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1. 发明授权

US08828079B2 Circulatory valve, system and method 有权
标题翻译：循环阀，系统和方法
公开(公告)号：US08828079B2
公开(公告)日：2014-09-09
申请号：US11881220
申请日：2007-07-26
申请人： Joseph M. Thielen , Jason P. Hill , Mark L. Jenson , William J. Drasler
发明人： Joseph M. Thielen , Jason P. Hill , Mark L. Jenson , William J. Drasler
IPC分类号： A61F2/24 , A61F2/966
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/2475 , A61F2/82 , A61F2/95 , A61F2002/9665 , A61F2210/0076 , A61F2230/0013
摘要： Apparatuses, systems, and methods for use in a vascular system. The apparatus include a circulatory valve having a valve frame in which frame members define frame cells. Frame cells include joints in opposing relationship, where the joints transition from a first stable equilibrium state through an unstable equilibrium state to a second stable equilibrium state as the joints are drawn towards each other.
摘要翻译：用于血管系统的装置，系统和方法。该装置包括具有阀框架的循环阀，其中框架构件限定框架单元。框架单元包括相对关系的关节，其中当关节被拉向彼此时，关节从第一稳定平衡状态转变到不稳定平衡状态到第二稳定平衡状态。

2. 发明申请

US20090030512A1 Circulatory valve, system and method 有权
标题翻译：循环阀，系统和方法
公开(公告)号：US20090030512A1
公开(公告)日：2009-01-29
申请号：US11881220
申请日：2007-07-26
申请人： Joseph M. Thielen , Jason P. Hill , Mark L. Jenson , William J. Drasler
发明人： Joseph M. Thielen , Jason P. Hill , Mark L. Jenson , William J. Drasler
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/2475 , A61F2/82 , A61F2/95 , A61F2002/9665 , A61F2210/0076 , A61F2230/0013
摘要： Apparatuses, systems, and methods for use in a vascular system. The apparatus include a circulatory valve having a valve frame in which frame members define frame cells. Frame cells include joints in opposing relationship, where the joints transition from a first stable equilibrium state through an unstable equilibrium state to a second stable equilibrium state as the joints are drawn towards each other.
摘要翻译：用于血管系统的装置，系统和方法。该装置包括具有阀框架的循环阀，其中框架构件限定框架单元。框架单元包括相对关系的关节，其中当关节被拉向彼此时，关节从第一稳定平衡状态转变到不稳定平衡状态到第二稳定平衡状态。

3. 发明申请

US20080269877A1 Systems and methods for valve delivery 审中-公开
标题翻译：阀门输送系统和方法
公开(公告)号：US20080269877A1
公开(公告)日：2008-10-30
申请号：US12012897
申请日：2008-02-05
申请人： Mark L. Jenson , William J. Drasler , Jason P. Hill , Joseph M. Thielen
发明人： Mark L. Jenson , William J. Drasler , Jason P. Hill , Joseph M. Thielen
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/243 , A61F2/2433 , A61F2/2475 , A61F2002/018 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2230/0006 , A61F2230/0069 , A61F2250/0059
摘要： A system having an elongate delivery catheter, an elongate mesh body including an expandable region positioned around at least a portion of the elongate delivery catheter, a retractable member that extends through the elongate delivery catheter to connect to the elonga'te mesh body, where the retractable member moves to radially expand the expandable region of the elongate mesh body from an undeployed state to an intermediate state. The system also includes a valve positioned around at least a portion of the elongate delivery catheter position, and a filter positioned around at least a portion of the elongate delivery catheter to filter and control fluid flow.
摘要翻译：一种具有细长递送导管的系统，细长网状体，其包括位于所述细长递送导管的至少一部分周围的可扩张区域;伸缩构件，其延伸穿过所述细长递送导管以连接到所述伸长网状体，伸缩构件移动以使细长网状体的可扩张区域从未部署状态向中间状态径向膨胀。该系统还包括位于细长输送导管位置的至少一部分周围的阀，以及围绕细长输送导管的至少一部分定位以过滤和控制流体流动的过滤器。

4. 发明授权

US08894682B2 PFO clip 有权
标题翻译： PFO剪辑
公开(公告)号：US08894682B2
公开(公告)日：2014-11-25
申请号：US11518753
申请日：2006-09-11
申请人： Joseph M. Thielen , Mark L. Jenson , William J. Drasler
发明人： Joseph M. Thielen , Mark L. Jenson , William J. Drasler
IPC分类号： A61B17/08 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/083 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00893
摘要： Embodiments for a device, system and method for occluding an opening in a septum. Embodiments of the device can include a first control component, a first elongate member that extends from the first control component, a second elongate member, a connecting member that positions the first elongate member adjacent the second elongate member and a retraction member releasably coupled to the first control component. The retraction member can be used to change a relative position of the first elongate member and the second elongate member of the device.
摘要翻译：用于封闭隔膜中的开口的装置，系统和方法的实施例。该装置的实施例可以包括第一控制部件，从第一控制部件延伸的第一细长部件，第二细长部件，将第一细长部件定位成邻近第二细长部件的连接部件和可释放地联接到第一控制组件。缩回构件可用于改变第一细长构件和装置的第二细长构件的相对位置。

