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    • 3. 发明授权
    • System and method for expansion of a computer
    • 用于扩展计算机的系统和方法
    • US5889976A
    • 1999-03-30
    • US737201
    • 1997-01-24
    • Paul CharlesWalter C. Peschke
    • Paul CharlesWalter C. Peschke
    • G06F13/24G06F1/16G06F13/36G06F13/38G06F13/40G06F13/42
    • G06F1/1632G06F13/385G06F13/4027G06F13/409
    • A system and method for interfacing at least one ISA and/or PCI compliant device with a PCMCIA compliant device socket (124) on a host computer (122) is disclosed. Preferably included in the system are structures to carry out the functions of; interrupt translation between the PCMCIA port and the ISA devices; direct memory access translation between the PCMCIA port and the ISA devices; translation of bus address latch enable signal between the PCMCIA port and the ISA devices; translation between memory read and memory write signal of the PCMCIA port and a system memory read signal and a system memory write signal of the ISA devices: translation between the PCMCIA port and 8 bit ISA devices; providing a clock signal to the ISA devices; supplying power to the ISA devices; and translation of the timing between the PCMCIA port and the ISA devices.
    • PCT No.PCT / US96 / 03248 Sec。 371日期1997年1月24日 102(e)日期1997年1月24日PCT 1996年3月7日PCT公布。 出版物WO96 / 27836 日期1996年9月12日公开了一种用于将至少一个ISA和/或PCI兼容设备与主计算机(122)上的与PCMCIA兼容的设备插座(124)进行接口的系统和方法。 包括在系统中的结构是具有以下功能的结构: PCMCIA端口和ISA设备之间的中断转换; 在PCMCIA端口和ISA设备之间直接存储器访问转换; 在PCMCIA端口和ISA设备之间转换总线地址锁存使能信号; PCMCIA端口的存储器读取和写入信号与ISA设备的系统存储器读取信号和系统存储器写入信号之间的转换:PCMCIA端口和8位ISA器件之间的转换; 向ISA设备提供时钟信号; 向ISA设备供电; 以及PCMCIA端口和ISA设备之间的时序转换。
    • 5. 再颁专利
    • System and method for expansion of a computer
    • 用于扩展计算机的系统和方法
    • USRE39052E1
    • 2006-03-28
    • US10107938
    • 1996-03-07
    • Paul CharlesWalter C. Peschke
    • Paul CharlesWalter C. Peschke
    • G06F13/00
    • G06F13/409G06F1/1632G06F13/385G06F13/4027
    • A system and method for interfacing at least one ISA and/or PCI compliant device with a PCMCIA compliant socket on a host computer is disclosed. The system is particularly useful to allow ISA and/or PCI compliant devices, which could not otherwise be used with a portable computer having a PCMCIA socket, to be used with such computers. The system can provide complete compatibility between a PCMCIA socket and ISA/PCI compliant devices even though such industry standards include contradictory requirements. The system allows a user to easily connect and disconnect numerous ISA and/or PCI compliant devices via a single PCMCIA socket commonly found on portable computers. Preferably included in the system are structures to carry out the functions of: interrupt translation between the PCMCIA port and the ISA devices; direct memory access translation between the PCMCIA port and the ISA devices; translation of a buss address latch enable signal between the PCMCIA port and the ISA devices; translation between a memory read signal and a memory write signal of the PCMCIA port and a system memory read signal and a system memory write signal of the ISA devices; translation between the PCMCIA port and 8 bit ISA devices; DRAM refresh of the ISA devices; providing a clock signal to the ISA devices; supplying power to the ISA devices; and, translation of the timing between the PCMCIA port and the ISA devices.
    • 公开了一种用于将至少一个ISA和/或PCI兼容设备与主计算机上的与PCMCIA兼容插座接口的系统和方法。 该系统特别有用的是允许ISA和/或PCI兼容的设备(其不能与具有PCMCIA插座的便携式计算机一起使用)与这种计算机一起使用。 该系统可以提供PCMCIA插槽和ISA / PCI兼容设备之间的完全兼容性,即使这些行业标准包括矛盾的要求。 该系统允许用户通过便携式计算机上通常发现的单个PCMCIA插座轻松连接和断开多个ISA和/或PCI兼容设备。 <?delete-start id =“DEL-S-00001”date =“20060328”?>系统中最好包括执行以下功能的结构:PCMCIA端口和ISA设备之间的中断转换; 在PCMCIA端口和ISA设备之间直接存储器访问转换; PCMCIA端口和ISA设备之间的总线地址锁存使能信号的转换; PCMCIA端口的存储器读取信号和存储器写入信号与ISA设备的系统存储器读取信号和系统存储器写入信号之间的转换; PCMCIA端口和8位ISA设备之间的转换; DRAM刷新的ISA设备; 向ISA设备提供时钟信号; 向ISA设备供电; 以及PCMCIA端口和ISA设备之间的定时转换。<?delete-end id =“DEL-S-00001”?>
    • 7. 再颁专利
    • System and method for expansion of a computer
    • 用于扩展计算机的系统和方法
    • USRE44628E1
    • 2013-12-03
    • US11369504
    • 2006-03-07
    • Paul CharlesWalter M. Peschke
    • Paul CharlesWalter M. Peschke
    • G06F13/00
    • A system and method for interfacing at least one ISA and/or PCI compliant device with a PCMCIA compliant socket on a host computer is disclosed. The system is particularly useful to allow ISA and/or PCI compliant devices, which could not otherwise be used with a portable computer having a PCMCIA socket, to be used with such computers. The system can provide complete compatibility between a PCMCIA socket and ISA /PCI compliant devices even though such industry standards include contradictory requirements. The system allows a user to easily connect and disconnect numerous ISA and/or PCI compliant devices via a single PCMCIA socket commonly found on portable computers. Preferably included in the system are structures to carry out the functions of: interrupt translation between the PCMCIA port and the ISA devices; direct memory access translation between the PCMCIA port and the ISA devices; translation of a buss address latch enable signal between the PCMCIA port and the ISA devices; translation between a memory read signal and a memory write signal of the PCMCIA port and a system memory read signal and a system memory write signal of the ISA devices; translation between the PCMCIA port and 8 bit ISA devices; DRAM refresh of the ISA devices; providing a clock signal to the ISA devices; supplying power to the ISA devices; and, translation of the timing between the PCMCIA port and the ISA devices.
