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    • 6. 发明授权
    • Method for preparing hydroxyphenyl carboxylic acid esters
    • 羟基苯基羧酸酯的制备方法
    • US06878843B2
    • 2005-04-12
    • US10311724
    • 2001-06-14
    • Christoph Kleiner
    • Christoph Kleiner
    • C07B61/00C07C67/03C07C69/732C07C69/76
    • C07C67/03C07C69/732
    • A process for the preparation of a compound of formula (I) wherein R1 and R2 are each independently of the other C1-C8alkyl, cyclopentyl or cyclohexyl, m is 1, 2 or 3, preferably 2, n is an integer from 1 to 30, and R3 is an n-valent radical from linear or branched C4-C30alkyl, which is optionally interrupted by one or more oxygen atoms, or (when n=1-12) an n-valent radical from C5-C12cycloalkyl, or a radical R4—[NR5—CmH2m—]p, R4 is hydrogen, an n-valent radical from linear or branched C4-C30alkyl, which is optionally interrupted by one or more —NR5— groups, or (when n=1-12) an n-valent radical from C5-C12cycloalkyl, R5 radicals, each independently of any other(s), are hydrogen or methyl or —CmH2m—, preferably hydrogen, and p corresponds to the number of —[NR5—CmH2m—] groups that gives n —CmH2m— radicals per molecule, by reaction of a compound of formula (II) wherein R is C1-C3alkyl, with a compound of formula (III) R3(OH)n  (III) wherein R3 and n have the definitions given, wherein the reaction takes place at a practically neutral acid value (pH) and in the presence of at least one alkali metal salt of an organic carboxylic acid, which salt is dissolved or suspended in the reaction mixture, or in the presence of a mixture of such alkali metal salts, (i) that alkali metal salt being formed from an alkali metal cation and an anion of an organic carboxylic acid and (ii) the organic carboxylic acid being at least partially volatile under the reaction conditions applied. Preferred alkali metal salts are alkali metal formate and alkali metal acetate.
    • 制备式(I)化合物的方法,其中R 1和R 2各自独立地为C 1 -C 8烷基,环戊基或环己基,m为1,2或3,优选2,n为1至30的整数, R 3是由C 1 -C 30烷基直链或支链任选被一个或多个氧原子中断的n价基团,或(当n = 1-12时)来自C 5 -C 12环烷基的n价基团或基团R 4 - [NR5-CmH2m-] p,R4是氢,任选地被一个或多个-NR 5 - 基团间隔的直链或支链C 4 -C 30烷基的n价基团,或(当n = 1-12时) 各自独立地为C 5 -C 12环烷基,R 5基团为氢或甲基或-C m H 2m,优选氢,且p对应于 - [NR 5 -C m H 2m]基团,其给出n -C m H 2 m - 通过其中R是C 1 -C 3烷基的式(II)化合物与式(III)化合物(其中R 3和n具有给定的定义)反应,其中反应在 几乎中性酸值(pH),并且在至少一种有机羧酸的碱金属盐的存在下,该盐被溶解或悬浮在反应混合物中,或在这种碱金属盐的混合物存在下 )所述碱金属盐由碱金属阳离子和有机羧酸的阴离子形成,和(ii)有机羧酸在施加的反应条件下至少部分挥发。 优选的碱金属盐是碱金属甲酸盐和碱金属乙酸盐。