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1. 发明授权

US09901731B2 Medical electrical lead having improved inductance 有权
公开(公告)号：US09901731B2
公开(公告)日：2018-02-27
申请号：US11343655
申请日：2006-01-31
申请人： Mark T. Marshall , Kevin R. Seifert
发明人： Mark T. Marshall , Kevin R. Seifert
IPC分类号： A61N1/05 , A61N1/37 , A61N1/08
CPC分类号： A61N1/056 , A61N1/08 , A61N1/3718
摘要： A conductor for connecting an electrode near a distal end of a medical electrical lead with an implantable medical device connected with a proximal end of the medical electrical lead includes a multi-filar coil wrapped around a central core. The multi-filar coil has an inductance of approximately 0.5 μH or greater, and the central core is non-conducting and provides reinforcement for the multi-filar coil.

2. 发明申请

US20130289644A1 FAULT TOLERANT IMPLANTABLE MEDICAL SYSTEM 有权
公开(公告)号：US20130289644A1
公开(公告)日：2013-10-31
申请号：US13457884
申请日：2012-04-27
申请人： Gonzalo Martinez , Mark T. Marshall , Kevin R. Seifert
发明人： Gonzalo Martinez , Mark T. Marshall , Kevin R. Seifert
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61B5/0215 , A61B2560/0276 , A61N1/04 , A61N1/0563 , A61N1/3628 , A61N1/36592 , A61N1/368 , A61N1/3706 , A61N1/3931 , A61N1/3937 , A61N1/3962 , A61N2001/0585 , A61N2001/083
摘要： The disclosure describes implantable medical systems that respond to occurrence of a lead-related condition by utilizing an elongated coil electrode in defining an alternative pacing therapy vector to maintain optimal drain of an IMD power supply. An exemplary system includes a medical electrical lead having an elongated electrode and an improved sensing and therapy delivery circuitry to provide the alternative pacing therapy vector responsive to the lead-related conditions. The system reconfigures the operation of the sensing and therapy delivery circuitry triggered by the switch to the alternative pacing therapy vector.

3. 发明申请

US20130289643A1 LEAD RECOGNITION FOR AN IMPLANTABLE MEDICAL SYSTEM 有权
标题翻译：可植入医疗系统的领导认可
公开(公告)号：US20130289643A1
公开(公告)日：2013-10-31
申请号：US13457859
申请日：2012-04-27
申请人： Mark T. Marshall , Gonzalo Martinez , Kevin R. Seifert
发明人： Mark T. Marshall , Gonzalo Martinez , Kevin R. Seifert
IPC分类号： A61N1/37
CPC分类号： A61N1/37282 , A61B5/042 , A61B5/0424 , A61B5/04288 , A61B5/686 , A61B5/7221 , A61B5/725 , A61B5/7282 , A61B5/746 , A61B2560/0276 , A61N1/05 , A61N1/3628 , A61N1/3706 , A61N2001/083
摘要： The disclosure describes implantable medical systems that respond to occurrence of a lead-related condition by utilizing an elongated coil electrode in defining an alternative pacing therapy vector to maintain optimal drain of an IMD power supply. An exemplary system includes a medical electrical lead having an elongated electrode and an improved sensing and therapy delivery circuitry to provide the alternative pacing therapy vector responsive to the lead-related conditions. The system includes circuitry for recognition of the lead type in order to respond to the occurrence of the lead-related condition.
摘要翻译：本公开描述了通过利用细长的线圈电极来定义替代的起搏治疗载体来保持IMD电源的最佳耗尽来响应引线相关状况的发生的可植入医疗系统。示例性系统包括具有细长电极的医疗电引线和改进的感测和治疗递送电路，以响应于引线相关条件提供替代起搏治疗载体。该系统包括用于识别引线类型以便响应引线相关状况的发生的电路。

