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1. 发明申请

US20130159045A1 ROBUST INVENTORY MANAGEMENT IN MULTI-STAGE INVENTORY NETWORKS WITH DEMAND SHOCKS 审中-公开
标题翻译：具有需求震动的多级存货网络中的稳健库存管理
公开(公告)号：US20130159045A1
公开(公告)日：2013-06-20
申请号：US13325672
申请日：2011-12-14
申请人： Markus R. Ettl , Marco Laumanns , Marek Petrik , Rajesh Kumar Ravi , Stefan Woerner
发明人： Markus R. Ettl , Marco Laumanns , Marek Petrik , Rajesh Kumar Ravi , Stefan Woerner
IPC分类号： G06Q10/08
CPC分类号： G06Q10/087
摘要： Robust inventory management for a supply chain network with multiple nodes may include generating a time-phased inventory deployment plan based on extreme samples and dynamic supply chain structure. The extreme samples of demand and supply chain scenarios, and dynamic supply chain structure including one or more resource constraints associated with one or more nodes in the supply chain network may be received from a user.
摘要翻译：具有多个节点的供应链网络的稳健库存管理可能包括基于极端样本和动态供应链结构生成时间段库存部署计划。可以从用户接收需求和供应链场景的极端样本以及包括与供应链网络中的一个或多个节点相关联的一个或多个资源约束的动态供应链结构。

2. 发明申请

US20120064101A1 Compounds and Methods Useful for Detection and Treatment of Cancer 有权
标题翻译：用于癌症检测和治疗的化合物和方法
公开(公告)号：US20120064101A1
公开(公告)日：2012-03-15
申请号：US13284660
申请日：2011-10-28
申请人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Ping Yuan
发明人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Ping Yuan
IPC分类号： A61K39/00 , C07K14/46 , C07K14/705 , C12N9/14 , G01N33/566 , A61K38/17 , A61P37/04 , C40B30/04 , A61P43/00 , C07H21/04 , A61K38/46
CPC分类号： G01N33/57419 , A61K2039/53 , C07K14/47
摘要： The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumours and HNPCC associated tumours. The compounds are useful for detection of disorders and in therapy such as immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumour specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumour cells for prevention and curative treatment of cancers and precancers.
摘要翻译：本发明涉及可用于检测和治疗与编码微卫星区域中的移码突变相关的病症的化合物和方法。这些化合物和方法适用于癌症，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤。该化合物可用于检测疾病和治疗如免疫治疗。诊断方法涉及基于针对针对体液中所述移码多肽的免疫学实体的检测而编码基因编码微卫星区域中的移码突变的与移码多肽相关的病症的诊断和预后评估。关于癌症的治疗，本发明涉及使用具有肿瘤特异性移码肽的组合混合物的免疫治疗以引发特异性针对肿瘤细胞的细胞毒性T细胞应答以预防和治疗癌症和预防剂的方法。

3. 发明授权

US08821864B2 Compounds and methods useful for detection and treatment of cancer 有权
标题翻译：可用于癌症检测和治疗的化合物和方法
公开(公告)号：US08821864B2
公开(公告)日：2014-09-02
申请号：US13284660
申请日：2011-10-28
申请人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Ping Yuan
发明人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Ping Yuan
IPC分类号： A61K39/395
CPC分类号： G01N33/57419 , A61K2039/53 , C07K14/47
摘要： The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds are useful for detection of disorders and in therapy such as immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumor specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumor cells for prevention and curative treatment of cancers and precancers.
摘要翻译：本发明涉及可用于检测和治疗与编码微卫星区域中的移码突变相关的病症的化合物和方法。这些化合物和方法适用于癌症，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤。该化合物可用于检测疾病和治疗如免疫治疗。诊断方法涉及基于针对针对体液中所述移码多肽的免疫学实体的检测而编码基因编码微卫星区域中的移码突变的与移码多肽相关的病症的诊断和预后评估。关于癌症的治疗，本发明涉及使用具有肿瘤特异性移码肽的组合混合物的免疫治疗以引发特异性针对肿瘤细胞的细胞毒性T细胞应答以预防和治疗癌症和预防剂的方法。

4. 发明授权

US08053552B2 Neopeptides and methods useful for detection and treatment of cancer 有权
标题翻译：用于检测和治疗癌症的新肽和方法
公开(公告)号：US08053552B2
公开(公告)日：2011-11-08
申请号：US10511698
申请日：2003-04-17
申请人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Ping Yuan
发明人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Ping Yuan
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： G01N33/57419 , A61K2039/53 , C07K14/47
摘要： The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds disclosed in the invention are useful for detection of disorders and in therapy such as e.g. immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumor specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumor cells for use in prevention as well as in curative treatment of cancers and precancers.
摘要翻译：本发明涉及可用于检测和治疗与编码微卫星区域中的移码突变相关的病症的化合物和方法。这些化合物和方法适用于癌症，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤。本发明中公开的化合物可用于疾病的检测和治疗中的检测。免疫治疗。诊断方法涉及基于针对针对体液中所述移码多肽的免疫学实体的检测而编码基因编码微卫星区域中的移码突变的与移码多肽相关的病症的诊断和预后评估。关于癌症的治疗，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤的治疗，本发明涉及使用具有肿瘤特异性移码肽的组合混合物的免疫治疗来引发细胞毒性T细胞应答的方法针对肿瘤细胞用于预防以及治疗癌症和预防药物。

