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1. 发明授权

US06235869B1 Absorbable polymers and surgical articles fabricated therefrom 有权
标题翻译：可吸收聚合物和由其制造的外科用品
公开(公告)号：US06235869B1
公开(公告)日：2001-05-22
申请号：US09416367
申请日：1999-10-09
申请人： Mark S. Roby , Lydmilla K. Kokish , Rooma M. Mehta , Jerry Y. Jonn
发明人： Mark S. Roby , Lydmilla K. Kokish , Rooma M. Mehta , Jerry Y. Jonn
IPC分类号： C08G6308
CPC分类号： D01F6/84 , A61L17/12 , A61L27/18 , A61L31/06 , C08L67/04
摘要： Synthetic absorbable medical devices made totally or in part from a random polymer comprising glycolide, lactide, trimethylene carbonate, and caprolactone are provided. The polymer can be fabricated into a monofilament which exhibits physical characteristics equivalent to or superior than gut sutures.
摘要翻译：提供了由包含乙交酯，丙交酯，三亚甲基碳酸酯和己内酯的无规聚合物全部或部分制备的合成可吸收医疗装置。聚合物可以制成单丝，其显示出等同于或优于肠缝线的物理特征。

2. 发明授权

US6165202A Absorbable polymers and surgical articles fabricated therefrom 有权
标题翻译：可吸收聚合物和由其制造的外科用品
公开(公告)号：US6165202A
公开(公告)日：2000-12-26
申请号：US326926
申请日：1999-06-05
申请人： Lydmilla K. Kokish , Rooma M. Mehta , Mark S. Roby , Jerry Y. Jonn
发明人： Lydmilla K. Kokish , Rooma M. Mehta , Mark S. Roby , Jerry Y. Jonn
IPC分类号： A61B17/00 , A61B17/06 , A61B17/064 , A61B19/00 , A61L15/26 , A61L17/12 , A61L27/18 , A61L31/04 , A61L31/06 , D01F6/84 , A61B17/04
CPC分类号： D01F6/84 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2090/3937 , A61L15/26 , A61L17/12 , A61L27/18 , A61L31/041 , A61L31/06 , C08L67/04
摘要： Synthetic absorbable medical devices made totally or in part from a random polymer comprising glycolide, lactde and caprolactone are provided. The polymer can be fabricated into a monofilament which exhibits physical characteristics equivalent to or superior than gut sutures.
摘要翻译：提供由包含乙交酯，乳糖和己内酯的无规聚合物全部或部分制备的合成可吸收医疗装置。聚合物可以制成单丝，其显示出等同于或优于肠缝线的物理特征。

3. 发明申请

US20100021414A1 Bioabsorbable Adhesive Compounds And Compositions 有权
标题翻译：生物可吸收粘合剂和组合物
公开(公告)号：US20100021414A1
公开(公告)日：2010-01-28
申请号：US12563653
申请日：2009-09-21
申请人： Mark S. Roby
发明人： Mark S. Roby
IPC分类号： A61L24/04
CPC分类号： C08G18/10 , A61K31/785 , A61L24/0042 , A61L24/043 , A61L24/046 , C08G18/3225 , C08G18/48 , C08G18/5024 , C08G18/73 , C08G18/735 , C08G18/771 , C08G2190/00 , C08G2230/00 , C09J175/02 , C09J175/04 , C09J175/08 , C08L71/02 , C08G18/50 , C08G18/3821
摘要： Bioabsorbable compounds which include a polyalkylene oxide backbone with two or more isocyanate substituents are useful as one component adhesives. Absorbable compositions useful as a two component adhesive contain a) a polyethylene oxide having two or more amine substituents with b) a bioabsorbable diisocyanate compound, or alternatively contain a) a polyethylene oxide having two or more isocyanate substituents with b) a bioabsorbable diamine compound, or, alternatively contain a) a bioabsorbable diisocyanate compound and b) a bioabsorbable diamine compound.
摘要翻译：包含具有两个或更多个异氰酸酯取代基的聚环氧烷主链的生物可吸收化合物可用作单组分粘合剂。可用作双组分粘合剂的可吸收组合物包含a）具有两个或多个胺取代基的聚环氧乙烷，b）生物可吸收二异氰酸酯化合物，或者备选地包含a）具有两个或多个异氰酸酯取代基的聚环氧乙烷，b）生物可吸收二胺化合物，或者可选地含有a）生物可吸收二异氰酸酯化合物和b）生物可吸收二胺化合物。