4. 发明授权

US08612021B2 Magnetic resonance imaging compatible medical electrical lead and method of making the same 有权
标题翻译：磁共振成像兼容的医用电导线及其制作方法
公开(公告)号：US08612021B2
公开(公告)日：2013-12-17
申请号：US13324406
申请日：2011-12-13
申请人： Kevin R. Seifert , Mark T. Marshall , Mariya Lazebnik
发明人： Kevin R. Seifert , Mark T. Marshall , Mariya Lazebnik
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/086 , Y10T29/49016 , Y10T29/49018
摘要： This disclosure describes an implantable medical lead, and method of making such a lead or components of the lead, that reduces the undesirable effects the fields generated by an MRI device may have on the implantable medical lead and the implantable medical device. The implantable medical lead includes an RF filter placed in series with an electrical path to an electrode of the lead. In one example, the RF filter may comprise a conductor wound in such a manner that it provides an inductance and capacitance that provides the RF filter with a resonant frequency, and in some instances, multiple resonant frequencies. At frequencies around the resonant frequency of the RF filter, the RF filter presents a high impedance, thereby blocking the signal from or at least attenuating the signal propagating to the electrode. At frequencies far from the resonant frequency, the RF filter presents a low impedance.
摘要翻译：本公开描述了可植入医疗引线以及制造引线的这种引线或部件的方法，其减少由MRI装置产生的磁场对可植入医疗引线和可植入医疗装置可能产生的不期望的影响。可植入医疗用引线包括与通向电极的电极的电路串联放置的RF滤波器。在一个示例中，RF滤波器可以包括以这样一种方式缠绕的导体，即，它提供了提供RF滤波器的谐振频率的电感和电容，并且在一些情况下提供多个谐振频率。在RF滤波器的谐振频率周围的频率处，RF滤波器呈现高阻抗，从而阻挡信号或至少衰减传播到电极的信号。在远离谐振频率的频率下，RF滤波器呈现低阻抗。

5. 发明申请

US20090082655A1 MEDICAL ELECTRICAL LEADS AND CONDUCTOR ASSEMBLIES THEREOF 有权
标题翻译：医用电气导线及导线组件
公开(公告)号：US20090082655A1
公开(公告)日：2009-03-26
申请号：US12234466
申请日：2008-09-19
申请人： Kevin R. Seifert , Gregory A. Boser , Mark T. Marshall
发明人： Kevin R. Seifert , Gregory A. Boser , Mark T. Marshall
IPC分类号： A61B5/04 , H02G15/08 , H01R43/00
CPC分类号： A61N1/056 , A61N1/05 , H01B7/0823 , Y10T29/49194
摘要： A conductor assembly for a medical electrical lead includes a web and plurality of conductors. The web includes a plurality of longitudinally extending elements, or sidewalls, each of which define a longitudinally extending lumen, and a plurality of longitudinally extending connectors, each of which join a pair of adjacent sidewalls. Each of the plurality of conductors extends within a corresponding lumen, and each may include an insulative jacket. If each conductor includes an insulative jacket, the jacket is preferably formed from one or more of the following materials: PEEK, PVDF and polysulfone. One or more of the connectors of the web may be flexible to allow for a connected separation, or a gap between adjacent sidewalls; and one or more of these connectors may further include a discrete wall section adapted to facilitate widening of the corresponding gap. Preferably the conductor assembly is coiled for incorporation into the lead.
摘要翻译：用于医疗电线的导体组件包括腹板和多个导体。腹板包括多个纵向延伸的元件或侧壁，每个侧壁限定纵向延伸的内腔，以及多个纵向延伸的连接器，每个连接件连接一对相邻的侧壁。多个导体中的每一个在相应的内腔内延伸，并且每个可以包括绝缘护套。如果每个导体包括绝缘护套，则护套优选由以下一种或多种材料形成：PEEK，PVDF和聚砜。纤维网的一个或多个连接器可以是柔性的，以允许连接的间隔或相邻侧壁之间的间隙; 并且这些连接器中的一个或多个可以进一步包括适于促进相应间隙加宽的离散壁部分。优选地，导体组件被卷绕以结合到引线中。

