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1. 发明申请

US20060046313A1 Cellular analysis using Raman surface scanning 有权
标题翻译：使用拉曼表面扫描的细胞分析
公开(公告)号：US20060046313A1
公开(公告)日：2006-03-02
申请号：US11027470
申请日：2004-12-30
申请人： Mark Roth , Tae-Woong Koo , Andrew Berlin , Selena Chan , Xing Su , Lei Sun
发明人： Mark Roth , Tae-Woong Koo , Andrew Berlin , Selena Chan , Xing Su , Lei Sun
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N33/54373 , G01N33/58 , Y10T436/10
摘要： Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.
摘要翻译：提供了用于使用用复合有机 - 无机纳米颗粒（COIN）标记的探针和嵌入探针部分所连接的聚合物基质内的COIN的微球来测定可能为活细胞的细胞样品的方法和装置。 COIN在激光照射下固有地产生SERS信号，使得COIN标记的探针特别适用于多种测定细胞的方法，包括可能包含在细胞内或细胞内的生物分子，其中大部分不是固有的拉曼活性的。本发明提供使用特异性和简并结合的夹心免疫测定的变体，组织样品和细胞微结构的反相测定方法，溶液置换和竞争测定等。还提供了用于实施本发明测定的系统和芯片。

2. 发明申请

US20070155022A1 Degenerate binding detection and protein identification using Raman spectroscopy nanoparticle labels 审中-公开
标题翻译：使用拉曼光谱纳米颗粒标签的简并结合检测和蛋白质鉴定
公开(公告)号：US20070155022A1
公开(公告)日：2007-07-05
申请号：US11325833
申请日：2005-12-30
申请人： Mineo Yamakawa , Narayan Sundararajan , Andrew Berlin , Selena Chan , Xing Su , Tae-Woong Koo , Lei Sun , Kung-Bin Sung , Mark Roth
发明人： Mineo Yamakawa , Narayan Sundararajan , Andrew Berlin , Selena Chan , Xing Su , Tae-Woong Koo , Lei Sun , Kung-Bin Sung , Mark Roth
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N33/54373 , G01N21/658
摘要： Embodiments of the present invention provide methods for determining the degenerate binding capabilities of antibodies. The methods provide information about degenerate binding capabilities without the use of involved procedures. Optionally, a molecule toward which an antibody exhibits degenerate binding ability may be identified through the use of a reporter, such as, a composite organic inorganic nanocluster (COIN). COINs are sensitive SERS (surface enhanced Raman spectroscopy) reporters capable of multiplex analysis of analytes.
摘要翻译：本发明的实施方案提供了确定抗体的简并结合能力的方法。该方法提供了关于退化绑定功能的信息，而不使用涉及的过程。任选地，可以通过使用报告物如复合有机无机纳米簇（COIN）来鉴定抗体显示简并结合能力的分子。 COINs是敏感的SERS（表面增强拉曼光谱）报告人能够多分析分析物。

3. 发明申请

US20060134714A1 Detection and identification of peptide and protein modifications 审中-公开
标题翻译：肽和蛋白质修饰的检测和鉴定
公开(公告)号：US20060134714A1
公开(公告)日：2006-06-22
申请号：US11202862
申请日：2005-08-11
申请人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
发明人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
IPC分类号： C12Q1/48 , C12Q1/34
CPC分类号： G01N33/6851 , G01N21/658 , G01N33/54373 , G01N33/68 , G01N33/6842 , G01N33/6848 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供了使用表面增强拉曼（SERS）和拉曼光谱法检测，鉴定，区分和定量蛋白质和肽的修饰状态的装置和方法。本发明的实施方案的应用包括例如蛋白质组广泛的修饰分析和分析，应用于疾病诊断，预后和药物疗效研究，酶活性分析和测定。

