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1. 发明授权

US07005447B2 Food product comprising hydroxymatairesinol 有权
标题翻译：食品包含羟基苦参碱
公开(公告)号：US07005447B2
公开(公告)日：2006-02-28
申请号：US10639530
申请日：2003-08-13
申请人： Markku Ahotupa , Christer Eckerman , Lauri Kangas , Sari Mäkelä , Niina Saarinen , Risto Santti , Anni Wärri
发明人： Markku Ahotupa , Christer Eckerman , Lauri Kangas , Sari Mäkelä , Niina Saarinen , Risto Santti , Anni Wärri
IPC分类号： A61K31/34 , A23L1/30
CPC分类号： A61K31/365 , A23L33/105 , A23V2002/00 , A23V2250/2132
摘要： A food product containing an effective amount of an active agent which is hydroxymatairesinol, a geometric isomer or stereoisomer thereof, or an acceptable salt thereof, or a mixture thereof, where the food product is selected from the group consisting of a nutritional supplement and a nutrient. The food product can increase the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on the administration of hydroxymatairesinol to the person.
摘要翻译：一种食品，其含有有效量的活性剂，其为羟基木薯油，其几何异构体或立体异构体，或其可接受的盐或其混合物，其中所述食品选自营养补充剂和营养物质。食品可以增加人血清中的内酰胺或羟基苦参碱的另一种代谢物，从而基于向该人施用羟基苦参碱，从而预防人或某些非癌症，激素依赖性疾病。

2. 发明授权

US06689809B2 Food additive or product or a pharmaceutical preparation, comprising hydroxymatairesinol 有权
标题翻译：食品添加剂或产品或药物制剂，包含羟基马来酰亚胺
公开(公告)号：US06689809B2
公开(公告)日：2004-02-10
申请号：US09972850
申请日：2001-10-10
申请人： Markku Ahotupa , Christer Eckerman , Lauri Kangas , Sari Mäkelä , Niina Saarinen , Risto Santti , Anni Wärri
发明人： Markku Ahotupa , Christer Eckerman , Lauri Kangas , Sari Mäkelä , Niina Saarinen , Risto Santti , Anni Wärri
IPC分类号： A61K3134
CPC分类号： A61K31/365 , A23L33/105 , A23V2002/00 , A23V2250/2132
摘要： This invention relates to methods for prevention of cancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person, based on administering of hydroxymatairesinol to said person. The invention also concerns a method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on administering of hydroxymatairesinol to said person. Furthermore, this invention relates to pharmaceutical preparations, food additives and food products comprising hydroxymatairesinol.
摘要翻译：本发明涉及基于向所述个体施用羟基苦参碱，预防人体中某些癌症，某些非癌症，激素依赖性疾病和/或心血管疾病的方法。本发明还涉及一种用于增加人血清中的内酰胺或羟基马来西林的另一种代谢物的水平，从而基于向所述人施用羟基马来西林，从而导致人体中预防癌症或某些非癌症，激素依赖性疾病。此外，本发明涉及药物制剂，食品添加剂和包含羟基木薯油的食品。

3. 发明授权

US06451849B1 USE OF HYDROXYMATAIRESINOL FOR PREVENTION OF CANCERS, NON-CANCER, HORMONE DEPENDENT DISEASES AND CARDIOVASCULAR DISEASES BY HYDROXYMATAIRESINOL, AND A PHARMACEUTICAL PREPARATION, FOOD ADDITIVE AND FOOD PRODUCT COMPRISING HYDROXYMATAIRESINOL 有权
标题翻译：羟丙基甲基纤维素用于预防癌症，非癌症，依赖于HORMONE的HORMONE依赖性疾病和心血管疾病，以及药物制剂，食品添加剂和包含羟基亚甲兰基的食品产品
公开(公告)号：US06451849B1
公开(公告)日：2002-09-17
申请号：US09281094
申请日：1999-03-30
申请人： Markku Ahotupa , Chester Eckerman , Lauri Kangas , Sari Mäkelä , Niina Saarinen , Risto Santti , Anni Wärri
发明人： Markku Ahotupa , Chester Eckerman , Lauri Kangas , Sari Mäkelä , Niina Saarinen , Risto Santti , Anni Wärri
IPC分类号： A61K3134
CPC分类号： A61K31/365 , A23L33/105 , A23V2002/00 , A23V2250/2132
摘要： This invention relates to methods for prevention of cancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person, based on administering of hydroxymatairesinol to said person. The invention also concerns a method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on administering of hydroxymatairesinol to said person. Furthermore, this invention relates to pharmaceutical preparations, food additives and food products comprising hydroxymatairesinol.
摘要翻译：本发明涉及基于向所述个体施用羟基苦参碱，预防人体中某些癌症，某些非癌症，激素依赖性疾病和/或心血管疾病的方法。本发明还涉及一种用于增加人血清中的内酰胺或羟基马来西林的另一种代谢物的水平，从而基于向所述人施用羟基马来西林，从而导致人体中预防癌症或某些非癌症，激素依赖性疾病。此外，本发明涉及药物制剂，食品添加剂和包含羟基木薯油的食品。