6. 发明授权

US07254451B2 Implantable lead including sensor 有权
标题翻译：可植入铅包括传感器
公开(公告)号：US07254451B2
公开(公告)日：2007-08-07
申请号：US10717791
申请日：2003-11-20
申请人： Kevin R. Seifert , Teresa A. Whitman , Brian T. McHenry , Mark T. Marshall , Thomas S. Ahern
发明人： Kevin R. Seifert , Teresa A. Whitman , Brian T. McHenry , Mark T. Marshall , Thomas S. Ahern
IPC分类号： A61N1/00
CPC分类号： A61N1/0563 , A61N1/057
摘要： An implantable lead includes a defibrillation electrode and a sensor coupled thereto. The electrode and sensor are positioned along a body of the lead such that, when a fixation element couples the lead to an endocardial surface of a right ventricle, the sensor is located in a high flow region and a portion of the defibrillation electrode is located in proximity to a right ventricular apex.
摘要翻译：可植入引线包括除颤电极和耦合到其上的传感器。电极和传感器沿着引线的主体定位，使得当固定元件将引线耦合到右心室的心内膜表面时，传感器位于高流动区域中，并且除颤电极的一部分位于靠近右心室顶点。

7. 发明授权

US08494656B2 Medical electrical leads and conductor assemblies thereof 有权
标题翻译：医用电线及其导线组件
公开(公告)号：US08494656B2
公开(公告)日：2013-07-23
申请号：US12234466
申请日：2008-09-19
申请人： Kevin R. Seifert , Greg A. Boser , Mark T. Marshall
发明人： Kevin R. Seifert , Greg A. Boser , Mark T. Marshall
IPC分类号： A61N1/375
CPC分类号： A61N1/056 , A61N1/05 , H01B7/0823 , Y10T29/49194
摘要： A conductor assembly for a medical electrical lead includes a web and plurality of conductors. The web includes a plurality of longitudinally extending elements, or sidewalls, each of which define a longitudinally extending lumen, and a plurality of longitudinally extending connectors, each of which join a pair of adjacent sidewalls. Each of the plurality of conductors extends within a corresponding lumen, and each may include an insulative jacket. If each conductor includes an insulative jacket, the jacket is preferably formed from one or more of the following materials: PEEK, PVDF and polysulfone. One or more of the connectors of the web may be flexible to allow for a connected separation, or a gap between adjacent sidewalls; and one or more of these connectors may further include a discrete wall section adapted to facilitate widening of the corresponding gap. Preferably the conductor assembly is coiled for incorporation into the lead.
摘要翻译：用于医疗电线的导体组件包括腹板和多个导体。腹板包括多个纵向延伸的元件或侧壁，每个侧壁限定纵向延伸的内腔，以及多个纵向延伸的连接器，每个连接件连接一对相邻的侧壁。多个导体中的每一个在相应的内腔内延伸，并且每个可以包括绝缘护套。如果每个导体包括绝缘护套，则护套优选由以下一种或多种材料形成：PEEK，PVDF和聚砜。纤维网的一个或多个连接器可以是柔性的，以允许连接的间隔或相邻侧壁之间的间隙; 并且这些连接器中的一个或多个可以进一步包括适于促进相应间隙加宽的离散壁部分。优选地，导体组件被卷绕以结合到引线中。

8. 发明申请

US20120209365A1 MAGNETIC RESONANCE IMAGING COMPATIBLE MEDICAL ELECTRICAL LEAD AND METHOD OF MAKING THE SAME 有权
标题翻译：磁共振成像兼容医用电线及其制造方法
公开(公告)号：US20120209365A1
公开(公告)日：2012-08-16
申请号：US13324406
申请日：2011-12-13
申请人： Kevin R. Seifert , Mark T. Marshall , Mariya Lazebnik
发明人： Kevin R. Seifert , Mark T. Marshall , Mariya Lazebnik
IPC分类号： A61N1/05 , H01P1/20 , H01P11/00
CPC分类号： A61N1/05 , A61N1/086 , Y10T29/49016 , Y10T29/49018
摘要： This disclosure describes an implantable medical lead, and method of making such a lead or components of the lead, that reduces the undesirable effects the fields generated by an MRI device may have on the implantable medical lead and the implantable medical device. The implantable medical lead includes an RF filter placed in series with an electrical path to an electrode of the lead. In one example, the RF filter may comprise a conductor wound in such a manner that it provides an inductance and capacitance that provides the RF filter with a resonant frequency, and in some instances, multiple resonant frequencies. At frequencies around the resonant frequency of the RF filter, the RF filter presents a high impedance, thereby blocking the signal from or at least attenuating the signal propagating to the electrode. At frequencies far from the resonant frequency, the RF filter presents a low impedance.
摘要翻译：本公开描述了可植入医疗引线以及制造引线的这种引线或部件的方法，其减少由MRI装置产生的磁场对可植入医疗引线和可植入医疗装置可能产生的不期望的影响。可植入医疗用引线包括与通向电极的电极的电路串联放置的RF滤波器。在一个示例中，RF滤波器可以包括以这样一种方式缠绕的导体，即，它提供了提供RF滤波器的谐振频率的电感和电容，并且在一些情况下提供多个谐振频率。在RF滤波器的谐振频率周围的频率处，RF滤波器呈现高阻抗，从而阻挡信号或至少衰减传播到电极的信号。在远离谐振频率的频率下，RF滤波器呈现低阻抗。