4. 发明授权

US07776547B2 Cellular analysis using Raman surface scanning 有权
标题翻译：使用拉曼表面扫描的细胞分析
公开(公告)号：US07776547B2
公开(公告)日：2010-08-17
申请号：US11027470
申请日：2004-12-30
申请人： Mark Roth , Andrew Berlin , Selena Chan , Tae-Woong Koo , Xing Su , Lei Sun
发明人： Mark Roth , Andrew Berlin , Selena Chan , Tae-Woong Koo , Xing Su , Lei Sun
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , G01N33/54373 , G01N33/58 , Y10T436/10
摘要： Methods and apparatus are provided for assaying cell samples, which may be living cells, using probes labeled with composite organic-inorganic nanoparticles (COINs) and microspheres with COINs embedded within a polymer matrix to which the probe moiety is attached. COINs intrinsically produce SERS signals upon laser irradiation, making COIN-labeled probes particularly suitable in a variety of methods for assaying cells, including biological molecules that may be contained on or within cells, most of which are not inherently Raman-active. The invention provides variations of the sandwich immunoassay employing both specific and degenerate binding, methods for reverse phase assay of tissue samples and cell microstructures, in solution displacement and competition assays, and the like. Systems and chips useful for practicing the invention assays are also provided.
摘要翻译：提供了用于使用用复合有机 - 无机纳米颗粒（COIN）标记的探针和嵌入探针部分所连接的聚合物基质内的COIN的微球来测定可能为活细胞的细胞样品的方法和装置。 COIN在激光照射下固有地产生SERS信号，使得COIN标记的探针特别适用于多种测定细胞的方法，包括可能包含在细胞内或细胞内的生物分子，其中大部分不是固有的拉曼活性的。本发明提供使用特异性和简并结合的夹心免疫测定的变体，组织样品和细胞微结构的反相测定方法，溶液置换和竞争测定等。还提供了用于实施本发明测定的系统和芯片。

5. 发明申请

US20060009914A1 Detection and identification of nucleic acid, peptide, and protein modifications 审中-公开
标题翻译：检测和鉴定核酸，肽和蛋白质修饰
公开(公告)号：US20060009914A1
公开(公告)日：2006-01-12
申请号：US10919699
申请日：2004-08-16
申请人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
发明人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6818 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modifications to nucleic acids, proteins, and peptides using SERS and Raman spectroscopy. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供用于使用SERS和拉曼光谱检测，鉴定，区分和定量对核酸，蛋白质和肽的修饰的装置和方法。本发明实施方案的应用包括在疾病诊断，预后和药物功效研究，酶活性分析和测定中的应用的蛋白质组广泛修饰分析和分析。

6. 发明授权

US07779571B1 Auto loader firearm accessory 有权
标题翻译：汽车装载枪械配件
公开(公告)号：US07779571B1
公开(公告)日：2010-08-24
申请号：US12150665
申请日：2008-04-29
申请人： Mark Roth
发明人： Mark Roth
IPC分类号： F41A9/00
CPC分类号： F41A9/26
摘要： The present invention can have an adjustable length adapter that attaches to the firearm, and in one embodiment directly to an existing load tube. A mounting assembly and an indexing assembly are further provided. The mounting assembly has a mounting plate with an alignment hole for allowing a shell to pass there through from an aligned tube and into the adapter. The indexing assembly indexes relative the mounting assembly to successively align one of a plurality of tubes with the alignment hole. As one tube fills, the invention can be rotated to index the next tube and tension a rotator that can be positioned generally parallel to the firearm barrel. This process can be repeated until all four tubes are full. Upon emptying of a tube, a pin can be automatically activated to allow the indexing assembly to rotate relative the mounting assembly to align the next successive tube.
摘要翻译：本发明可以具有附接到枪支的可调节长度的适配器，并且在一个实施例中可以直接连接到现有的负载管。还提供了安装组件和分度组件。安装组件具有带有对准孔的安装板，用于允许壳体从对准的管道进入到适配器中。分度组件相对于安装组件进行索引，以使多个管中的一个与对准孔连续对准。当一个管填充时，本发明可以旋转以对下一个管进行索引并且张紧可以大致平行于枪械枪筒定位的转子。这个过程可以重复，直到所有四个管都满了。在排空管时，可以自动启动销以允许分度组件相对于安装组件旋转以对准下一个连续的管。

7. 发明授权

US07610577B1 Method for developing platform independent launchable applications 有权
标题翻译：开发平台独立可启动应用程序的方法
公开(公告)号：US07610577B1
公开(公告)日：2009-10-27
申请号：US10978517
申请日：2004-11-01
申请人： Mark Roth
发明人： Mark Roth
IPC分类号： G06F9/44
CPC分类号： G06F8/71 , G06F8/60 , G06F9/44542
摘要： A method, computer program product, and system for providing launchable application source code are presented. A determination is made regarding which target platforms a launchable application executable will be run on. Once the platforms have been determined, a cross platform executable is generated using the launchable application source code. Platform specific executables are also generated for each selected platform. The cross platform executable is then combined with the platform specific executable for the platform to provide the platform independent launchable application. The platform specific executable is launched by an Operating System as part of a system service, such as a screensaver, and calls the cross platform executable which is executed on a virtual machine running on the platform.
摘要翻译：提出了一种提供可启动应用程序源代码的方法，计算机程序产品和系统。确定可运行可启动应用程序可执行文件的目标平台。一旦确定了平台，就可以使用可启动的应用程序源代码生成跨平台可执行文件。还为每个选定的平台生成平台特定的可执行文件。然后将跨平台可执行程序与平台特定的可执行文件组合，以提供平台独立的可启动应用程序。平台特定的可执行文件由操作系统作为系统服务的一部分（如屏幕保护程序）启动，并调用在平台上运行的虚拟机上执行的跨平台可执行文件。