4. 发明申请

US20100016891A1 HETEROGENEOUS YARNS FOR SURGICAL ARTICLES 审中-公开
标题翻译：手术用异味纱
公开(公告)号：US20100016891A1
公开(公告)日：2010-01-21
申请号：US12504954
申请日：2009-07-17
申请人： John J. Kennedy , Joshua Stopek , Mark S. Roby
发明人： John J. Kennedy , Joshua Stopek , Mark S. Roby
IPC分类号： A61B17/04
CPC分类号： A61L31/129 , A61L17/105 , A61L31/125 , C08L23/06 , C08L67/00 , C08L2203/12 , D02G3/448 , D04C1/02 , D04C1/12 , D10B2321/02 , D10B2331/04 , D10B2403/0311 , D10B2509/00 , D10B2509/04 , C08L67/02
摘要： Heterogeneous yarns containing strands of dissimilar materials are usefull in forming surgical device.
摘要翻译：含有异种材料的不均匀纱线在形成手术装置中是有用的。

5. 发明授权

US06527749B1 Two component dispenser system 失效
标题翻译：双组分分配器系统
公开(公告)号：US06527749B1
公开(公告)日：2003-03-04
申请号：US09595961
申请日：2000-06-19
申请人： Mark S. Roby , Ernie Aranyi , Richard Yagami , H. Jonathan Tovey
发明人： Mark S. Roby , Ernie Aranyi , Richard Yagami , H. Jonathan Tovey
IPC分类号： A61M500
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2017/2837
摘要： An applicator is provided for dispensing a first and a second protein solution to form a biological adhesive where the solutions can be deflected by a deflection assembly during dispensing for the adhesive to cover a broad or limited area. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing a first component, and a second reservoir containing a second component. The first and second components are preferably fibrinogen and thrombin which intermix with water to form the first and second protein solutions, respectively. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. The solutions intermix on an application site to form a fibrin sealant. In an alternate embodiment, the applicator includes two valves. A first valve opens and closes the proximal ends of two conduit assemblies for introducing water or other substance to the reservoirs. A second valve opens and closes the distal ends of the two conduit assemblies to permit and prevent the dispensing of the protein solutions.
摘要翻译：提供施用器用于分配第一和第二蛋白质溶液以形成生物粘合剂，其中在分配粘合剂以覆盖宽的或有限的区域期间，溶液可被偏转组件偏转。施加器包括壳体，该壳体具有壳体头部，用于在其中封装包含第一部件的第一储存器和包含第二部件的第二储存器。第一和第二组分优选分别与水混合以形成第一和第二蛋白质溶液的纤维蛋白原和凝血酶。壳体还包括限定纵向轴线的细长主体部分，用于在其中封闭具有分别与第一和第二储存器连通的第一和第二导管的导管组件。溶液在应用场所混合形成纤维蛋白密封胶。在替代实施例中，施加器包括两个阀。第一阀打开和关闭两个导管组件的近端，用于将水或其他物质引入储存器。第二阀打开和关闭两个导管组件的远端以允许和防止蛋白质溶液的分配。

