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1. 发明申请

US20090148404A1 COMPOSITIONS AND METHODS FOR ELIMINATING UNDESIRED SUBPOPULATIONS OF T CELLS IN PATIENTS WITH IMMUNOLOGICAL DEFECTS RELATED TO AUTOIMMUNITY AND ORGAN OR HEMATOPOIETIC STEM CELL TRANSPLANTATION 有权
标题翻译：用于消除患有免疫缺陷的T细胞与自身免疫性和有机体或HEMATOPOIETIC干细胞移植相关的免疫缺陷的组合物和方法
公开(公告)号：US20090148404A1
公开(公告)日：2009-06-11
申请号：US12324593
申请日：2008-11-26
申请人： Ronald J. Berenson , Mark Bonyhadi , Dale Kalamasz
发明人： Ronald J. Berenson , Mark Bonyhadi , Dale Kalamasz
IPC分类号： A61K39/395 , C12N5/08 , A61K38/20 , A61P37/00 , A61K35/12
CPC分类号： C12N5/0087 , A61K35/17 , C12N5/0636 , C12N2501/48 , C12N2502/1114 , Y02A50/475
摘要： The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
摘要翻译：本发明一般涉及用于刺激T细胞的方法，更具体地，涉及从T细胞的混合群体中消除T细胞的不希望的（例如，自身反应，同种异体反应，致病）亚群的方法，从而恢复所述T细胞的正常免疫谱 T细胞。本发明还涉及细胞的组合物，包括具有恢复的免疫谱的刺激的T细胞及其用途。

2. 发明申请

US20100092436A1 COMPOSITIONS AND METHODS FOR RESTORING IMMUNE RESPONSIVENESS IN PATIENTS WITH IMMUNOLOGICAL DEFECTS 审中-公开
标题翻译：在免疫缺陷患者中恢复免疫应答的组合物和方法
公开(公告)号：US20100092436A1
公开(公告)日：2010-04-15
申请号：US12556282
申请日：2009-09-09
申请人： Mark Bonyhadi , Ronald J. Berenson
发明人： Mark Bonyhadi , Ronald J. Berenson
IPC分类号： A61K35/12 , A61P35/00 , A61P31/12 , A61P7/06
CPC分类号： C07K16/2818 , A61K2039/5158 , A61K2039/57 , C07K16/2809 , C12N5/0636 , C12N2501/51 , C12N2501/515
摘要： The present invention relates generally to methods for stimulating, activating, and maintaining or increasing the polyclonality of expressed TCRs in a population of T cells. In the various embodiments, cells are stimulated with a surface, wherein the surface has attached thereto one or more agents that ligate a cell surface moiety of at least a portion of the T cells and stimulates at least a portion of the T cells, yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement. Also provided are methods for producing T-cells for the use in diagnostics and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having increased polyclonality produced by these processes are further provided.
摘要翻译：本发明一般涉及用于刺激，激活和维持或增加T细胞群体中表达的TCR的多克隆性的方法。在各种实施方案中，用表面刺激细胞，其中所述表面附着有一种或多种与T细胞的至少一部分的细胞表面部分连接并且刺激至少一部分T细胞的试剂，产生增强的增殖，细胞信号转导和/或细胞表面部分聚集。在某些方面，通过细胞表面部分连接来刺激细胞群体例如T细胞群体的方法通过使细胞群与表面连接，提供一种或多种连接细胞表面部分从而诱导细胞的试剂刺激，细胞表面部分聚集和/或受体信号传导增强。还提供了用于产生用于诊断和治疗各种适应症（包括癌症，病毒感染和免疫相关疾病）的T细胞的方法。还提供了由这些方法产生的具有增加的多克隆性的细胞的组成。

