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1. 发明授权

US08656908B2 Aerosol delivery systems and methods 有权
标题翻译：气溶胶输送系统和方法
公开(公告)号：US08656908B2
公开(公告)日：2014-02-25
申请号：US13099261
申请日：2011-05-02
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/00 , A61M15/00 , B05B17/06
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

2. 发明申请

US20110203580A1 AEROSOL DELIVERY SYSTEMS AND METHODS 有权
标题翻译：航空运输系统和方法
公开(公告)号：US20110203580A1
公开(公告)日：2011-08-25
申请号：US13099261
申请日：2011-05-02
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/00
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

3. 发明申请

US20090223513A1 Aerosol delivery systems and methods 有权
标题翻译：气溶胶输送系统和方法
公开(公告)号：US20090223513A1
公开(公告)日：2009-09-10
申请号：US10587814
申请日：2005-04-01
申请人： Mark J Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/02 , A61M11/00
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

4. 发明授权

US07954486B2 Aerosol delivery systems and methods 有权
标题翻译：气溶胶输送系统和方法
公开(公告)号：US07954486B2
公开(公告)日：2011-06-07
申请号：US10587814
申请日：2005-04-01
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/00 , A61M15/00 , B05B17/06
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

5. 发明授权

US08544462B2 Systems and methods for aerosol delivery of agents 有权
标题翻译：用于药剂气溶胶输送的系统和方法
公开(公告)号：US08544462B2
公开(公告)日：2013-10-01
申请号：US11796313
申请日：2007-04-27
申请人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
发明人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
IPC分类号： A61M11/00 , B05B17/06
CPC分类号： A61M11/005 , A61M11/001 , A61M11/06 , A61M15/0033 , A61M15/0066 , A61M15/0085 , A61M15/08 , A61M16/0057 , A61M16/0666 , A61M16/107 , A61M16/14 , A61M2205/07 , A61M2205/071 , A61M2205/3606 , A61M2205/8206 , A61M2205/8225 , A61M2205/825
摘要： Aerosol delivery systems and methods for delivering an agent to a patient are described herein. In particular embodiments, an insulated receptacle is connected to a housing and holds a vial of an agent to be delivered to a patient. The vial is located in an inverted position within the receptacle. One or more reusable thermal packs can be located on the inner sides of the receptacle, to maintain a selected temperature surrounding the vial. The agent is administered to a patient by placing a prong into one of the patient's orifices and then activating an aerosol delivery system. Such systems can include jet aerosolization and pneumatic and ultrasonic nebulizers and preferably are portable.
摘要翻译：本文描述了用于将药剂递送至患者的气溶胶递送系统和方法。在特定实施例中，绝缘容器连接到壳体并且保持待递送给患者的药剂瓶。小瓶位于插座内的倒置位置。一个或多个可重复使用的热包装可以位于容器的内侧，以保持围绕小瓶的选定温度。通过将一个插入物插入患者的一个孔中，然后激活气雾剂输送系统，向患者施用该药剂。这样的系统可以包括喷雾雾化和气动和超声雾化器，并且优选是便携式的。

6. 发明授权

US07225807B2 Systems and methods for aerosol delivery of agents 有权
标题翻译：用于药剂气溶胶输送的系统和方法
公开(公告)号：US07225807B2
公开(公告)日：2007-06-05
申请号：US10471620
申请日：2002-03-13
申请人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
发明人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
IPC分类号： A61M15/00 , A61M16/10 , A61M16/00 , A61M15/08 , A61M11/00 , F16K11/00 , G05D11/02
CPC分类号： A61M11/005 , A61M11/001 , A61M11/06 , A61M15/0033 , A61M15/0066 , A61M15/0085 , A61M15/08 , A61M16/0057 , A61M16/0666 , A61M16/107 , A61M16/14 , A61M2205/07 , A61M2205/071 , A61M2205/3606 , A61M2205/8206 , A61M2205/8225 , A61M2205/825
摘要： Aerosol delivery systems and methods for delivering an agent to a patient are described herein. The present invention includes embodiments comprising an insulated receptacle connected to a body to hold a vial of an agent to be delivered to a patient. The vial is located in an inverted position within the receptacle and connected to the housing. One or more reusable thermal packs can be located on the inner sides of the receptacle, to maintain a selected temperature surrounding the vial. The agent is administered to a patient by placing a prong into one of the patient's orifices and then activating an aerosol delivery system. Such systems comprise jet aerosolization and pneumatic and ultrasonic nebulizers and preferably are portable.
摘要翻译：本文描述了用于将药剂递送至患者的气溶胶递送系统和方法。本发明包括实施例，该实施例包括连接到身体的绝缘插座，用于保持要递送给患者的药剂瓶。小瓶位于插座内的倒置位置并连接到外壳。一个或多个可重复使用的热包装可以位于容器的内侧，以保持围绕小瓶的选定温度。通过将一个插入物插入患者的一个孔中，然后激活气雾剂输送系统，向患者施用该药剂。这种系统包括喷雾雾化和气动和超声雾化器，并且优选是便携式的。

