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1. 发明授权

US09359605B2 Method of treating cancer by inhibition of DNA repair proteins 有权
标题翻译：通过抑制DNA修复蛋白治疗癌症的方法
公开(公告)号：US09359605B2
公开(公告)日：2016-06-07
申请号：US14004416
申请日：2012-03-12
申请人： Mark Vincent , Peter J. Ferguson , Mateusz Rytelewski
发明人： Mark Vincent , Peter J. Ferguson , Mateusz Rytelewski
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , A61K31/7088 , A61K31/7105 , A61K31/7115
CPC分类号： C12N15/1135 , A61K31/198 , A61K31/282 , A61K31/502 , A61K31/513 , A61K31/7088 , A61K31/7105 , A61K31/7115 , A61K31/713 , A61K33/24 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2320/31 , C12Y201/01045 , C12N2310/3521 , C12N2310/3525 , A61K2300/00
摘要： Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense oligonucleotides can be used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.
摘要翻译：提供了使用针对DNA双链断裂修复蛋白（例如BRCA2或RAD51）的反义寡核苷酸治疗癌症的方法。反义寡核苷酸可以单独使用或与其他癌症治疗组合使用，特别是与导致DNA损伤，DNA修复抑制或DNA合成抑制的疗法，如放射线剂，铂药物，烷化剂，PARP抑制剂，或胸苷酸合酶抑制剂。

2. 发明授权

US4106877A Lobular pin 失效
标题翻译：小叶针
公开(公告)号：US4106877A
公开(公告)日：1978-08-15
申请号：US723765
申请日：1976-09-16
申请人： Peter J. Ferguson
发明人： Peter J. Ferguson
IPC分类号： F16B19/02 , F16B21/12 , F16B21/14 , F16B19/00
CPC分类号： F16B21/12 , F16B19/02 , Y10T403/1624 , Y10T403/559 , Y10T403/7086
摘要： A pin has a pilot point of uniform width throughout 360.degree. and a body containing a cross section of arcuate polygonal lobular configuration, also of uniform width but wider than the point. The pin may be driven into a circular hole in a member such that the lobes of the pin are elastically deformed in compression to enhance the grip between the pin and the member and with there being regions of stress relief on the member intermediate the lobes. The hole in the member may also be reshaped into a lobular form. The uniform body width approximates the minimum diameter of the hole in the member. Furthermore, the pin is of a range of lobulation sufficient to span a wide range of hole diameter tolerances.
摘要翻译：一个销具有360度均匀宽度的导向点和一个包含弓形多边形小叶构造的横截面的主体，其宽度均匀但宽于点。销可以被驱动到构件中的圆形孔中，使得销的凸角在压缩中弹性变形以增强销和构件之间的夹紧，并且在该凸起上方的构件上存在应力释放区域。构件中的孔也可以重新成形为小叶形。均匀的身体宽度近似于构件中孔的最小直径。此外，该销具有足以跨越宽范围的孔径公差的分叶的范围。

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