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1. 发明申请

US20130052700A1 BIOCATALYTIC OXIDATION PROCESS WITH ALKL GENE PRODUCT 有权
标题翻译：含ALKL基因产物的生物氧化氧化过程
公开(公告)号：US20130052700A1
公开(公告)日：2013-02-28
申请号：US13642412
申请日：2011-03-15
申请人： Markus Poetter , Andreas Schmid , Bruno Buehler , Hans-Georg Hennemann , Mattijs Kamiel Julsing , Steffen Schaffer , Thomas Haas , Manfred Schrewe , Sjef Cornelissen , Martin Roos , Harald Haeger
发明人： Markus Poetter , Andreas Schmid , Bruno Buehler , Hans-Georg Hennemann , Mattijs Kamiel Julsing , Steffen Schaffer , Thomas Haas , Manfred Schrewe , Sjef Cornelissen , Martin Roos , Harald Haeger
IPC分类号： C12P7/62 , C12P7/26 , C12P7/24 , C12P7/04 , C12P13/00 , C12P7/64 , C12N1/21 , C12N1/13 , C12P7/40 , C12P7/02
CPC分类号： C07K14/21 , C12P7/02 , C12P7/24 , C12P7/42 , C12P7/62 , C12P7/6436 , C12Y114/15003
摘要： The invention provides a biocatalytic process for oxidation of organic compounds with the aid of an alkL gene product, and microorganisms used in this process.
摘要翻译：本发明提供了借助于alkL基因产物和在该方法中使用的微生物来氧化有机化合物的生物催化方法。

2. 发明申请

US20100324257A1 OMEGA-AMINO CARBOXYLIC ACIDS, OMEGA-AMINO CARBOXYLIC ACID ESTERS, OR RECOMBINANT CELLS WHICH PRODUCE LACTAMS THEREOF 有权
标题翻译：欧米加氨基羧酸，欧米加氨基羧酸酯，或其生产其乳酸的重组细胞
公开(公告)号：US20100324257A1
公开(公告)日：2010-12-23
申请号：US12742318
申请日：2008-12-12
申请人： Andreas Karau , Volker Sieber , Thomas Haas , Harald Haeger , Katrin Grammann , Bruno Buehler , Lars Blank , Andreas Schmid , Guido Jach , Bernd Lalla , Andreas Mueller , Katrin Schullehner , Peter Welters , Thorsten Eggert , Andrea Weckbecker
发明人： Andreas Karau , Volker Sieber , Thomas Haas , Harald Haeger , Katrin Grammann , Bruno Buehler , Lars Blank , Andreas Schmid , Guido Jach , Bernd Lalla , Andreas Mueller , Katrin Schullehner , Peter Welters , Thorsten Eggert , Andrea Weckbecker
IPC分类号： C08G69/08 , C12N1/00 , C12N1/21 , C12P13/00 , C12P17/10 , C07C229/00 , C07D225/00 , C08G73/06
CPC分类号： C12N15/52 , C08G69/08 , C08G69/14 , C12P13/005
摘要： The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ω-aminocarboxylic acids, more ω-aminocarboxylic acid esters or more lactams derived from ω-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ω-aminocarboxylic acids, of ω-aminocarboxylic acid esters or of lactams derived from ω-aminocarboxylic acids, the ω-aminocarboxylic acids, ω-aminocarboxylic acid esters or lactams derived from ω-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ω-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.
摘要翻译：本发明涉及一种相对于其野生型经遗传修饰的细胞，因此与野生型相比，能够产生更多的ω-氨基羧酸，更多的ω-氨基羧酸酯或更多来源于ω的内酰胺氨基羧酸，起始于羧酸或羧酸酯。此外，本发明涉及生产转基因细胞的方法，可通过该方法获得的细胞，ω-氨基羧酸酯或ω-氨基羧酸衍生的内酰胺的生产ω-氨基羧酸的方法酸，ω-氨基羧酸，ω-氨基羧酸酯或衍生自可通过该方法得到的ω-氨基羧酸的内酰胺，制备基于ω-氨基羧酸或基于内酰胺的聚酰胺的方法和可通过该方法获得的聚酰胺。