7. 发明申请

US20120118283A1 Systems and methods for aerosol delivery of agents 有权
标题翻译：用于药剂气溶胶输送的系统和方法
公开(公告)号：US20120118283A1
公开(公告)日：2012-05-17
申请号：US11796313
申请日：2007-04-27
申请人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
发明人： Mark James Papania , James J. Barry , Nabil A. Elkouh , Mark C. Bagley
IPC分类号： A61M11/02
CPC分类号： A61M11/005 , A61M11/001 , A61M11/06 , A61M15/0033 , A61M15/0066 , A61M15/0085 , A61M15/08 , A61M16/0057 , A61M16/0666 , A61M16/107 , A61M16/14 , A61M2205/07 , A61M2205/071 , A61M2205/3606 , A61M2205/8206 , A61M2205/8225 , A61M2205/825
摘要： Aerosol delivery systems and methods for delivering an agent to a patient are described herein. The present invention includes embodiments comprising an insulated receptacle connected to a body to hold a vial of an agent to be delivered to a patient. The vial is located in an inverted position within the receptacle and connected to the housing. One or more reusable thermal packs can be located on the inner sides of the receptacle, to maintain a selected temperature surrounding the vial. The agent is administered to a patient by placing a prong into one of the patient's orifices and then activating an aerosol delivery system. Such systems comprise jet aerosolization and pneumatic and ultrasonic nebulizers and preferably are portable.
摘要翻译：本文描述了用于将药剂递送至患者的气溶胶递送系统和方法。本发明包括实施例，该实施例包括连接到身体的绝缘插座，用于保持要递送给患者的药剂瓶。小瓶位于插座内的倒置位置并连接到外壳。一个或多个可重复使用的热包装可以位于容器的内侧，以保持围绕小瓶的选定温度。通过将一个插入物插入患者的一个孔中，然后激活气雾剂输送系统，向患者施用该药剂。这样的系统包括喷雾雾化和气动和超声雾化器，并且优选是便携式的。

8. 发明申请

US20100255247A1 Protective Cover System Including a Corrosion Inhibitor and Method of Inhibiting Corrosion of a Metallic Object 审中-公开
标题翻译：包括腐蚀抑制剂的保护盖系统和抑制金属物体腐蚀的方法
公开(公告)号：US20100255247A1
公开(公告)日：2010-10-07
申请号：US12816954
申请日：2010-06-16
申请人： Nabil A. Elkouh , Jeffrey J. Breedlove , Bruce R. Pilvelait
发明人： Nabil A. Elkouh , Jeffrey J. Breedlove , Bruce R. Pilvelait
IPC分类号： B32B3/06 , B32B3/26
CPC分类号： B32B3/04 , B32B1/00 , B32B3/08 , B32B3/26 , B32B5/06 , B32B5/16 , B32B5/18 , B32B5/26 , B32B27/18 , B32B2264/00 , B32B2266/06 , B32B2307/714 , B32B2307/724 , B32B2307/726 , B65D81/24 , C23F11/02 , C23F15/00 , Y10T428/163 , Y10T428/164 , Y10T428/187 , Y10T428/19 , Y10T428/192 , Y10T428/24008 , Y10T428/24017 , Y10T428/24025 , Y10T428/24777 , Y10T428/24785 , Y10T428/249953 , Y10T428/249981 , Y10T442/2139 , Y10T442/2164 , Y10T442/2221 , Y10T442/2508 , Y10T442/3472 , Y10T442/3496 , Y10T442/3707 , Y10T442/3854 , Y10T442/3976 , Y10T442/668 , Y10T442/673 , Y10T442/674 , Y10T442/696 , Y10T442/699
摘要： A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
摘要翻译：一种用于抑制金属物体腐蚀的保护罩系统。保护盖系统包括用于限定邻近金属物体的微环境的盖和用于将一种或多种腐蚀抑制剂释放到微环境中的腐蚀抑制源。