5. 发明授权

US08430837B2 Thrombectomy apparatus and method 有权
标题翻译：血栓切除装置及方法
公开(公告)号：US08430837B2
公开(公告)日：2013-04-30
申请号：US12026317
申请日：2008-02-05
申请人： Mark L. Jenson , William J. Drasler , Joseph M. Thielen
发明人： Mark L. Jenson , William J. Drasler , Joseph M. Thielen
IPC分类号： A61N1/30
CPC分类号： A61B17/32037 , A61B17/221 , A61B2017/2212 , A61F2/013
摘要： A thrombectomy system may include an elongate shaft that defines a high pressure lumen and a low pressure lumen. The high pressure lumen may terminate near an end of the low pressure lumen. An expandable capture basket may be disposed near the end of the low pressure lumen. A thrombectomy apparatus may include an elongate shaft, an evacuation lumen extending within the elongate shaft and a high pressure lumen extending within the elongate shaft. A capture apparatus may be disposed within a wire lumen that extends within the elongate shaft such that the capture apparatus extends distally from the wire lumen.
摘要翻译：血栓切除系统可以包括限定高压腔和低压腔的细长轴。高压腔可以在低压腔的端部附近终止。可扩张的捕获篮可以设置在低压腔的端部附近。血栓切除装置可以包括细长轴，在细长轴内延伸的抽空腔和在细长轴内延伸的高压腔。捕获装置可以设置在细长轴内延伸的线腔内，使得捕获装置从线腔向远侧延伸。

6. 发明申请

US20080312645A1 Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation 审中-公开
标题翻译：血管密封装置和使用凝块增强气球和电场的方法
公开(公告)号：US20080312645A1
公开(公告)日：2008-12-18
申请号：US12026067
申请日：2008-02-05
申请人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
发明人： William J. Drasler , Tracee Eidenschink , Joseph M. Thielen , Mark L. Jenson , Anu Sadasiva
IPC分类号： A61B18/14 , A61M29/02
CPC分类号： A61B18/14 , A61B17/0057 , A61B2017/00654 , A61N1/18 , A61N1/32
摘要： An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed through the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons
摘要翻译：公开了一种用于封闭血管壁中的开口的装置和方法。该装置包括至少一个构件，其延伸穿过通过表皮和皮下皮肤层形成的组织通道并且穿过血管中的开口。该构件包括近端和远端，远端可靠近血管壁中的开口定位。正电极位于远端附近，负极位于近端的旁边。当电极通电时，电极之间产生电场，血细胞被吸引到正电极，并且在开口处形成血栓在血管壁。该构件可以包括在远端处的气囊，以暂时阻断从血管到组织道的血流，以促进血栓的形成。此外，气囊的形状可以被调整以促进血栓的形成，包括但不限于创建口袋和自支撑气球

7. 发明授权

US06558366B1 Thrombectomy method 失效
标题翻译：血栓切除术
公开(公告)号：US06558366B1
公开(公告)日：2003-05-06
申请号：US08349665
申请日：1994-12-05
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61M3100
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A method of and apparatus for removing a thrombus deposit from the cardiovascular system of a patient without the need to surgically access the location of the thrombus deposit via a cut-down or other surgical procedure. A catheter is inserted percutaneously into the patient at a convenient location either directly or over a previously positioned guide wire. The distal end of the catheter is advanced under fluoroscopy to the site of the thrombus deposit. A balloon is inflated to stabilize the position of the distal end of the catheter within the center of the vessel lumen. A flexible metal tube conveys an extremely high pressure stream of sterile saline solution to at least one jet at the distal end of the catheter. At least one jet positions the thrombus deposit for emulsification by at least one other jet. By directing the jets toward the orifice of the large evacuation lumen of the catheter, a stagnation pressure is induced which propels the emulsion proximally for disposal. The rate of proximal flow of effluent is metered to correspond with the distal flow of saline solution to ensure minimal local impact on the vasculature at the site of the thrombus deposit.
摘要翻译：一种用于从患者的心血管系统中去除血栓沉积物的方法和装置，而不需要通过切割或其它外科手术手术地进入血栓沉积物的位置。在方便的位置，将导管经皮插入患者中，直接或超过预先定位的导丝。导管的远端在荧光透视下前进到血栓沉积部位。气囊膨胀以将导管的远端的位置稳定在血管内腔的中心内。柔性金属管将非常高压的无菌盐水溶液流传送到导管远端处的至少一个射流。至少一个喷射器通过至少一个其它喷射器将血栓沉积物定位成乳化。通过将射流引导到导管的大抽空腔的孔口，引起停滞压力，其推动乳剂向近端处理。流出物的近端流量计量以与盐溶液的远端流动相对应，以确保对血栓沉积部位的脉管系统的局部影响最小。

