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1. 发明授权

US07636160B2 System for detecting markers 有权
标题翻译：检测标记系统
公开(公告)号：US07636160B2
公开(公告)日：2009-12-22
申请号：US12321781
申请日：2009-01-26
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura, legal representative
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

2. 发明授权

US07636159B2 Time-delay integration in detection of labeled beads 有权
公开(公告)号：US07636159B2
公开(公告)日：2009-12-22
申请号：US12283957
申请日：2008-09-17
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura, legal representative
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

3. 发明申请

US20090021735A1 Time-delay integration in detection of labeled beads 有权
标题翻译：标记珠的检测时延整合
公开(公告)号：US20090021735A1
公开(公告)日：2009-01-22
申请号：US12283957
申请日：2008-09-17
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
IPC分类号： G01N21/62
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

4. 发明申请

US20110236964A1 DNA Sequencing System 有权
标题翻译： DNA测序系统
公开(公告)号：US20110236964A1
公开(公告)日：2011-09-29
申请号：US13153902
申请日：2011-06-06
申请人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
发明人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
IPC分类号： C12M1/34
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

5. 发明申请

US20090135421A1 System for detecting markers 有权
公开(公告)号：US20090135421A1
公开(公告)日：2009-05-28
申请号：US12321781
申请日：2009-01-26
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

6. 发明授权

US07978326B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US07978326B2
公开(公告)日：2011-07-12
申请号：US12630683
申请日：2009-12-03
申请人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura, legal representative
发明人： Mark F. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

7. 发明申请

US20120196296A1 DNA Sequencing System 有权
标题翻译： DNA测序系统
公开(公告)号：US20120196296A1
公开(公告)日：2012-08-02
申请号：US13442143
申请日：2012-04-09
申请人： Mark E. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
发明人： Mark E. Oldham , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice G. Shigeura
IPC分类号： G01N21/64
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

8. 发明申请

US20130011842A1 DNA Sequencing System 有权
标题翻译： DNA测序系统
公开(公告)号：US20130011842A1
公开(公告)日：2013-01-10
申请号：US13619298
申请日：2012-09-14
申请人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice Shigeura
发明人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , John S. Shigeura , Janice Shigeura
IPC分类号： G01N21/64
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

9. 发明授权

US07468793B2 Time-delay integration in electrophoretic detection systems 有权
标题翻译：电泳检测系统中的时延整合
公开(公告)号：US07468793B2
公开(公告)日：2008-12-23
申请号：US11012664
申请日：2004-12-15
申请人： Eric S. Nordman , Richard T. Reel , John S. Shigeura
发明人： Eric S. Nordman , Richard T. Reel , John S. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721
摘要： An apparatus for detecting analytes in a sample is provided. The apparatus includes: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with non-coherent radiation; a detector array disposed for collecting light signals emitted from markers in the detection zone excited by the radiation, the detector array having an output; and a system coupled to the detector array for effecting time delay integration of the charges on the detector array corresponding to the light signals by accumulating the charges before reading the charges at the output of the detector array. Other apparatus and methods for detecting analytes in a sample are also provided.
摘要翻译：提供了一种用于检测样品中分析物的装置。该装置包括：具有检测区域的一个或多个通道; 设置用于以非相干辐射照射检测区域的一个或多个照射源; 检测器阵列，被设置用于收集由所述辐射激发的所述检测区域中的标记物发出的光信号，所述检测器阵列具有输出; 以及耦合到检测器阵列的系统，用于通过在读取检测器阵列的输出端的电荷之前累积电荷来实现对与光信号对应的检测器阵列上的电荷的时间延迟积分。还提供了用于检测样品中分析物的其它装置和方法。

10. 发明申请

US20100103416A1 DNA Sequencing System 有权
标题翻译： DNA测序系统
公开(公告)号：US20100103416A1
公开(公告)日：2010-04-29
申请号：US12630683
申请日：2009-12-03
申请人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , Janice S. Shigeura
发明人： Mark F. OLDHAM , Eric S. Nordman , Richard T. Reel , Janice S. Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

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