Grenz
发明人： Martin Blumenfeld , Mark A. Sanders , Joseph J. Talghader , Jesse R. Grenz
IPC分类号： G01N21/03
CPC分类号： G06T1/0007 , B01J2219/00529 , B01J2219/00702
摘要： A system and method using an electronic light detector array, e.g., a CCD or a CMOS-based detector array, is used to acquire a visual image of a biological sample that includes biological material associated with a biological material holding structure (e.g., a DNA spot array on a DNA chip, protein bands in a 2-D gel, etc.). For example, fluorescence from a biological sample may be detected.

3. 发明授权

US06784982B1 Direct mapping of DNA chips to detector arrays 有权
标题翻译：将DNA芯片直接映射到检测器阵列
公开(公告)号：US06784982B1
公开(公告)日：2004-08-31
申请号：US09434027
申请日：1999-11-04
申请人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders
发明人： Martin Blumenfeld , Joseph J. Talghader , Mark A. Sanders
IPC分类号： G06K974
CPC分类号： G06T1/0007 , B01J2219/00529 , B01J2219/00702
摘要： A device for detecting the pattern of polynucleic acid hybridization to a surface, the device includes (a) a positioning device for receiving a nucleic acid chip and keeping the chip in a sampling position, the nucleic acid chip being an object with a flat sample surface and an opposed surface that is joined to the sample surface by a thickness, with the sample surface having sequences of nucleic acids immobilized thereto, with each sequence being immobilized to a particular chip address. And, (b) an electronic light detector array, the detector array comprising detector pixels, the detector pixels being sensors located at particular detector pixel addresses, wherein the sampling position places the sample surface of the chip at a well-defined position relative to the electronic light detector array so that light leaving a chip address is substantially directed onto at least one detector pixel with an address that is correlated to the chip address.
摘要翻译：一种用于检测与表面的多核酸杂交的模式的装置，所述装置包括（a）用于接收核酸芯片并将芯片保持在采样位置的定位装置，所述核酸芯片是具有平坦样品表面的物体以及与样品表面连接的相对表面，其中样品表面具有固定在其上的核酸序列，每个序列被固定在特定的芯片地址上。以及（b）电子光检测器阵列，所述检测器阵列包括检测器像素，所述检测器像素是位于特定检测器像素地址处的传感器，其中所述采样位置将所述芯片的样品表面相对于所述检测器像素地址放置在明确定义的位置电子光检测器阵列，使得离开芯片地址的光基本上被引导到具有与芯片地址相关的地址的至少一个检测器像素。

4. 发明授权

US06228634B1 Thermal cycling or temperature control device and method using alumina plate 失效
标题翻译：热循环或温度控制装置和使用氧化铝板的方法
公开(公告)号：US06228634B1
公开(公告)日：2001-05-08
申请号：US09389896
申请日：1999-09-03
申请人： Martin Blumenfeld , Jonathan Chaplin
发明人： Martin Blumenfeld , Jonathan Chaplin
IPC分类号： C12M302
CPC分类号： B01L7/52 , C12Q1/6841 , G01N1/28
摘要： A thermal cycling device comprising a ceramic sample plate, and method of use thereof, is provided. The device is adapted for in situ thermal processing of biological samples on planar substrates, in particular amplification of nucleic acids. The device comprises electrical heating means attached to the ceramic sample plate, and forced air cooling means.
摘要翻译：提供了包括陶瓷样品板的热循环装置及其使用方法。该装置适用于平面底物上的生物样品的原位热处理，特别是核酸的扩增。该装置包括附接到陶瓷样品板的电加热装置和强制空气冷却装置。

5. 发明授权

US06300124B1 Device and method to directly control the temperature of microscope slides 失效
标题翻译：直接控制显微镜载玻片温度的装置和方法
公开(公告)号：US06300124B1
公开(公告)日：2001-10-09
申请号：US09432012
申请日：1999-11-02
申请人： Martin Blumenfeld , Avram Bar-Cohen , Gregory T. Cibuzar , Peter Schiller , Mehmet Arik
发明人： Martin Blumenfeld , Avram Bar-Cohen , Gregory T. Cibuzar , Peter Schiller , Mehmet Arik
IPC分类号： C12M134
CPC分类号： B01L7/52
摘要： A thermal cycling device for use with self-heating microscope slides is provided.
摘要翻译：提供了一种用于自热显微镜载玻片的热循环装置

6. 发明申请

US20070121111A1 Imaging of Biological Samples 审中-公开
标题翻译：生物样品成像
公开(公告)号：US20070121111A1
公开(公告)日：2007-05-31
申请号：US11566594
申请日：2006-12-04
申请人： Martin Blumenfeld , Mark Sanders , Joseph Talghader , Jesse Grenz
发明人： Martin Blumenfeld , Mark Sanders , Joseph Talghader , Jesse Grenz
IPC分类号： G01J3/30 , G01N21/25
CPC分类号： G06T1/0007 , B01J2219/00529 , B01J2219/00702
摘要： A system and method using an electronic light detector array, e.g., a CCD or a CMOS-based detector array, is used to acquire a visual image of a biological sample that includes biological material associated with a biological material holding structure (e.g., a DNA spot array on a DNA chip, protein bands in a 2-D gel, etc.). For example, fluorescence from a biological sample may be detected.
摘要翻译：使用电子光检测器阵列（例如CCD或基于CMOS的检测器阵列）的系统和方法用于获取生物样品的视觉图像，其包括与生物材料保持结构相关的生物材料（例如，DNA DNA芯片上的斑点阵列，2-D凝胶中的蛋白质条带等）。例如，可以检测来自生物样品的荧光。