6. 发明授权

US5939191A Coated gut suture 失效
标题翻译：涂层肠缝合
公开(公告)号：US5939191A
公开(公告)日：1999-08-17
申请号：US880303
申请日：1997-06-23
申请人： Steven L. Bennett , Ying Jiang , Mark S. Roby , Nagabhushanam Totakura
发明人： Steven L. Bennett , Ying Jiang , Mark S. Roby , Nagabhushanam Totakura
IPC分类号： A61L17/08 , A61L17/14 , C08G63/08 , C08G63/64 , C08G63/664 , C09D167/04 , B05D1/36 , A61B17/04
CPC分类号： A61L17/08 , A61L17/145 , C08G63/08 , C08G63/64 , C08G63/664 , C09D167/04 , Y10T428/2933 , Y10T428/2938 , Y10T428/2967
摘要： A gut suture is coated with a bioabsorbable copolymer obtained by polymerizing a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of polyhydric alcohol as initiator. The coated gut suture can be packaged in the absence of conventional tubing fluid, i.e., in the dry state, while at the same time retaining flexibility, pliability and resistance to fray. In an alternative embodiment, a gut suture is coated with a pre-coating composition prior to being coated with the bioabsorbable copolymer.
摘要翻译：在多元醇作为引发剂的存在下，通过聚合主要量的ε-己内酯和少量的至少一种其它可共聚单体获得的生物可吸收共聚物涂布肠缝合线。涂覆的肠缝合线可以在不存在常规管道流体的情况下被包装，即处于干燥状态，同时保持柔韧性，柔韧性和抗磨损性。在替代实施例中，在用生物可吸收共聚物涂覆之前，用预涂组合物涂覆肠缝合线。

7. 发明授权

US5543218A Bioabsorbable copolymer and coating composition containing same 失效
标题翻译：生物可吸收共聚物和含有它的涂料组合物
公开(公告)号：US5543218A
公开(公告)日：1996-08-06
申请号：US440855
申请日：1995-05-15
申请人： Steven L. Bennett , Mark S. Roby
发明人： Steven L. Bennett , Mark S. Roby
IPC分类号： A61L17/08 , A61L17/14 , C08G63/08 , C08G63/64 , C08G63/664 , A61B19/00 , D06M15/00
CPC分类号： A61L17/08 , A61L17/145 , C08G63/08 , C08G63/64 , C08G63/664 , Y10T428/2933 , Y10T428/2938
摘要： A bioabsorbable copolymer is obtained from the polymerization of a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of a polyhydric alcohol initiator. The copolymer is useful, inter alia, as a coating for a surgical suture.
摘要翻译：在多元醇引发剂的存在下，从大量ε-己内酯和少量至少一种其它可共聚单体的聚合获得生物可吸收共聚物。该共聚物尤其用作外科缝合的涂层。

8. 发明授权

US4429080A Synthetic copolymer surgical articles and method of manufacturing the same 失效
标题翻译：合成共聚物外科用品及其制造方法
公开(公告)号：US4429080A
公开(公告)日：1984-01-31
申请号：US394347
申请日：1982-07-01
申请人： Donald J. Casey , Mark S. Roby
发明人： Donald J. Casey , Mark S. Roby
IPC分类号： A61L17/00 , A61K9/20 , A61L17/12 , C08G63/08 , C08G63/64 , C08G63/76 , C08L67/00
CPC分类号： C08G63/64 , A61K9/204 , A61L17/12 , C08G63/08
摘要： A triblock copolymer having a proportion of units having the formula: ##STR1## as the end blocks, and the formula (I) randomly combined with a proportion of units having the formula: ##STR2## as the middle block finds particular advantageous use in manufacturing absorbable monofilament sutures and other surgical articles. A surgical article is manufactured from a synthetic absorbable copolymer formed by copolymerizing glycolide with 1,3-dioxan-2-one (trimethylene carbonate) wherein a combination of the monomers is substantially completely polymerized before the addition of the other monomer in the presence of a difunctional initiator at or below about 180.degree. C.; glycolide is added and the temperature increased up to about the melting point of poly glycolide to form a triblock copolymer with a proportion of units having the formula: ##STR3## as the end blocks, and the formula (I) randomly combined with a proportion of units having the formula: ##STR4## as the middle block.
摘要翻译：具有下列结构式的单元比例的三嵌段共聚物作为末端嵌段，式（I）与下式的单元比例随机组合：作为中间嵌段在制造可吸收的单丝缝合线和其它外科用品时发现特别有利的用途。手术用品由由乙交酯与1,3-二恶烷-2-酮（三亚甲基碳酸酯）共聚形成的合成可吸收共聚物制成，其中单体的组合在加入其它单体之前基本上完全聚合，双官能引发剂在约180℃或低于约180℃。加入乙交酯并将温度升高至约聚乙交酯的熔点，形成具有下式的单元比例的三嵌段共聚物作为末端嵌段，式（I）随机与一部分具有以下公式的单位：（II）作为中间块。

