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1. 发明授权

US06796978B2 Medical laser therapy device 有权
标题翻译：医疗激光治疗仪
公开(公告)号：US06796978B2
公开(公告)日：2004-09-28
申请号：US10043465
申请日：2002-01-10
申请人： Mario Gerlach , Martin Wiechmann , Olaf Kittelmann , Diegeo Zimare , Michael Kempe , Dirk Muehlhoff , Alexander Kalies
发明人： Mario Gerlach , Martin Wiechmann , Olaf Kittelmann , Diegeo Zimare , Michael Kempe , Dirk Muehlhoff , Alexander Kalies
IPC分类号： A62B1820
CPC分类号： A61F9/009 , A61B90/30 , A61F9/008 , A61F2009/00855 , A61N5/062
摘要： A medical laser therapy device, particularly for use in ophthalmology and surgery, comprises a controllable pump module with a coupling element for a waveguide, a beam control device in the form of a waveguide for supplying the pumping radiation delivered by the pump module to the applicator which is provided with a coupling element for the waveguide for introducing a target beam and/or treatment beam into the eye to be treated. The device is primarily characterized in that the pump module has laser diodes whose electromagnetic pumping radiation is in the spectral range from 800 nm to 815 nm, and in that an optics module is provided which couples the pumping radiation into the waveguide, in that the beam control device is an Nd-doped waveguide laser with a double core or single core and a suitable reflecting coating of the fiber end faces, the waveguide forming a laser cavity with radiation in a frequency range between 1050 nm and 1070 nm, in that the applicator is a laser slit lamp with zoom system having a device for frequency doubling which preferably comprises nonlinear optical material or periodically poled nonlinear optical material, in that the applicator has a device for power monitoring and a device for illuminating and observing the operating field, and in that the applicator has a target beam device whose radiation is coupled collinearly into the beam path for the therapy radiation by a suitable beamsplitter. The medical therapy device is constructed in a modular manner.
摘要翻译：特别是用于眼科和手术的医疗激光治疗装置包括具有用于波导的耦合元件的可控泵模块，波导形式的束控制装置，用于将由泵模块输送的泵浦辐射提供给施加器其设置有用于波导的耦合元件，用于将目标束和/或治疗束引入待治疗的眼睛。该装置的主要特征在于，泵模块具有激光二极管，其电磁泵浦辐射在800nm至815nm的光谱范围内，并且提供将泵浦辐射耦合到波导中的光学模块，控制装置是具有双芯或单芯的Nd掺杂波导激光器和光纤端面的合适的反射涂层，波导形成在1050nm和1070nm之间的频率范围内的辐射的激光腔，因为施加器是具有变倍系统的激光裂隙灯，其具有用于倍频的装置，其优选地包括非线性光学材料或周期性极化的非线性光学材料，因为施加器具有用于功率监测的装置和用于照明和观察操作场的装置施加器具有目标射束装置，其辐射线通过合适的节点共线地耦合到用于治疗辐射的射束路径中 msplitter。医疗设备以模块化的方式构造。