4. 发明申请

US20070117864A1 Composition for preventing and treating hepatoma 审中-公开
标题翻译：用于预防和治疗肝癌的组合物
公开(公告)号：US20070117864A1
公开(公告)日：2007-05-24
申请号：US10572945
申请日：2004-12-24
申请人： Kazumi Yagasaki , Yutaka Miura , Daiki Miura , Risto Santti , Niina Saarinen
发明人： Kazumi Yagasaki , Yutaka Miura , Daiki Miura , Risto Santti , Niina Saarinen
IPC分类号： A61K31/365
CPC分类号： A61K36/15 , A23L33/105 , A23V2002/00 , A61K31/365 , C07D307/33 , A23V2200/308 , A23V2250/21
摘要： The present invention provides a liver cancer prophylactic and therapeutic composition, and the present invention relates to a liver cancer prophylactic and therapeutic composition characterized in that this composition contains compounds that have a hepatoma proliferation inhibiting effect as active ingredients, these compounds comprising enterolactone (ENL) or plant lignan precursors of the same; a liver cancer prophylactic and therapeutic drug characterized in that this drug comprises compounds that have a hepatoma proliferation inhibiting effect, these compounds being enterolactone (ENL) or plant lignan precursors of the same, and a pharmacologically permissible carrier component; and a functional food product material characterized in that this food product material is formed by mixing compounds that have a hepatoma proliferation inhibiting effect, these compounds being enterolactone (ENL) or plant lignan precursors of the same as functional components with a food product material.
摘要翻译：本发明提供肝癌预防和治疗组合物，本发明涉及肝癌预防和治疗组合物，其特征在于该组合物含有作为活性成分具有肝癌增殖抑制作用的化合物，这些化合物包括肠内酯（ENL）或植物木酚素前体; 一种肝癌预防和治疗药物，其特征在于该药物包括具有肝癌增殖抑制作用的化合物，这些化合物是肠内酯（ENL）或其植物木酚素前体，以及药理学上允许的载体组分; 以及功能食品，其特征在于，通过混合具有肝癌增殖抑制作用的化合物，这些化合物是肠内酯（ENL）或与功能组分相同的植物木酚素前体与食品材料形成。

5. 发明授权

US07345073B2 Method for treating cryptorchidism 失效
标题翻译：治疗隐睾的方法
公开(公告)号：US07345073B2
公开(公告)日：2008-03-18
申请号：US11245026
申请日：2005-10-07
申请人： Tomi Streng , Sari Mäkelä , Risto Santti , Matti Poutanen , Xiangdong Li
发明人： Tomi Streng , Sari Mäkelä , Risto Santti , Matti Poutanen , Xiangdong Li
IPC分类号： A61K31/41
CPC分类号： A61K31/415 , A61K31/4172 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/505
摘要： The present invention relates to a method and pharmaceutical composition for the treatment of male individuals suffering from cryptorchidism comprising administering to said individuals an effective amount of an aromatase inhibitor, preferably finrozole.
摘要翻译：本发明涉及用于治疗患有隐睾症的男性个体的方法和药物组合物，包括向所述个体施用有效量的芳香酶抑制剂，优选氟他唑。

6. 发明授权

US06316431B1 Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men and method to study the dyssynergia in male rodents 有权
标题翻译：使用芳香酶抑制剂治疗男性雄激素降低雌激素比例和逼尿肌尿道括约肌屈肌退化症的方法，研究男性啮齿类动物的脱发
公开(公告)号：US06316431B1
公开(公告)日：2001-11-13
申请号：US09581128
申请日：2000-09-19
申请人： Risto Santti , Antti Talo , Tomi Streng , Kaija Halonen , Lauri Kangas , Risto Lammintausta
发明人： Risto Santti , Antti Talo , Tomi Streng , Kaija Halonen , Lauri Kangas , Risto Lammintausta
IPC分类号： A61K3156
CPC分类号： A61K31/568 , A61K31/00 , A61K31/4196 , A61K31/437 , A61K31/4545 , A61K31/5685
摘要： This invention relates to the use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ration (DATER) as well as to a method for the treatment of detrusor urethral sphincter dyssnergia (DUSD) in men.
摘要翻译：本发明涉及芳香酶抑制剂用于治疗雄激素降低至雌激素比例（DATER）的用途以及用于治疗男性逼尿肌尿道括约肌绒毛麻醉症（DUSD）的方法。

