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1. 发明申请

US20050227367A1 Methods for stabilizing 5-azacytidine in plasma 有权
标题翻译：稳定血浆中5-氮杂胞苷的方法
公开(公告)号：US20050227367A1
公开(公告)日：2005-10-13
申请号：US10823394
申请日：2004-04-13
申请人： Marsha Luna , Larry Eden , Steven Burmaster
发明人： Marsha Luna , Larry Eden , Steven Burmaster
IPC分类号： G01N33/00 , G01N33/49
CPC分类号： G01N33/491 , Y10T436/147777 , Y10T436/17 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The invention provides methods for stabilizing 5-azacytidine against hydrolysis in plasma. By extracting the 5-azacytidine into acetonitrile and zinc sulfate, the 5-azacytidine can be stored for at least about 3 hours at about room temperature, and for at least about 4 days at about −70° C. If the acetonitrile is removed and evaporated to dryness, the 5-azacytidine in the resulting residue is stable for at least about 14 months at about −70° C. The invention also provides methods for determining the 5-azacytidine in acetonitrile, or in the acetonitrile residue, using, for example, high-performance liquid chromatography. The methods of the invention permit a significant time interval between the initial processing of the whole blood sample and the time of 5-azacytidine determination.
摘要翻译：本发明提供了稳定5-氮杂胞苷抗血浆中水解的方法。通过将5-氮杂胞苷提取到乙腈和硫酸锌中，5-氮杂胞苷可以在约室温下储存至少约3小时，并在约-70℃下储存至少约4天。如果除去乙腈，蒸发至干，所得残留物中的5-氮杂胞苷在约-70℃下稳定至少约14个月。本发明还提供了在乙腈或乙腈残留物中测定5-氮杂胞苷的方法，使用例如，高效液相色谱。本发明的方法允许全血样品的初始处理和5-氮杂胞苷测定时间之间的显着时间间隔。

2. 发明授权

US07192781B2 Methods for stabilizing 5-azacytidine in plasma 有权
标题翻译：稳定血浆中5-氮杂胞苷的方法
公开(公告)号：US07192781B2
公开(公告)日：2007-03-20
申请号：US10823394
申请日：2004-04-13
申请人： Marsha Luna , Larry Eden , Steven Burmaster
发明人： Marsha Luna , Larry Eden , Steven Burmaster
IPC分类号： G01N33/00 , G01N1/18
CPC分类号： G01N33/491 , Y10T436/147777 , Y10T436/17 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The invention provides methods for stabilizing 5-azacytidine against hydrolysis in plasma. By extracting the 5-azacytidine into acetonitrile and zinc sulfate, the 5-azacytidine can be stored for at least about 3 hours at about room temperature, and for at least about 4 days at about −70° C. If the acetonitrile is removed and evaporated to dryness, the 5-azacytidine in the resulting residue is stable for at least about 14 months at about −70° C. The invention also provides methods for determining the 5-azacytidine in acetonitrile, or in the acetonitrile residue, using, for example, high-performance liquid chromatography. The methods of the invention permit a significant time interval between the initial processing of the whole blood sample and the time of 5-azacytidine determination.
摘要翻译：本发明提供了稳定5-氮杂胞苷抗血浆中水解的方法。通过将5-氮杂胞苷提取到乙腈和硫酸锌中，5-氮杂胞苷可以在约室温下储存至少约3小时，并在约-70℃下储存至少约4天。如果除去乙腈，蒸发至干，所得残留物中的5-氮杂胞苷在约-70℃下稳定至少约14个月。本发明还提供了在乙腈或乙腈残留物中测定5-氮杂胞苷的方法，使用例如，高效液相色谱。本发明的方法允许全血样品的初始处理和5-氮杂胞苷测定时间之间的显着时间间隔。

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