3. 发明授权

US07541184B2 Activation and expansion of cells 有权
标题翻译：细胞的活化和扩增
公开(公告)号：US07541184B2
公开(公告)日：2009-06-02
申请号：US10762210
申请日：2004-01-20
申请人： Ronald J. Berenson , Che Law , Mark Bonyhadi , Narinder Saund , Stewart Craig , Alan Hardwick , Dale Kalamasz , David McMillen , Harjinder Singh Chana
发明人： Ronald J. Berenson , Che Law , Mark Bonyhadi , Narinder Saund , Stewart Craig , Alan Hardwick , Dale Kalamasz , David McMillen , Harjinder Singh Chana
IPC分类号： C12N5/00
CPC分类号： A61L27/3804 , A61K2035/124 , A61K2039/5158 , A61K2039/57 , A61L27/3895 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2821 , C07K16/2827 , C07K16/2833 , C07K16/2845 , C07K16/2854 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K16/289 , C07K16/2896 , C12N5/0635 , C12N5/0636 , C12N5/0647 , C12N2500/32 , C12N2501/23 , C12N2501/51 , C12N2501/515 , C12N2501/53 , C12N2501/59 , C12N2533/12 , C12N2533/14 , C12N2533/18 , C12N2533/30 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/90
摘要： The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embodiments, cells are activated and expanded to very high densities in a short period of time. In certain embodiments, cells are activated and expanded to very high numbers of cells in a short period of time. Compositions of cells activated and expanded by the methods herein are further provided.
摘要翻译：本发明一般涉及用于激活和扩增细胞的方法，更具体地，涉及一种激活和/或刺激细胞的新方法，其使这种细胞的扩增最大化以达到显着高的密度。在各种实施例中，细胞被激活并在短时间内扩展到非常高的密度。在某些实施方案中，细胞在短时间内被激活并扩增至非常高数量的细胞。进一步提供通过本文方法激活和扩增的细胞的组成。

4. 发明授权

US08821945B2 Method for transdermal iontophoretic delivery of chelated agents 有权
标题翻译：螯合剂透皮离子电渗递送方法
公开(公告)号：US08821945B2
公开(公告)日：2014-09-02
申请号：US12459862
申请日：2009-07-07
申请人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
发明人： Mir Imran , Mir Hashim , Sanjay Patel , Ronald J. Berenson
IPC分类号： A01N59/16 , A01N59/26 , A61N1/30
CPC分类号： A61K41/0047 , A61K9/0009 , A61K9/703 , A61K9/7084 , A61K33/26 , A61K33/42 , A61K41/00 , A61N1/0496 , A61N1/30 , A61N1/325
摘要： Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
摘要翻译：实施方案提供用于经皮递送螯合化合物的装置，系统和方法。一个实施方案提供了用于治疗贫血的螯合铁络合物的离子电渗疗法透皮递送的方法。将包含活性电极和螯合铁络合物的第一贴片施加到皮肤上; 还应用了包含电极的第二贴片。然后从活性电极将电流输送到皮肤。螯合络合物通过电流从电流传递穿过皮肤，铁在运输过程中与皮肤基本上不发生色素反应，因此由于不溶性氧化产物的形成，皮肤几乎或没有纹身。然后通过吞噬作用或相关过程解离复合物以释放铁，其中它可被转铁蛋白或铁蛋白结合并携带到其它部位用于储存或代谢使用。

5. 发明申请

US20110033946A1 DETECTION OF SHORT-CHAIN FATTY ACIDS IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：检测生物样品中短链脂肪酸
公开(公告)号：US20110033946A1
公开(公告)日：2011-02-10
申请号：US12834720
申请日：2010-07-12
申请人： Ronald J. Berenson , Patrick Bobbitt , Zhongping Lin
发明人： Ronald J. Berenson , Patrick Bobbitt , Zhongping Lin
IPC分类号： G01N33/50
CPC分类号： G01N30/88 , G01N2030/8822 , Y10T436/201666
摘要： Described herein is a method of detecting and/or quantifying analytes, such as short-chain fatty acids. Analysis for the presence and/or quantity of the small molecule can be performed on a biological sample from a subject. In some embodiments, a liquid chromatography/mass spectrometry (LC-MS/MS) instrumentation is combined with a solid-phase extraction (SPE). Methods of derivatization can also be incorporated with LC-MS/MS and SPE instrumentation to detect and quantify target analytes. In addition to derivation, methods of reconstituting derivatized molecules can also be incorporated with LC-MS/MS and SPE instrumentation to detect and quantify target analytes.
摘要翻译：本文描述了检测和/或定量分析物的方法，例如短链脂肪酸。可以对来自受试者的生物样品进行小分子的存在和/或数量的分析。在一些实施方案中，将液相色谱/质谱（LC-MS / MS）仪器与固相萃取（SPE）组合。衍生化方法也可以与LC-MS / MS和SPE仪器结合，以检测和定量目标分析物。除了衍生之外，重组衍生化分子的方法也可以与LC-MS / MS和SPE仪器结合，以检测和定量目标分析物。

