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1. 发明授权

US06572543B1 Sensor, method of sensor implant and system for treatment of respiratory disorders 有权
公开(公告)号：US06572543B1
公开(公告)日：2003-06-03
申请号：US09589002
申请日：2000-06-06
申请人： Mark A. Christopherson , John L. Sommer , Johann J. Neisz
发明人： Mark A. Christopherson , John L. Sommer , Johann J. Neisz
IPC分类号： A61B500
CPC分类号： A61B5/03 , A61B5/7207 , A61N1/3601
摘要： An implantable sensing device includes a sensing element and a mounting element. The mounting element has a first end and a second end with a longitudinal axis therethrough. The sensing element is positioned at the first end of the mounting element with the mounting element having a length that is adjustable along the longitudinal axis. The mounting element includes a sleeve having a first open end and a second open end with the longitudinal axis therethrough. The sensing element is positioned in the second open end and includes a lead body connected thereto extending through the second open end. The sleeve includes an outer sleeve member coupled for adjustment along the longitudinal axis with respect to an inner sleeve member. Further, the mounting element may include a flexible element about the first open end extending outwardly relative to the longitudinal axis and a flange element extending outwardly relative to the longitudinal axis from at least a portion of the second end. The device can be implanted in a bone with the flange element and the flexible element for direct or indirect contact with the anterior and posterior surface of the bone. A method of implanting the sensor includes providing a sensing element and drilling a hole in a bone. The hole extends to the intrathoracic cavity. The sensing element is inserted into the hole and positioned in communication with a region in the intrathoracic cavity. The hole is drilled in the manubrium. When the flexible element is inserted into the hole, the flexible element about the first open end collapses towards the longitudinal axis and when the sensor mounting assembly is removed from the hole, the flexible element collapses towards the longitudinal axis during removal. Methods for providing stimulation of a patient to treat respiratory disorders using the sensor are also provided as are stimulation systems for providing stimulation of a patient to treat respiratory disorders.

2. 发明授权

US6099479A Method and apparatus for operating therapy system 失效
标题翻译：手术治疗系统的方法和装置
公开(公告)号：US6099479A
公开(公告)日：2000-08-08
申请号：US683808
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz
发明人： Mark A. Christopherson , Johann J. Neisz
IPC分类号： A61N1/378 , A61F9/007 , A61N1/08 , A61N1/36 , A61B5/08
CPC分类号： A61N1/3601
摘要： A method for operating an implantable therapy system to conserve energy includes providing an implantable sensing device that generates a signal as a function of a physiological parameter of a patient during a treatment period. The signal is monitored during at least portions of the treatment period to detect a physiological event for use in controlling therapy of the patient during the treatment period. Energy consumption by the sensing device is terminated during the treatment period for at least portions of the treatment period when signal monitoring is not performed. Another method for operating an implantable therapy system for conserving energy includes providing an implantable component for performance of a function during a treatment period for the therapy system. The implantable component is operable in at least a first state during the treatment period and a second state outside of the treatment period; the first state using more energy than the second state. The implantable component is operated in the first state when performance of the function during a treatment period is required and operated in the second state when performance of the function is not required outside the treatment period. Another method of operating an implantable therapy system includes monitoring a periodic physiological parameter for controlling therapy of a patient during a treatment period. The measured physiological period for the parameter of the patient is compared to at least one predetermined period threshold to determine nonperiodic behavior of the monitored periodic physiological parameter and suspending therapy of the patient as a function thereof. Systems for use with such methods are also provided.
摘要翻译：用于操作可植入治疗系统以节省能量的方法包括提供可植入感测装置，其在治疗期间产生作为患者生理参数的函数的信号。在治疗周期的至少部分期间监测信号以检测在治疗期间用于控制患者治疗的生理事件。在不执行信号监视的情况下，处理期间的至少部分处理期间，感测装置的能量消耗被终止。用于操作用于节省能量的可植入治疗系统的另一种方法包括提供用于治疗系统的治疗周期期间执行功能的可植入组件。可植入部件在治疗期间至少处于第一状态，处于治疗期以外的第二状态; 第一个状态比第二个状态使用更多的能量。当处理期间的功能的执行需要并且在第二状态下操作时，可植入部件在第一状态下操作，当在治疗周期之外不需要执行功能时。操作可植入治疗系统的另一种方法包括监测周期性生理参数，用于在治疗期间控制患者的治疗。将测量的患者参数的生理期与至少一个预定周期阈值进行比较，以确定所监视的周期性生理参数的非周期性行为以及作为其功能的患者的暂停治疗。还提供了与这种方法一起使用的系统。