9. 发明授权

US09037263B2 System and method for implantable medical device lead shielding 有权
标题翻译：可植入医疗器械铅屏蔽的系统和方法
公开(公告)号：US09037263B2
公开(公告)日：2015-05-19
申请号：US12112889
申请日：2008-04-30
申请人： Mark T. Marshall
发明人： Mark T. Marshall
IPC分类号： A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61N1/0563 , A61N1/0472 , A61N1/048 , A61N1/08 , A61N1/086
摘要： An implantable medical device (IMD) can include a cardiac pacemaker or an implantable cardioverter-defibrillator (ICD). Various portions of the IMD, such as a device body, a lead body, or a lead tip, can be provided to reduce or dissipate a current and heat induced by various external environmental factors. According to various embodiments, features can be incorporated into the lead body, the lead tip, or the IMD body to reduce the creation of an induced current, or dissipate the induced Current and heat created due to an induced current in the lead. For example, an IMD can include at least one outer conductive member and a first electrode. The first electrode can be in electrical communication with the at least one outer conductive member. The first electrode can dissipate a current induced in the at least one outer conductive member via a first portion of the anatomical structure.
摘要翻译：可植入医疗装置（IMD）可包括心脏起搏器或植入式心律转复除颤器（ICD）。可以提供IMD的各个部分，例如装置主体，引线主体或引线头，以减少或消散由各种外部环境因素引起的电流和热量。根据各种实施例，可以将特征结合到引线本体，引线尖端或IMD体中，以减少感应电流的产生，或者消散由于引线中的感应电流而产生的感应电流和热量。例如，IMD可以包括至少一个外部导电构件和第一电极。第一电极可以与至少一个外部导电构件电连通。第一电极可以经由解剖结构的第一部分消散在至少一个外部导电构件中感应的电流。

10. 发明授权

US08903512B2 Medical system including a novel bipolar pacing pair 有权
标题翻译：医疗系统包括一个新颖的双极起搏对
公开(公告)号：US08903512B2
公开(公告)日：2014-12-02
申请号：US10630547
申请日：2003-07-29
申请人： Mark T. Marshall , Teresa A. Whitman , Eduardo N. Warman , Jeffrey M. Gillberg , Matthew D. Bonner , Mark L. Brown
发明人： Mark T. Marshall , Teresa A. Whitman , Eduardo N. Warman , Jeffrey M. Gillberg , Matthew D. Bonner , Mark L. Brown
IPC分类号： A61N1/05 , A61N1/368 , A61N1/37
CPC分类号： A61N1/057 , A61N1/0568 , A61N1/0573 , A61N1/368 , A61N1/3702 , A61N2001/0585
摘要： An implantable electrical medical system comprises a low voltage cathode electrode assembly, including a cathode surface adapted for, intimate contact with electrically active tissue, and a low voltage anode electrode assembly, including an anode surface and a porous layer extending over the anode surface. The cathode surface and the anode surface function as a bipolar pair for pacing and the porous layer extending over the anode surface allows conduction therethrough and prevents the anode surface from contacting the electrically active tissue in order to prevent anodal stimulation.
摘要翻译：可植入电气医疗系统包括低电压阴极电极组件，其包括适于与电活性组织紧密接触的阴极表面，以及包括在阳极表面上延伸的阳极表面和多孔层的低压阳极电极组件。阴极表面和阳极表面用作用于起搏的双极对，并且在阳极表面上延伸的多孔层允许通过其传导，并且防止阳极表面接触电活性组织以防止阳极刺激。

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