5. 发明申请

US20050239070A1 Neopeptides and methods useful for detection and treatment of cancer 有权
标题翻译：用于检测和治疗癌症的新肽和方法
公开(公告)号：US20050239070A1
公开(公告)日：2005-10-27
申请号：US10511698
申请日：2003-04-17
申请人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Yuan
发明人： Magnus Von Knebel-Doeberitz , Johannes Gebert , Michael Linnebacher , Stefan Woerner , Ruediger Ridder , Peer Bork , Yan Yuan
IPC分类号： C07K14/47 , C12Q1/68 , C07H21/04 , C07K14/82 , G01N33/574
CPC分类号： G01N33/57419 , A61K2039/53 , C07K14/47
摘要： The present invention relates to compounds and methods useful for the detection and treatment of disorders associated with frameshift mutations in coding microsatellite regions. The compounds and methods are applicable in cancers, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors. The compounds disclosed in the invention are useful for detection of disorders and in therapy such as e.g. immuno-therapy. The diagnostic methods relate to diagnosis and prognostic assessment of disorders associated with frameshift polypeptides originating from frameshift mutations in coding microsatellite regions of genes based on the detection of immunological entities directed against said frameshift polypeptides in body fluids. With respect to the treatment of cancer, especially of DNA mismatch repair deficient (MMR) sporadic tumors and HNPCC associated tumors, the invention pertains to methods which use immuno therapy with combinatorial mixtures of tumor specific frameshift peptides to elicit a cytotoxic T-cell response specifically directed against tumor cells for use in prevention as well as in curative treatment of cancers and precancers.
摘要翻译：本发明涉及可用于检测和治疗与编码微卫星区域中的移码突变相关的病症的化合物和方法。这些化合物和方法适用于癌症，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤。本发明中公开的化合物可用于疾病的检测和治疗中的检测。免疫治疗。诊断方法涉及基于针对针对体液中所述移码多肽的免疫学实体的检测而编码基因编码微卫星区域中的移码突变的与移码多肽相关的病症的诊断和预后评估。关于癌症的治疗，特别是DNA错配修复缺陷（MMR）散发性肿瘤和HNPCC相关肿瘤的治疗，本发明涉及使用具有肿瘤特异性移码肽的组合混合物的免疫治疗来引发细胞毒性T细胞应答的方法针对肿瘤细胞用于预防以及治疗癌症和预防药物。

6. 发明授权

US5909174A Control device, especially for vehicle braking light control 失效
标题翻译：控制装置，特别适用于车辆制动灯控制
公开(公告)号：US5909174A
公开(公告)日：1999-06-01
申请号：US821043
申请日：1997-03-20
申请人： Juergen Dietz , Armin Staehle , Stefan Woerner
发明人： Juergen Dietz , Armin Staehle , Stefan Woerner
IPC分类号： B60Q1/44 , B60Q11/00
CPC分类号： B60Q11/002 , B60Q1/44
摘要： A control device is provided with a controllable element and a control unit that delivers an output signal which, when a control command signal applied to the input side is at an activating level, continuously or periodically assumes an activating level and continuously assumes a deactivating level when the control command signal is at a deactivating level or there is a functional failure of the control unit. The control device incorporates a redundancy logic unit that logically links the control command signal with the output signal of the control unit to form the control signal for the controllable element in such fashion that when the output signal of the control unit is continuously at its deactivating level, the control signal, corresponding to the control command signal, is at its activating or deactivating level, while otherwise the control signal is at its activating or deactivating signal level depending on the level of the output signal of the control unit. The control device can be used for controlling the brake lights of a vehicle.
摘要翻译：控制装置设置有可控元件和控制单元，其输出输出信号，当输入侧的控制命令信号处于激活电平时，连续或周期性地采取激活电平并且连续地呈现去激活电平，控制指令信号处于去激活水平或控制单元的功能故障。控制装置包括冗余逻辑单元，其将控制命令信号与控制单元的输出信号逻辑地链接以形成可控元件的控制信号，使得当控制单元的输出信号连续处于其去激活水平时对应于控制命令信号的控制信号处于其激活或去激活级别，否则控制信号根据控制单元的输出信号的电平处于其激活或去激活信号电平。控制装置可以用于控制车辆的刹车灯。

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