2. 发明授权

US06872202B2 Laser slit lamp with laser radiation source 有权
标题翻译：激光裂隙灯带激光辐射源
公开(公告)号：US06872202B2
公开(公告)日：2005-03-29
申请号：US10043463
申请日：2002-01-10
申请人： Mario Gerlach , Martin Wiechmann , Olaf Kittelmann , Diego Zimare , Michael Kempe , Dirk Muehlhoff , Alexander Kalies
发明人： Mario Gerlach , Martin Wiechmann , Olaf Kittelmann , Diego Zimare , Michael Kempe , Dirk Muehlhoff , Alexander Kalies
IPC分类号： A61B18/20 , A61B3/135 , A61F9/007 , A61F9/008 , G02B21/06 , A61B18/18
CPC分类号： G02B21/06 , A61B3/135 , A61F9/008 , A61F9/00821 , A61F9/009 , A61F2009/00863 , A61F2009/00891
摘要： A laser slit lamp comprising a slit lamp base, a slit lamp head and a slit lamp microscope. The laser slit lamp is connected with an applicator. It comprises a device for uniting radiation from at least two radiation sources collinearly and for directing the radiation of a treatment beam or working beam onto the location to be treated in or on the eye of a patient, a device for generating a target beam or marking beam for targeting and observing the location to be treated in or on the eye, and an adjusting device in the applicator for changing the intensity and diameter of the working beam spot used for treatment. The radiation sources are laser radiation sources arranged in the slit lamp head, in the slit lamp base or in the slit lamp microscope for generating the working beam, illumination beam and/or target beam. Devices for control, regulation and monitoring are likewise arranged in the interior of the slit lamp.
摘要翻译：一种激光裂隙灯，包括狭缝灯座，裂隙灯头和裂隙灯显微镜。激光裂隙灯与施加器连接。它包括用于将来自至少两个辐射源的辐射并联并用于将治疗光束或工作光束的辐射引导到患者眼中或眼睛上待处理的位置的装置，用于产生目标光束或标记用于瞄准和观察在眼睛中或眼睛上待处理的位置的光束，以及用于改变用于治疗的作用光束斑点的强度和直径的施加器中的调节装置。辐射源是布置在裂隙灯头，裂隙灯底座或狭缝灯显微镜中用于产生工作光束，照明光束和/或目标光束的激光辐射源。用于控制，调节和监视的装置同样设置在裂隙灯的内部。

3. 发明申请

US20060106371A1 Device and method for meansuring an optical penetration in a tissue 有权
标题翻译：用于在组织中进行光学穿透的装置和方法
公开(公告)号：US20060106371A1
公开(公告)日：2006-05-18
申请号：US10525424
申请日：2003-08-22
申请人： Dirk Muhlhoff , Michael Kempe , Markus Strehle , Mario Gerlach , Markus Sticker , Mark Bischoff
发明人： Dirk Muhlhoff , Michael Kempe , Markus Strehle , Mario Gerlach , Markus Sticker , Mark Bischoff
IPC分类号： A61F9/008 , A61B18/18
CPC分类号： A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/00814 , A61F9/00825 , A61F9/00827 , A61F9/0084 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00872 , A61F2009/00874
摘要： The invention relates to a device for measuring an optical penetration that is triggered in a tissue underneath the tissue surface by means of therapeutic laser radiation which a laser-surgical device concentrates in a treatment focus located in said tissue. The inventive device is provided with a detection beam path comprising a lens system which couples radiation emanating from the tissue underneath the tissue surface into the detection beam path. A detector device generating a detection signal which indicates the spatial dimension and/or position of the optical penetration in the issue is arranged downstream of the detection beam path.
摘要翻译：本发明涉及一种用于测量通过治疗激光辐射在组织表面下方的组织中触发的光学穿透的装置，激光手术装置集中在位于所述组织中的治疗焦点。本发明的装置设置有检测光束路径，该检测光束路径包括将从组织表面下方的组织发出的辐射耦合到检测光束路径中的透镜系统。产生检测信号的检测器装置被布置在检测光束路径的下游，该检测信号指示在问题中的光学穿透的空间维度和/或位置。

4. 发明授权

US08808279B2 Device and method for measuring an optical break-through in a tissue 有权
标题翻译：用于测量组织中光学穿透的装置和方法
公开(公告)号：US08808279B2
公开(公告)日：2014-08-19
申请号：US10525424
申请日：2003-08-22
申请人： Dirk Mühlhoff , Michael Kempe , Markus Strehle , Mario Gerlach , Markus Sticker , Mark Bischoff , Dick Manfred , Michael Bergt
发明人： Dirk Mühlhoff , Michael Kempe , Markus Strehle , Mario Gerlach , Markus Sticker , Mark Bischoff , Dick Manfred , Michael Bergt
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/00814 , A61F9/00825 , A61F9/00827 , A61F9/0084 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00872 , A61F2009/00874
摘要： The invention relates to a device for measuring an optical penetration that is triggered in a tissue underneath the tissue surface by means of therapeutic laser radiation which a laser-surgical device concentrates in a treatment focus located in said tissue. The inventive device is provided with a detection beam path comprising a lens system which couples radiation emanating from the tissue underneath the tissue surface into the detection beam path. A detector device generating a detection signal which indicates the spatial dimension and/or position of the optical penetration in the issue is arranged downstream of the detection beam path.
摘要翻译：本发明涉及一种用于测量通过治疗激光辐射在组织表面下方的组织中触发的光学穿透的装置，激光手术装置集中在位于所述组织中的治疗焦点。本发明的装置设置有检测光束路径，该检测光束路径包括将从组织表面下方的组织发出的辐射耦合到检测光束路径中的透镜系统。产生检测信号的检测器装置被布置在检测光束路径的下游，该检测信号指示在问题中的光学穿透的空间维度和/或位置。

