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1. 发明授权

US09816149B2 Diagnostic transcript and splice patterns of HR-HPV in different cervical lesions 有权
公开(公告)号：US09816149B2
公开(公告)日：2017-11-14
申请号：US13101020
申请日：2011-05-04
申请人： Markus Schmitt , Lutz Gissmann , Michael Pawlita , Daniela Hoefler
发明人： Markus Schmitt , Lutz Gissmann , Michael Pawlita , Daniela Hoefler
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/708 , C12Q1/6883
摘要： The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention.

2. 发明申请

US20110275059A1 Diagnostic Transcript and Splice Patterns of HR-HPV in Different Cervical Lesions 有权
标题翻译： HR-HPV在不同宫颈病变中的诊断睾丸和融合模式
公开(公告)号：US20110275059A1
公开(公告)日：2011-11-10
申请号：US13101020
申请日：2011-05-04
申请人： Markus Schmitt , Lutz Gissmann , Michael Pawlita , Daniela Hoefler
发明人： Markus Schmitt , Lutz Gissmann , Michael Pawlita , Daniela Hoefler
IPC分类号： C12Q1/68 , C07K16/08 , C07H21/04
CPC分类号： C12Q1/708 , C12Q1/6883
摘要： The present invention relates to a method for differentiating in a subject with HR-HPV between a severe form of HR-HPV infection and a mild form of HR-HPV infection. It further is concerned with a composition comprising a probe oligonucleotide mixture, a device, and a kit for use in conjunction with the method of the invention.
摘要翻译：本发明涉及一种在严重形式的HR-HPV感染与轻度形式的HR-HPV感染之间区分HR-HPV的受试者的方法。它还涉及包含探针寡核苷酸混合物，装置和与本发明的方法结合使用的试剂盒的组合物。

3. 发明授权

US09803253B2 Diagnostic transcript and splice patterns of HPV16 in different cervical lesions 有权
公开(公告)号：US09803253B2
公开(公告)日：2017-10-31
申请号：US13128201
申请日：2009-11-09
申请人： Markus Schmitt , Lutz Gissmann , Michael Pawlita
发明人： Markus Schmitt , Lutz Gissmann , Michael Pawlita
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/708 , C12Q2545/113
摘要： A method is described for differentiating in a subject with HPV16 between (i) a severe form of HPV16 infection and (ii) a mild form of HPV16 infection based on determining the amount of a first gene product and a second gene product in a sample of a subject and calculating a ratio of the amount of the first gene product and the amount of the second gene product. A composition is also described, including an oligonucleotide mixture, and also a kit and a device adapted to carry out the described method.

4. 发明申请

US20120040334A1 Diagnostic Transcript and Splice Patterns of HPV16 in Different Cervical Lesions 有权
标题翻译： HPV16在不同宫颈病变中的诊断睾丸和融合模式
公开(公告)号：US20120040334A1
公开(公告)日：2012-02-16
申请号：US13128201
申请日：2009-11-09
申请人： Markus Schmitt , Lutz Gissmann , Michael Pawlita
发明人： Markus Schmitt , Lutz Gissmann , Michael Pawlita
IPC分类号： C12Q1/70 , C12M1/34
CPC分类号： C12Q1/708 , C12Q2545/113
摘要： The present invention relates to a method for differentiating in a subject with HPV16 between (i) a severe form of HPV16 infection and (ii) a mild form of HPV16 infection based on determining the amount of a first gene product and a second gene product in a sample of a subject and calculating a ratio of the amount of said first gene product and the amount of said second gene product. Further envisaged by the present invention is a composition comprising an oligonucleotide mixture. Also envisaged by the present invention are a kit and a device adapted to carry out the method of the present invention.
摘要翻译：本发明涉及一种用于在（i）严重形式的HPV16感染和（ii）轻度形式的HPV16感染之间的HPV16差异化的方法，其基于确定第一基因产物和第二基因产物的量计算受试者的样品并计算所述第一基因产物的量与所述第二基因产物的量的比率。本发明进一步设想的是包含寡核苷酸混合物的组合物。本发明还设想了适用于实施本发明方法的试剂盒和装置。

