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1. 发明授权

US08092529B2 Meniscus regeneration device 有权
标题翻译：半月板再生装置
公开(公告)号：US08092529B2
公开(公告)日：2012-01-10
申请号：US10195794
申请日：2002-07-15
申请人： Prasanna Malaviya , Herbert Eugene Schwartz , Terrence David Whalen , Mark Joseph Pelo , Philip Joseph Jenks , Pamela Lynn Plouhar , Jerry Lee Lower
发明人： Prasanna Malaviya , Herbert Eugene Schwartz , Terrence David Whalen , Mark Joseph Pelo , Philip Joseph Jenks , Pamela Lynn Plouhar , Jerry Lee Lower
IPC分类号： A61F2/08
CPC分类号： A61L27/3654 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00526 , A61B2017/0475 , A61B2017/06057 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3683 , A61L27/3691 , A61L27/3852 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Methods and devices are provided for regenerating a meniscus. The devices comprise a layer of toughened naturally occurring extracellular matrix. The devices may, optionally, further comprise a biologic material to provide a framework for meniscus regeneration. The methods comprise the steps of removing a portion of a meniscus to provide a space, and inserting a device comprising a layer of toughened naturally occurring extracellular matrix into the space.
摘要翻译：提供了用于再生半月板的方法和装置。该装置包括一层增韧的天然存在的细胞外基质。所述装置可以任选地进一步包括生物材料以提供弯液面再生的框架。所述方法包括以下步骤：去除弯液面的一部分以提供空间，以及将包含增韧的天然存在的细胞外基质层的装置插入到所述空间中。

2. 发明授权

US08337537B2 Device from naturally occurring biologically derived materials 有权
标题翻译：来自天然存在的生物衍生物质的装置
公开(公告)号：US08337537B2
公开(公告)日：2012-12-25
申请号：US10483465
申请日：2002-07-15
申请人： Mark Joseph Pelo , Pamela Lynn Plouhar , Herbert Eugene Schwartz , Prasanna Malaviya , Terrence David Whalen
发明人： Mark Joseph Pelo , Pamela Lynn Plouhar , Herbert Eugene Schwartz , Prasanna Malaviya , Terrence David Whalen
IPC分类号： A61B17/86
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/0412 , A61B2017/044 , A61B2017/0458 , A61B2017/0475 , A61B2017/06057 , A61B2017/0641 , A61B2017/0646 , A61B2017/0647 , A61B2017/0648 , A61F2/0063 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/0864 , A61F2002/087 , A61F2002/0888 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3633 , A61L27/3645 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Orthopaedic devices are disclosed. The devices include a part that is made of extracellular matrix material that has been hardened. One method of hardening the extracellular matrix is to comminute naturally occurring extracellular matrix and dry the comminuted material. The hardened extracellular matrix material can be machined to form a variety of orthopaedic devices.
摘要翻译：矫形装置被公开。这些装置包括由已经硬化的细胞外基质材料制成的部分。硬化细胞外基质的一种方法是粉碎天然存在的细胞外基质并干燥粉碎的材料。硬化的细胞外基质材料可以加工成多种矫形装置。

3. 发明授权

US07871440B2 Unitary surgical device and method 有权
标题翻译：单一手术装置及方法
公开(公告)号：US07871440B2
公开(公告)日：2011-01-18
申请号：US11609114
申请日：2006-12-11
申请人： Herbert E. Schwartz , Prasanna Malaviya , Amit K. Singla , Pamela Lynn Plouhar , Mark Joseph Pelo
发明人： Herbert E. Schwartz , Prasanna Malaviya , Amit K. Singla , Pamela Lynn Plouhar , Mark Joseph Pelo
IPC分类号： A61F2/08
CPC分类号： A61B17/064 , A61B17/0401 , A61B17/06166 , A61B17/0642 , A61B2017/00004 , A61B2017/0458 , A61B2017/06057 , A61B2017/0646 , A61B2017/0647 , A61F2/30749 , A61F2/30756 , A61F2/3872 , A61F2002/30751
摘要： Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15,17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus. The second group of devices can be used either as an insert to be placed between and approximated to the inner surfaces of the tear or as an insert to replace a void in the meniscus left after a meniscectomy.
摘要翻译：公开了单一手术装置（10）。所示装置中的一组具有连接到固定长度缝合线的一对生物相容的生物可再吸收锚固件（16,18）。在手术前，锚（16,18）和缝合线的固定长度彼此连接。另一组单一手术装置具有在手术之前连接到基座（21）的一对固定机构（15,17）。所示装置的第二组通常包括作为基底（21）的一部分或支撑在基底（21）上的细胞外基质材料。细胞外基质材料用作组织再生材料。在第二组单一手术装置中，所示的固定机构通常包括基部中的缝合线，锚固件或预先形成的孔。所有图示的单一外科手术装置可用于修复损坏的半月板。第一组单一外科手术装置可用于近似弯月面撕裂的内表面。第二组装置可以用作插入物，放置在泪液的内表面之间并且近似于泪液的内表面，或者作为插入物来替代半月板切除术后留下的半月板中的空隙。

