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1. 发明授权

US5466581A Method for quantifying BPI in body fluids 失效
标题翻译：定量体液中BPI的方法
公开(公告)号：US5466581A
公开(公告)日：1995-11-14
申请号：US175276
申请日：1993-12-29
申请人： Mark L. White , Stephen F. Carroll , Jeremy K.-k. Ma
发明人： Mark L. White , Stephen F. Carroll , Jeremy K.-k. Ma
IPC分类号： G01N33/564 , G01N33/569 , G01N33/68 , G01N33/53 , C12Q1/00 , G01N33/543
CPC分类号： G01N33/6893 , G01N33/564 , G01N33/56911
摘要： The present invention provides an immunoassay method for screening for gram negative sepsis in a subject, in which the concentration of extracellular BPI in a plasma sample from the subject is determined and compared with a standard concentration of BPI indicative of gram negative sepsis.
摘要翻译：本发明提供用于筛选受试者中革兰氏阴性败血症的免疫测定方法，其中测定来自受试者的血浆样品中的细胞外BPI的浓度并与指示革兰氏阴性败血症的BPI的标准浓度进行比较。

2. 发明授权

US5466580A Method for quantifying BPI in body fluids 失效
标题翻译：定量体液中BPI的方法
公开(公告)号：US5466580A
公开(公告)日：1995-11-14
申请号：US125677
申请日：1993-09-22
申请人： Mark L. White , Stephen F. Carroll , Jeremy K. Ma
发明人： Mark L. White , Stephen F. Carroll , Jeremy K. Ma
IPC分类号： G01N33/564 , G01N33/569 , G01N33/68 , G01N33/53 , C12Q1/00 , G01N33/543
CPC分类号： G01N33/6893 , G01N33/564 , G01N33/56911
摘要： The present invention provides a method for quantifying the presence of extracellular BPI in body fluids including blood in a subject comprising conducting a BPI immunoassay on plasma obtained from said subject.
摘要翻译：本发明提供了一种量化包括受试者在内的血液中的体液中的细胞外BPI的存在的方法，包括对从所述受试者获得的血浆进行BPI免疫测定。

3. 发明授权

US5484705A Method for quantifying lipopolysaccharide binding protein 失效
标题翻译：脂多糖结合蛋白的定量方法
公开(公告)号：US5484705A
公开(公告)日：1996-01-16
申请号：US186811
申请日：1994-01-24
申请人： Mark L. White , Stephen F. Carroll , Jeremy K. Ma
发明人： Mark L. White , Stephen F. Carroll , Jeremy K. Ma
IPC分类号： G01N33/53 , G01N33/566 , G01N33/569 , G01N33/68 , C12Q1/00
CPC分类号： G01N33/68 , G01N33/56911 , Y10S436/811 , Y10S436/815 , Y10S436/821
摘要： The present invention provides a method for quantifying the presence of extracellular LBP in body fluids including blood in a subject comprising conducting an LBP immunoassay on plasma obtained from said subject.
摘要翻译：本发明提供了一种量化包括受试者在内的血液的体液中的细胞外LBP的存在的方法，包括对从所述受试者获得的血浆进行LBP免疫测定。

4. 发明授权

US07712306B2 Dynamic control of selective non-catalytic reduction system for semi-batch-fed stoker-based municipal solid waste combustion 有权
标题翻译：用于半分批供料的基于垃圾的城市固体废物燃烧的选择性非催化还原系统的动态控制
公开(公告)号：US07712306B2
公开(公告)日：2010-05-11
申请号：US11960148
申请日：2007-12-19
申请人： Mark L. White , Stephen G. Deduck
发明人： Mark L. White , Stephen G. Deduck
IPC分类号： F01N3/00
CPC分类号： B01D53/56 , B01D2251/2062
摘要： The present invention controls reagent flow levels in a selective non-catalytic reduction (SNCR) system by more accurately predicting Nitrogen Oxides (NOx) production with a municipal waste combustor. In one embodiment, the reagent levels correspond with measured furnace temperatures. The reagent levels may have a baseline level from prior measured NOx that is then modified according to temperatures measurements. A slow controller may use NOx measurements over an extended period to define a base regent level, and a fast controller may use additional information such as the furnace temperature to modify the base regent level. The fast controller may further receive two additional signals that are added individually or together to maximize NOx control while minimizing ammonia slip from the reagent. The two signals are a feed-forward signal from the combustion controller and a feedback signal from an ammonia analyzer downstream of the combustion zone.
摘要翻译：本发明通过更准确地预测用城市垃圾燃烧器产生氮氧化物（NOx）来控制选择性非催化还原（SNCR）系统中的试剂流量水平。在一个实施方案中，试剂水平对应于测量的炉温。试剂水平可以具有来自先前测量的NOx的基准水平，然后根据温度测量来修改。慢速控制器可以在长时间内使用NOx测量来定义基准摄氏度，并且快速控制器可以使用诸如炉温度的附加信息来修改基本摄氏度。快速控制器可以进一步接收两个附加信号，这些附加信号被单独或一起添加以最大化NOx控制，同时最小化来自试剂的氨滑移。两个信号是来自燃烧控制器的前馈信号和来自燃烧区下游的氨分析器的反馈信号。

5. 发明授权

US09885711B2 Screening methods 有权
公开(公告)号：US09885711B2
公开(公告)日：2018-02-06
申请号：US12890590
申请日：2010-09-24
申请人： Mark L. White , Marina Roell , John Corbin , Robert Bauer , Daniel Bedinger
发明人： Mark L. White , Marina Roell , John Corbin , Robert Bauer , Daniel Bedinger
IPC分类号： G01N33/53 , G01N33/557 , G01N33/68
CPC分类号： G01N33/557 , G01N33/6854 , G01N2500/02 , G01N2500/20
摘要： The present invention provides polypeptide binding agents, e.g. antibodies, that exhibit the ability to kinetically modulate the binding and signaling of biological signaling complexes, e.g., receptor-ligand complexes; methods of identifying such polypeptide binding agents, methods of making such polypeptide binding agents, compositions comprising such polypeptide binding agents, and methods of using such polypeptide binding agents.