5. 发明申请

US20110176206A1 Microscope Having an Adjustment Device for the Focus Range 有权
标题翻译：具有调焦装置的显微镜用于对焦范围
公开(公告)号：US20110176206A1
公开(公告)日：2011-07-21
申请号：US13121886
申请日：2009-09-22
申请人： Ralf Wolleschensky , Michael Kempe
发明人： Ralf Wolleschensky , Michael Kempe
IPC分类号： G02B21/00
CPC分类号： G02B21/006 , G02B21/0068 , G02B21/241 , G02B2207/114
摘要： A microscope with means for adjusting the focal range, comprising a first objective lens for transmitting the object light of an illuminated object in the direction of a detector, with a second objective lens being disposed in the direction of the light upstream of the detector, which second objective lens is followed by a first mirror that can be adjusted in the direction of the optical axis, with at least one second mirror for transmitting light from the first objective lens in the direction of the second objective lens and from the second objective lens to the detector being disposed in the optical path, which second mirror is a fully reflective mirror, or a microscope with means for adjusting the focal range, comprising a first objective lens for transmitting the object light of an illuminated object in the direction of a detector, with a second objective lens being disposed in the direction of light upstream of the detector, which second objective lens is followed by a first mirror that can be adjusted in the direction of the optical axis, with a polarizing beam splitter for splitting the object light into two components that are oriented perpendicular to each other being disposed between the first and the second objective lens for light transmission.
摘要翻译：一种具有用于调节焦距范围的装置的显微镜，包括用于在检测器的方向上传送被照射物体的物体的第一物镜，其中第二物镜沿检测器上游的光的方向设置，第二物镜之后是可以在光轴方向上调节的第一反射镜，具有至少一个第二反射镜，用于在第二物镜的方向上从第一物镜透射光并从第二物镜传播光所述检测器设置在所述光路中，所述第二反射镜是完全反射镜，或具有用于调节所述焦距的装置的显微镜，所述显微镜包括用于沿检测器的方向透射被照射物体的物体的第一物镜，其中第二物镜沿着检测器上游的光的方向设置，该第二物镜后面是第一镜像 r可以在光轴的方向上调整，其中偏振分束器用于将物体光分成两个彼此垂直取向的分量，这两个分量被布置在第一和第二物镜之间用于透光。

6. 发明授权

US07605976B1 Method and device for changing light in an adjustable manner 有权
标题翻译：用于以可调节的方式改变光的方法和装置
公开(公告)号：US07605976B1
公开(公告)日：2009-10-20
申请号：US11416455
申请日：2006-05-03
申请人： Ralf Wolleschensky , Michael Kempe , Peter Klopfleisch
发明人： Ralf Wolleschensky , Michael Kempe , Peter Klopfleisch
IPC分类号： G02B21/06
CPC分类号： G01J3/4406 , G01J3/02 , G01J3/021 , G01J3/0224 , G01J3/0229 , G01J3/14 , G01N21/21 , G01N21/6445 , G01N21/6458 , G01N2021/6417 , G02B21/0068 , G02B21/0076 , G02B26/0816 , G02B27/143 , G02B27/283
摘要： Method and device for changing the illumination light and/or specimen light with respect to its spectral composition and/or intensity in an adjustable manner, wherein a spatial separation into the radiation components of different polarization is carried out with the first polarization means (Pol 1), a spectral spatial splitting of at least one radiation component is carried out with the first dispersion means (Disp1), and the polarization state of at least one part of the spectrally spatially split radiation component is changed, wherein a reflection of the illumination light and/or the detection light is carried out.
摘要翻译：用于以可调节的方式改变照明光和/或样本光的方法和装置，其中利用第一偏振装置（Pol 1）执行不同偏振的辐射分量的空间分离），利用第一色散装置（Disp1）执行至少一个辐射分量的光谱空间分裂，并且改变光谱空间分裂的辐射分量的至少一部分的偏振状态，其中照明光的反射和/或检测光。

