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1. 发明授权

US08852866B2 Method for producing and identifying soluble protein domains 有权
标题翻译：生产和鉴定可溶性蛋白质结构域的方法
公开(公告)号：US08852866B2
公开(公告)日：2014-10-07
申请号：US10494895
申请日：2002-11-08
申请人： Mark McAlister , Renos Savva , Laurence Pearl , Chrisostomos Prodromou , Paul C Driscoll
发明人： Mark McAlister , Renos Savva , Laurence Pearl , Chrisostomos Prodromou , Paul C Driscoll
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/53 , C12P21/06
CPC分类号： G01N33/6842 , C12N15/1093 , C12N15/1096 , C12Q1/683 , C12Q1/686 , C40B30/04 , G01N33/6803 , G01N33/6845 , G01N2500/04 , G01N2500/20 , C12Q2521/531
摘要： Methods for producing and identifying fragments of proteins, and more particularly to methods for generating and identifying soluble protein domains are disclosed based on a method for generating a library of nucleic acid fragments from nucleic acid encoding a desired polypeptide, and more especially a library of essentially, randomly sampled fragments of coding DNA sequence predominantly of defined size range and a method for selecting cloned gene fragments from the library that encode soluble protein domains.
摘要翻译：基于用于从编码所需多肽的核酸产生核酸片段文库的方法，更具体地说，本质上是用于产生和鉴定蛋白质片段的方法，更具体地，涉及产生和鉴定可溶性蛋白质结构域的方法，编码主要在规定大小范围内的DNA序列的随机取样片段，以及从编码可溶性蛋白质结构域的文库中选择克隆的基因片段的方法。

2. 发明申请

US20050019773A1 Method for producing and identifying soluble protein domains 有权
标题翻译：生产和鉴定可溶性蛋白质结构域的方法
公开(公告)号：US20050019773A1
公开(公告)日：2005-01-27
申请号：US10494895
申请日：2002-11-08
申请人： Mark McAlister , Renos Savva , Laurence Pearl , Chrisostomos Prodromou , Paul Driscoll
发明人： Mark McAlister , Renos Savva , Laurence Pearl , Chrisostomos Prodromou , Paul Driscoll
IPC分类号： C12N15/09 , C07K1/22 , C07K14/00 , C07K19/00 , C12N1/21 , C12N15/10 , C12Q1/34 , C12Q1/42 , C12Q1/68 , C40B30/04 , C40B40/02 , C40B50/06 , G01N33/68 , C12P19/34
CPC分类号： G01N33/6842 , C12N15/1093 , C12N15/1096 , C12Q1/683 , C12Q1/686 , C40B30/04 , G01N33/6803 , G01N33/6845 , G01N2500/04 , G01N2500/20 , C12Q2521/531
摘要： Methods for producing and identifying fragments of proteins, and more particularly to methods for generating and identifying soluble protein domains are disclosed based on a method for generating a library of nucleic acid fragments from nucleic acid encoding a desired polypeptide, and more especially a library of essentially, randomly sampled fragments of coding DNA sequence predominantly of defined size range and a method for selecting cloned gene fragments from the library that encode soluble protein domains.
摘要翻译：基于用于从编码所需多肽的核酸产生核酸片段文库的方法，更具体地说，本质上是用于产生和鉴定蛋白质片段的方法，更具体地，涉及产生和鉴定可溶性蛋白质结构域的方法，编码主要在规定大小范围内的DNA序列的随机取样片段，以及从编码可溶性蛋白质结构域的文库中选择克隆的基因片段的方法。

3. 发明申请

US20050176060A1 Crystal structure 审中-公开
标题翻译：水晶结构
公开(公告)号：US20050176060A1
公开(公告)日：2005-08-11
申请号：US10362026
申请日：2001-08-17
申请人： Neil McDonald , Judith Murray-Rust , James Leiper , Mark McAlister , Patrick John Vallance
发明人： Neil McDonald , Judith Murray-Rust , James Leiper , Mark McAlister , Patrick John Vallance
IPC分类号： G01N23/20 , A61K38/46 , A61K45/00 , A61P3/06 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/06 , A61P25/18 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C12N9/78 , C12N15/55 , C12Q1/34 , G01N33/48 , G01N33/483 , G01N33/68 , G01N33/53 , G01N33/50 , G06F19/00
CPC分类号： C12N9/78 , C07K2299/00 , C12Q1/34 , G01N33/6803
摘要： Structural coordinates obtainable by subjecting a crystal comprising a dimethylarginine dimethylaminohydrolase (DDAH) or a fragment thereof or an argininc deliminase (DI) or a fragment thercof to X-ray diffraction measurements and deducing the structural coordinales from the diffraction measurements arc used to identify, screen, characteristic, design or modify a chemical entity. The chemical entities so generated may be used in methods of Therapy or to identify the presence or absence of a DDAH or DI substrate.
摘要翻译：通过使包含二甲基精氨酸二甲基氨基水解酶（DDAH）或其片段的晶体或精氨酸分离酶（DI）或片段抗体的晶体进行X射线衍射测量并从衍射测量中推导结构配位体获得的结构坐标用于鉴定筛选，特征，设计或修改化学实体。如此产生的化学物质可用于治疗方法或鉴定DDAH或DI底物的存在或不存在。

