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1. 发明授权

US4556563A Synergistic antiphlogistic compositions and methods of use 失效
标题翻译：协同消炎药组合物和使用方法
公开(公告)号：US4556563A
公开(公告)日：1985-12-03
申请号：US474750
申请日：1983-03-10
申请人： Marianna Pongor nee Csakvari , Gabor Nagy , Gabor Horvath , Maria David nee Kenez , Sandor Bozsoky , Sandor Virag , Katalin Marmarosi nee Kellner
发明人： Marianna Pongor nee Csakvari , Gabor Nagy , Gabor Horvath , Maria David nee Kenez , Sandor Bozsoky , Sandor Virag , Katalin Marmarosi nee Kellner
IPC分类号： A61K31/40 , A61K31/505 , A61P29/00 , A61K31/60
CPC分类号： A61K31/505 , Y10S514/96 , Y10S514/966
摘要： The invention relates to synergistic antiphlogistic pharmaceutical compositions comprising a pyrido [1,2-a]-pyrimidine derivative of the Formula I ##STR1## wherein R.sup.1 and R.sup.2 are lower alkyl and R.sup.3 stands for lower alkoxycarbonyl or carbamoyl and the dotted line represents an optionally hydrogenated band or a salt or quaternary salt thereof and 1-[p-chloro-benzoly]-2-methyl-5-methoxy-indolyl-3-acetic acid of the Formula II ##STR2## The advantage of the compositions is that as a result of the synergistic activity of the compound of the Formula I, the antiphlogistic Indomethacin of the Formula II can be administered in a significantly lower doses and consequently the unfavorable side effects of the latter compound are mitigated.
摘要翻译：本发明涉及包含式I的吡啶并[1,2-a] - 嘧啶衍生物（I）的协同消炎药物组合物，其中R1和R2是低级烷基，R3代表低级烷氧基羰基或氨基甲酰基，虚线代表任选氢化的带或其盐或季盐和式II的1- [对氯 - 苯并[2-氯苯基] -2-甲基-5-甲氧基 - 吲哚基-3-乙酸。（II）组合物是由于式I化合物的协同作用的结果，可以以显着较低的剂量施用式II的消炎药吲哚美辛，从而减轻后一种化合物的不良副作用。

2. 发明授权

US4840949A Oxadiazole-alkyl-purine derivatives useful as antitussive agents 失效
标题翻译：用作镇咳剂的恶二唑 - 烷基嘌呤衍生物
公开(公告)号：US4840949A
公开(公告)日：1989-06-20
申请号：US107693
申请日：1987-10-09
申请人： Dezso Korbonits , Emil Minker , Zoltan Vargai , Gergely Heja , Gabor Kovacs , Agnes Gottsegen , Sandor Antus , Sandor Virag , Andrea Bolehovszky , Jeno Marton , Katalin Marmarosi nee Kellner , Lorand Debreczeni , Laszlo Tardos , Peter Kormoczy , Vera Gergely , Gabor Horvath
发明人： Dezso Korbonits , Emil Minker , Zoltan Vargai , Gergely Heja , Gabor Kovacs , Agnes Gottsegen , Sandor Antus , Sandor Virag , Andrea Bolehovszky , Jeno Marton , Katalin Marmarosi nee Kellner , Lorand Debreczeni , Laszlo Tardos , Peter Kormoczy , Vera Gergely , Gabor Horvath
IPC分类号： C07D473/04 , A61K31/52 , A61K31/522 , A61P11/04 , A61P11/14 , C07D271/06 , C07D273/02 , C07D473/06
CPC分类号： C07D473/06
摘要： The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene andR.sup.1 represents C.sub.1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C.sub.5-6 cycloalkyl or aminoalkyl of the Formula --(CH.sub.2).sub.n --NR.sup.2 R.sup.3 in which group n is an integer 1-3; R.sup.2 and R.sup.3 each stand for hydrogen or C.sub.1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; orR.sup.1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzylThe compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.
摘要翻译：本发明涉及式I的新型氧化噻唑烷基嘌呤衍生物及其药学上可接受的盐，其中A代表C1-4亚烷基，R1代表C1-6烷基，羟基烷基，卤代烷基，羧基烷基，C5-6环烷基或其中基团n为整数1-3的式 - （CH 2）n -NR 2 R 3的氨基烷基; R 2和R 3各自代表氢或C 1-4烷基或与它们相连的相邻氮原子一起形成5-或6-元含氮杂环，其可以任选地包含另外的氮原子或氧原子作为杂原子; 或R 1代表苯基，羟基苯基，羧基苯基，苄基或二甲氧基苄基。式I化合物可以通过本身已知的方法制备，并且可用于作为止咳剂的治疗。