3. 发明授权

US5944680A Respiratory effort detection method and apparatus 失效
标题翻译：呼吸力检测方法和装置
公开(公告)号：US5944680A
公开(公告)日：1999-08-31
申请号：US674494
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz , John Hammargren
发明人： Mark A. Christopherson , Johann J. Neisz , John Hammargren
IPC分类号： A61B5/08 , A61B5/03 , A61B5/07 , A61B5/113 , A61N1/36 , A61B19/00 , A61N1/08 , A61N1/10 , A61N1/18
CPC分类号： A61B5/03 , A61B5/07 , A61B5/113 , A61N1/3601
摘要： A method of predicting critical points in patient respiration includes monitoring at least one characteristic of a respiratory effort waveform of a patient to detect a respiratory event. A refractory period is defined that includes a hard refractory period during which time the respiratory event cannot be responded to and a soft refractory period following the hard refractory period. The respiratory event outside of the refractory period is detected as a function of a first set of predetermined parameters for the monitored at least one characteristic and the respiratory event within the soft refractory period is detected as a function of a second set of predetermined parameters for the monitored at least one characteristic. The respiratory event may be inspiration onset and the characteristic of the respiratory effort waveform monitored is at least one of slope and amplitude. The refractory period may be defined based on detection of inspiration offset and further may be defined based on inspiration offset, an average respiratory period, and an average time of inspiration. Further, stimulation may be provided in response to a detected inspiration onset. Another method of predicting critical points includes sampling the amplitude of the respiratory effort waveform of a patient. A sample signal is generated representative of at least one characteristic of the respiratory effort waveform based on each amplitude sample. The sample signals representative of the at least one characteristic of the respiratory effort waveform are monitored and a respiratory event is detected as a function of at least two sample signals. Apparatus and systems for use with such methods are also described.
摘要翻译：预测患者呼吸中的关键点的方法包括监测患者的呼吸努力波形的至少一个特征以检测呼吸事件。定义了不应期，其包括难治性期间，在此期间呼吸事件不能应对，并且在难治性难治期之后的软不应期。根据所监测的至少一个特征的第一组预定参数来检测不应期的外部呼吸事件，并且根据第二组预定参数检测软不应期内的呼吸事件的功能。监控至少一个特征。呼吸事件可以是启发开始，并且所监测的呼吸努力波形的特征是斜率和幅度中的至少一个。可以基于吸气偏移的检测来定义不应期，并且可以基于吸气偏移，平均呼吸周期和平均呼吸时间来定义不应期。此外，可以响应于检测到的吸气开始来提供刺激。预测关键点的另一种方法包括对患者的呼吸努力波形的振幅进行采样。基于每个振幅样本产生代表呼吸努力波形的至少一个特性的采样信号。监测表示呼吸努力波形的至少一个特征的样本信号，并且根据至少两个采样信号检测呼吸事件。还描述了与这种方法一起使用的装置和系统。

4. 发明授权

US5895360A Gain control for a periodic signal and method regarding same 失效
标题翻译：增益控制周期信号和方法相关
公开(公告)号：US5895360A
公开(公告)日：1999-04-20
申请号：US673718
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz
发明人： Mark A. Christopherson , Johann J. Neisz
IPC分类号： A61B5/08 , A61N1/36 , A61N1/37 , A61B5/02
CPC分类号： A61N1/3601 , A61N1/3704
摘要： A gain control method for providing a gain controlled signal representative of a periodic physiological parameter of a patient includes providing a signal characteristic of the periodic physiological parameter. The periodic physiological parameter includes a plurality of periodic cycles. Gain of the signal is updated only once per periodic cycle following detection of a periodic event. The updating is performed by monitoring an amplitude of the signal between detection of periodic events and comparing the amplitude to a gain control amplitude threshold. Gain of the signal is updated as a function of the comparison. Further, gain is updated following expiration of a predetermined period of time if a periodic event is not detected within the predetermined period of time. The physiological parameter may be respiratory effort. An apparatus for providing such gain control is also provided.
摘要翻译：用于提供表示患者的周期性生理参数的增益控制信号的增益控制方法包括提供周期性生理参数的特征信号。周期性生理参数包括多个周期周期。在检测到周期性事件之后，每周期周期，信号的增益只会更新一次。通过监视周期性事件的检测之间的信号的幅度并将幅度与增益控制幅度阈值进行比较来执行更新。作为比较的函数更新信号的增益。此外，如果在预定时间段内没有检测到周期性事件，则在预定时间段期满之后更新增益。生理参数可能是呼吸力。还提供了一种用于提供这种增益控制的装置。