3. 发明授权

US09012227B2 ω-Aminocarboxylic acids, ω-aminocarboxylic acid esters, or recombinant cells which produce lactams thereof 有权
标题翻译： ω-氨基羧酸，ω-氨基羧酸酯或产生其内酰胺的重组细胞
公开(公告)号：US09012227B2
公开(公告)日：2015-04-21
申请号：US12742318
申请日：2008-12-12
申请人： Andreas Karau , Volker Sieber , Thomas Haas , Harald Haeger , Katrin Grammann , Bruno Buehler , Lars Blank , Andreas Schmid , Guido Jach , Bernd Lalla , Andreas Mueller , Katrin Schullehner , Peter Welters , Thorsten Eggert , Andrea Weckbecker
发明人： Andreas Karau , Volker Sieber , Thomas Haas , Harald Haeger , Katrin Grammann , Bruno Buehler , Lars Blank , Andreas Schmid , Guido Jach , Bernd Lalla , Andreas Mueller , Katrin Schullehner , Peter Welters , Thorsten Eggert , Andrea Weckbecker
IPC分类号： C12N15/74 , C12N15/00 , C12N15/52 , C08G69/08 , C08G69/14 , C12P13/00
CPC分类号： C12N15/52 , C08G69/08 , C08G69/14 , C12P13/005
摘要： The present invention relates to a cell, which has been genetically modified relative to its wild type, so that in comparison with its wild type it is able to produce more ω-aminocarboxylic acids, more ω-aminocarboxylic acid esters or more lactams derived from ω-aminocarboxylic acids, starting from carboxylic acids or carboxylic acid esters. Furthermore, the present invention relates to a method for the production of a genetically modified cell, the cells obtainable by this method, a method for the production of ω-aminocarboxylic acids, of ω-aminocarboxylic acid esters or of lactams derived from ω-aminocarboxylic acids, the ω-aminocarboxylic acids, ω-aminocarboxylic acid esters or lactams derived from ω-aminocarboxylic acids obtainable by this method, a method for the production of polyamides based on ω-aminocarboxylic acids or based on lactams and the polyamides obtainable by this method.
摘要翻译：本发明涉及一种相对于其野生型经遗传修饰的细胞，因此与野生型相比，能够产生更多的ω-氨基羧酸，更多的ω-氨基羧酸酯或更多来源于ω的内酰胺氨基羧酸，起始于羧酸或羧酸酯。此外，本发明涉及生产转基因细胞的方法，可通过该方法获得的细胞，ω-氨基羧酸酯或ω-氨基羧酸衍生的内酰胺的生产ω-氨基羧酸的方法酸，ω-氨基羧酸，ω-氨基羧酸酯或衍生自可通过该方法得到的ω-氨基羧酸的内酰胺，制备基于ω-氨基羧酸或基于内酰胺的聚酰胺的方法和可通过该方法获得的聚酰胺。

4. 发明申请

US20100145082A1 METHOD FOR PROCESSING COALESCENCE-INHIBITED EMULSIONS FROM WHOLE-CELL BIOTRANSFORMATIONS WITH COMPRESSED OR SUPERCRITICAL GASES,IN PARTICULAR WITH CARBON DIOXIDE 失效
标题翻译：从具有压缩或超临界气体（特别是二氧化碳）的全细胞生物降解过程中处理含有抑制性乳剂的方法
公开(公告)号：US20100145082A1
公开(公告)日：2010-06-10
申请号：US12452769
申请日：2008-07-20
申请人： Gabriele Sadowski , Andreas Schmid , Bruno Buehler , Michael Goernert , Christoph Brandenbusch
发明人： Gabriele Sadowski , Andreas Schmid , Bruno Buehler , Michael Goernert , Christoph Brandenbusch
IPC分类号： C07D301/32
CPC分类号： C12N1/02 , B01D17/044 , B01D17/047 , B01D21/02 , C12N1/06
摘要： The method presented represents a possibility for separating emulsions derived from whole-cell biotransformations, which method makes it possible to effectively separate stable emulsions derived from typical biocatalytic two-phase processes that result in connection with such a biotransformation, by means of at least one compressed or supercritical gas. In this connection, a supercritical extraction to obtain the valuable product can follow directly, because of the use of compressed or supercritical gas as the separation agent. It is unimportant, in this connection, whether the valuable product is present in the aqueous or the organic phase. Recycling of the organic phase is possible, since the surfactant cell components, which are decisively responsible for the formation of the stable emulsion, can be separated off by means of sedimentation, because of the treatment. The separation that is achieved remains in existence even after the compressed or supercritical gas has gassed out, so that aside from extraction, other methods for product isolation can also follow, if this is necessary. In this connection, the invention contains tremendous potential for industrial use of biocatalytical two-phase processes, which are of great interest economically and ecologically.
摘要翻译：所提出的方法代表了分离衍生自全细胞生物转化的乳液的可能性，该方法使得有可能通过至少一种压缩的方法有效地分离来自典型的生物催化两相过程的稳定乳剂，其导致与这种生物转化的连接或超临界气体。在这方面，由于使用压缩或超临界气体作为分离剂，所以获得有价物质的超临界萃取可以直接进行。在这方面，有价值的产品是否存在于水相或有机相中是不重要的。有机相的回收是可能的，因为由于处理，可以通过沉降来分离出决定性地负责形成稳定乳液的表面活性剂细胞成分。即使在压缩或超临界气体放气之后，仍然存在分离，因此除了提取之外，如果需要，也可以遵循其他用于产物分离的方法。在这方面，本发明在生物催化二相工艺的工业化应用方面具有巨大的潜力，这在生产和经济上都是非常有意义的。

