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1. 发明授权

US06306567B1 Aggregated dyes for radiation-sensitive elements 失效
标题翻译：用于辐射敏感元件的聚集染料
公开(公告)号：US06306567B1
公开(公告)日：2001-10-23
申请号：US09731447
申请日：2000-12-07
申请人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
发明人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
IPC分类号： G03C173
CPC分类号： G03C1/832 , C09B67/008
摘要： A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption half bandwidth of less than 55 nm.
摘要翻译：一种分散体，其包含其中分散有式（I）的聚集染料的水性介质：其中X是氧或硫; R 1 -R 4各自独立地表示未取代或取代的烷基，未取代或取代的芳基或未取代或取代的杂芳基; L1，L2和L3各自独立地表示取代或未取代的次甲基; M +表示质子或无机或有机阳离子; 并且n为0,1,2或3，并且其中所述分散体中的聚集染料的吸收半值带宽小于55nm。

2. 发明授权

US06291149B1 Aggregated dyes for radiation-sensitive elements 失效
公开(公告)号：US06291149B1
公开(公告)日：2001-09-18
申请号：US09733787
申请日：2000-12-07
申请人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
发明人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
IPC分类号： G03C173
CPC分类号： G03C1/832 , C09B67/008
摘要： A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption halfbandwidth of less than 55 nm.

3. 发明授权

US5922523A Filter dyes for photographic elements 失效
标题翻译：用于照相元件的滤色染料
公开(公告)号：US5922523A
公开(公告)日：1999-07-13
申请号：US565460
申请日：1995-11-30
申请人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo
发明人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo
IPC分类号： G03C1/83
CPC分类号： G03C1/832
摘要： A photographic element contains a filter dye of the Formula (I): ##STR1## wherein R.sup.1 -R.sup.4 each independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group; L.sup.1, L.sup.2 and L.sup.3 each independently represent substituted or unsubstituted methine groups; M.sup.+ represents a proton or an inorganic or organic cation.
摘要翻译：照相元件含有式（I）的滤色剂：其中R 1 -R 4各自独立地表示取代或未取代的烷基，取代或未取代的芳基或取代或未取代的杂芳基; L1，L2和L3各自独立地表示取代或未取代的次甲基; M +表示质子或无机或有机阳离子。

4. 发明授权

US06300046B1 Aggregated dyes for radiation-sensitive elements 失效
公开(公告)号：US06300046B1
公开(公告)日：2001-10-09
申请号：US09731448
申请日：2000-12-07
申请人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
发明人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
IPC分类号： G03C173
CPC分类号： G03C1/832 , C09B67/008
摘要： A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption halfbandwidth of less than 55 nm.

5. 发明授权

US06342339B2 Aggregated dyes for radiation-sensitive elements 失效
标题翻译：用于辐射敏感元件的聚集染料
公开(公告)号：US06342339B2
公开(公告)日：2002-01-29
申请号：US09733786
申请日：2000-12-07
申请人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
发明人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
IPC分类号： G03C173
CPC分类号： G03C1/832 , C09B67/008
摘要： A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption halfbandwidth of less than 55 nm.
摘要翻译：一种分散体，其包含其中分散有式（I）的聚集染料的水性介质：其中X是氧或硫; R 1 -R 4各自独立地表示未取代或取代的烷基，未取代或取代的芳基或未取代或取代的杂芳基; L1，L2和L3各自独立地表示取代或未取代的次甲基; M +表示质子或无机或有机阳离子; 并且n为0,1,2或3，并且其中所述分散体中的聚集染料的吸收半带宽小于55nm。

6. 发明授权

US06183944B2 Aggregated dyes for radiation-sensitive elements 失效
标题翻译：用于辐射敏感元件的聚集染料
公开(公告)号：US06183944B2
公开(公告)日：2001-02-06
申请号：US08565480
申请日：1995-11-30
申请人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
发明人： Margaret Jones Helber , William James Harrison , Elizabeth Ann Gallo , Mary Christine Brick , Steven Wade Kortum , Gary Norman Barber
IPC分类号： G03C173
CPC分类号： G03C1/832 , C09B67/008
摘要： A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption halfbandwidth of less than 55 nm.
摘要翻译：一种分散体，其包含其中分散有式（I）的聚集染料的水性介质：其中X是氧或硫; R 1 -R 4各自独立地表示未取代或取代的烷基，未取代或取代的芳基或未取代或取代的杂芳基; L1，L2和L3各自独立地表示取代或未取代的次甲基; M +表示质子或无机或有机阳离子; 并且n为0,1,2或3，并且其中所述分散体中的聚集染料的吸收半带宽小于55nm。

7. 发明申请

US20110054495A1 DEVICE FOR DELIVERING A CLIP WITHIN A PATIENT 审中-公开
标题翻译：用于在病人身上传送夹子的装置
公开(公告)号：US20110054495A1
公开(公告)日：2011-03-03
申请号：US12549104
申请日：2009-08-27
申请人： Tatyana Ventura , William James Harrison
发明人： Tatyana Ventura , William James Harrison
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/068 , A61B17/083 , A61B17/10 , A61B2017/00004 , A61B2017/00296 , A61B2017/00336 , A61B2017/00477 , A61B2017/00623 , A61B2017/0065 , A61B2017/00659 , A61B2017/00668 , A61B2017/0641
摘要： The invention generally relates to a system for closing an aperture in a patient, such as an aperture in a vessel wall of a patient. In certain embodiments, the invention provides a system for closing an aperture in a patient including a delivery device that is attachable to and removable from an exterior of an introducer sheath, and a clip releasably disposed within the delivery device.
摘要翻译：本发明一般涉及一种用于封闭患者中的孔的系统，例如患者的血管壁中的孔。在某些实施例中，本发明提供了一种用于封闭患者中的孔的系统，包括能够从引导器护套的外部附接和移除的输送装置，以及可释放地设置在输送装置内的夹子。