3. 发明授权

US4670440A Medicinal norfloxacin salts 失效
标题翻译：药用诺氟沙星盐
公开(公告)号：US4670440A
公开(公告)日：1987-06-02
申请号：US854395
申请日：1986-04-21
申请人： Tamas Szuts , Peter Szentmiklosi , Jozsef Lengyel , Istvan Hermecz , Lelle Vasvari nee Debreczy , Agnes Horvath , Geza Kerszturi , Gabor Kovacs , Gabor Horvath , Katalin Marmarosi nee Kellner
发明人： Tamas Szuts , Peter Szentmiklosi , Jozsef Lengyel , Istvan Hermecz , Lelle Vasvari nee Debreczy , Agnes Horvath , Geza Kerszturi , Gabor Kovacs , Gabor Horvath , Katalin Marmarosi nee Kellner
IPC分类号： A23K1/16 , A61K31/4709 , A61K31/495 , A61K31/496 , A61P31/04 , C07C67/00 , C07C213/00 , C07C215/40 , C07D215/56 , C07D401/10 , C07D401/04
CPC分类号： C07D215/56
摘要： N,N,N-trimethyl-2-hydroxyethyl-ammonium-[1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-quinolizine-3-carboxylate] of the formula I ##STR1## as a norfloxacin antimicrobial salt capable of enteral administration.
摘要翻译： N，N，N-三甲基-2-羟乙基 - 铵 - [1-乙基-6-氟-4-氧代-7-（1-对异哌嗪基）-1,4-二氢 - 喹嗪-3-羧酸酯] 配方I 作为能够肠内给药的诺氟沙星抗微生物盐。

4. 发明授权

US08299319B2 Plants having improved growth characteristics and a method for making the same 失效
标题翻译：具有改善的生长特性的植物及其制备方法
公开(公告)号：US08299319B2
公开(公告)日：2012-10-30
申请号：US12404741
申请日：2009-03-16
申请人： Gabor Horvath , Sylvie Tarayre , Eva Kondorosi , Valerie Frankard
发明人： Gabor Horvath , Sylvie Tarayre , Eva Kondorosi , Valerie Frankard
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8261 , Y02A40/146
摘要： The present invention concerns a method for improving plant growth characteristics by increasing expression in a plant of a nucleic acid encoding a CCS52 protein and/or by increasing level and/or activity in a plant of a CCS52 protein. The invention also relates to transgenic plants having improved growth characteristics, such as increased plant size, increased organ size or increased number of organs, which plants have increased expression of a nucleic acid encoding a CCS52 protein.
摘要翻译：本发明涉及通过增加植物中编码CCS52蛋白的核酸的表达和/或通过增加CCS52蛋白的植物中的水平和/或活性来改善植物生长特性的方法。本发明还涉及具有改善的生长特征的转基因植物，例如增加的植物大小，增加的器官大小或增加的器官数目，该植物具有增加编码CCS52蛋白的核酸的表达。

5. 发明授权

US5298496A Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same 失效
标题翻译： 3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5298496A
公开(公告)日：1994-03-29
申请号：US793389
申请日：1992-01-02
申请人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
发明人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
IPC分类号： A61K31/41 , A61K31/4245 , A61K31/535 , A61K31/5375 , A61K47/40 , A61K47/48 , A61P9/08 , A61P9/10 , C07D265/28 , C07D271/04 , C07D295/30 , C07D413/04 , C08B37/00 , C08B37/06 , C08B37/16
CPC分类号： C08B37/0015 , C07D271/04 , Y10S514/821 , Y10S514/969
摘要： The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same.The inclusion complex of 3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared bya) reacting the 3-morpholino-sydnonimine or its salt in an aqueous medium with a cyclodextrin derivative and the complex is isolated from the solution by dehydratation, orb) high energy milling of 3-morpholino-sydnonimine or its salt and a cyclodextrin derivative.
摘要翻译： PCT No.PCT / HU91 / 00013 Sec。 371日期1992年1月2日 102（e）日期1992年1月2日PCT 1991年3月28日PCT。本发明涉及3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物。由环糊精衍生物形成的3-吗啉代 - 顺式亚胺或其盐的包合络合物是通过以下步骤制备的：a）使3-吗啉代 - 脱水亚胺或其盐在水性介质中与环糊精衍生物反应，并通过脱水从溶液中分离复合物，或b）3-吗啉代 - 二氢亚胺或其盐和环糊精衍生物的高能研磨。

6. 发明申请

US20120053081A1 TOLL-LIKE RECEPTOR-BASED BIOSENSORS 有权
标题翻译：类似基于受体的生物传感器
公开(公告)号：US20120053081A1
公开(公告)日：2012-03-01
申请号：US13265250
申请日：2010-04-23
申请人： Eicke Latz , Gabor Horvath
发明人： Eicke Latz , Gabor Horvath
IPC分类号： C40B30/04 , G01N33/566 , C12Q1/68 , G01N33/569 , B82Y15/00
CPC分类号： C07K14/705 , G01N33/566 , G01N33/56911
摘要： Compositions and methods for detecting Toll-like receptor binding to ligands and test compounds are disclosed herein.
摘要翻译：本文公开了用于检测Toll样受体结合配体和测试化合物的组合物和方法。

