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1. 发明授权

US06972176B2 KVLQT1—a long QT syndrome gene 有权
标题翻译： KVLQT1 - 长QT综合征基因
公开(公告)号：US06972176B2
公开(公告)日：2005-12-06
申请号：US10368643
申请日：2003-02-20
申请人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski , Qing Wang
发明人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski , Qing Wang
IPC分类号： A01K67/027 , A61K48/00 , A61P9/06 , C07K14/46 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/577 , G01N33/58 , G01N33/68
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
摘要翻译：公开了与长QT综合征相关的基因的KVLQT1和KCNE1的内含子/外显子连接序列的基因组结构。另外公开了两种基因ARE的附加序列数据。还公开了KVLQT1中新发现的突变，导致长QT综合征。内含子/外显子连接序列数据允许引物对的设计来扩增和序列两个基因的所有外显子。这可以用于筛选引起长QT综合征的突变的存在。可以进行检测以筛选人们在DNA或蛋白质中存在突变。 DNA和蛋白质也可用于筛选可用于治疗或预防长QT综合征发生的药物的测定中。

2. 发明授权

US06582913B1 Diagnostic method for KVLQT1—a long QT syndrome gene 有权
标题翻译： KVLQT1-长QT综合征基因的诊断方法
公开(公告)号：US06582913B1
公开(公告)日：2003-06-24
申请号：US09597731
申请日：2000-06-19
申请人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
发明人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
摘要翻译：公开了与长QT综合征相关的基因的KVLQT1和KCNE1的内含子/外显子连接序列的基因组结构。另外公开了两种基因ARE的附加序列数据。还公开了KVLQT1中新发现的突变，导致长QT综合征。内含子/外显子连接序列数据允许设计引物对来扩增和序列两个基因的所有外显子。这可以用于筛选引起长QT综合征的突变的存在。可以进行检测以筛选人们在DNA或蛋白质中存在突变。 DNA和蛋白质也可用于筛选可用于治疗或预防长QT综合征发生的药物的测定中。

3. 发明授权

US06277978B1 KVLQT1—a long QT syndrome gene 有权
标题翻译： KVLQT1 - 长QT综合征基因
公开(公告)号：US06277978B1
公开(公告)日：2001-08-21
申请号：US09135010
申请日：1998-08-17
申请人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
发明人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
IPC分类号： C07K14705
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes are also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
摘要翻译：公开了与长QT综合征相关的基因的KVLQT1和KCNE1的内含子/外显子连接序列的基因组结构。还公开了两个基因的附加序列数据。还公开了KVLQT1中新发现的突变，导致长QT综合征。内含子/外显子连接序列数据允许设计引物对来扩增和序列两个基因的所有外显子。这可以用于筛选引起长QT综合征的突变的存在。可以进行检测以筛选人们在DNA或蛋白质中存在突变。 DNA和蛋白质也可用于筛选可用于治疗或预防长QT综合征发生的药物的测定中。

4. 发明授权

US06451534B1 KVLQT1—a long QT syndrome gene 有权
标题翻译： KVLQT1 - 长QT综合征基因
公开(公告)号：US06451534B1
公开(公告)日：2002-09-17
申请号：US09597732
申请日：2000-06-19
申请人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
发明人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
摘要翻译：公开了与长QT综合征相关的基因的KVLQT1和KCNE1的内含子/外显子连接序列的基因组结构。另外公开了两种基因ARE的附加序列数据。还公开了KVLQT1中新发现的突变，导致长QT综合征。内含子/外显子连接序列数据允许设计引物对来扩增和序列两个基因的所有外显子。这可以用于筛选引起长QT综合征的突变的存在。可以进行检测以筛选人们在DNA或蛋白质中存在突变。 DNA和蛋白质也可用于筛选可用于治疗或预防长QT综合征发生的药物的测定中。