5. 发明授权

US09034604B2 Composition comprising an oligonucleotide mixture for the detection of contaminations in cell cultures 有权
标题翻译：组合物，其包含用于检测细胞培养物中污染物的寡核苷酸混合物
公开(公告)号：US09034604B2
公开(公告)日：2015-05-19
申请号：US12920095
申请日：2009-03-05
申请人： Markus Schmitt , Michael Pawlita
发明人： Markus Schmitt , Michael Pawlita
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q1/6881 , C12Q1/701 , C12Q1/702 , C12Q1/705 , C12Q2600/16
摘要： The present invention relates to a method for determining contaminations in a cell culture sample comprising the steps of: a) contacting a sample of a cell culture suspected to comprise contaminations with a composition comprising oligonucleotides under conditions which allow for amplification of polynucleotides, wherein said oligonucleotides comprise oligonucleotides of at least three different groups of oligonucleotides, and b) determining the contaminations based on the amplified polynucleotides obtained by using the oligonucleotide groups of step (a). Moreover, the invention relates to a composition comprising an oligonucleotide mixture. Further encompassed by the present invention is a composition comprising a probe oligonucleotide mixture. Finally, the present invention also relates to kits comprising said oligonucleotide mixtures.
摘要翻译：本发明涉及一种用于确定细胞培养物样品中污染物的方法，包括以下步骤：a）在允许扩增多核苷酸的条件下，将怀疑含有污染物的细胞培养物样品与包含寡核苷酸的组合物接触，其中所述寡核苷酸包含至少三种不同组寡核苷酸的寡核苷酸，和b）基于通过使用步骤（a）的寡核苷酸组获得的扩增多核苷酸来测定污染物。此外，本发明涉及包含寡核苷酸混合物的组合物。本发明进一步包括的是包含探针寡核苷酸混合物的组合物。最后，本发明还涉及包含所述寡核苷酸混合物的试剂盒。

6. 发明授权

US08202694B2 Composition comprising an oligonucleotide mixture for improved detection of human papillomavirus genotypes 有权
标题翻译：包含用于改善人乳头状瘤病毒基因型检测的寡核苷酸混合物的组合物
公开(公告)号：US08202694B2
公开(公告)日：2012-06-19
申请号：US12675355
申请日：2008-08-26
申请人： Markus Schmitt , Tim Waterboer , Michael Pawlita
发明人： Markus Schmitt , Tim Waterboer , Michael Pawlita
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/708 , C12Q2537/143 , C12Q2549/119
摘要： The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.
摘要翻译：本发明涉及包含寡核苷酸混合物的组合物。此外，本发明涉及用于诊断受试者样品中不同HPV基因型的所述寡核苷酸混合物的用途。进一步包括用于诊断受试者样品中不同HPV基因型的方法和进行所述方法的试剂盒。

7. 发明申请

US20110027778A1 COMPOSITION COMPRISING AN OLIGONUCLEOTIDE MIXTURE FOR IMPROVED DETECTION OF HUMAN PAPILLOMAVIRUS GENOTYPES 有权
标题翻译：包含用于改善人类斑马鱼基因组检测的寡核苷酸混合物的组合物
公开(公告)号：US20110027778A1
公开(公告)日：2011-02-03
申请号：US12675355
申请日：2008-08-26
申请人： Markus Schmitt , Tim Waterboer , Michael Pawlita
发明人： Markus Schmitt , Tim Waterboer , Michael Pawlita
IPC分类号： C12Q1/68
CPC分类号： C12Q1/708 , C12Q2537/143 , C12Q2549/119
摘要： The present invention relates to a composition comprising an oligonucleotide mixture. Moreover, the present invention relates to the use of said oligonucleotide mixture for diagnosing different HPV genotypes in a sample of a subject. Further encompassed is a method for diagnosing different HPV genotypes in a sample of a subject and a kit carrying out said method.
摘要翻译：本发明涉及包含寡核苷酸混合物的组合物。此外，本发明涉及用于诊断受试者样品中不同HPV基因型的所述寡核苷酸混合物的用途。进一步包括用于诊断受试者样品中不同HPV基因型的方法和进行所述方法的试剂盒。

8. 发明申请

US20130116136A1 PROBES FOR GENOTYPING LOW-RISK-HPV 审中-公开
标题翻译：探索低风险HPV的基因研究
公开(公告)号：US20130116136A1
公开(公告)日：2013-05-09
申请号：US13515757
申请日：2010-12-14
申请人： Markus Schmitt , Michael Pawlita
发明人： Markus Schmitt , Michael Pawlita
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： The current invention is concerned with a composition comprising at least one probe oligonucleotide each for the nucleotide sequences of the invention, said probe oligonucleotides specifically hybridizing to the sense strand or the antisense strand of said nucleotide sequences. Moreover, the present invention relates to a method for the identification of low-risk HPV types in a sample comprising the steps of a) contacting a sample with an amplification composition allowing amplification of at least one region of the HPV genome specifically hybridizing to at least one of the probe oligonucleotides of the current invention under conditions which allow for the amplification of polynucleotides and b) identifying low-risk HPV genotypes in said sample based on the amplified polynucleotides obtained in step a) by hybridizing the amplified polynucleotides with at least one labelled probe oligonucleotide of the current invention while said amplified polynucleotides are present in the same reaction container. The invention also relates to the use of a composition of the current invention for identifying low-risk HPV hi a sample and to a kit comprising the composition of the invention and/or adopted for carrying out the method of the invention and an instruction manual.
摘要翻译：本发明涉及包含至少一种针对本发明的核苷酸序列的探针寡核苷酸的组合物，所述探针寡核苷酸与所述核苷酸序列的有义链或反义链特异性杂交。此外，本发明涉及一种用于鉴定样品中低风险HPV类型的方法，包括以下步骤：a）使样品与扩增组合物接触，所述扩增组合物允许扩增HPV基因组的至少一个区域，特异性杂交至少在允许扩增多核苷酸的条件下，本发明的探针寡核苷酸之一，以及b）基于步骤a）中获得的扩增多核苷酸鉴定所述样品中的低风险HPV基因型，通过将扩增的多核苷酸与至少一个标记的而所述扩增的多核苷酸存在于同一反应容器中的本发明的探针寡核苷酸。本发明还涉及本发明的组合物在样品中鉴定低风险HPV的用途，以及包含本发明组合物和/或用于实施本发明方法和使用说明书的试剂盒的用途。