    • 公开了一种用于将至少一个ISA和/或PCI兼容设备与主计算机上的与PCMCIA兼容插座接口的系统和方法。 该系统特别有用的是允许ISA和/或PCI兼容的设备(其不能与具有PCMCIA插座的便携式计算机一起使用)与这种计算机一起使用。 该系统可以提供PCMCIA插槽和ISA / PCI兼容设备之间的完全兼容性,即使这些行业标准包括矛盾的要求。 该系统允许用户通过便携式计算机上通常发现的单个PCMCIA插座轻松连接和断开多个ISA和/或PCI兼容设备。 包括在系统中的结构是执行以下功能的结构:PCMCIA端口和ISA设备之间的中断转换; 在PCMCIA端口和ISA设备之间直接存储器访问转换; PCMCIA端口和ISA设备之间的总线地址锁存使能信号的转换; PCMCIA端口的存储器读取信号和存储器写入信号与ISA设备的系统存储器读取信号和系统存储器写入信号之间的转换; PCMCIA端口和8位ISA设备之间的转换; DRAM刷新的ISA设备; 向ISA设备提供时钟信号; 向ISA设备供电; 以及PCMCIA端口和ISA设备之间的时序转换。
    • 8. 发明申请
    • Immobilization of oligonucleotides and proteins in sugar-containing hydrogels
    • 寡糖和蛋白质在含糖水凝胶中的固定
    • US20050019884A1
    • 2005-01-27
    • US10627143
    • 2003-07-25
    • Mark SpectorDavid StengerCharles PattersonBrett MartinPaul Charles
    • Mark SpectorDavid StengerCharles PattersonBrett MartinPaul Charles
    • A61K9/00C07H1/00C07H15/00C08J3/00C12M1/34C12N11/00C12Q20060101C12Q1/00C12Q1/68G01N33/543G01N33/548
    • G01N33/548G01N33/54353
    • We describe the novel use of a sugar-containing hydrogels as very highly porous, aqueous support material for the immobilization of oligonucleotides, peptides, proteins, antigens, antibodies, polysaccharides, and other biomolecules for sensor applications. The unusually large sizes of the interconnected pores allow large target molecules to pass rapidly into and through the gel and bind to immobilized biomolecules. An additional advantage of the sugar-containing hydrogels are their extremely low non-specific absorption of labeled target molecules, providing low background levels. State-of-the-art hydrogel materials do not have this type of homogeneous interconnected macroporosity, thus large target molecules cannot readily diffuse through them. In addition, they nearly always experience non-specific (background) absorption of labeled target molecules, limiting their usefulness in sensor applications. This invention provides a method for preparing a sugar polyacrylate hydrogel with functional chemical groups which covalently bond oligonucleotides and peptides. A method for copolymerizing acrylate-terminated oligonucleotides with sugar acrylate monomers and diacrylate cross-linking agents is also provided.
    • 我们描述了含糖水凝胶作为用于固定寡核苷酸,肽,蛋白质,抗原,抗体,多糖和其他用于传感器应用的生物分子的非常高度多孔的水性载体材料的新用途。 互连孔的异常大尺寸允许大的目标分子快速通过并穿过凝胶并结合固定的生物分子。 含糖水凝胶的另外的优点是它们非常低的标记靶分子的非特异性吸收,提供低的背景水平。 最先进的水凝胶材料不具有这种类型的均匀相互连接的大孔隙度,因此大的靶分子不能容易地通过它们扩散。 此外,它们几乎总是经历非特异性(背景)吸收标记的靶分子,限制了它们在传感器应用中的用途。 本发明提供了制备具有共价键合寡核苷酸和肽的功能化学基团的糖聚丙烯酸酯水凝胶的方法。 还提供了将丙烯酸酯封端的寡核苷酸与糖丙酯单体和二丙烯酸酯交联剂共聚的方法。