5. 发明授权

US06420124B1 KVLQT1—a long qt syndrome gene 有权
标题翻译： KVLQT1-长qt综合征基因
公开(公告)号：US06420124B1
公开(公告)日：2002-07-16
申请号：US09597735
申请日：2000-06-19
申请人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
发明人： Mark T. Keating , Michael C. Sanguinetti , Mark E. Curran , Gregory M. Landes , Timothy D. Connors , Timothy C. Burn , Igor Splawski
IPC分类号： G01N3353
CPC分类号： C07K14/47 , A01K2217/05 , A61K48/00 , C07K14/705 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The genomic structure including the sequence of the intron/exon junctions is disclosed for KVLQT1 and KCNE1 which are genes associated with long QT syndrome. Additional sequence data for the two genes ARE also disclosed. Also disclosed are newly found mutations in KVLQT1 which result in long QT syndrome. The intron/exon junction sequence data allow for the design of primer pairs to amplify and sequence across all of the exons of the two genes. This can be used to screen persons for the presence of mutations which cause long QT syndrome. Assays can be performed to screen persons for the presence of mutations in either the DNA or proteins. The DNA and proteins may also be used in assays to screen for drugs which will be useful in treating or preventing the occurrence of long QT syndrome.
摘要翻译：公开了与长QT综合征相关的基因的KVLQT1和KCNE1的内含子/外显子连接序列的基因组结构。另外公开了两种基因ARE的附加序列数据。还公开了KVLQT1中新发现的突变，导致长QT综合征。内含子/外显子连接序列数据允许设计引物对来扩增和序列两个基因的所有外显子。这可以用于筛选引起长QT综合征的突变的存在。可以进行检测以筛选人们在DNA或蛋白质中存在突变。 DNA和蛋白质也可用于筛选可用于治疗或预防长QT综合征发生的药物的测定中。

6. 发明授权

US5599673A Long QT syndrome genes 失效
标题翻译：长QT综合征基因
公开(公告)号：US5599673A
公开(公告)日：1997-02-04
申请号：US401512
申请日：1995-03-09
申请人： Mark T. Keating , Mark E. Curran , Qing Wang
发明人： Mark T. Keating , Mark E. Curran , Qing Wang
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/68 , C07H21/04 , C12N15/00 , C12P19/34
CPC分类号： C12Q1/6883 , C07K14/705 , A61K38/00 , C12Q2600/156 , C12Q2600/172 , Y10T436/143333
摘要： The invention relates to the identification of the molecular basis of long QT syndrome. More specifically, the invention has identified that SCN5A and HERG cause long QT syndrome. Molecular variants of the SCN5A and HERG genes contribute to the syndrome. The analysis of these genes will provide an early diagnosis of subjects with long QT syndrome. The diagnostic methods comprise analyzing the nucleic acid sequences of the SCN5A or HERG genes of an individual to be tested and comparing them with the nucleic acid sequence of the native, nonvariant genes. Alternatively, the amino acid sequences of SCN5A or HERG may be analyzed for mutations which cause long QT syndrome. Presymptomatic diagnosis of long QT syndrome will enable practitioners to treat this disorder using existing medical therapy.
摘要翻译：本发明涉及长QT综合征的分子基础鉴定。更具体地说，本发明已经确定SCN5A和HERG引起长QT综合征。 SCN5A和HERG基因的分子变体有助于该综合征。这些基因的分析将为长期QT综合征的受试者提供早期诊断。诊断方法包括分析待测试个体的SCN5A或HERG基因的核酸序列，并将其与天然非变性基因的核酸序列进行比较。或者，可以分析导致长QT综合征的突变的SCN5A或HERG的氨基酸序列。长期QT综合征的症状诊断将使实践者能够使用现有的药物治疗来治疗这种疾病。