4. 发明申请

US20080294193A1 UNITARY SURGICAL DEVICE AND METHOD 审中-公开
标题翻译：单位外科手术和方法
公开(公告)号：US20080294193A1
公开(公告)日：2008-11-27
申请号：US11928710
申请日：2007-10-30
申请人： HERBERT E. SCHWARTZ , Prasanna Malaviya , Amit K. Singla , Pamela Lynn Plouhar , Mark Joseph Pelo
发明人： HERBERT E. SCHWARTZ , Prasanna Malaviya , Amit K. Singla , Pamela Lynn Plouhar , Mark Joseph Pelo
IPC分类号： A61B17/04 , A61B17/06
CPC分类号： A61B17/064 , A61B17/0401 , A61B17/06166 , A61B17/0642 , A61B2017/00004 , A61B2017/0458 , A61B2017/0464 , A61B2017/06057 , A61B2017/06176 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2002/2817 , A61F2002/30062 , A61F2002/30131 , A61F2002/30281 , A61F2002/30294 , A61F2002/30306 , A61F2002/30429 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30841 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0086 , A61F2230/0091 , A61F2230/0097 , A61L27/18 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/3852 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15,17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus. The second group of devices can be used either as an insert to be placed between and approximated to the inner surfaces of the tear or as an insert to replace a void in the meniscus left after a meniscectomy.
摘要翻译：公开了单一手术装置（10）。所示装置中的一组具有连接到固定长度缝合线的一对生物相容的生物可再吸收锚固件（16,18）。在手术前，锚（16,18）和缝合线的固定长度彼此连接。另一组单一手术装置具有在手术之前连接到基座（21）的一对固定机构（15,17）。所示装置的第二组通常包括作为基底（21）的一部分或支撑在基底（21）上的细胞外基质材料。细胞外基质材料用作组织再生材料。在第二组单一手术装置中，所示的固定机构通常包括基部中的缝合线，锚固件或预先形成的孔。所有图示的单一外科手术装置可用于修复损坏的半月板。第一组单一外科手术装置可用于近似弯月面撕裂的内表面。第二组装置可以用作插入物，放置在泪液的内表面之间并且近似于泪液的内表面，或者作为插入物来替代半月板切除术后留下的半月板中的空隙。