7. 发明申请

US20090250632A1 Method and Arrangement for Collimated Microscopic Imaging 审中-公开
标题翻译：准直显微镜成像的方法和布置
公开(公告)号：US20090250632A1
公开(公告)日：2009-10-08
申请号：US12444290
申请日：2007-10-02
申请人： Michael Kempe , Gerhard Krampert , Matthias Wald , Ralf Wolleschensky
发明人： Michael Kempe , Gerhard Krampert , Matthias Wald , Ralf Wolleschensky
IPC分类号： G01N21/64
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/0032 , G02B21/0072 , G02B21/0076
摘要： A method and arrangement for collimated microscopic imaging, including a first illumination of a sample in at least one region for exciting fluorescence, and a spatially resolving detection of the sample light by detector elements, the detection being associated with the region, wherein by means of a second illumination a sub-division of the region into separate fluorescent partial regions occurs, which are associated with the detector elements. The separation of the partial regions is carried out by the spatial separation of the fluorescent regions by means of intermediate regions having reduced fluorescence or no fluorescence, and/or by means of different spectral properties of the fluorescence from the partial regions.
摘要翻译：一种用于准直显微镜成像的方法和装置，包括用于激发荧光的至少一个区域中的样品的第一照明，以及由检测器元件对样品光进行空间分辨检测，所述检测与所述区域相关联，其中通过发生与检测器元件相关联的区域的分割成分离的荧光部分区域的第二照明。部分区域的分离是通过荧光区域通过具有减少的荧光或无荧光的中间区域和/或通过来自部分区域的荧光的不同光谱性质的空间分离来进行的。

8. 发明授权

US07333213B2 Confocal microscopy 失效
标题翻译：共焦显微镜
公开(公告)号：US07333213B2
公开(公告)日：2008-02-19
申请号：US10103927
申请日：2002-03-22
申请人： Michael Kempe
发明人： Michael Kempe
IPC分类号： G01B9/02
CPC分类号： G02B21/0064 , G02B21/0056 , G02B21/008
摘要： An improved confocal microscope system is provided which images sections of tissue utilizing heterodyne detection. The system has a synthesized light source for producing a single beam of light of multiple, different wavelengths using multiple laser sources. The beam from the synthesized light source is split into an imaging beam and a reference beam. The phase of the reference beam is then modulated, while confocal optics scan and focus the imaging beam below the surface of the tissue and collect from the tissue returned light of the imaging beam. The returned light of the imaging beam and the modulated reference beam are combined into a return beam, such that they spatially overlap and interact to produce heterodyne components. The return beam is detected by a photodetector which converts the amplitude of the return beam into electrical signals in accordance with the heterodyne components. The signals are demodulated and processed to produce an image of the tissue section on a display. The system enables the numerical aperture of the confocal optics to be reduced without degrading the performance of the system.
摘要翻译：提供了一种改进的共焦显微镜系统，其利用外差检测对组织的部分进行成像。该系统具有使用多个激光源产生多个不同波长的单光束的合成光源。来自合成光源的光束被分成成像光束和参考光束。然后对参考光束的相位进行调制，而共焦光学器件扫描并将成像光束聚焦在组织表面下方并从成像光束的组织返回光中收集。成像光束和调制参考光束的返回光被组合成返回光束，使得它们在空间上重叠并相互作用以产生外差分量。返回光束由光电检测器检测，光电检测器根据外差分量将返回光束的幅度转换成电信号。信号被解调和处理以在显示器上产生组织部分的图像。该系统可以减少共焦光学元件的数值孔径，而不会降低系统的性能。

