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1. 发明申请

US20060054502A1 Localized Chemical Microgradients 有权
标题翻译：本地化学微生物
公开(公告)号：US20060054502A1
公开(公告)日：2006-03-16
申请号：US10711327
申请日：2004-09-10
申请人： Mark Peterman , David Bloom
发明人： Mark Peterman , David Bloom
IPC分类号： C07K1/26 , G01N27/447
CPC分类号： B01D57/02 , G01N27/447
摘要： A device for creating microgradients in solution is disclosed. The device contains a microfluidic channel with openings at each end and two or more small apertures to a bath. Electrodes are placed in the openings at either end of the channel and an electrical power supply is connected to the electrodes. Several distinct current paths exist from one end of the channel to the other. For example current may flow from one electrode, through a portion of the channel, through an aperture into the bath, back through another aperture into the channel, and along another portion of the channel to the other electrode. Current flows along all possible connected paths when an electric field is applied along the channel and induces fluid flow into and out of the apertures in the channel. Fluid flow through the apertures results in the formation of microgradients in solution near the microfluidic channel device.
摘要翻译：公开了一种用于在溶液中产生微梯度的装置。该装置包含在每个端部具有开口并且具有两个或更多个小孔的微流体通道。电极放置在通道两端的开口处，电源连接到电极。从通道的一端到另一端存在若干不同的电流路径。例如，电流可以从一个电极流过通道的一部分，通过孔进入槽，通过另一个孔返回到通道中，并且沿通道的另一部分流向另一个电极。当沿着通道施加电场并且使流体流入和流出通道中的孔时，电流沿着所有可能的连接路径流动。通过孔的流体流动导致在微流体通道装置附近的溶液中形成微梯度。

2. 发明申请

US20060130692A1 Alignment tool for precise pattern transfer 失效
标题翻译：校准工具，用于精确的图案转移
公开(公告)号：US20060130692A1
公开(公告)日：2006-06-22
申请号：US10905210
申请日：2004-12-21
申请人： Mark Peterman , David Bloom
发明人： Mark Peterman , David Bloom
IPC分类号： B41F1/34
CPC分类号： G03F9/7034 , G02B21/0024 , G02B21/26 , G03F9/7026 , G03F9/7042 , G03F9/7088
摘要： Multi-point confocal microscopy, bright field microscope imaging, computer-controlled positioning stages, and an algorithm for automated leveling are the basis for a powerful but simple tool for aligning stamps used in precise pattern transfer to substrates. The system is relatively inexpensive and brings a capability similar to that of a photolithographic mask aligner to the world of elastomeric-stamp-based lithography. Alignment of the stamp and substrate is possible without contact between the two before printing.
摘要翻译：多点共聚焦显微镜，明视野显微镜成像，计算机控制定位阶段和自动调平算法是用于将精确图案转印到基板上使用的标记对齐的强大而简单的工具的基础。该系统相对便宜，并且具有与光刻掩模对准器类似的功能，适用于基于弹性体印记的光刻领域。在打印之前，印模和基板的对准可以在两者之间没有接触。

3. 发明申请

US20060114544A1 Polarization light modulator 有权
标题翻译：极化光调制器
公开(公告)号：US20060114544A1
公开(公告)日：2006-06-01
申请号：US11336277
申请日：2006-01-20
申请人： David Bloom , Mark Peterman
发明人： David Bloom , Mark Peterman
IPC分类号： G02F1/01
CPC分类号： G02B26/06 , G02B26/0808 , G02B26/0825 , G02B27/283
摘要： Polarization light modulators are based on an interferometric design in which a polarizing beam splitter serves as a polarizer and analyzer. A polarization displacement device shifts orthogonally polarized light beams parallel to the long axis of their elongated cross sections. Phase shifts are imparted to the orthogonally polarized beams by linear array MEMS optical phase shift devices. The output of the light modulator is a line image which may be scanned to form a two-dimensional image. Features to improve brightness, contrast and overall compactness of design are disclosed.
摘要翻译：偏振光调制器基于干涉测量设计，其中偏振分束器用作偏振器和分析器。偏振位移装置使平行于其细长截面的长轴的正交偏振光束移位。通过线性阵列MEMS光学相移装置将相移赋予正交偏振光束。光调制器的输出是可以被扫描以形成二维图像的线图像。公开了提高设计亮度，对比度和整体紧凑性的特征。

