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1. 发明授权

US08039007B2 Polypeptides from Neisseria meningitidis 失效
标题翻译：脑膜炎奈瑟菌多肽
公开(公告)号：US08039007B2
公开(公告)日：2011-10-18
申请号：US12306920
申请日：2007-06-29
申请人： Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
发明人： Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
IPC分类号： A61K39/095 , C07H21/04 , C07K14/22
CPC分类号： C07K14/22 , A61K38/00
摘要： Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
摘要翻译：公开了各种特定的脑膜炎球菌蛋白质。本发明提供了相关多肽，核酸，抗体和方法。这些都可以用于治疗或预防脑膜炎球菌引起的疾病和/或感染的药物，例如细菌性脑膜炎。

2. 发明申请

US20060166344A1 Bacterial outer memberane vesicles 审中-公开
标题翻译：细菌外囊泡
公开(公告)号：US20060166344A1
公开(公告)日：2006-07-27
申请号：US10526113
申请日：2003-09-01
申请人： Mariagrazia Pizza , Davide Serruto , Rino Rappuoli
发明人： Mariagrazia Pizza , Davide Serruto , Rino Rappuoli
IPC分类号： C12N9/00
CPC分类号： A61K39/095 , A61K2039/55555 , C07K14/22 , C12N1/06 , C12N1/20 , C12N13/00
摘要： Existing methods of meningococcal OMV preparation involve the use of detergent during disruption of the bacterial membrane. According to the invention, membrane disruption is performed substantially in the absence of detergent. The resulting OMVs which retain important bacterial immunogenic components, particularly (i) the protective NspA surface protein, (ii) protein NMB2132 and (iii) protein NMB 1870. A Typical process involves the following steps: (a) treating bacterial cells in the substantial absence of detergent; (b) centrifuging the composition from step (a) to separate the outer membrane vesicles from treated cells and cell debris, and collecting the supernatant; (c) performing a high speed centrifugation of the supernatant from step (b) and collecting the outer membrane vesicles in a pellet; (d) re-dispersing the pellet from step (c) in a buffer; (e) performing a second high speed centrifugation in accordance with step (c), collecting the outer membrane vesicles in a pellet; (f) re-dispersing the pellet from step (e) in an aqueous medium.
摘要翻译：脑膜炎球菌OMV制剂的现有方法涉及在细菌膜破坏期间使用洗涤剂。根据本发明，膜破坏基本上在没有洗涤剂的情况下进行。所产生的OMV保留了重要的细菌免疫原性成分，特别是（i）保护性NspA表面蛋白，（ii）蛋白NMB2132和（iii）蛋白NMB1870。典型的方法包括以下步骤：（a）不含洗涤剂; （b）将来自步骤（a）的组合物离心以将外膜囊泡与经处理的细胞和细胞碎片分离，并收集上清液; （c）对来自步骤（b）的上清液进行高速离心并将颗粒中的外膜囊泡收集; （d）将来自步骤（c）的沉淀物重新分散在缓冲液中; （e）根据步骤（c）进行第二高速离心，将外膜囊泡收集在颗粒中; （f）将来自步骤（e）的沉淀物重新分散在水性介质中。

3. 发明申请

US20120027801A1 POLYPEPTIDES FROM NEISSERIA MENINGITIDIS 失效
标题翻译：来自NEISSERIA MENINGITIDIS的多糖
公开(公告)号：US20120027801A1
公开(公告)日：2012-02-02
申请号：US13272982
申请日：2011-10-13
申请人： Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
发明人： Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
IPC分类号： A61K39/095 , C07K7/06 , A61P37/04 , C07K16/12 , C07H21/04 , A61K38/16 , C07K14/22 , C07K7/08
CPC分类号： C07K14/22 , A61K38/00
摘要： Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
摘要翻译：公开了各种特定的脑膜炎球菌蛋白质。本发明提供了相关多肽，核酸，抗体和方法。这些都可以用于治疗或预防脑膜炎球菌引起的疾病和/或感染的药物，例如细菌性脑膜炎。

4. 发明授权

US08491918B2 Polypeptides from Neisseria meningitidis 失效
标题翻译：脑膜炎奈瑟菌多肽
公开(公告)号：US08491918B2
公开(公告)日：2013-07-23
申请号：US13272982
申请日：2011-10-13
申请人： Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
发明人： Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
IPC分类号： A61K39/095 , C07H21/04 , C07K14/22
CPC分类号： C07K14/22 , A61K38/00
摘要： Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
摘要翻译：公开了各种特定的脑膜炎球菌蛋白质。本发明提供了相关多肽，核酸，抗体和方法。这些都可以用于治疗或预防脑膜炎球菌引起的疾病和/或感染的药物，例如细菌性脑膜炎。

