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1. 发明授权

US4441216A Tissue heart valve and stent 失效
标题翻译：组织心脏瓣膜和支架
公开(公告)号：US4441216A
公开(公告)日：1984-04-10
申请号：US327081
申请日：1981-12-03
申请人： Marian I. Ionescu , Jay A. Lenker , Robert F. Rosenbluth
发明人： Marian I. Ionescu , Jay A. Lenker , Robert F. Rosenbluth
IPC分类号： A61F2/24 , A61F1/22
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2220/0075 , Y10S623/90
摘要： An improved stent for prosthetic tissue heart valves having upright legs which have radiused upper tips which are approximately one-half the width of prior art stent legs is disclosed. These narrow tipped stent legs reduce stress induced in the leaflets by curvature of the leaflets around the tips of the stent legs in the closed position, extending the service life of the valve. Tabs are added to the tips of the stent legs to add structural strength. These tabs can be tapered or straight but their bottom portions must be narrower than the stent leg. The tabs have a plurality of holes in them through which coaptation stitches are passed. The coaptation stitch can be two separate stitches, one in a first plane and one in a second plane at 90.degree. to the first plane, or, in the preferred embodiment, a single figure eight stitch passing through the holes in the tab in a plane coincident with the long axis of the stent leg.

2. 发明授权

US4388735A Low profile prosthetic xenograft heart valve 失效
标题翻译：低调假体异种移植心脏瓣膜
公开(公告)号：US4388735A
公开(公告)日：1983-06-21
申请号：US203804
申请日：1980-11-03
申请人： Marian I. Ionescu , Jay A. Lenker , Robert F. Rosenbluth , Louis Seiler, Jr.
发明人： Marian I. Ionescu , Jay A. Lenker , Robert F. Rosenbluth , Louis Seiler, Jr.
IPC分类号： A61F2/24 , A61F1/22
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2220/0075 , Y10S623/90
摘要： Prosthetic heart valves comprising an annular, right cylindrical, metal stent covered with fabric to which a glutaraldehyde-stabilized pericardial valving element formed of three leaflets, each having a plateau on a truncated triangle extending higher at the center than at the edges, and formed as a cylinder having a diameter substantially equal to the diameter of the stent, and having a low profile is disclosed.
摘要翻译：假体心脏瓣膜包括用织物覆盖的环形的右圆柱形金属支架，戊二醛稳定的心包瓣元件由三个小叶形成，每个叶片在中心处比在边缘处更高的截顶三角形，并形成为公开了具有基本上等于支架直径的直径并且具有低轮廓的圆柱体。

3. 发明授权

US4629459A Alternate stent covering for tissue valves 失效
标题翻译：替代组织瓣膜支架覆盖
公开(公告)号：US4629459A
公开(公告)日：1986-12-16
申请号：US566133
申请日：1983-12-28
申请人： Marian I. Ionescu , Jay A. Lenker , Philip S. Yang
发明人： Marian I. Ionescu , Jay A. Lenker , Philip S. Yang
IPC分类号： A61F2/24 , A61L27/00
CPC分类号： A61F2/2412 , A61F2220/0075 , Y10S623/90
摘要： A prosthetic heart valve comprising a stent having an annular base and a plurality of legs extending upwardly from said base; a valve element circumscribing said stent and attached thereto, said valving element comprising a number of cooperating valve leaflets equal to the number of said legs; and a layer of biologically-compatible material secured to said stent and positioned between said stent and said leaflets, said layer having a smooth, non-abrasive outer surface and covering all of the surfaces of said stent that, in the absence of said layer, would contact the mobile portions of said leaflets during the normal function of the valve.
摘要翻译：一种假体心脏瓣膜，包括具有环形基部和从所述基部向上延伸的多个腿的支架; 围绕所述支架并附接到其上的阀元件，所述阀元件包括多个等于所述支腿数量的配合的瓣叶; 以及固定到所述支架并定位在所述支架和所述小叶之间的生物相容材料层，所述层具有光滑的非研磨性外表面并且覆盖所述支架的所有表面，所述表面在没有所述层的情况下，将在阀的正常功能期间接触所述传单的移动部分。