5. 发明授权

US08431358B2 Method for processing coalescence-inhibited emulsions from whole-cell biotransformations with compressed or supercritical gases 失效
标题翻译：用压缩或超临界气体从全细胞生物转化处理聚结抑制乳剂的方法
公开(公告)号：US08431358B2
公开(公告)日：2013-04-30
申请号：US12452769
申请日：2008-07-20
申请人： Gabriele Sadowski , Andreas Schmid , Bruno Buehler , Michael Goernert , Christoph Brandenbusch
发明人： Gabriele Sadowski , Andreas Schmid , Bruno Buehler , Michael Goernert , Christoph Brandenbusch
IPC分类号： C12P1/00
CPC分类号： C12N1/02 , B01D17/044 , B01D17/047 , B01D21/02 , C12N1/06
摘要： The method separates emulsions derived from whole-cell biotransformations, including stable emulsions derived from typical biocatalytic two-phase processes that result with such a biotransformation. A supercritical extraction to obtain the valuable product can follow directly, because of the use of compressed or supercritical gas as the separation agent. It is unimportant whether the valuable product is present in the aqueous or the organic phase. Recycling of the organic phase is possible, since the surfactant cell components decisively responsible for the formation of the stable emulsion can be separated off via sedimentation, because of the treatment. The achieved separation remains in existence even after the gas has gassed out, so that aside from extraction, other methods for product isolation can also follow, if necessary.
摘要翻译：该方法分离衍生自全细胞生物转化的乳液，包括衍生自通过这种生物转化产生的典型生物催化两相过程的稳定乳剂。由于采用压缩或超临界气体作为分离剂，因此获得有价物质的超临界萃取可以直接进行。有价值的产品是否存在于水相或有机相中是不重要的。有机相的回收是可能的，因为由于处理，可以通过沉淀分离决定性地负责形成稳定乳液的表面活性剂细胞成分。实现的分离仍然存在，即使在气体放出之后，除了提取之外，如果需要，也可以遵循用于产物分离的其它方法。

6. 发明申请

US20050060066A1 Device and method for remote operation of a vehicle from a mother vehicle 审中-公开
标题翻译：从母车辆远程操作车辆的装置和方法
公开(公告)号：US20050060066A1
公开(公告)日：2005-03-17
申请号：US10896662
申请日：2004-07-22
申请人： Bruno Buehler , Urban Thoeni
发明人： Bruno Buehler , Urban Thoeni
IPC分类号： G05D1/00 , G06F17/00
CPC分类号： G05D1/0038 , G05D2201/0213
摘要： A device (10) having a first vehicle (11) and a second vehicle (13) which are connected to one another via a communication link (12). The first vehicle (11) has operational units (21), which are actuated in the typical way during driving. In the first vehicle (11), there are connections (23) for transmitting vehicle information (24) which is correlated to the actuation of the operational units (21). Switching means (28) are used for the purpose of switching over the first vehicle (11) from a driving mode into a remote operation mode. A transmitter (27) is used for converting the vehicle information (24) into signals and for transmitting the signals from the first vehicle (11) to the second vehicle (13). The second vehicle (13) includes a receiver (31) for receiving the signals and for converting them into control information. In addition, control elements (32) are provided, which are activatable from the first vehicle (11) by actuating the operational units (21), after the switching means (28) have been brought into the remote operation mode.
摘要翻译：具有经由通信链路（12）彼此连接的第一车辆（11）和第二车辆（13）的装置（10）。第一车辆（11）具有在驾驶期间以典型方式致动的操作单元（21）。在第一车辆（11）中，存在用于传送与操作单元（21）的致动相关的车辆信息（24）的连接（23）。切换装置（28）用于将第一车辆（11）从驾驶模式切换到远程操作模式。发射器（27）用于将车辆信息（24）转换为信号并将信号从第一车辆（11）发送到第二车辆（13）。第二车辆（13）包括用于接收信号并将其转换成控制信息的接收器（31）。此外，在切换装置（28）进入远程操作模式之后，提供控制元件（32），其通过致动操作单元（21）可从第一车辆（11）激活。

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