8. 发明申请

US20050147692A1 Methods, compositions and devices for inducing stasis in tissues and organs 有权
标题翻译：用于诱导组织和器官淤滞的方法，组合物和装置
公开(公告)号：US20050147692A1
公开(公告)日：2005-07-07
申请号：US10972063
申请日：2004-10-22
申请人： Mark Roth
发明人： Mark Roth
IPC分类号： A01N1/02 , A61K33/00 , A61K33/04 , A61K51/00 , B65D81/20 , C12M1/04 , C12N5/00 , C12N15/06
CPC分类号： C12N5/00 , A01N1/02 , A01N1/0221 , C12N2500/02
摘要： The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservation methods and apparatuses for preserving tissue for transplantation purposes is provided.
摘要翻译：本发明涉及使用氧拮抗剂诱导组织中的淤滞，包括全部或部分器官。它包括用于在组织中实现淤滞的方法和装置，以保护和/或保护它们。在具体实施方案中，提供了用于保持用于移植的组织的保存方法和装置。

9. 发明申请

US20050053912A1 Methods for inducing reversible stasis 审中-公开
标题翻译：诱发可逆性淤滞的方法
公开(公告)号：US20050053912A1
公开(公告)日：2005-03-10
申请号：US10480430
申请日：2002-06-10
申请人： Mark Roth , Pamela Padilla
发明人： Mark Roth , Pamela Padilla
IPC分类号： A01N1/02 , C12N1/04 , C12N5/02 , G01N33/50 , A01N1/00 , C12Q1/00
CPC分类号： G01N33/5011 , A01N1/02 , A01N1/0278 , C12N1/04 , G01N33/5082 , G01N33/5088
摘要： The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.
摘要翻译：本发明涉及在缺氧或缺氧条件下培养生物材料以诱导淤滞或悬浮动画的组合物和方法。包括筛选引起淤滞的化合物或增加瘀血能力的化合物的方法。这种方法具有保护生物材料以及减少或预防生物材料创伤的后果。还考虑了用于筛选在缺氧条件下比正常氧条件下活性或更有活性的化合物的方法。这样的方法可用于鉴定将在其中肿瘤细胞存活的缺氧条件下操作的抗肿瘤化合物。

10. 发明申请

US20070078113A1 Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms 有权
标题翻译：用于增强细胞，组织，器官和生物体的生存能力的方法，组合物和制品
公开(公告)号：US20070078113A1
公开(公告)日：2007-04-05
申请号：US11408734
申请日：2006-04-20
申请人： Mark Roth , Mike Morrison , Eric Blackstone , Dana Miller
发明人： Mark Roth , Mike Morrison , Eric Blackstone , Dana Miller
IPC分类号： A61K31/66 , A61K31/555 , A61K31/185 , A61K31/165 , A61K31/275 , A61K31/26 , A61K31/095 , A61K31/21
CPC分类号： A61K33/04 , A01N1/02 , A01N1/0226 , A61K31/095 , A61K31/165 , A61K31/185 , A61K31/21 , A61K31/26 , A61K31/275 , A61K31/555 , A61K31/66 , A61K45/06 , Y10S514/921 , A61K2300/00
摘要： The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.
摘要翻译：本发明涉及氧还原剂和其它活性化合物在体内或生物体中的细胞，组织和/或器官中的用途，除了提高其生存性之外，还可用于其中。它包括组合物，方法，制品和用于提高生存能力的装置，以及用于在这些生物材料中的任何一种中实现淤滞或止血，从而保存和/或保护它们。在具体实施方案中，还使用所述活性化合物进行器官移植，热疗，伤口愈合，出血性休克，旁路手术的心脏停搏，神经变性，低温和癌症的治疗方法和装置。

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