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1. 发明申请

US20100129424A9 Contact drug delivery system 有权
标题翻译：接触药物输送系统
公开(公告)号：US20100129424A9
公开(公告)日：2010-05-27
申请号：US11346770
申请日：2006-02-03
申请人： Mark Byrne , Siddarth Venkatesh
发明人： Mark Byrne , Siddarth Venkatesh
IPC分类号： A61F2/00
CPC分类号： A61L27/54 , A61K9/0051 , A61L27/52 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/452 , A61L2300/602 , B29K2105/0035 , B29L2011/0041 , G02B1/043
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having coamplexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶是使用生物模板形成的，该生物模板是药物，或者在结构上与药物相似的官能化单体，优选具有取样位点，和使用合适的引发剂共聚的交联单体。形成的识别聚合物水凝胶的络合位点优选模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来递送药物的隐形眼镜。

2. 发明申请

US20060177483A1 Contact drug delivery system 有权
标题翻译：接触药物输送系统
公开(公告)号：US20060177483A1
公开(公告)日：2006-08-10
申请号：US11346770
申请日：2006-02-03
申请人： Mark Byrne , Siddarth Venkatesh
发明人： Mark Byrne , Siddarth Venkatesh
IPC分类号： A61F2/00
CPC分类号： A61L27/54 , A61K9/0051 , A61L27/52 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/452 , A61L2300/602 , B29K2105/0035 , B29L2011/0041 , G02B1/043
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having coamplexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶是使用生物模板形成的，该生物模板是药物，或者在结构上类似于药物，功能化单体，优选具有取样位点，以及使用合适的引发剂共聚的交联单体。形成的识别聚合物水凝胶的络合位点优选模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来递送药物的隐形眼镜。

3. 发明授权

US09238003B2 Extended or continuous wear silicone hydrogel contact lenses for the extended release of comfort molecules 有权
标题翻译：延长或连续穿硅胶水凝胶隐形眼镜，以延长舒适分子的释放
公开(公告)号：US09238003B2
公开(公告)日：2016-01-19
申请号：US13765495
申请日：2013-02-12
申请人： Mark E. Byrne , Siddarth Venkatesh , Charles White , Maryam Ali
发明人： Mark E. Byrne , Siddarth Venkatesh , Charles White , Maryam Ali
IPC分类号： A61K9/00 , A61L27/52 , A61L27/54 , B29K105/00 , B29L11/00 , G02B1/04
CPC分类号： A61K9/0051 , A61L27/52 , A61L27/54 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/452 , A61L2300/602 , B29K2105/0035 , B29L2011/0041 , G02B1/043 , C08L101/14
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed by using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the invention is a contact lens for delivering a drug through contact with an eye.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶通过使用生物模板来形成，所述生物模板是药物，或者与药物结构相似，优选具有络合位点的官能化单体和使用合适的引发剂共聚的交联单体。形成的识别聚合物水凝胶的络合位点优选模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来输送药物的隐形眼镜。

4. 发明申请

US20120087971A1 CONTACT DRUG DELIVERY SYSTEM 有权
标题翻译：联系药物递送系统
公开(公告)号：US20120087971A1
公开(公告)日：2012-04-12
申请号：US13328836
申请日：2011-12-16
申请人： Mark E. Byrne , Siddarth Venkatesh
发明人： Mark E. Byrne , Siddarth Venkatesh
IPC分类号： A61K9/00 , A61P27/14 , A61P27/02 , A61K38/18 , A61K31/4523
CPC分类号： A61L27/54 , A61K9/0051 , A61L27/52 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/452 , A61L2300/602 , B29K2105/0035 , B29L2011/0041 , G02B1/043
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed by using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶通过使用生物模板来形成，所述生物模板是药物，或者与药物结构相似，优选具有络合位点的官能化单体和使用合适的引发剂共聚的交联单体。形成的识别聚合物水凝胶的络合位点优选模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来递送药物的隐形眼镜。