4. 发明授权

US08132666B2 Adjustable conveyor guide 有权
标题翻译：可调式输送机导轨
公开(公告)号：US08132666B2
公开(公告)日：2012-03-13
申请号：US12707792
申请日：2010-02-18
申请人： Mark McAlister , Timothy Povey , Ian Spence
发明人： Mark McAlister , Timothy Povey , Ian Spence
IPC分类号： B65G21/20
CPC分类号： B65G21/2072
摘要： This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width of a channel through which an article may be conveyed to be varied. The guide rails are adjustable to accommodate containers of differing sizes.
摘要翻译：本发明涉及包括输送机导轨单元的输送机引导件，例如在处理不同尺寸的容器的自动化处理管线上使用的那些。将一个或多个导轨用于输送机引导件的侧面，以确保物品遵循期望的路径。本发明提供了一种可调输送机导轨单元，其包括可操作以设置在多个离散位置中的引导构件，从而允许物品可以被输送的通道的宽度被改变。导轨可调节以适应不同尺寸的容器。

5. 发明申请

US20100200373A1 ADJUSTABLE CONVEYOR GUIDE 有权
标题翻译：可调节输送机指南
公开(公告)号：US20100200373A1
公开(公告)日：2010-08-12
申请号：US12707792
申请日：2010-02-18
申请人： Mark McAlister , Timothy Povey , Ian Spence
发明人： Mark McAlister , Timothy Povey , Ian Spence
IPC分类号： B65G21/20
CPC分类号： B65G21/2072
摘要： This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width of a channel through which an article may be conveyed to be varied. The guide rails are adjustable to accommodate containers of differing sizes.
摘要翻译：本发明涉及包括输送机导轨单元的输送机引导件，例如在处理不同尺寸的容器的自动化处理管线上使用的那些。将一个或多个导轨用于输送机引导件的侧面，以确保物品遵循期望的路径。本发明提供了一种可调输送机导轨单元，其包括可操作以设置在多个离散位置中的引导构件，从而允许物品可以被输送的通道的宽度被改变。导轨可调节以适应不同尺寸的容器。

6. 发明申请

US20080116042A1 Adjustable Conveyor Guide 审中-公开
标题翻译：可调式输送机指南
公开(公告)号：US20080116042A1
公开(公告)日：2008-05-22
申请号：US11661729
申请日：2005-08-25
申请人： Mark McAlister , Timothy Povey
发明人： Mark McAlister , Timothy Povey
IPC分类号： B65G21/20
CPC分类号： B65G21/2072 , B65G2201/0244
摘要： This invention relates to conveyor guides comprising conveyor guide rail units, such as those used on automated handling lines where containers of different sizes are processed. One or more guide rails are employed to the sides of the conveyor guide to ensure that articles follow a desired path. This invention provides an adjustable conveyor guide rail unit that comprises a guide member operable to be set in a plurality of discrete positions, thereby allowing the width and/or height of a channel through which an article may be conveyed to be varied. The guide rails are adjustable to accommodate containers of differing sizes.
摘要翻译：本发明涉及包括输送机导轨单元的输送机引导件，例如在处理不同尺寸的容器的自动化处理管线上使用的那些。将一个或多个导轨用于输送机引导件的侧面，以确保物品遵循期望的路径。本发明提供了一种可调输送机导轨单元，其包括可操作以设置在多个离散位置中的引导构件，从而允许物品可以被输送通过的通道的宽度和/或高度变化。导轨可调节以适应不同尺寸的容器。

7. 发明申请

US20080020416A1 Enzyme and Preparation Method 审中-公开
标题翻译：酶及制备方法
公开(公告)号：US20080020416A1
公开(公告)日：2008-01-24
申请号：US10598280
申请日：2005-03-07
申请人： Mark McAlister , Antonio Pineda-Lucena
发明人： Mark McAlister , Antonio Pineda-Lucena
IPC分类号： C12N9/72 , C12N15/58 , C12Q1/37 , C12N15/62
CPC分类号： C12N9/6462 , C12Y304/21073
摘要： A method for preparing a soluble protein comprising urokinase-type plasminogen activator (uPA) or an active fragment thereof, or a variant of either of these which has uPA activity, which method comprises contacting said protein with a buffer at a pH of from 8.5-10.5, said buffer comprising a reducing agent and an oxidising agent which forms a redox pair, wherein the reducing agent is present in excess compared to the oxidising agent, and wherein the reducing agent is present in a concentration of at least 5 mM. Material obtainable in this way forms a further aspect of the invention. It has been refolded in a “native-like” form and is useful in studies such as N.M.R. analysis to detect ligands.
摘要翻译：一种制备包含尿激酶型纤溶酶原激活物（uPA）或其活性片段的可溶性蛋白质的方法，或其中具有uPA活性的其中任一种的变体，该方法包括使所述蛋白质与pH为8.5〜 10.5，所述缓冲液包含形成氧化还原对的还原剂和氧化剂，其中所述还原剂与氧化剂相比存在过量，并且其中所述还原剂以至少5mM的浓度存在。以这种方式获得的材料形成本发明的另一方面。它已经以“本土化”形式重新折叠，并且在诸如N.M.R.的研究中是有用的。分析检测配体。

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