专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070004721A1 Pteridine derivatives for the treatment of septic shock and tnf-a-related diseases 审中-公开
标题翻译：蝶啶衍生物用于治疗败血性休克和tnf-a相关疾病
公开(公告)号：US20070004721A1
公开(公告)日：2007-01-04
申请号：US10595161
申请日：2004-09-13
申请人： Mark Jozef Albert Waer , Piet André Herdewijn , Steven De Jonghe , Arnaud Didier Marie Marchand , Lin Yuan , Sefrioui El Hassane
发明人： Mark Jozef Albert Waer , Piet André Herdewijn , Steven De Jonghe , Arnaud Didier Marie Marchand , Lin Yuan , Sefrioui El Hassane
IPC分类号： A61K31/5377 , A61K31/525
CPC分类号： C07D475/10 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D475/04 , C07D475/08 , A61K2300/00
摘要： This invention relates to the use of a group of pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydroderivatives and enantiomers, for the manufacture of a medicament for the prevention or treatment of TNF-α related disorders.
摘要翻译：本发明涉及一组蝶啶衍生物，其药学上可接受的盐，N-氧化物，溶剂合物，二氢和四氢衍生物和对映异构体在制备用于预防或治疗TNF-α相关疾病的药物中的用途。

2. 发明授权

US07501513B2 Immunosuppressive effects of pteridine derivatives 失效
标题翻译：蝶啶衍生物的免疫抑制作用
公开(公告)号：US07501513B2
公开(公告)日：2009-03-10
申请号：US10595126
申请日：2004-08-27
申请人： Mark Jozef Albert Waer , Piet André Maurits Maria Herdewijn , Wolfgang Eugen Pfleiderer , Arnaud Didier Marie Marchand , Steven Cesar Alfons De Jonghe
发明人： Mark Jozef Albert Waer , Piet André Maurits Maria Herdewijn , Wolfgang Eugen Pfleiderer , Arnaud Didier Marie Marchand , Steven Cesar Alfons De Jonghe
IPC分类号： C07D475/08
CPC分类号： C07D475/10 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K38/13 , C07D471/04 , C07D475/04 , C07D475/08 , A61K2300/00
摘要： This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydro-derivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.
摘要翻译：本发明涉及一组三取代和四取代的蝶啶衍生物，其药学上可接受的盐，N-氧化物，溶剂化物，二氢和四氢衍生物和对映异构体，其具有特别期望的药物性质，特别是高活性免疫抑制剂，以及作为这在治疗移植排斥和/或某些炎性疾病的治疗中是有用的。这些化合物也可用于预防或治疗心血管疾病，过敏性疾病，中枢神经系统疾病和细胞增殖性疾病。

3. 发明申请

US20150038494A1 Thiazolopyrimidine Modulators as Immunosuppressive Agents 有权
标题翻译：噻唑并嘧啶调节剂作为免疫抑制剂
公开(公告)号：US20150038494A1
公开(公告)日：2015-02-05
申请号：US14518480
申请日：2014-10-20
申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
发明人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
IPC分类号： C07D473/32 , A61K31/5513 , C07D473/18 , A61K31/5377 , A61K31/517 , A61K45/06
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义。本发明还涉及其制备方法及其药物组合物。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗疾病和病理状况的药物，例如但不限于免疫和自身免疫病症，器官和细胞移植排斥。

4. 发明授权

US08901132B2 Thiazolopyrimidine modulators as immunosuppressive agents 有权
标题翻译：噻唑并嘧啶调节剂作为免疫抑制剂
公开(公告)号：US08901132B2
公开(公告)日：2014-12-02
申请号：US13255429
申请日：2010-03-15
申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
发明人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
IPC分类号： A61K31/519 , C07D495/02 , C07D513/22 , C07D513/04
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义。本发明还涉及其制备方法及其药物组合物。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗疾病和病理状况的药物，例如但不限于免疫和自身免疫病症，器官和细胞移植排斥。

5. 发明申请

US20120046278A1 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS 有权
标题翻译：作为免疫抑制剂的三氮丙啶调节剂
公开(公告)号：US20120046278A1
公开(公告)日：2012-02-23
申请号：US13255429
申请日：2010-03-15
申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
发明人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
IPC分类号： A61K31/519 , A61K31/496 , A61K31/5377 , A61P35/00 , A61K31/551 , A61P37/02 , A61P37/06 , C07D495/04 , C07D487/04
CPC分类号： C07D473/32 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D473/18 , C07D513/04
摘要： The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
摘要翻译：本发明涉及式I，II，III或IV化合物和/或其药学上可接受的加成盐和/或其立体异构体和/或其溶剂合物，其中R1，R2，R3，R4，R5， R6，R7，R8，R9，R11和R12如权利要求1中所定义。本发明还涉及其制备方法及其药物组合物。本发明还涉及所述化合物作为生物活性成分的用途，更具体地说，作为用于治疗疾病和病理状况的药物，例如但不限于免疫和自身免疫病症，器官和细胞移植排斥。