8. 发明申请

US20100034748A1 Molecular imaging probes based on loaded reactive nano-scale latex 审中-公开
标题翻译：基于负载的反应性纳米级胶乳的分子成像探针
公开(公告)号：US20100034748A1
公开(公告)日：2010-02-11
申请号：US12221839
申请日：2008-08-07
申请人： Guizhi Li , John William Harder , William James Harrison
发明人： Guizhi Li , John William Harder , William James Harrison
IPC分类号： A61K49/18 , C08K5/3417 , B32B1/00 , A61K49/04
CPC分类号： A61K49/0032 , A61K49/0093 , C08K5/34 , C08K5/55 , Y10T428/2982 , C08L33/14
摘要： The present invention relates to a loaded reactive nanoscale latex particle synthesized from mixture of monomers containing water insoluble monomers, at least two ethylenically functionalities monomers, halo-aromatic-polyethyleneglycol-methacrylate, polyethyleneglycolacrylate containing macromonomers, and up to 10 wt % other ethylenic monomers different from above monomers. The reactive halo-aromatic groups on the surface of latex particle are servable as linkers to react with peptides, antibodies, nucleic acids, ligands or other biomolecules.
摘要翻译：本发明涉及由含有水不溶性单体，至少两种烯键式官能团单体，卤代芳族聚乙二醇 - 甲基丙烯酸酯，含聚乙二醇丙烯酸酯的大分子单体和至多10重量％的其它乙烯单体的混合物的混合物合成的负载的反应性纳米尺寸胶乳颗粒从上述单体。胶乳颗粒表面上的反应性卤代芳族基团可作为接头与肽，抗体，核酸，配体或其他生物分子反应。

9. 发明申请

US20120172655A1 IMPELLER HOUSING FOR PERCUTANEOUS HEART PUMP 有权
标题翻译：用于心脏心脏泵的叶轮外壳
公开(公告)号：US20120172655A1
公开(公告)日：2012-07-05
申请号：US13343617
申请日：2012-01-04
申请人： Robert L. Campbell , Keif Fitzgerald , William James Harrison , Boris Leschinsky , Thomas M. Mallison , Mark W. McBride , Adam Roslund , Daniel A. Walters , Phyllis Yuen
发明人： Robert L. Campbell , Keif Fitzgerald , William James Harrison , Boris Leschinsky , Thomas M. Mallison , Mark W. McBride , Adam Roslund , Daniel A. Walters , Phyllis Yuen
IPC分类号： A61M1/10 , A61M25/00
CPC分类号： A61M25/04 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1024 , A61M1/1034 , A61M1/122 , A61M1/125 , A61M2025/0024 , A61M2025/0096
摘要： Disclosed herein are heart pumps that include a catheter assembly and that can be applied percutaneously. Some embodiments include a locking device that prevents components of the catheter assembly from being separated when in use. The catheter assembly can include an expandable tip. In some embodiments, the catheter assembly includes a housing having a wall structure, a portion of which can have a bulbuous shape or can be deformable. In other embodiments, the housing can be configured to reduce fluttering or deflection of the housing and/or to maintain a gap between the housing and an impeller blade disposed therein.
摘要翻译：本文公开了包括导管组件并且可以经皮应用的心脏泵。一些实施例包括锁定装置，其防止导管组件的组件在使用时被分离。导管组件可包括可扩张尖端。在一些实施例中，导管组件包括具有壁结构的壳体，其一部分可具有球形形状或可变形。在其他实施例中，壳体可以被配置为减少壳体的颤动或偏转和/或在壳体和设置在其中的叶轮叶片之间保持间隙。

10. 发明申请

US20090082843A1 SELF-EXPANDING STENT WITH ENHANCED DELIVERY PRECISION AND STENT DELIVERY SYSTEM 有权
标题翻译：具有增强的交付精度和STENT交付系统的自我扩张
公开(公告)号：US20090082843A1
公开(公告)日：2009-03-26
申请号：US12238219
申请日：2008-09-25
申请人： Daniel L. Cox , Matthew J. Fitz , William James Harrison , Michael D. Schultz , Joseph A. Ventura
发明人： Daniel L. Cox , Matthew J. Fitz , William James Harrison , Michael D. Schultz , Joseph A. Ventura
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2002/9517 , A61F2230/0013
摘要： The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent. The proximal end of the outer tubular member is attached to a pull-back handle which is slidably mounted on the base of the housing assembly. When the pull-back handle is retracted, the restraining sheath is retracted to deploy the sheath, while the inner tubular member remains stationary.
摘要翻译：本发明涉及用于植入体腔如动脉的自扩张支架。支架由多个可径向扩张的圆柱形元件组成，通常在共同的纵向支架轴线上对准并且通过以共线布置放置在支架上的多个互连构件相互连接，以产生至少一个连续的脊柱，其沿着支架本发明还涉及用于将支架植入容器中的支架输送系统，该支架包括具有约束护套的外管状构件和具有安装在其上的压缩支架的远端的内管状构件。内部管状构件的近端连接到壳体组件，当外部管状构件缩回以展开支架时，壳体组件防止内部管状构件移动。外管状构件的近端附接到可滑动地安装在壳体组件的基部上的拉回手柄。当拉回手柄缩回时，约束护套被缩回以展开护套，同时内部管状构件保持静止。

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