4. 发明授权

US07147865B2 Artificial synapse chip 失效
标题翻译：人工突触芯片
公开(公告)号：US07147865B2
公开(公告)日：2006-12-12
申请号：US10713565
申请日：2003-11-13
申请人： Harvey A. Fishman , David Bloom , Stacey F. Bent , Mark C. Peterman , Jaan Noolandi , Neville Mehenti
发明人： Harvey A. Fishman , David Bloom , Stacey F. Bent , Mark C. Peterman , Jaan Noolandi , Neville Mehenti
IPC分类号： A61F2/14
CPC分类号： G06N3/061 , A61N1/0543 , A61N1/30 , A61N1/326 , A61N1/36046 , C12N5/0619 , C12N2503/00 , C12N2535/10
摘要： Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to the fluid to or through the aperture. The electrical means may take the form of electroosmotic force, piezoelectric movement of a diaphragm or electrolysis of a solution. The electrical means may be external to the host, implanted in the host or may be photodiodes activated by light, particularly where the neuronal site is associated with the retina.
摘要翻译：提供了用于向神经元部位施用流体的装置和方法。该装置包括储存器，与储存器流体连接的孔，以及用于将流体移动到或穿过孔的电气装置。电气装置可以采取电渗力的形式，隔膜的压电运动或溶液的电解。电气装置可以在宿主外部，植入宿主中，或者可以是由光激活的光电二极管，特别是在神经元部位与视网膜相关联的地方。

5. 发明授权

US08947253B2 Immersive vehicle multimedia system 有权
标题翻译：沉浸式车载多媒体系统
公开(公告)号：US08947253B2
公开(公告)日：2015-02-03
申请号：US12503551
申请日：2009-07-15
申请人： David Bloom , Jeff Zabel
发明人： David Bloom , Jeff Zabel
IPC分类号： H04N7/18 , B60K35/00 , H04N21/414
CPC分类号： H04N7/18 , B60K35/00 , H04N21/41422
摘要： The invention relates to an immersive vehicle multimedia system that that is affected by vehicle sensors and collected data concerning environmental. The immersive vehicle multimedia system includes a vehicle, at least one sensor or other vehicle component gathering input as data from an external and internal vehicle environment, an immersive multimedia device connected to each sensor, and media content run through the multimedia device. The media content includes a primary script and a secondary script, the secondary script depending on the gathered input.
摘要翻译：本发明涉及一种身临其境的车载多媒体系统，其受到车辆传感器的影响并收集有关环境的数据。沉浸式车载多媒体系统包括车辆，至少一个传感器或其他车辆部件收集来自外部和内部车辆环境的数据，连接到每个传感器的沉浸式多媒体设备，以及通过多媒体设备运行的媒体内容。媒体内容包括主脚本和辅助脚本，辅助脚本取决于收集的输入。

6. 发明申请

US20110016497A1 Immersive Vehicle Multimedia System 有权
标题翻译：沉浸式车载多媒体系统
公开(公告)号：US20110016497A1
公开(公告)日：2011-01-20
申请号：US12503551
申请日：2009-07-15
申请人： David Bloom , Jeff Zabel
发明人： David Bloom , Jeff Zabel
IPC分类号： H04N7/18
CPC分类号： H04N7/18 , B60K35/00 , H04N21/41422
摘要： The invention relates to an immersive vehicle multimedia system that that is affected by vehicle sensors and collected data concerning environmental. The immersive vehicle multimedia system includes a vehicle, at least one sensor or other vehicle component gathering input as data from an external and internal vehicle environment, an immersive multimedia device connected to each sensor, and media content run through the multimedia device. The media content includes a primary script and a secondary script, the secondary script depending on the gathered input.
摘要翻译：本发明涉及一种身临其境的车载多媒体系统，其受到车辆传感器的影响并收集有关环境的数据。沉浸式车载多媒体系统包括车辆，至少一个传感器或其他车辆部件收集来自外部和内部车辆环境的数据，连接到每个传感器的沉浸式多媒体设备，以及通过多媒体设备运行的媒体内容。媒体内容包括主脚本和辅助脚本，辅助脚本取决于收集的输入。

7. 发明申请

US20060187518A1 Differential Interferometric light modulator and image display device 有权
标题翻译：差分干涉光调制器和图像显示装置
公开(公告)号：US20060187518A1
公开(公告)日：2006-08-24
申请号：US11391008
申请日：2006-03-28
申请人： David Bloom
发明人： David Bloom
IPC分类号： G02F1/03
CPC分类号： G02B26/0841 , G02B26/06
摘要： A light modulator incorporates a polarization sensitive prism and a novel MEMS ribbon device to impart a relative phase shift to polarization components of an incident light beam. A linear array of phase shifting elements in the MEMS device creates a linear image which is scanned to form a two dimensional scene. Alternatively the deflection of each cantilever in a linear array of atomic force microscope cantilevers may be measured simultaneously.
摘要翻译：光调制器包括偏振敏感棱镜和新颖的MEMS带状器件，以对入射光束的偏振分量施加相对相移。 MEMS器件中的相移元件的线性阵列产生被扫描以形成二维场景的线性图像。或者，可以同时测量每个悬臂在原子力显微镜悬臂的线性阵列中的偏转。