9. 发明授权

US07910129B2 Carbodiimide crosslinking of functionalized polyethylene glycols 有权
标题翻译：官能化聚乙二醇的碳二亚胺交联
公开(公告)号：US07910129B2
公开(公告)日：2011-03-22
申请号：US11635344
申请日：2006-12-06
申请人： John Kennedy , Mark S. Roby , Ahmad R. Hadba
发明人： John Kennedy , Mark S. Roby , Ahmad R. Hadba
IPC分类号： A61F13/00
CPC分类号： C08L71/02 , A61K31/74 , A61L24/0042 , A61L24/043 , C08G65/329 , C08G65/332 , C08L79/00 , C08L79/08 , C08L2666/14
摘要： A synthetic composition is provided which includes an acid-functional polymer having at least one pendant acid group, an amine-functional polymer having at least one pendant amine group, and a coupling agent. The synthetic composition can be used in human and animal medical applications as an adhesive or sealant.
摘要翻译：提供了一种合成组合物，其包括具有至少一个侧链酸基的酸官能聚合物，具有至少一个侧基胺基的胺官能聚合物和偶联剂。合成组合物可用作人和动物医疗应用中的粘合剂或密封剂。

10. 发明授权

US06315788B1 Composite materials and surgical articles made therefrom 失效
标题翻译：由其制成的复合材料和外科用品
公开(公告)号：US06315788B1
公开(公告)日：2001-11-13
申请号：US09032694
申请日：1998-02-28
申请人： Mark S. Roby
发明人： Mark S. Roby
IPC分类号： A61B1700
CPC分类号： A61L15/26 , A61L17/04 , A61L17/12 , A61L17/145 , A61L27/48 , A61L31/129 , C08L67/04
摘要： Composite materials have a core portion formed from a polyalkylene oxide initiated block copolymer having one of the blocks made from hard phase forming monomers and another of the blocks made from random copolymers of soft phase forming monomers and at least one shell portion formed from a block copolymer having one of the blocks made from hard phase forming monomers and another of the blocks made from random copolymers of soft phase forming monomers joined to the core portion. Hard phase forming monomers include glycolide and lactide while soft phase forming monomers include 1,4 dioxane-2-one, 1,3 dioxane-2-one and caprolactone. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The composite materials may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.
摘要翻译：复合材料具有由聚环氧烷引发的嵌段共聚物形成的核心部分，其具有由硬相形成单体制成的嵌段之一和由软相形成单体的无规共聚物制成的嵌段和由嵌段共聚物形成的至少一个壳部分具有由硬相形成单体制成的块中的一个和由与形成芯部的结合的软相形成单体的无规共聚物制成的另一嵌段。硬相形成单体包括乙交酯和丙交酯，而软相形成单体包括1,4-二恶烷-2-酮，1,3-二恶烷-2-酮和己内酯。在优选实施例中，芯部与外壳部分共挤出以形成复合丝或片。复合材料可以用作缝线或形成用于植入生物体内的医疗装置或外科用品。

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