4. 发明授权

US5007898A Balloon dilatation catheter 失效
标题翻译：气球扩张导管
公开(公告)号：US5007898A
公开(公告)日：1991-04-16
申请号：US201686
申请日：1988-06-02
申请人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene
发明人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene
IPC分类号： A61M29/02
CPC分类号： A61M29/02 , A61M2025/0004 , A61M2025/1072
摘要： Disclosed is an apparatus and method for the treatment of the symptoms of obstructive prostatism. The apparatus comprises an expandable dilatation catheter and an axially elongate sheath, adapted for transurethral insertion via the external opening of the urethra. The sheath is ellipsoid in cross-section, and provides an initial path through which the catheter and a standard cystoscope lens is guided. Disposed near the proximal end of the expandable dilation portion of the catheter is a plurality of irrigation ports. A saline solution travels through an irrigation conduit and is secreted through the irrigation ports so as to flush away blood, etc., away from the lens of a cystoscope and provides the urologist with an unobstructed view of the dilation catheter and external urethral sphincter muscle. Once the catheter has been properly positioned with respect to both the bladder neck and the sphincter, the dilation balloon may be inflated to force open the affected prostatic urethra and eliminate the obstruction.

5. 发明授权

US5074855A Urinary incontinence pad 失效
标题翻译：尿失禁垫
公开(公告)号：US5074855A
公开(公告)日：1991-12-24
申请号：US639921
申请日：1991-01-10
申请人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene
发明人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene
IPC分类号： A61F2/00 , A61F5/44 , A61F5/48 , A61F13/15
CPC分类号： A61F13/47209 , A61F2/0009 , A61F5/4401 , A61F5/48 , A61F13/82
摘要： A device for controlling urinary incontinence in a human female, comprising a resilient pad, configured to seal against and occlude the urethral meatus of the user. The pad includes a base that is adapted to seat against the vestibule of the user's vulva, anteriorly of the vaginal orifice, thereby covering the urethral meatus. An adhesive is provided on the base to seal against and occlude the urethral meatus, and to retain the pad in place against the vestibule. The pad has lateral edges that fit inside the labia minora of the user, to aid in retention of the device. The surface of the pad opposite the base is formed into a longitudinal stiffening ridge that extends into the interlabial space. A handle is attached to the ridge to facilitate removal.
摘要翻译：一种用于控制人类雌性尿失禁的装置，包括弹性垫，其构造成密封和封闭使用者的尿道口。该垫包括适于抵靠使用者外阴前庭的阴道的阴前口的底座，从而覆盖尿道口。在基部上设置粘合剂以密封和封闭尿道口，并将垫保持在与前庭相对的位置。垫具有适合使用者阴唇内侧的侧边缘，以帮助保持装置。与基座相对的垫的表面形成为延伸到阴唇间空间的纵向加强脊。手柄连接到脊以便于移除。

6. 发明授权

US5030227A Balloon dilation catheter 失效
标题翻译：气球扩张导管
公开(公告)号：US5030227A
公开(公告)日：1991-07-09
申请号：US360088
申请日：1989-06-01
申请人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Barry M. Calvarese
发明人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Barry M. Calvarese
IPC分类号： A61B8/14 , A61B5/04 , A61B5/0488 , A61F2/82 , A61M25/00 , A61M25/10 , A61M29/02
CPC分类号： A61M25/1011 , A61M29/02 , A61M2025/0004 , A61M2025/1072
摘要： Disclosed is an apparatus and method for the treatment of the symptoms of obstructive prostatism. The apparatus comprises an expandable dilation catheter and preferably an axially elongate sheath, adapted for transurethral insertion via the external opening of the urethra. The sheath is ellipsoid in cross-section, and provides an initial path through which the catheter and a standard cystoscope lens is guided. The dilation catheter or the sheath are provided with a non-radiological locating means for positioning the dilation portion of the catheter with respect to an anatomical landmark. Once the catheter has been properly positioned with respect to both the bladder neck and the sphincter, the dilation balloon may be inflated to force open the affected prostatic urethra and eliminate the obstruction.
摘要翻译：公开了一种治疗阻塞性前列腺症症状的装置和方法。该装置包括可膨胀的扩张导管，优选地是轴向细长的护套，适于经由尿道的外部开口经尿道插入。护套是椭圆形的横截面，并且提供了导管和标准的膀胱镜镜片被引导通过的初始路径。扩张导管或护套设置有非放射性定位装置，用于相对于解剖学标记定位导管的扩张部分。一旦导管已经相对于膀胱颈和括约肌适当地定位，则膨胀气球可以被充气以迫使打开受影响的前列腺尿道并消除阻塞。