6. 发明授权

US06599881B1 Antithrombotic materials and methods 失效
标题翻译：抗血栓材料和方法
公开(公告)号：US06599881B1
公开(公告)日：2003-07-29
申请号：US09610785
申请日：2000-07-06
申请人： Mark L. White , William Steve Ammons
发明人： Mark L. White , William Steve Ammons
IPC分类号： A61K3800
CPC分类号： A61K38/1751 , A61K38/49 , Y10S514/822 , Y10S530/829 , A61K2300/00
摘要： Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.
摘要翻译：提供抗血栓形成材料和方法用于治疗其中施用治疗有效量的BPI蛋白产物的血栓形成障碍。

7. 发明授权

US06107280A Antithrombotic materials and methods 失效
公开(公告)号：US06107280A
公开(公告)日：2000-08-22
申请号：US299319
申请日：1999-04-26
申请人： Mark L. White , William Steve Ammons
发明人： Mark L. White , William Steve Ammons
IPC分类号： A61K38/00 , A61K31/00 , A61K38/17 , A61K38/49 , A61P7/00 , A61P7/02 , A61P9/00 , C07K14/47 , A61K38/16
CPC分类号： A61K38/1751 , A61K38/49 , Y10S514/822 , Y10S530/829
摘要： Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.

8. 发明申请

US20080148713A1 DYNAMIC CONTROL OF SELECTIVE NON-CATALYTIC REDUCTION SYSTEM FOR SEMI-BATCH-FED STOKER-BASED MUNICIPAL SOLID WASTE COMBUSTION 有权
标题翻译：选择性非催化还原系统的动态控制系统，用于基于半自动储罐的城市固体废物燃烧
公开(公告)号：US20080148713A1
公开(公告)日：2008-06-26
申请号：US11960148
申请日：2007-12-19
申请人： Mark L. White , Stephen G. Deduck
发明人： Mark L. White , Stephen G. Deduck
IPC分类号： F01N9/00
CPC分类号： B01D53/56 , B01D2251/2062
摘要： The present invention controls reagent flow levels in a selective non-catalytic reduction (SNCR) system by more accurately predicting Nitrogen Oxides (NOx) production with a municipal waste combustor. In one embodiment, the reagent levels correspond with measured furnace temperatures. The reagent levels may have a baseline level from prior measured NOx that is then modified according to temperatures measurements. A slow controller may use NOx measurements over an extended period to define a base regent level, and a fast controller may use additional information such as the furnace temperature to modify the base regent level. The fast controller may further receive two additional signals that are added individually or together to maximize NOx control while minimizing ammonia slip from the reagent. The two signals are a feed-forward signal from the combustion controller and a feedback signal from an ammonia analyzer downstream of the combustion zone.
摘要翻译：本发明通过更准确地预测用城市垃圾燃烧器产生氮氧化物（NOx）来控制选择性非催化还原（SNCR）系统中的试剂流量水平。在一个实施方案中，试剂水平对应于测量的炉温。试剂水平可以具有来自先前测量的NOx的基准水平，然后根据温度测量来修改。慢速控制器可以在长时间内使用NOx测量来定义基准摄氏度，并且快速控制器可以使用诸如炉温度的附加信息来修改基本摄氏度。快速控制器可以进一步接收两个附加信号，这些附加信号被单独或一起添加以最大化NOx控制，同时最小化来自试剂的氨滑移。两个信号是来自燃烧控制器的前馈信号和来自燃烧区下游的氨分析器的反馈信号。

9. 发明授权

US5935930A Antithrombotic materials and methods 失效
公开(公告)号：US5935930A
公开(公告)日：1999-08-10
申请号：US63465
申请日：1998-04-20
申请人： Mark L. White , William Steve Ammons
发明人： Mark L. White , William Steve Ammons
IPC分类号： A61K38/00 , A61K31/00 , A61K38/17 , A61K38/49 , A61P7/00 , A61P7/02 , A61P9/00 , C07K14/47 , A61K38/16
CPC分类号： A61K38/1751 , A61K38/49 , Y10S514/822 , Y10S530/829
摘要： Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.

10. 发明授权

US5741779A Antithrombotic materials and methods 失效
公开(公告)号：US5741779A
公开(公告)日：1998-04-21
申请号：US644290
申请日：1996-05-10
申请人： Mark L. White , William Steve Ammons
发明人： Mark L. White , William Steve Ammons
IPC分类号： A61K38/00 , A61K31/00 , A61K38/17 , A61K38/49 , A61P7/00 , A61P7/02 , A61P9/00 , C07K14/47 , A61K38/16 , A61K38/36 , C07K14/435
CPC分类号： A61K38/1751 , A61K38/49 , Y10S514/822 , Y10S530/829
摘要： Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.

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