9. 发明授权

US07759265B2 Protective cover system including a corrosion inhibitor and method of inhibiting corrosion of a metallic object 有权
标题翻译：保护罩系统，包括腐蚀抑制剂和抑制金属物体腐蚀的方法
公开(公告)号：US07759265B2
公开(公告)日：2010-07-20
申请号：US11669264
申请日：2007-01-31
申请人： Nabil A. Elkouh , Jeffrey J. Breedlove , Bruce R. Pilvelait
发明人： Nabil A. Elkouh , Jeffrey J. Breedlove , Bruce R. Pilvelait
IPC分类号： B32B5/02 , B32B27/04 , B65D65/02
CPC分类号： B32B3/04 , B32B1/00 , B32B3/08 , B32B3/26 , B32B5/06 , B32B5/16 , B32B5/18 , B32B5/26 , B32B27/18 , B32B2264/00 , B32B2266/06 , B32B2307/714 , B32B2307/724 , B32B2307/726 , B65D81/24 , C23F11/02 , C23F15/00 , Y10T428/163 , Y10T428/164 , Y10T428/187 , Y10T428/19 , Y10T428/192 , Y10T428/24008 , Y10T428/24017 , Y10T428/24025 , Y10T428/24777 , Y10T428/24785 , Y10T428/249953 , Y10T428/249981 , Y10T442/2139 , Y10T442/2164 , Y10T442/2221 , Y10T442/2508 , Y10T442/3472 , Y10T442/3496 , Y10T442/3707 , Y10T442/3854 , Y10T442/3976 , Y10T442/668 , Y10T442/673 , Y10T442/674 , Y10T442/696 , Y10T442/699
摘要： A protective cover system for inhibiting corrosion of a metallic object. The protective cover system includes a cover for defining a microenvironment adjacent a metallic object and a corrosion inhibitor source for releasing one or more corrosion inhibitors into the microenvironment.
摘要翻译：一种用于抑制金属物体腐蚀的保护罩系统。保护盖系统包括用于限定邻近金属物体的微环境的盖和用于将一种或多种腐蚀抑制剂释放到微环境中的腐蚀抑制源。

10. 发明授权

US06379789B1 Thermally-sprayed composite selective emitter 失效
标题翻译：热喷涂复合选择性发射极
公开(公告)号：US06379789B1
公开(公告)日：2002-04-30
申请号：US09678904
申请日：2000-10-04
申请人： Christopher J. Crowley , Nabil A. Elkouh , Patrick J. Magari
发明人： Christopher J. Crowley , Nabil A. Elkouh , Patrick J. Magari
IPC分类号： B32B1800
CPC分类号： C04B41/009 , C04B41/5045 , C04B41/52 , C04B41/87 , C04B41/89 , H02S10/30 , Y10T428/265 , C04B41/4527 , C04B41/5046 , C04B41/522 , C04B41/4529 , C04B41/4574 , C04B41/5122 , C04B35/10 , C04B35/565 , C04B35/505
摘要： A composite emitter (100) for a thermophotovoltaic cell and other applications, and a method of forming the composite emitter. The composite emitter includes a substrate (102) and a selective emitter layer (104) composed of at least one substantially pure ceramic oxide selective emitter material applied to the substrate using a thermal spraying method. The substrate is preferably made of a durable material such as a silicon-based material or a refractory metal oxide. In one embodiment, the selective emitter layer may be composed of two or more selective emitter materials. In another embodiment, the composite emitter may further include a reflective metal layer (106). The method includes providing a substrate and plasma spraying one or more selective emitter materials onto the substrate to a thickness of between about 10 microns and about 400 microns to form the selective emitter layer. Preferably, the selective emitter layer has an in situ density of between 80% and 95% of the bulk density of the selective emitter material used.
摘要翻译：用于热光伏电池的复合发射器（100）和其它应用，以及形成复合发射极的方法。复合发射器包括基板（102）和选择性发射极层（104），其由至少一个基本上纯的陶瓷氧化物选择性发射体材料构成，该材料使用热喷涂法施加到基板。衬底优选由诸如硅基材料或难熔金属氧化物的耐用材料制成。在一个实施例中，选择性发射极层可以由两个或更多个选择性发射极材料组成。在另一个实施例中，复合发射器还可以包括反射金属层（106）。该方法包括提供衬底和等离子体将一种或多种选择性发射体材料喷射到衬底上至约10微米至约400微米的厚度以形成选择性发射极层。优选地，选择性发射极层的原位密度为所使用的选择性发射极材料的体积密度的80％至95％。

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