6. 发明授权

US07276506B2 Immunosuppressive effects of pteridine derivatives 失效
标题翻译：蝶啶衍生物的免疫抑制作用
公开(公告)号：US07276506B2
公开(公告)日：2007-10-02
申请号：US10651604
申请日：2003-08-29
申请人： Mark Jozef Albert Waer , Piet André Maurits Maria Herdewijn , Wolfgang Eugen Pfleiderer
发明人： Mark Jozef Albert Waer , Piet André Maurits Maria Herdewijn , Wolfgang Eugen Pfleiderer
IPC分类号： C07D475/04 , A61K31/4985
CPC分类号： C07D475/10 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K38/13 , C07D471/04 , C07D475/04 , C07D475/08 , A61K2300/00
摘要： This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, having the formula: wherein X represents an oxygen atom or a group with the formula NZ and wherein: R1 C1-7 alkyl or arylalkyl; Z is a group independently defined as R1 or the group NZ together with R1 is an optionally substituted heterocyclic group containing at least one nitrogen atom; R2 is amino or acylamino; R4 is an atom or a group selected from the group consisting of hydrogen; C1-7 alkyl; and C1-7 alkoxy; and R3 is an atom or a group selected from the group consisting of aryl optionally substituted with one or more substituents selected from the group consisting of halogen, C1-7 alkyl, and C1-7 alkoxy, their pharmaceutically acceptable salts, and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and being useful in the treatment in transplant rejection, certain inflammatory diseases, cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.
摘要翻译：本发明涉及一组具有下式的三取代和四取代蝶啶衍生物：其中X表示氧原子或式NZ的基团，其中：R 1 C 1-7 烷基或芳基烷基; Z是独立地定义为R 1或基团NZ与R 1一起为任选取代的含有至少一个氮原子的杂环基; R 2是氨基或酰氨基; R 4是选自氢的原子或基团; C 1-7烷基; 和C 1-7烷氧基; 并且R 3是选自以下的原子或基团：任选被一个或多个选自以下的取代基取代的芳基：卤素，C 1-7烷基和C 1-7烷氧基，其药学上可接受的盐和对映异构体，具有意想不到的期望的药物性质，特别是高活性免疫抑制剂，并且可用于移植排斥反应中的某些炎症疾病，心血管疾病，过敏性疾病，中枢神经系统疾病和细胞增殖性疾病。

7. 发明授权

US07253176B1 Immunosuppressive effects of 8-substituted xanthine derivatives 失效
标题翻译： 8-取代黄嘌呤衍生物的免疫抑制作用
公开(公告)号：US07253176B1
公开(公告)日：2007-08-07
申请号：US09564200
申请日：2000-05-04
申请人： Mark Jozef Albert Waer , Piet André´ M. M. Herdewijn , Wolfgang Eugen Pfleiderer
发明人： Mark Jozef Albert Waer , Piet André´ M. M. Herdewijn , Wolfgang Eugen Pfleiderer
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K45/06 , A61K2300/00
摘要： The invention relates to a novel use of 8-substituted xanthine derivatives for the manufacture of a medicament for the treatment of auto-immuno disorders.
摘要翻译：本发明涉及8-取代黄嘌呤衍生物在制备用于治疗自身免疫疾病的药物中的新用途。

8. 发明授权

US06946465B2 Immunosuppressive effects of pteridine derivatives 失效
标题翻译：蝶啶衍生物的免疫抑制作用
公开(公告)号：US06946465B2
公开(公告)日：2005-09-20
申请号：US10444158
申请日：2003-05-23
申请人： Mark Jozef Albert Waer , Piet André Maurits Maria Herdewijn , Wolfgang Eugen Pfleiderer
发明人： Mark Jozef Albert Waer , Piet André Maurits Maria Herdewijn , Wolfgang Eugen Pfleiderer
IPC分类号： A61K31/505 , A61K31/52 , A61K31/535 , A61K31/57 , A61K38/13 , C07D475/02 , A61K31/519
CPC分类号： C07D475/02 , A61K31/505 , A61K31/52 , A61K31/535 , A61K31/57 , A61K38/13 , C07F9/6561 , A61K2300/00
摘要： Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, being represented by the general formula (I). are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.
摘要翻译：已经公开了蝶啶环的1,3,6和7位的取代基的单取代或多取代的2-硫杂环辛烷，4-硫杂环嗪或2,4-二硫柳嗪的新型多取代的蝶啶（lumazines）及其药学上可接受的盐由通式（I）表示。在制备特别用于治疗或预防CNS病症，细胞增殖性病症，病毒感染，免疫或自身免疫病症或移植排斥的药物组合物中作为生物活性成分是有用的。还公开了本发明的蝶啶衍生物与免疫抑制剂或免疫调节剂药物，抗肿瘤药物或抗病毒剂的组合，其具有潜在的协同效应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式