9. 发明申请

US20080007730A1 Microscope with higher resolution and method for increasing same 有权
标题翻译：显微镜具有更高的分辨率和增加方法
公开(公告)号：US20080007730A1
公开(公告)日：2008-01-10
申请号：US11806459
申请日：2007-05-31
申请人： Michael Kempe
发明人： Michael Kempe
IPC分类号： G01J3/30
CPC分类号： G02B21/0056 , G02B21/0076
摘要： Microscope with higher resolution with partial spatial superposition in the illumination by an excitation beam and a de-excitation beam and/or a switching beam in a fluorescing sample, whereby the light from the sample is deflected, whereby, in the excitation beam and/or in the de-excitation and/or the switching beam, at least one combination of devices exercising circular and radial influence on the spatial phase is provided.
摘要翻译：具有较高分辨率的显微镜，其中通过荧光样品中的激发光束和去激发光束和/或切换光束在照明中具有部分空间叠加，由此来自样品的光被偏转，由此在激发光束和/或在去激励和/或切换光束中，提供对空间相位进行圆周和径向影响的装置的至少一个组合。

10. 发明申请

US20050244589A1 POLYMERS FOR ORIENTATION AND STABILITY OF LIQUID CRYSTALS 失效
标题翻译：聚合物用于液晶的定向和稳定性
公开(公告)号：US20050244589A1
公开(公告)日：2005-11-03
申请号：US10993575
申请日：2004-11-19
申请人： Julia Kornfield , Michael Kempe
发明人： Julia Kornfield , Michael Kempe
IPC分类号： G02F1/1334 , C09K19/02 , C09K19/38 , C09K19/54 , C09K19/56 , G02F1/1337 , G02F1/137 , C09K19/52 , G02F1/1333
CPC分类号： C09K19/542 , G02F1/133703 , G02F2001/13775 , Y10T428/10 , Y10T428/1036
摘要： An electro-optically active polymer gel material comprising a high molecular weight alignment polymer adapted to be homogeneously dispersed throughout a liquid crystal to control the alignment of the liquid crystal molecules and/or confer mechanical stability is provided. The electro-optically active polymer gel comprises a homogenous gel in which the polymer strands of the gel are provided in low concentration and are well solvated by the small molecule liquid crystal without producing unacceptable slowing of its electrooptic response. During formation of the gel, a desired orientation is locked into the gel by physical or chemical cross-linking of the polymer chains. The electro-optically active polymer is then utilized to direct the orientation in the liquid crystal gel in the “field off” state of a liquid crystal display. The electro-optically active polymer also provides a memory of the mesostructural arrangement of the liquid crystal and acts to suppress the formation of large scale deviations, such as, for example, fan-type defects in a FLC when subjected to a mechanical shock. A method of making an electro-optically active polymer gel material and an electrooptic device utilizing the electro-optically active polymer gel of the present invention is also provided.
摘要翻译：提供一种电光活性聚合物凝胶材料，其包含适于均匀分散在液晶中以控制液晶分子取向和/或赋予机械稳定性的高分子量对准聚合物。电光活性聚合物凝胶包含均匀的凝胶，其中凝胶的聚合物链以低浓度提供并且被小分子液晶很好地溶剂化，而不会导致其电光响应的不可接受的减慢。在形成凝胶期间，通过聚合物链的物理或化学交联将期望的取向锁定在凝胶中。然后使用电光活性聚合物将液晶凝胶中的取向引导到液晶显示器的“截止”状态。电光活性聚合物还提供液晶的介观结构布置的记忆，并且用于抑制大尺度偏差的形成，例如当受到机械冲击时FLC中的扇形缺陷。还提供了制造电光活性聚合物凝胶材料的方法和利用本发明的电光活性聚合物凝胶的电光装置。

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