5. 发明授权

US08349351B2 Contact drug delivery system 有权
标题翻译：接触药物输送系统
公开(公告)号：US08349351B2
公开(公告)日：2013-01-08
申请号：US11346770
申请日：2006-02-03
申请人： Mark E. Byrne , Siddarth Venkatesh
发明人： Mark E. Byrne , Siddarth Venkatesh
IPC分类号： A61K9/00
CPC分类号： A61L27/54 , A61K9/0051 , A61L27/52 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/452 , A61L2300/602 , B29K2105/0035 , B29L2011/0041 , G02B1/043
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶是使用生物模板形成的，该生物模板是药物，或者在结构上类似于药物，优选具有络合位点的官能化单体和使用合适的引发剂共聚的交联单体。形成的识别聚合物水凝胶的络合位点优选模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来递送药物的隐形眼镜。

6. 发明申请

US20080124378A1 Therapeutic contact lenses with anti-fungal delivery 有权
标题翻译：具有抗真菌传递的治疗性隐形眼镜
公开(公告)号：US20080124378A1
公开(公告)日：2008-05-29
申请号：US11985262
申请日：2007-11-13
申请人： Mark E. Byrne , Allison Collins , Asa D. Vaughan , Siddarth Venkatesh
发明人： Mark E. Byrne , Allison Collins , Asa D. Vaughan , Siddarth Venkatesh
IPC分类号： A61K9/00
CPC分类号： A61K9/0051
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimic receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. A system in accordance with an embodiment of the invention is a contact lens for delivering a drug through contact with an eye. In a particular embodiment of the invention, the drug is an anti-microbial, such as an anti-fungal agent for treatment of large animals, such as horses.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶是使用生物模板形成的，该生物模板是药物，或者在结构上类似于药物，优选具有络合位点的官能化单体和使用合适的引发剂共聚的交联单体。形成的识别性聚合物水凝胶的络合位点优选地模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来输送药物的隐形眼镜。在本发明的一个具体实施方案中，该药物是抗微生物剂，例如用于治疗大型动物如马的抗真菌剂。

7. 发明授权

US08404271B2 Contact drug delivery system 有权
标题翻译：接触药物输送系统
公开(公告)号：US08404271B2
公开(公告)日：2013-03-26
申请号：US13328836
申请日：2011-12-16
申请人： Mark E. Byrne , Siddarth Venkatesh
发明人： Mark E. Byrne , Siddarth Venkatesh
IPC分类号： A61K9/00
CPC分类号： A61L27/54 , A61K9/0051 , A61L27/52 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/426 , A61L2300/452 , A61L2300/602 , B29K2105/0035 , B29L2011/0041 , G02B1/043
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed by using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimics receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. The system in accordance with an embodiment of the intention is a contact lens for delivering a drug through contact with an eye.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶通过使用生物模板来形成，所述生物模板是药物，或者与药物结构相似，优选具有络合位点的官能化单体和使用合适的引发剂共聚的交联单体。形成的识别聚合物水凝胶的络合位点优选模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来递送药物的隐形眼镜。

8. 发明授权

US08349352B2 Therapeutic contact lenses with anti-fungal delivery 有权
标题翻译：具有抗真菌传递的治疗性隐形眼镜
公开(公告)号：US08349352B2
公开(公告)日：2013-01-08
申请号：US11985262
申请日：2007-11-13
申请人： Mark E. Byrne , Allison Collins , Asa D. Vaughan , Siddarth Venkatesh
发明人： Mark E. Byrne , Allison Collins , Asa D. Vaughan , Siddarth Venkatesh
IPC分类号： A61K9/00
CPC分类号： A61K9/0051
摘要： A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed preferably mimic receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. A system in accordance with an embodiment of the invention is a contact lens for delivering a drug through contact with an eye. In a particular embodiment of the invention, the drug is an anti-microbial, such as an anti-fungal agent for treatment of large animals, such as horses.
摘要翻译：公开了一种药物递送系统。药物递送系统包括识别性聚合物水凝胶，药物通过其接触生物组织而被递送。识别性聚合物水凝胶是使用生物模板形成的，该生物模板是药物，或者在结构上类似于药物，优选具有络合位点的官能化单体和使用合适的引发剂共聚的交联单体。形成的识别性聚合物水凝胶的络合位点优选地模拟靶生物组织的受体位点，生物识别或生物作用机制。根据本发明的实施例的系统是用于通过与眼睛接触来输送药物的隐形眼镜。在本发明的一个具体实施方案中，该药物是抗微生物剂，例如用于治疗大型动物如马的抗真菌剂。

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