8. 发明授权

US6096001A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US6096001A
公开(公告)日：2000-08-01
申请号：US351616
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M25/00 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one jet at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet(s) is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet(s) can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the tip of the catheter.
摘要翻译：一种用于从心血管系统去除血栓或其他组织沉积物的装置，在患者的人体中发现的天然或合成的小管或腔，而不需要经由切口或外科手术来进入血栓或其他组织沉积物的位置其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端处的至少一个射流。至少一个射流指向大排气腔或其他靶的开口。喷气机负责提供局部的负压，其将组织夹带到喷射器中从碎片的分解中。这种喷射器还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎片驱动出排出管腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的容积式泵向导管的尖端提供高压盐水。

9. 发明申请

US20080065149A1 PFO clip 有权
标题翻译： PFO剪辑
公开(公告)号：US20080065149A1
公开(公告)日：2008-03-13
申请号：US11518753
申请日：2006-09-11
申请人： Joseph M. Thielen , Mark L. Jenson , William J. Drasler
发明人： Joseph M. Thielen , Mark L. Jenson , William J. Drasler
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/083 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00893
摘要： Embodiments for a device, system and method for occluding an opening in a septum. Embodiments of the device can include a first control component, a first elongate member that extends from the first control component, a second elongate member, a connecting member that positions the first elongate member adjacent the second elongate member and a retraction member releasably coupled to the first control component. The retraction member can be used to change a relative position of the first elongate member and the second elongate member of the device.
摘要翻译：用于封闭隔膜中的开口的装置，系统和方法的实施例。该装置的实施例可以包括第一控制部件，从第一控制部件延伸的第一细长部件，第二细长部件，将第一细长部件定位成邻近第二细长部件的连接部件和可释放地联接到第一控制组件。缩回构件可用于改变第一细长构件和装置的第二细长构件的相对位置。

10. 发明授权

US06129697A Thrombectomy and tissue removal device 失效
标题翻译：血栓切除术和组织清除装置
公开(公告)号：US06129697A
公开(公告)日：2000-10-10
申请号：US351610
申请日：1994-12-08
申请人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
发明人： William J. Drasler , Robert G. Dutcher , Mark L. Jenson , Joseph M. Thielen , Emmanuil I. Protonotarios
IPC分类号： A61B17/22 , A61B17/32 , A61B17/20
CPC分类号： A61B17/32037 , A61B17/3203
摘要： A device for removing a thrombus or other tissue deposit from the cardiovascular system, or from a natural or synthetic tubule or cavity found in the human body of a patient without the need to surgically access the location of the thrombus or other tissue deposit via a cut-down or other surgical procedure. A flexible metal or high pressure plastic tube conveys an extremely high pressure stream of sterile saline or other physiologic solution to at least one orifice at the distal end of the catheter. At least one jet is directed at the opening of a large exhaust lumen or other target. The jet is responsible for providing a localized negative pressure which entrains tissue into the jet from break-up of the debris. This jet can also provide stagnation pressure in the exhaust lumen which drives the tissue or thrombotic debris out of the exhaust lumen. Operation of the device with tip pressure greater than 500 psi provides this device with the entrainment and exhaust characteristics which contribute to its effectiveness. The rate of exhaust of tissue debris is metered to ensure minimal local impact on the vasculature at the site of the thrombus deposit. A fluid metering means, such as a roller pump, controls the rate of exhaust such that it is in balance with the saline input or can be adjusted to be greater or less than the input. A positive displacement pump operating at steady or pulsatile flow provides the high pressure saline to the distal end of the catheter.
摘要翻译：一种用于从心血管系统或从患者人体中发现的天然或合成的小管或腔中除去血栓或其它组织沉积物的装置，而不需要通过切口手术地进入血栓或其它组织沉积物的位置下降或其他外科手术。柔性金属或高压塑料管将非常高压的无菌盐水或其他生理溶液流输送到导管远端的至少一个孔口。至少一个射流指向大排气腔或其他靶的开口。该喷气机负责提供局部负压，其将组织夹带到喷射器中从碎片的分解中。该射流还可以在排气腔中提供停滞压力，其将组织或血栓形成的碎屑驱出排气腔。尖端压力大于500 psi的设备的操作为该设备提供了有助于其有效性的夹带和排气特性。计量组织碎片的排气速率，以确保局部对血栓沉积部位脉管系统的局部影响最小。诸如辊式泵的流体计量装置控制排气速率，使其与盐水输入平衡，或者可以将其调节为大于或小于输入。以稳定或脉动流动运行的正排量泵将高压盐水提供给导管的远端。

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