6. 发明申请

US20100130910A1 Patches and method for the transdermal delivery of a therapeutically effective amount of iron 有权
标题翻译：用于透皮递送治疗有效量的铁的补片和方法
公开(公告)号：US20100130910A1
公开(公告)日：2010-05-27
申请号：US12459183
申请日：2009-06-25
申请人： Ronald J. Berenson
发明人： Ronald J. Berenson
IPC分类号： A61N1/30
CPC分类号： A61K9/703 , A61K9/0009 , A61K9/0021 , A61K9/7023 , A61K31/295 , A61K33/26 , A61K38/1816 , A61K45/06 , A61N1/0444 , A61N1/0448 , A61N1/303 , A61K2300/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.
摘要翻译：本发明的实施方案提供了将含铁组合物透皮递送给患有铁缺乏症的个体的补片。许多实施方案提供用于透皮递送治疗有效量的铁的离子电渗贴剂。贴剂包括电极和含有用于递送治疗有效量的铁的包含离子铁的组合物的储存器。各种实施方案提供使用离子电渗贴剂的实施方案的方法，用于将治疗有效量的铁递送至患有一种更多形式的铁缺乏症（包括缺铁性贫血）的个体。这些方法可用于治疗和/或预防缺铁。输送铁的量可以根据各种治疗参数（如患者体重，铁缺乏的类型和量）进行调整。

7. 发明授权

US5378624A Methods for removing ligands from a particle surface 失效
标题翻译：从颗粒表面去除配体的方法
公开(公告)号：US5378624A
公开(公告)日：1995-01-03
申请号：US513056
申请日：1990-04-23
申请人： Ronald J. Berenson , Dale R. Peterson
发明人： Ronald J. Berenson , Dale R. Peterson
IPC分类号： C12P21/08 , C12Q1/24 , G01N33/50 , G01N33/53 , G01N33/538 , G01N33/569 , C12N1/02 , C12N5/08 , C12N7/02
CPC分类号： G01N33/5005 , C12Q1/24 , G01N33/538 , G01N33/569 , Y10S436/824 , Y10S436/828
摘要： A method is provided for removing a second ligand from a particle surface without substantially affecting the particle surface, comprising the step of exposing the particle to a first ligand immobilized onto a support, wherein the particle is exposed under conditions and for a residence time sufficient to allow the second ligand to desorb from the particle surface, and wherein the first ligand has an affinity for the second ligand that is at least two orders of magnitude greater than the affinity of the second ligand for the particle surface, such that the second ligand is removed from the particle surface without substantially affecting the particle surface.
摘要翻译：提供了一种用于从颗粒表面除去第二配体而不显着影响颗粒表面的方法，包括将颗粒暴露于固定在载体上的第一配体的步骤，其中所述颗粒在条件下暴露并且停留时间足以允许第二配体从颗粒表面解吸，并且其中第一配体对第二配体具有比第二配体对于颗粒表面的亲和力大至少两个数量级的亲和力，使得第二配体为从颗粒表面去除而基本上不影响颗粒表面。