9. 发明申请

US20130029319A1 MEANS AND METHODS FOR PREDICTING THE RISK OF MORTALITY OF PATIENTS WITH HPV POSITIVE OROPHARYNGEAL SQUAMOUS CELL CANCER 审中-公开
标题翻译：用于预测HPV阳性OROPHARYNGEAL SQUAMOUS细胞癌患者的死亡风险的手段和方法
公开(公告)号：US20130029319A1
公开(公告)日：2013-01-31
申请号：US13556588
申请日：2012-07-24
申请人： Markus SCHMITT , Michael Pawlita , Dana Holzinger , Franz Bosch
发明人： Markus SCHMITT , Michael Pawlita , Dana Holzinger , Franz Bosch
IPC分类号： C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to the field of diagnostic measures. In particular, the present invention relates to a method for predicting the risk of mortality in a subject suffering from low viral load HPV (human papillomavirus) positive oropharyngeal squamous cell cancer. The method is based on the determination of the amount of an E6* gene product and the amount an E1̂E4 gene product of HPV in a sample from said subject. Moreover, the method is based on determining the presence of absence of an E1C gene product of HPV. The present invention further relates to a method for predicting the risk of mortality in a subject suffering from HPV (human papillomavirus) positive oropharyngeal squamous cell cancer based on the determination of copy number of HPV per cancer cell.
摘要翻译：本发明涉及诊断措施领域。特别地，本发明涉及用于预测患有低病毒载量HPV（人乳头瘤病毒）阳性口咽鳞状细胞癌的受试者的死亡风险的方法。该方法基于来自所述受试者的样品中E6 *基因产物的量的确定和HPV的E1E4基因产物的量的量。此外，该方法基于确定HPV的E1C基因产物的存在。本发明还涉及基于每个癌细胞的HPV拷贝数的确定来预测患有HPV（人乳头瘤病毒）阳性口咽鳞状细胞癌的受试者的死亡风险的方法。

10. 发明申请

US20110091885A1 COMPOSITION COMPRISING AN OLIGONUCLEOTIDE MIXTURE FOR THE DETECTION OF CONTAMINATIONS IN CELL CULTURES 有权
标题翻译：包含寡核苷酸混合物的组合物用于检测细胞培养物中的污染
公开(公告)号：US20110091885A1
公开(公告)日：2011-04-21
申请号：US12920095
申请日：2009-03-05
申请人： Markus Schmitt , Michael Pawlita
发明人： Markus Schmitt , Michael Pawlita
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q1/6881 , C12Q1/701 , C12Q1/702 , C12Q1/705 , C12Q2600/16
摘要： The present invention relates to a method for determining contaminations in a cell culture sample comprising the steps of: a) contacting a sample of a cell culture suspected to comprise contaminations with a composition comprising oligonucleotides under conditions which allow for amplification of polynucleotides, wherein said oligonucleotides comprise oligonucleotides of at least three different groups of oligonucleotides, and b) determining the contaminations based on the amplified polynucleotides obtained by using the oligonucleotide groups of step (a). Moreover, the invention relates to a composition comprising an oligonucleotide mixture. Further encompassed by the present invention is a composition comprising a probe oligonucleotide mixture. Finally, the present invention also relates to kits comprising said oligonucleotide mixtures.
摘要翻译：本发明涉及一种用于确定细胞培养物样品中污染物的方法，包括以下步骤：a）在允许扩增多核苷酸的条件下，将怀疑含有污染物的细胞培养物样品与包含寡核苷酸的组合物接触，其中所述寡核苷酸包含至少三种不同组寡核苷酸的寡核苷酸，和b）基于通过使用步骤（a）的寡核苷酸组获得的扩增多核苷酸来测定污染物。此外，本发明涉及包含寡核苷酸混合物的组合物。本发明进一步包括的是包含探针寡核苷酸混合物的组合物。最后，本发明还涉及包含所述寡核苷酸混合物的试剂盒。

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