5. 发明授权

US07163563B2 Unitary surgical device and method 有权
标题翻译：单一手术装置及方法
公开(公告)号：US07163563B2
公开(公告)日：2007-01-16
申请号：US10195344
申请日：2002-07-15
申请人： Herbert E. Schwartz , Prasanna Malaviya , Amit K. Singla , Pamela Lynn Plouhar , Mark Joseph Pelo
发明人： Herbert E. Schwartz , Prasanna Malaviya , Amit K. Singla , Pamela Lynn Plouhar , Mark Joseph Pelo
IPC分类号： A61F2/02
CPC分类号： A61B17/064 , A61B17/0401 , A61B17/06166 , A61B17/0642 , A61B2017/00004 , A61B2017/0458 , A61B2017/0464 , A61B2017/06057 , A61B2017/06176 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2002/2817 , A61F2002/30062 , A61F2002/30131 , A61F2002/30281 , A61F2002/30294 , A61F2002/30306 , A61F2002/30429 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30841 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0086 , A61F2230/0091 , A61F2230/0097 , A61L27/18 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/3852 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each other prior to surgery. Another group of unitary surgical devices has a pair of fixating mechanisms (15,17) connected to a base (21) prior to surgery. The second group of illustrated devices generally includes extracellular matrix material either as part of the base (21) or supported on the base (21). The extracellular matrix material serves as tissue regenerating material. In the second group of unitary surgical devices, the fixating mechanisms illustrated generally comprise suture, anchors or pre-formed holes in the base. All of the illustrated unitary surgical devices are useful in repairing a damaged meniscus. The first group of unitary surgical devices can be used to approximate inner surfaces of a tear in the meniscus. The second group of devices can be used either as an insert to be placed between and approximated to the inner surfaces of the tear or as an insert to replace a void in the meniscus left after a meniscectomy.
摘要翻译：公开了单一手术装置（10）。所示装置中的一组具有连接到固定长度缝合线的一对生物相容的生物可再吸收锚固件（16,18）。在手术前，锚（16,18）和缝合线的固定长度彼此连接。另一组单一手术装置具有在手术之前连接到基座（21）的一对固定机构（15,17）。所示装置的第二组通常包括作为基底（21）的一部分或支撑在基底（21）上的细胞外基质材料。细胞外基质材料用作组织再生材料。在第二组单一手术装置中，所示的固定机构通常包括基部中的缝合线，锚固件或预先形成的孔。所有图示的单一外科手术装置可用于修复损坏的半月板。第一组单一外科手术装置可用于近似弯月面撕裂的内表面。第二组装置可以用作插入物，放置在泪液的内表面之间并且近似于泪液的内表面，或者作为插入物来替代半月板切除术后留下的半月板中的空隙。

6. 发明授权

US08012205B2 Cartilage repair and regeneration device 有权
标题翻译：软骨修复和再生装置
公开(公告)号：US08012205B2
公开(公告)日：2011-09-06
申请号：US10195606
申请日：2002-07-15
申请人： Pamela Lynn Plouhar , Prasanna Malaviya , Herbert Eugene Schwartz
发明人： Pamela Lynn Plouhar , Prasanna Malaviya , Herbert Eugene Schwartz
IPC分类号： A61F2/08
CPC分类号： A61L27/3852 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/0475 , A61B2017/06057 , A61B2017/0641 , A61B2017/0646 , A61B2017/0647 , A61F2/0063 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/30749 , A61F2/30756 , A61F2/3094 , A61F2/30965 , A61F2/3872 , A61F2/442 , A61F2002/2817 , A61F2002/2839 , A61F2002/30032 , A61F2002/30062 , A61F2002/30131 , A61F2002/30153 , A61F2002/30199 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30225 , A61F2002/30233 , A61F2002/30261 , A61F2002/30281 , A61F2002/30293 , A61F2002/30294 , A61F2002/30429 , A61F2002/30611 , A61F2002/30677 , A61F2002/30678 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2002/30785 , A61F2002/30841 , A61F2002/30848 , A61F2002/30878 , A61F2002/30891 , A61F2002/30892 , A61F2002/30914 , A61F2002/30957 , A61F2002/3096 , A61F2002/30971 , A61F2002/30975 , A61F2210/0004 , A61F2220/0025 , A61F2230/0013 , A61F2230/0019 , A61F2230/0063 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2240/001 , A61F2240/004 , A61F2250/003 , A61F2250/0063 , A61F2250/0067 , A61F2310/00365 , A61L27/18 , A61L27/3604 , A61L27/3633 , A61L27/3654 , A61L27/3683 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： A cartilage repair device comprises a scaffold, for example a naturally occurring extracellular matrix material, and a biological lubricant. The biological lubricant is applied to the naturally occurring extracellular matrix material.
摘要翻译：软骨修复装置包括支架，例如天然存在的细胞外基质材料和生物润滑剂。将生物润滑剂施用于天然存在的细胞外基质材料。