5. 发明授权

US6132384A Sensor, method of sensor implant and system for treatment of respiratory disorders 失效
公开(公告)号：US6132384A
公开(公告)日：2000-10-17
申请号：US673246
申请日：1996-06-26
申请人： Mark A. Christopherson , John L. Sommer , Johann J. Neisz
发明人： Mark A. Christopherson , John L. Sommer , Johann J. Neisz
IPC分类号： A61B5/00 , A61B5/03 , A61B5/08 , A61B5/097 , A61N1/36
CPC分类号： A61B5/03 , A61N1/3601 , A61B5/7207
摘要： An implantable sensing device includes a sensing element and a mounting element. The mounting element has a first end and a second end with a longitudinal axis therethrough. The sensing element is positioned at the first end of the mounting element with the mounting element having a length that is adjustable along the longitudinal axis. The mounting element includes a sleeve having a first open end and a second open end with the longitudinal axis therethrough. The sensing element is positioned in the second open end and includes a lead body connected thereto extending through the second open end. The sleeve includes an outer sleeve member coupled for adjustment along the longitudinal axis with respect to an inner sleeve member. Further, the mounting element may include a flexible element about the first open end extending outwardly relative to the longitudinal axis and a flange element extending outwardly relative to the longitudinal axis from at least a portion of the second end. The device can be implanted in a bone with the flange element and the flexible element for direct or indirect contact with the anterior and posterior surface of the bone. A method of implanting the sensor includes providing a sensing element and drilling a hole in a bone. The hole extends to the intrathoracic cavity. The sensing element is inserted into the hole and positioned in communication with a region in the intrathoracic cavity. The hole is drilled in the manubrium. When the flexible element is inserted into the hole, the flexible element about the first open end collapses towards the longitudinal axis and when the sensor mounting assembly is removed from the hole, the flexible element collapses towards the longitudinal axis during removal. Methods for providing stimulation of a patient to treat respiratory disorders using the sensor are also provided as are stimulation systems for providing stimulation of a patient to treat respiratory disorders.

6. 发明授权

US6021352A Diagnostic testing methods and apparatus for implantable therapy devices 失效
标题翻译：用于植入式治疗装置的诊断测试方法和装置
公开(公告)号：US6021352A
公开(公告)日：2000-02-01
申请号：US673717
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz , Shahram Malek , Todd Goblish
发明人： Mark A. Christopherson , Johann J. Neisz , Shahram Malek , Todd Goblish
IPC分类号： A61B5/08 , A61N1/08 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37211 , A61N1/08 , A61N1/3601 , A61N1/37247
摘要： A testing method for use with a patient stimulation system includes providing a stimulation system including a patient control unit. The patient control unit initiates and terminates treatment periods. At least one period of stimulation to stimulate the patient is automatically provided upon initiating a treatment period. Another method includes a system test method for use with a therapy system. The method includes providing a therapy system having a plurality of components; the therapy system physiologically interacting with a patient. A diagnostic self test of a component of the therapy system is performed internally to the system to determine if the component is functioning properly at a time when the therapy system is not interacting physiologically with the patient. Apparatus for using such methods are also provided.
摘要翻译：用于患者刺激系统的测试方法包括提供包括患者控制单元的刺激系统。患者控制单元启动并终止治疗期。在开始治疗期间，自动提供刺激患者的至少一个刺激周期。另一种方法包括与治疗系统一起使用的系统测试方法。该方法包括提供具有多个部件的治疗系统; 治疗系统在生理上与患者相互作用。在治疗系统的部件的诊断自我测试在系统内部执行以确定组件是否在治疗系统与患者生理上没有相互作用的时候正常工作。还提供了使用这种方法的装置。

7. 发明授权

US08475357B2 Sling delivery system and method of use 有权
公开(公告)号：US08475357B2
公开(公告)日：2013-07-02
申请号：US12984422
申请日：2011-01-04
申请人： David R. Staskin , Johann J. Neisz , John W. Westrum, Jr. , Gary A. Rocheleau , Kimberly A. Anderson , Eva S. Snitkin
发明人： David R. Staskin , Johann J. Neisz , John W. Westrum, Jr. , Gary A. Rocheleau , Kimberly A. Anderson , Eva S. Snitkin
IPC分类号： A61F2/02
CPC分类号： A61B17/3468 , A61B17/04 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06004 , A61B17/06066 , A61B17/06109 , A61B17/30 , A61B17/3211 , A61B17/42 , A61B50/30 , A61B90/02 , A61B2017/0046 , A61B2017/00805 , A61B2017/0454 , A61B2017/06009 , A61B2017/06014 , A61B2017/06042 , A61B2017/06085 , A61B2017/320044 , A61F2/0045
摘要： An apparatus and method of use are disclosed to treat urological disorders. The biocompatible device includes a handle, needle, dilator and sling assembly configured to be minimally invasive and provide sufficient support to the target site. In addition, the configuration of the sling assembly also allows the sling to be adjusted during and/or after implantation. The device and treatment procedure are highly effective and produce little to no side effects or complications. Further, operative risks, pain, infections and post operative stays are reduced, thereby improving patient quality of life.