7. 发明授权

US5054875A Fiber-optic equalizer 失效
标题翻译：光纤均衡器
公开(公告)号：US5054875A
公开(公告)日：1991-10-08
申请号：US561176
申请日：1990-08-01
申请人： Mark E. Curran
发明人： Mark E. Curran
IPC分类号： G02B6/26 , G02B6/34 , H04B10/2581
CPC分类号： G02B6/29358 , G02B6/26 , H04B10/2581
摘要： A multi-mode optical fiber segment having partially reflecting mirrors on each end functions as a resonant cavity with respect to the modulation frequency when the length of the fiber is equal to one-half the modulation wavelength of the light injected into the fiber. Modulated light is injected through a hole in the mirror at one end, either from a fiber, a waveguide, or directly from a laser diode. The core diameter of the cavity fiber is limited only by the requirement that it must be much larger than the input hole. Light exits though a hole in the mirror opposite the input hole. Upon entry into the resonant cavity, light is subject to multi-modal propagation resulting in dispersion. The resultant output light of the fiber is lower overall in intensity, but its useful frequency response is expanded by the bandpass half-skirt of the fiber-optic filter.
摘要翻译：当纤维的长度等于注入光纤的光的调制波长的二分之一时，在每个端部上具有部分反射镜的多模光纤段相对于调制频率用作谐振腔。调制光通过光纤，波导或直接来自激光二极管的一端的反射镜中的孔注入。腔体光纤的芯径仅受到必须比输入孔大得多的要求的限制。光通过镜子的入口孔相对的孔而离开。在进入谐振腔时，光经受多模式传播，导致分散。光纤的合成输出光强度总体较低，但其有用的频率响应由光纤滤波器的带通半裙部扩展。

8. 发明授权

US5166509A Optical modulator noise nonlinearity reduction circuit 失效
标题翻译：光调制器噪声非线性降低电路
公开(公告)号：US5166509A
公开(公告)日：1992-11-24
申请号：US610958
申请日：1990-11-09
申请人： Mark E. Curran
发明人： Mark E. Curran
IPC分类号： H04B10/155
CPC分类号： H04B10/5051 , H04B10/50593 , H04B10/588
摘要： An optical modulator or laser source has a detector for detecting its output signal and for producing a corresponding output signal. A tapping device is connected to tap off a portion of the input modulation signal as a reference signal. The reference signal is compared and subtracted from the detector output signal by a subtraction unit in order to produce an error output signal which will be proportional to the laser noise/distortion components. This error signal is amplified and connected to an external modulator linked to the laser optical output and intensity modulates the laser output signal by the error signal in order to reduce or cancel the noise and distortion components in the signal.
摘要翻译：光调制器或激光源具有用于检测其输出信号并产生相应的输出信号的检测器。连接分接装置以分接输入调制信号的一部分作为参考信号。通过减法单元将参考信号从检测器输出信号进行比较和减去，以产生与激光噪声/失真分量成比例的误差输出信号。该误差信号被放大并连接到与激光光输出连接的外部调制器，并通过误差信号强度调制激光输出信号，以便减少或消除信号中的噪声和失真分量。

9. 发明授权

US5113244A Fiber optic combiner/splitter 失效
标题翻译：光纤组合器/分路器
公开(公告)号：US5113244A
公开(公告)日：1992-05-12
申请号：US651635
申请日：1991-02-06
申请人： Mark E. Curran
发明人： Mark E. Curran
IPC分类号： G02B6/28 , H04B10/2581
CPC分类号： H04B10/2581 , G02B6/2848
摘要： The fiber optic combiner/splitter is a positive and negative axicon combination which can convert a ring-shaped beam into a solid beam. The positive half of the axicon is effectively a plano-convex lens where the convex surface is generally a shallow cone. The flat surface of the lens abuts each end of an array of single mode fibers which are arranged in a ring configuration around a support member. The negative half of the axicon is effectively a plano-concave lens which is complementary to the positive lens. The focused beams from the positive half of the axicon are combined to form a single beam which is then directed into a single optical fiber. For conversions in the reverse direction, light is taken from a single multimode fiber and expanded into a ring-like pattern. The ring of light is picked up by the ring of single mode fibers. Each single mode fiber receives an equal amount of optical energy or power to provide good efficiency in splitting of the multiplexed beam.
摘要翻译：光纤组合器/分路器是一个正负的轴锥组合，可将环形梁转换为实心光束。旋转三棱镜的正半部实际上是平凸透镜，其中凸表面通常是浅锥体。透镜的平坦表面邻接围绕支撑构件布置成环形结构的单模光纤阵列的每一端。正面透镜的负半部实际上是与正透镜互补的平凹透镜。将聚焦光束从正面半轴组合起来形成单个光束，然后将其导入单个光纤。对于相反方向的转换，从单个多模光纤采集光并扩展成环状图案。光环由单模光纤环拾取。每个单模光纤接收等量的光能或功率，以便在多路复用光束的分割中提供良好的效率。

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