7. 发明授权

US5093359A Primycin components and process for the separation of the antibiotic complex 失效
标题翻译： PRIMYCIN组分和分离抗生素复合物的方法
公开(公告)号：US5093359A
公开(公告)日：1992-03-03
申请号：US400688
申请日：1989-08-30
申请人： Imre Szilagi , Gyula Dekany , Judit Frank , Gabor Horvath , Gabor Kulcsar
发明人： Imre Szilagi , Gyula Dekany , Judit Frank , Gabor Horvath , Gabor Kulcsar
IPC分类号： A61K31/365 , C07D313/00 , C07H17/08 , C12P17/08 , C12P19/62
CPC分类号： A61K31/70 , C07H17/08 , C12P19/62
摘要： The invention relates to the components of primycin antibiotic complex and the salts thereof and to the process for the separation of the individual components by chromatography. A further object of the invention is a synergistic antimicrobial composition containing the said components and a process for the preparation thereof.

8. 发明授权

US5723762A Transgenic plants expressing a prokaryotic ammonium dependent asparagine synthetase 失效
公开(公告)号：US5723762A
公开(公告)日：1998-03-03
申请号：US465526
申请日：1995-06-05
申请人： Denes Dudits , Katalin Paulovics , Katalin Kalman , Janos Gyorgyey , Ferenc Nagy , Laszlo Bako , Gabor Horvath , Peter Eckes , Gunter Donn
发明人： Denes Dudits , Katalin Paulovics , Katalin Kalman , Janos Gyorgyey , Ferenc Nagy , Laszlo Bako , Gabor Horvath , Peter Eckes , Gunter Donn
IPC分类号： A01H5/00 , C12N5/10 , C12N9/00 , C12N15/52 , C12N15/82 , A01H5/10
CPC分类号： C12N9/93 , C12N15/8261 , C12N15/8277
摘要： The gene asnA which encodes a prokaryotic ammonium-specific asparagine synthetase (ASN-A) can be introduced into plant cells. Such transformed cells and plants developed therefrom not only tolerate glutamine synthetase inhibitors but are effectively stimulated by such herbicides.

9. 发明授权

US4796516A Actuator providing guided linear displacement 失效
标题翻译：执行器提供引导线性位移
公开(公告)号：US4796516A
公开(公告)日：1989-01-10
申请号：US944752
申请日：1986-12-22
申请人： Gabor Horvath
发明人： Gabor Horvath
IPC分类号： F15B15/02 , F15B15/08
CPC分类号： F15B15/02 , Y10S92/01
摘要： An improved linear guiding mechanism with a standing part and a moving part which have respective uniform cross sections. A pair of spaced guiding channels is formed between these parts and respective linear ball bearings are arranged in both channels that interconnect the two parts. The channel walls are abutting the balls via steel bars extending along the channels. Preferably the standing part defines a cylinder in which a piston is moved and its shaft is connected to the moving part. The parts are made of light and soft material such as aluminum or plastic and manufactured by extrusion technique. The rather high variation of dimensions of such parts are compensated by means of biasing forces that press the channels together, and the biasing forces are sufficiently high to resist operational load. The length of the ball bearings is at least the half of the maximum stroke.
摘要翻译：一种具有立体部分和移动部分的改进的线性引导机构，其具有相应的均匀横截面。在这些部件之间形成一对间隔开的引导通道，并且在两个通道中布置相应的直线球轴承，这两个通道互连两部分。通道壁通过沿通道延伸的钢筋抵靠球。优选地，竖立部分限定了一个气缸，其中活塞被移动并且其轴连接到移动部件。这些部件由轻质和软质材料制成，如铝或塑料，并通过挤出技术制造。通过将通道压在一起的偏置力补偿这些部件的相当高的尺寸变化，并且偏置力足够高以抵抗操作负载。球轴承的长度至少为最大行程的一半。

10. 发明授权

US09409968B2 Toll-like receptor-based biosensors 有权
标题翻译：基于Toll样受体的生物传感器
公开(公告)号：US09409968B2
公开(公告)日：2016-08-09
申请号：US13265250
申请日：2010-04-23
申请人： Eicke Latz , Gabor Horvath
发明人： Eicke Latz , Gabor Horvath
IPC分类号： G01N33/53 , C07K14/705 , G01N33/566 , G01N33/569 , C07K14/00
CPC分类号： C07K14/705 , G01N33/566 , G01N33/56911
摘要： Compositions and methods for detecting Toll-like receptor binding to ligands and test compounds are disclosed herein.
摘要翻译：本文公开了用于检测Toll样受体结合配体和测试化合物的组合物和方法。

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