7. 发明授权

US5336208A Urinary incontinence pad 失效
标题翻译：尿失禁垫
公开(公告)号：US5336208A
公开(公告)日：1994-08-09
申请号：US810845
申请日：1991-12-20
申请人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Rodney A. Brenneman , Patrick A. Maley
发明人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Rodney A. Brenneman , Patrick A. Maley
IPC分类号： A61F2/00 , A61F5/44 , A61F5/455 , A61F5/48 , A61F13/00 , A61F13/15 , A61B5/00 , A61F13/20
CPC分类号： A61F13/47209 , A61F2/0009 , A61F5/4401 , A61F5/48 , A61F13/82
摘要： A device for managing urinary incontinence in a human female includes a resilient body resilient adapted to fit between the labia minora and the floor of the vestibule of the vulva, thereby occluding the urethral meatus. An adhesive is applied to the body to provide a sealing engagement with the urethral meatus. In a first embodiment, the body has a base that seats against the floor of the vestibule, and a pair of flexible, lateral flaps that engage the labia minora. A layer of adhesive is applied to the base. A layer of highly-absorbant, hydrophilic material may be situated between the base and the adhesive layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second embodiment, the body is substantially tubular, with the adhesive applied to the exterior surface of the body. In the first and second embodiments, the body is preferably formed of a biodegradable material. In a third embodiment, the body is a flexible bladder or sac, filled with a suitable liquid or gel, that conformingly fits between the labia minora and the floor of the vestibule so as to occlude the urethral meatus. The exterior surface of the bladder is coated with an adhesive to provide a sealing engagement with the meatus. In all embodiments, the preferred adhesive is a mixture of poly 2-hydroxyethyl methacrylate and polyethylene glycol.
摘要翻译：用于管理人类女性尿失禁的装置包括弹性体，弹性体适于适应阴唇小阴唇和外阴前庭的地板之间，从而封闭尿道口。将粘合剂施加到身体以提供与尿道口的密封接合。在第一实施例中，身体具有抵靠前庭地板的基部和与小阴唇接合的一对柔性侧片。将一层粘合剂施加到基底上。一层高吸收性亲水材料可以位于基底和粘合剂层之间，和/或一层稀松布材料可以如此定位。主体可以具有纵向脊，其后边缘具有指孔，以便于装置的安装和拆卸。在第二实施例中，主体基本上是管状的，其中粘合剂施加到主体的外表面。在第一和第二实施例中，主体优选地由生物可降解材料形成。在第三实施例中，身体是柔性膀胱或囊，填充有合适的液体或凝胶，其适形地配合在小阴唇和前庭的地板之间，以封闭尿道口。膀胱的外表面涂覆有粘合剂以提供与口腔的密封接合。在所有实施方案中，优选的粘合剂是聚2-羟乙基甲基丙烯酸酯和聚乙二醇的混合物。

8. 发明授权

US5312430A Balloon dilation catheter 失效
标题翻译：气球扩张导管
公开(公告)号：US5312430A
公开(公告)日：1994-05-17
申请号：US722899
申请日：1991-06-28
申请人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Barry M. Calvarese
发明人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Barry M. Calvarese
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61K49/00 , A61K51/04 , A61K51/12 , A61M25/10 , A61M29/02 , G01N33/574 , A61M5/00
CPC分类号： A61K51/1206 , A61F2/958 , A61K51/0485 , A61M25/1011 , A61M29/02 , G01N33/57423 , A61F2002/30187 , A61F2002/9583 , A61F2230/0034 , A61K2121/00 , A61K2123/00 , A61M2025/0004 , A61M2025/0008 , A61M2025/1072
摘要： Disclosed is an apparatus and method for the treatment of the symptoms of obstructive prostatism. The apparatus comprises an expandable dilation catheter and preferably an axially elongate sheath, adapted for transurethral insertion via the external opening of the urethra. The sheath is ellipsoid in cross-section, and provides an initial path through which the catheter and a standard cystoscope lens is guided. The dilation catheter or the sheath are provided with a non-radiological locating means for positioning the dilation portion of the catheter with respect to an anatomical landmark. Once the catheter has been properly positioned with respect to both the bladder neck and the sphincter, the dilation balloon may be inflated to force open the affected prostatic urethra and eliminate the obstruction.
摘要翻译：公开了一种治疗阻塞性前列腺症症状的装置和方法。该装置包括可膨胀的扩张导管，优选地是轴向细长的护套，适于经由尿道的外部开口经尿道插入。护套是椭圆形的横截面，并且提供了导管和标准的膀胱镜镜片被引导通过的初始路径。扩张导管或护套设置有非放射性定位装置，用于相对于解剖学标记定位导管的扩张部分。一旦导管已经相对于膀胱颈和括约肌适当地定位，则膨胀气球可以被充气以迫使打开受影响的前列腺尿道并消除阻塞。