8. 发明申请

US20070154456A1 Insulated herpesvirus-derived gene expression cassettes for sustained and regulatable gene expression 有权
标题翻译：用于持续和可调节基因表达的绝缘疱疹病毒来源的基因表达盒
公开(公告)号：US20070154456A1
公开(公告)日：2007-07-05
申请号：US10590136
申请日：2005-02-17
申请人： David Bloom , Antonio Amelio
发明人： David Bloom , Antonio Amelio
IPC分类号： A61K48/00 , C12N15/86 , C12N15/861
CPC分类号： A61K31/713 , A61K48/00 , C12N15/85 , C12N15/86 , C12N2710/16611 , C12N2710/16622 , C12N2710/16633 , C12N2710/16642 , C12N2710/16643 , C12N2830/007 , C12N2830/40 , C12N2830/60
摘要： Disclosed are genetic expression cassettes, and vector comprising them useful for the delivery of nucleic acid segments encoding selected therapeutic constructs (including for example, peptides, polypeptides, ribozymes, and catalytic RN molecules), to selected cells and tissues of vertebrate animals. The disclosed genetic constructs are useful in the development of gene therapy vectors, including for example, viral vectors such as HSV, retroviral, lentiviral, AV, and rAAV vectors. The expression cassettes disclosed herein provide new tools in the field of gene therapy, and for the treatment of mammalian, and in particular, human diseases, disorders, and dysfunctions. The disclosed compositions may be utilized in a variety of investigative, diagnostic and therapeutic regimens, including the prevention and treatment of a variety of human diseases.
摘要翻译：公开了遗传表达盒和包含它们的载体，其可用于将编码所选择的治疗构建体（包括例如肽，多肽，核酶和催化性RN分子）的核酸片段递送至脊椎动物的选定细胞和组织。所公开的遗传构建体可用于开发基因治疗载体，包括例如病毒载体如HSV，逆转录病毒，慢病毒，AV和rAAV载体。本文公开的表达盒提供了在基因治疗领域和用于治疗哺乳动物，特别是人类疾病，障碍和功能障碍领域的新工具。所公开的组合物可以用于多种调查，诊断和治疗方案，包括预防和治疗各种人类疾病。

9. 发明申请

US20060141940A1 Intelligent bridge between PSTN and asynchronous communication channel 审中-公开
标题翻译： PSTN与异步通信通道之间的智能桥梁
公开(公告)号：US20060141940A1
公开(公告)日：2006-06-29
申请号：US11248502
申请日：2005-10-12
申请人： David Bloom , William Basser
发明人： David Bloom , William Basser
IPC分类号： H04B1/38
CPC分类号： G01D4/002 , Y02B90/241 , Y04S20/32 , Y04S20/46
摘要： An intelligent communications bridge device (“Meterpod”) of a remote Supervisory Control and Data Acquisition (SCADA) system advantageously facilitates monitoring, reporting and control of public utility meters. The Meterpod is an intelligent gateway that installs onto existing metering and monitoring equipment and provides a wireless communications link from the remote equipment being monitored or controlled to the host computer or program tracking or controlling the device providing clear advantages over existing remote telemetry equipment in that it can (1) support any wireless communications protocol, including CDMA, GSM/GPRS, VSAT, and GPRS standards, (2) be installed and configured in minutes by regular maintenance personnel, and (3) provide control capabilities beyond the remote device by utilizing a broad array of additional interfaces (RJ-11, Ethernet, RS-232 and RS-485) that all come standard, supporting customer sites that cannot be monitored using existing fixed wireless or radio frequency (RF) monitoring solutions.
摘要翻译：远程监控和数据采集（SCADA）系统的智能通信桥接设备（“Meterpod”）有利于便于监控，报告和控制公用事业电表。 Meterpod是一个安装在现有计量和监控设备上的智能网关，并提供从被监视或控制的远程设备到主机的无线通信链路，或跟踪或控制设备的程序，提供比现有远程遥测设备明显的优势，因为它可以（1）支持任何无线通信协议，包括CDMA，GSM / GPRS，VSAT和GPRS标准，（2）由常规维护人员在几分钟内进行安装和配置，（3）通过利用远程设备提供超出远程设备的控制能力广泛的附加接口（RJ-11，以太网，RS-232和RS-485）都符合标准，支持使用现有固定无线或射频（RF）监控解决方案无法监控的客户站点。

10. 发明申请

US20060116340A1 Herpesvirus ribozymes and vectors 有权
标题翻译：疱疹病毒核酶和载体
公开(公告)号：US20060116340A1
公开(公告)日：2006-06-01
申请号：US10808042
申请日：2004-03-24
申请人： Alfred Lewin , David Bloom , Gregory Schultz , Sonal Tuli , Jia Liu
发明人： Alfred Lewin , David Bloom , Gregory Schultz , Sonal Tuli , Jia Liu
IPC分类号： A61K48/00 , C12N5/06 , C07H21/02
CPC分类号： C07K14/005 , C12N2510/02 , C12N2710/16622
摘要： Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.
摘要翻译：合成针对HSV复制（ICP4，UL20，UL30和UL54）关键组分的锤头核酶，并显示出在体外测定中有效切割编码这些成分的一部分的靶RNA。建立了稳定表达这些核酶的几种克隆细胞系。与未转染细胞相比，用抗HSV核酶稳定转染的细胞中HSV介导的斑块形成显着降低。

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