8. 发明授权

US08088131B2 Surgical suture passers and methods 有权
标题翻译：手术缝合路人及方法
公开(公告)号：US08088131B2
公开(公告)日：2012-01-03
申请号：US12586571
申请日：2009-09-24
申请人： Brian P. Watschke , Robert E. Lund , S. Robert Kovac , John W. Westrum, Jr. , Johann J. Neisz , Timothy A. Bachman , Gary A. Rocheleau , Robert S. Runman
发明人： Brian P. Watschke , Robert E. Lund , S. Robert Kovac , John W. Westrum, Jr. , Johann J. Neisz , Timothy A. Bachman , Gary A. Rocheleau , Robert S. Runman
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/0482 , A61B17/0483 , A61B17/12013
摘要： A surgical instrument for suturing soft tissue is disclosed. The surgical instrument is capable of probing tissue, and preferably provides tactile feedback concerning the condition of the tissue. The instrument can then be used to pass and retrieve a suture without the need for an additional suture retrieval tool.
摘要翻译：公开了一种用于缝合软组织的手术器械。手术器械能够探测组织，并且优选提供关于组织状况的触觉反馈。然后可以使用该仪器来传递和检索缝合线，而不需要额外的缝合线取出工具。

9. 发明授权

US07867161B2 Sling delivery system and method of use 有权
标题翻译：运送系统及使用方法
公开(公告)号：US07867161B2
公开(公告)日：2011-01-11
申请号：US11203136
申请日：2005-08-15
申请人： David R. Staskin , Johann J. Neisz , John W. Westrum, Jr. , Gary R. Rocheleau , Kimberly A. Anderson , Eva S. Snitkin
发明人： David R. Staskin , Johann J. Neisz , John W. Westrum, Jr. , Gary R. Rocheleau , Kimberly A. Anderson , Eva S. Snitkin
IPC分类号： A61F2/02
CPC分类号： A61B17/3468 , A61B17/04 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06004 , A61B17/06066 , A61B17/06109 , A61B17/30 , A61B17/3211 , A61B17/42 , A61B50/30 , A61B90/02 , A61B2017/0046 , A61B2017/00805 , A61B2017/0454 , A61B2017/06009 , A61B2017/06014 , A61B2017/06042 , A61B2017/06085 , A61B2017/320044 , A61F2/0045
摘要： An apparatus and method of use are disclosed to treat urological disorders. The biocompatible device includes a handle, needle, dilator and sling assembly configured to be minimally invasive and provide sufficient support to the target site. In addition, the configuration of the sling assembly also allows the sling to be adjusted during and/or after implantation. The device and treatment procedure are highly effective and produce little to no side effects or complications. Further, operative risks, pain, infections and post operative stays are reduced, thereby improving patient quality of life.
摘要翻译：公开了一种用于治疗泌尿系统疾病的装置和方法。生物相容性装置包括手柄，针，扩张器和吊带组件，其构造为微创并且向目标部位提供足够的支撑。此外，吊索组件的构造还允许在植入期间和/或之后调整吊索。该装置和治疗方法非常有效，并且几乎不产生副作用或并发症。此外，手术风险，疼痛，感染和术后停留减少，从而改善患者的生活质量。

10. 发明授权

US07267645B2 Surgical instrument and method 有权
标题翻译：手术器械及方法
公开(公告)号：US07267645B2
公开(公告)日：2007-09-11
申请号：US10616926
申请日：2003-07-11
申请人： Kimberly A. Anderson , Johann J. Neisz , Gary A. Rocheleau , John W. Westrum, Jr. , David R. Staskin
发明人： Kimberly A. Anderson , Johann J. Neisz , Gary A. Rocheleau , John W. Westrum, Jr. , David R. Staskin
IPC分类号： A61F2/02
CPC分类号： A61B17/0482 , A61B17/04 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06004 , A61B17/06066 , A61B17/06109 , A61B17/30 , A61B17/3211 , A61B17/42 , A61B50/30 , A61B90/02 , A61B2017/0046 , A61B2017/00805 , A61B2017/06009 , A61B2017/06014 , A61B2017/06042 , A61B2017/06085 , A61F2/0045
摘要： An apparatus and method of use are disclosed to treat urological disorders. The invention is a repositionable handle for an arcuate needle configured to be minimally invasive. The invention is for use with a sling assembly that allows a sling to be controllably implanted in a therapeutically effective position. The device and treatment procedure are highly effective and produce little to no side effects or complications. Further, operative risks, pain, infections and post operative stays are reduced.
摘要翻译：公开了一种用于治疗泌尿系统疾病的装置和方法。本发明是用于弓形针的可重新定位的手柄，其被配置为微创。本发明用于吊索组件，其允许吊带被可控地植入治疗有效位置。该装置和治疗方法非常有效，并且几乎不产生副作用或并发症。此外，手术风险，疼痛，感染和术后停留减少。

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