5. 发明授权

US09259462B2 Developments in meningococcal outer membrane vesicles 有权
标题翻译：脑膜炎球菌外膜囊泡的发展
公开(公告)号：US09259462B2
公开(公告)日：2016-02-16
申请号：US13822238
申请日：2011-09-09
申请人： Davide Serruto , Mariagrazia Pizza , Isabel Delany
发明人： Davide Serruto , Mariagrazia Pizza , Isabel Delany
IPC分类号： A61K39/02 , A61K39/095 , C07K14/22 , C12N1/20 , C12N1/38 , A61K39/00
CPC分类号： A61K39/095 , A61K2039/523 , C07K14/22 , C12N1/20 , C12N1/38 , C12N9/1085 , C12Y205/01072
摘要： A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant of an antigen of interest.
摘要翻译：本发明的第一方面提供脑膜炎球菌外膜囊泡，其中NHBA过度表达。本发明的第二方面提供其中NadA过度表达的脑膜炎球菌外膜囊泡。本发明的第三方面提供了一组细菌菌株，其每个成员都是同基因的，除了在每个菌株中编码感兴趣抗原的不同变体的单个基因。

6. 发明授权

US09636393B2 Compositions comprising Neisseria meningitidis antigens from serogroups B and C 有权
公开(公告)号：US09636393B2
公开(公告)日：2017-05-02
申请号：US10148533
申请日：2000-11-29
申请人： Marzia Monica Giuliani , Mariagrazia Pizza , Rino Rappuoli
发明人： Marzia Monica Giuliani , Mariagrazia Pizza , Rino Rappuoli
IPC分类号： A61K39/095 , A61K39/00 , A61K39/42 , A61K47/48 , A61K39/116
CPC分类号： A61K39/095 , A61K39/116 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068
摘要： International patent application WO99/61053 discloses immunogenic compositions that comprise N. meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N. meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae, DTP, HBV, etc.).

7. 发明授权

US08398999B2 Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870 有权
公开(公告)号：US08398999B2
公开(公告)日：2013-03-19
申请号：US13556139
申请日：2012-07-23
申请人： Vega Masignani , Maria Scarselli , Rino Rappuoli , Mariagrazia Pizza , Marzia Monica Giuliani
发明人： Vega Masignani , Maria Scarselli , Rino Rappuoli , Mariagrazia Pizza , Marzia Monica Giuliani
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.

8. 发明申请

US20130064846A1 NEISSERIAL ANTIGENS 审中-公开
标题翻译： NEISSERIAL抗原
公开(公告)号：US20130064846A1
公开(公告)日：2013-03-14
申请号：US13593464
申请日：2012-08-23
申请人： Vincenzo SCARLATO , Vega Masignani , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
发明人： Vincenzo SCARLATO , Vega Masignani , Rino Rappuoli , Mariagrazia Pizza , Guido Grandi
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译：本发明提供脑膜炎奈瑟菌（A＆B）菌株和来自淋病奈瑟氏球菌的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。

9. 发明授权

US08226960B2 Chimeric, hybrid and tandem polypeptides of meningococcal NMB1870 有权
标题翻译：脑膜炎球菌NMB1870的嵌合，杂交和串联多肽
公开(公告)号：US08226960B2
公开(公告)日：2012-07-24
申请号：US12085413
申请日：2006-11-27
申请人： Vega Masignani , Maria Scarselli , Rino Rappuoli , Mariagrazia Pizza , Marzia Monica Giuliani
发明人： Vega Masignani , Maria Scarselli , Rino Rappuoli , Mariagrazia Pizza , Marzia Monica Giuliani
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。序列可以从一个NMB1870家族代替到另一个家族的相应位置。来自不同家族的NMB1870序列的蛋白质可以彼此连接。

10. 发明申请

US20120135024A1 NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS 有权
公开(公告)号：US20120135024A1
公开(公告)日：2012-05-31
申请号：US13070448
申请日：2011-03-23
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61P31/04 , C07K7/08 , A61P37/02 , C07K14/22 , C07K7/06
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

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