7. 发明授权

US07799089B2 Reinforced small intestinal submucosa 有权
标题翻译：加强小肠粘膜下层
公开(公告)号：US07799089B2
公开(公告)日：2010-09-21
申请号：US11548071
申请日：2006-10-10
申请人： Pamela Lynn Plouhar , Prasanna Malaviya , Joe W. Ferguson , Mora Carolynne Melican
发明人： Pamela Lynn Plouhar , Prasanna Malaviya , Joe W. Ferguson , Mora Carolynne Melican
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61F2/0063 , A61F2/08 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3641 , A61L27/40 , C08L67/04
摘要： Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.
摘要翻译：提供了用于软组织附着，加强或构造的生物假体装置。该装置包括一片天然存在的细胞外基质和与天然存在的细胞外基质部分相连的一片合成网。

8. 发明授权

US07819918B2 Implantable tissue repair device 有权
标题翻译：植入式组织修复装置
公开(公告)号：US07819918B2
公开(公告)日：2010-10-26
申请号：US10747349
申请日：2003-12-29
申请人： Prasanna Malaviya , Herbert E. Schwartz , Anthony D. Zannis , Terrence David Whalen , Philip Joseph Jenks
发明人： Prasanna Malaviya , Herbert E. Schwartz , Anthony D. Zannis , Terrence David Whalen , Philip Joseph Jenks
IPC分类号： A61F2/08
CPC分类号： A61B17/0642 , A61B17/0401 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61F2/0063 , A61F2/30756 , A61F2/3094 , A61F2/3872 , A61F2002/2817 , A61F2002/30062 , A61F2002/30156 , A61F2002/30266 , A61F2002/30281 , A61F2002/30324 , A61F2002/30576 , A61F2002/30677 , A61F2002/30678 , A61F2002/30733 , A61F2002/30957 , A61F2002/30971 , A61F2210/0004 , A61F2230/0023 , A61F2230/0082 , A61F2230/0086 , A61F2250/0036 , A61F2310/00293 , A61F2310/00365 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3654 , A61L27/56 , A61L31/005 , A61L2430/06 , C08L67/04
摘要： An implantable tissue repair device has a cover and tissue regeneration material. The cover includes a top panel and a bottom panel joined together along a leading edge. The tissue regeneration material is positioned between the top and bottom panels. The cover includes a continuous sheet of biocompatible material extending across the edge and into the top panel and bottom panel. The cover is thicker along the leading edge than at least a portion of the top panel and thicker than at least a portion of the bottom panel. At least a portion of one of the panels covering the tissue regeneration material is thicker than a portion of the other panel covering the tissue regeneration material. A method of making the device is also disclosed.
摘要翻译：可植入组织修复装置具有盖和组织再生材料。该盖包括沿前缘连接在一起的顶板和底板。组织再生材料位于顶板和底板之间。盖子包括延伸穿过边缘并进入顶部面板和底部面板的生物相容性材料的连续片材。所述盖沿着所述前缘比所述顶板的至少一部分更厚，并且比所述底板的至少一部分厚。覆盖组织再生材料的一个面板中的至少一部分比覆盖组织再生材料的另一个面板的一部分厚。还公开了制造该器件的方法。

9. 发明授权

US08876761B2 Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods 有权
标题翻译：肠内制动诱导管腔内治疗物质洗脱装置及方法
公开(公告)号：US08876761B2
公开(公告)日：2014-11-04
申请号：US13104313
申请日：2011-05-10
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M31/00 , A61K9/00 , A61M5/142 , A61F5/00 , A61N1/05 , A61M39/02 , A61F2/04 , A61N1/36 , A61N1/372
CPC分类号： A61M31/002 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F2002/045 , A61K9/0065 , A61M5/14276 , A61M39/0208 , A61M2210/106 , A61M2210/1064 , A61N1/0509 , A61N1/36007 , A61N1/37205
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质从植入物到胃肠道。

10. 发明授权

US08603023B2 Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods 有权
标题翻译：肠内制动诱导管腔内治疗物质洗脱装置及方法
公开(公告)号：US08603023B2
公开(公告)日：2013-12-10
申请号：US13105029
申请日：2011-05-11
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, Jr. , Jason L. Harris , Christopher J. Hess , Thomas W. Huitema , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, Jr. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M5/00 , A61M29/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F5/0079 , A61F2002/045
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

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