8. 发明授权

US5262334A Method for immunoselection of cells using avidin and biotin 失效
公开(公告)号：US5262334A
公开(公告)日：1993-11-16
申请号：US769529
申请日：1991-10-03
申请人： Ronald J. Berenson , William I. Bensinger
发明人： Ronald J. Berenson , William I. Bensinger
IPC分类号： A61M1/36 , C12N13/00 , A61K35/14 , C12N5/00 , G01N33/530
CPC分类号： A61M1/3687 , A61M1/3693
摘要： The selectivity of immunoselection systems employing insolubilized avidin and biotinylated specific antibody is amplified, and nonspecific recovery is improved, by employing an indirect sandwich technique using a biotin-conjugated antispecies immunoglobulin that is directed to one or more nonbiotinylated specific antibodies in conjunction with insolubilized avidin. Specific cell populations can be removed and recovered from bone marrow, providing excellent recovery of bone marrow and preservation of hematopoietic stem cells for transplantation. Mixed populations of T cells or of tumor cells can be conveniently and simultaneously removed with minimal manipulation of the marrow cells. An improved positive immunoselection method provides viable and functional recovered cells, e.g., hematopoietic stem cells or activated killer cells, that can be clinically employed.

9. 发明申请

US20210252256A1 MICROSTRUCTURES TO ATTACH APPLIANCES TO TISSUES 有权
公开(公告)号：US20210252256A1
公开(公告)日：2021-08-19
申请号：US17180217
申请日：2021-02-19
申请人： Ronald J. Berenson , Cheuk Yin Paul Leung , Nick Rogerson
发明人： Ronald J. Berenson , Cheuk Yin Paul Leung , Nick Rogerson
IPC分类号： A61M25/02 , A61B5/145 , A61B5/00 , A61B5/257 , A61B5/28 , A61B5/291 , A61F13/00 , A61F13/02
摘要： An attachment device used to attach appliances to tissue can incorporate microstructures. A medical device system can comprise a coupling device comprising a base layer, a coupling attached to an air side of the base layer, a microstructure attached to a skin side of the base layer and a patient interaction feature, and an appliance comprising a structure mounted to the coupling to interface with the patient interaction feature. An appliance device comprises a base layer, an appliance structure attached to an air side of the base layer, and a microstructure attached to a skin side of the base layer. An appliance attachment system comprises an appliance, a first component comprising an adhesive backing containing microstructures that are configured to attach to skin, and a second component configured to attach the appliance to the first component.

10. 发明申请

US20100130912A1 Patches and methods for the transdermal delivery of a therapeutically effective amount of iron 有权
标题翻译：用于透皮递送治疗有效量的铁的补片和方法
公开(公告)号：US20100130912A1
公开(公告)日：2010-05-27
申请号：US12459186
申请日：2009-06-25
申请人： Ronald J. Berenson
发明人： Ronald J. Berenson
IPC分类号： A61N1/30
CPC分类号： A61K9/703 , A61K9/0009 , A61K9/0021 , A61K9/7023 , A61K31/295 , A61K33/26 , A61K38/1816 , A61K45/06 , A61N1/0444 , A61N1/0448 , A61N1/303 , A61K2300/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of iron-containing compositions to an individual suffering from an iron deficiency. Many embodiments provide an iontophoretic patch for the transdermal delivery of a therapeutically effective amount of iron. The patch comprises an electrode and a reservoir containing a composition comprising ionic iron for the delivery of the therapeutically effective amount of iron. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a therapeutically effective amount of iron to an individual suffering from one more forms of iron deficiency including iron deficiency anemia. Such methods can be used for treating and/or preventing the iron deficiency. The amount of delivered iron can be adjusted depending upon various treatment parameters such as patient weight and type and amount of iron deficiency.
摘要翻译：本发明的实施方案提供了将含铁组合物透皮递送给患有铁缺乏症的个体的补片。许多实施方案提供用于透皮递送治疗有效量的铁的离子电渗贴剂。贴剂包括电极和含有用于递送治疗有效量的铁的包含离子铁的组合物的储存器。各种实施方案提供使用离子电渗贴剂的实施方案的方法，用于将治疗有效量的铁递送至患有一种更多形式的铁缺乏症（包括缺铁性贫血）的个体。这些方法可用于治疗和/或预防缺铁。输送铁的量可以根据各种治疗参数（如患者体重，铁缺乏的类型和量）进行调整。

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