7. 发明授权

US5972921A Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men 失效
标题翻译：使用芳香酶抑制剂治疗男性雄激素降低与雌激素比例及逼尿肌尿道括约肌息肉
公开(公告)号：US5972921A
公开(公告)日：1999-10-26
申请号：US989447
申请日：1997-12-12
申请人： Risto Santti , Antti Talo , Tomi Streng , Kaija Halonen , Lauri Kangas , Risto Lammintausta
发明人： Risto Santti , Antti Talo , Tomi Streng , Kaija Halonen , Lauri Kangas , Risto Lammintausta
IPC分类号： A61K45/00 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/437 , A61K31/4545 , A61K31/5685 , A61P3/04 , A61P5/24 , A61P13/02 , A61P15/08 , A61P15/10 , A61K31/56 , A61K31/44 , A61K31/445
CPC分类号： A61K31/568 , A61K31/00 , A61K31/4196 , A61K31/437 , A61K31/4545 , A61K31/5685
摘要： The invention relates to a method for the treatment of detrusor urethral sphincter dyssynergia in men, said method comprising administering to the patient an effective amount of an aromatase inhibitor. The invention also concerns a method for the treatment of decreased androgen to estrogen ratio in men, said method comprising administering to the patient an effective amount of an aromatase inhibitor.
摘要翻译：本发明涉及一种用于治疗男性逼尿肌尿道括约肌屈肌松弛症的方法，所述方法包括向患者施用有效量的芳香酶抑制剂。本发明还涉及一种治疗男性雄激素降低雌激素比例的方法，所述方法包括向患者施用有效量的芳香酶抑制剂。

8. 发明授权

US07825107B2 Method of treating men suffering from chronic nonbacterial prostatitis with SERM compounds or aromatase inhibitors 有权
标题翻译：用SERM化合物或芳香酶抑制剂治疗慢性非细菌性前列腺炎男性的方法
公开(公告)号：US07825107B2
公开(公告)日：2010-11-02
申请号：US11751846
申请日：2007-05-22
申请人： Risto Santti , Tomi Streng , Jenni Bernoulli , Emrah Yatkin
发明人： Risto Santti , Tomi Streng , Jenni Bernoulli , Emrah Yatkin
IPC分类号： A61K31/56 , A61K31/19 , A61K31/16
CPC分类号： A61K31/085 , A61K45/06 , A61K2300/00
摘要： A method for treatment or prevention of chronic nonbacterial prostatitis in individuals without urethral sphincter dysfunction, comprises administering an effective amount of (i) a selective estrogen receptor modulator (SERM) having estrogen antagonist effect in the prostate, (ii) an aromatase inhibitor, and/or (iii) an antiestrogen.
摘要翻译：一种在没有尿道括约肌功能障碍的个体中治疗或预防慢性非细菌性前列腺炎的方法，包括给予有效量的（i）在前列腺中具有雌激素拮抗作用的选择性雌激素受体调节剂（SERM），（ii）芳香酶抑制剂和 /或（iii）抗雌激素。

9. 发明申请

US20100305158A1 METHOD FOR THE TREATMENT OR PREVENTION OF LOWER URINARY TRACT SYMPTOMS 审中-公开
标题翻译：治疗或预防下尿路症状的方法
公开(公告)号：US20100305158A1
公开(公告)日：2010-12-02
申请号：US12856738
申请日：2010-08-16
申请人： Risto Santti , Tomi Streng
发明人： Risto Santti , Tomi Streng
IPC分类号： A61K31/4535 , A61P13/02 , A61P13/08 , A61K31/085
CPC分类号： A61K31/085 , A61K31/00 , A61K31/01 , A61K31/02 , A61K31/03 , A61K31/045 , A61K31/05 , A61K31/075 , A61K31/138 , A61K31/192 , A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/4164 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/55 , A61K31/565
摘要： This invention concerns a method for treatment or prevention of lower urinary tract symptoms with or without pelvic pain in an individual, said method comprising administering to the individual an effective amount of a selective estrogen receptor modulator, or an isomer, isomer mixture or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及用于治疗或预防患有或不伴有个体的盆腔疼痛的下尿路症状的方法，所述方法包括向个体施用有效量的选择性雌激素受体调节剂或异构体异构体混合物或药学上可接受的的盐。

10. 发明申请

US20080021111A1 METHOD OF TREATING MEN SUFFERING FROM CHRONIC NONBACTERIAL PROSTATITIS WITH SERM COMPOUNDS OR AROMATASE INHIBITORS 有权
标题翻译：使用SERM化合物或芳香酶抑制剂治疗慢性非细菌性前列腺增生症的方法
公开(公告)号：US20080021111A1
公开(公告)日：2008-01-24
申请号：US11751846
申请日：2007-05-22
申请人： Risto Santti , Tomi Streng , Jenni Bernoulli , Emrah Yatkin
发明人： Risto Santti , Tomi Streng , Jenni Bernoulli , Emrah Yatkin
IPC分类号： A61K31/085 , A61P29/00 , A61P35/00
CPC分类号： A61K31/085 , A61K45/06 , A61K2300/00
摘要： A method for treatment or prevention of chronic nonbacterial prostatitis in individuals without urethral sphincter dysfunction, comprises administering an effective amount of (i) a selective estrogen receptor modulator (SERM) having estrogen antagonist effect in the prostate, (ii) an aromatase inhibitor, and/or (iii) an antiestrogen.
摘要翻译：一种在没有尿道括约肌功能障碍的个体中治疗或预防慢性非细菌性前列腺炎的方法，包括给予有效量的（i）在前列腺中具有雌激素拮抗作用的选择性雌激素受体调节剂（SERM），（ii）芳香酶抑制剂和 /或（iii）抗雌激素。

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