9. 发明授权

US5002558A Adjustable urethral catheter and method for treating obstructive prostatism 失效
标题翻译：可调尿道导管及治疗阻塞性前列腺炎的方法
公开(公告)号：US5002558A
公开(公告)日：1991-03-26
申请号：US397579
申请日：1989-08-23
申请人： Lester A. Klein , Robert F. Rosenbluth , Jay A. Lenker , Barry M. Calvarese
发明人： Lester A. Klein , Robert F. Rosenbluth , Jay A. Lenker , Barry M. Calvarese
IPC分类号： A61F2/958 , A61M29/02
CPC分类号： A61M29/02 , A61M25/1002 , A61M2025/1068
摘要： A urethral catheter having an adjustable dilating balloon length for dilating a prostatic urethra and a method for using same. The device includes a catheter to which a Foley balloon is affixed at the distal end, and to which a dilating balloon is annularly affixed, and includes means to independently expand and contract the balloons. Concentrically encompassing the catheter is a sheath or ring, which in one embodiment slides along the outside of the catheter. With the method of the present invention, the affected prostatic urethra is measured using a cystoscope and a calibrated catheter or other known measurement means. The sheath of an adjustable catheter of one embodiment of the present invention is set to the measured length by covering a portion of the dilating balloon with the sheath. The dilating catheter is inserted through the urethra until the balloon at the distal end is located within the bladder, at which point it is inflated and the dilating catheter is anchored in position. Then the dilating balloon is inflated to force the prostate away from the urethra. The dilating balloon may be left in place for periods of up to an hour or more to optimize the dilation effect, at which point the balloons are deflated and the dilating catheter is removed. With a further embodiment, the length of the dilating balloon is adjusted by severing portions of an adjustable length sheath to expose the length of balloon desired.
摘要翻译：具有用于扩张前列腺尿道的可调节扩张球囊长度的尿道导管及其使用方法。该装置包括导管，其中Foley气球被固定在远端，并且扩张气囊环形固定到该导管，并且包括用于独立地膨胀和收缩气囊的装置。集中包围导管是护套或环，其在一个实施例中沿着导管的外部滑动。利用本发明的方法，使用膀胱镜和校准的导管或其他已知的测量手段来测量受影响的前列腺尿道。通过用护套覆盖一部分扩张球囊，将本发明的一个实施例的可调节导管的护套设定为测量的长度。扩张导管穿过尿道插入，直到远端的球囊位于膀胱内，此时充气，扩张导管固定在适当的位置。然后扩张气囊被充气以迫使前列腺远离尿道。扩张气球可以留在适当位置达一个小时或更长的时间以优化扩张效果，此时气囊被放气并且扩张导管被去除。在另一个实施例中，通过切断可调节长度护套的部分来调节扩张气囊的长度以暴露所需球囊的长度。

10. 发明授权

US5527336A Flow obstruction treatment method 失效
标题翻译：流阻治疗方法
公开(公告)号：US5527336A
公开(公告)日：1996-06-18
申请号：US398049
申请日：1995-03-02
申请人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Barry M. Calvarese
发明人： Robert F. Rosenbluth , Jay A. Lenker , George R. Greene , Barry M. Calvarese
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61M25/10 , A61M29/02 , A61M29/00
CPC分类号： A61F2/958 , A61M25/1011 , A61M29/02 , A61F2002/30187 , A61F2002/9583 , A61F2230/0034 , A61M2025/0004 , A61M2025/1072
摘要： Disclosed is an apparatus and method for the treatment of the symptoms of obstructive prostatism. The apparatus comprises an expandable dilation catheter and preferably an axially elongate sheath, adapted for transurethral insertion via the external opening of the urethra. The sheath is ellipsoid in cross-section, and provides an initial path through which the catheter and a standard cystoscope lens is guided. The dilation catheter or the sheath are provided with a non-radiological locating means for positioning the dilation portion of the catheter with respect to an anatomical landmark. Once the catheter has been properly positioned with respect to both the bladder neck and the sphincter, the dilation balloon may be inflated to force open the affected prostatic urethra and eliminate the obstruction.
摘要翻译：公开了一种治疗阻塞性前列腺症症状的装置和方法。该装置包括可膨胀的扩张导管，优选地是轴向细长的护套，适于经由尿道的外部开口经尿道插入。护套是椭圆形的横截面，并且提供了导管和标准的膀胱镜镜片被引导通过的初始路径。扩张导管或护套设置有非放射性定位装置，用于相对于解剖学标记定位导管的扩张部分。一旦导管已经相对于膀胱颈和括约肌适当地定位，则膨胀气球可以被充气以迫使打开受影响的前列腺尿道并消除阻塞。

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