7. 发明授权

US06733729B2 Apparatus for generating a temperature gradient and methods for using the gradient to characterize molecular interactions 有权
标题翻译：用于产生温度梯度的装置和使用梯度表征分子相互作用的方法
公开(公告)号：US06733729B2
公开(公告)日：2004-05-11
申请号：US09853806
申请日：2001-05-11
申请人： Martin Blumenfeld , Mark Fisher , Fred Williamson , Gregory T. Cibuzar , Brian G. Van Ness
发明人： Martin Blumenfeld , Mark Fisher , Fred Williamson , Gregory T. Cibuzar , Brian G. Van Ness
IPC分类号： G01N2101
CPC分类号： G01N33/54366 , B01L3/5027 , B01L7/54 , B01L2200/12 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/1827 , G01N33/54333
摘要： A novel apparatus for generating temperature gradients is described. The apparatus includes a semiconductive wafer and electrical connectors attached to, preferably, one of the edges of the wafer. Methods for transferring the temperature gradients to strata are described. The temperature gradients on the strata can be used for analyses of molecules, particularly biological macromolecules. The present invention also includes improved methods for determining the thermal stability of binding complexes.
摘要翻译：描述了一种用于产生温度梯度的新型装置。该装置包括半导体晶片和连接到，优选地，晶片的边缘中的一个的电连接器。描述了将温度梯度传递到地层的方法。地层上的温度梯度可用于分子，特别是生物大分子的分析。本发明还包括用于测定结合复合物的热稳定性的改进方法。

8. 发明授权

US06610470B2 Apparatus for generating a temperature gradient and methods for using the gradient to characterize molecular interactions 有权
公开(公告)号：US06610470B2
公开(公告)日：2003-08-26
申请号：US09853964
申请日：2001-05-11
申请人： Martin Blumenfeld , Mark Fisher , Fred Williamson , Gregory T. Cibuzar , Brian G. Van Ness
发明人： Martin Blumenfeld , Mark Fisher , Fred Williamson , Gregory T. Cibuzar , Brian G. Van Ness
IPC分类号： C12Q100
CPC分类号： G01N33/54366 , B01L3/5027 , B01L7/54 , B01L2200/12 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/1827 , G01N33/54333
摘要： A novel apparatus for generating temperature gradients is described. The apparatus includes a semiconductive wafer and electrical connectors attached to, preferably, one of the edges of the wafer. Methods for transferring the temperature gradients to strata are described. The temperature gradients on the strata can be used for analyses of molecules, particularly biological macromolecules. The present invention also includes improved methods for determining the thermal stability of binding complexes.

9. 发明授权

US06544477B1 Apparatus for generating a temperature gradient 有权
标题翻译：用于产生温度梯度的装置
公开(公告)号：US06544477B1
公开(公告)日：2003-04-08
申请号：US09630172
申请日：2000-08-01
申请人： Martin Blumenfeld , Mark Fisher , Fred Williamson , Gregory T. Cibuzar , Brian G. Van Ness
发明人： Martin Blumenfeld , Mark Fisher , Fred Williamson , Gregory T. Cibuzar , Brian G. Van Ness
IPC分类号： G01N3348
CPC分类号： G01N33/54366 , B01L3/5027 , B01L7/54 , B01L2200/12 , B01L2300/0816 , B01L2300/0819 , B01L2300/0822 , B01L2300/1827 , G01N33/54333
摘要： A novel apparatus for generating temperature gradients is described. The apparatus includes a semiconductive wafer and electrical connectors attached to, preferably, one of the edges of the wafer. Methods for transferring the temperature gradients to strata are described. The temperature gradients on the strata can be used for analyses of molecules, particularly biological macromolecules. The present invention also includes improved methods for determining the thermal stability of binding complexes.
摘要翻译：描述了一种用于产生温度梯度的新型装置。该装置包括半导体晶片和连接到，优选地，晶片的边缘中的一个的电连接器。描述了将温度梯度传递到地层的方法。地层上的温度梯度可用于分子，特别是生物大分子的分析。本发明还包括用于测定结合复合物的热稳定性的改进方法。

10. 发明授权

US6074868A Alumina plate method and device for controlling temperature 失效
标题翻译：氧化铝板法及温度控制装置
公开(公告)号：US6074868A
公开(公告)日：2000-06-13
申请号：US810641
申请日：1997-03-03
申请人： Martin Blumenfeld
发明人： Martin Blumenfeld
IPC分类号： F28F21/04 , B01L7/00 , C12M1/00 , C12Q1/68 , G01N1/28 , C12M3/02
CPC分类号： B01L7/52 , C12Q1/6841 , G01N1/28
摘要： A thermal cycling device comprising a ceramic sample plate, and method of use thereof, is provided.
摘要翻译：提供了包括陶瓷样品板的热循环装置及其使用方法。

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